Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INZ4_LEIDO

TriTrypDb:

LdBPK_260600.1 , LdCL_260011700 , LDHU3_26.0800

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8INZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INZ4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006633	fatty acid biosynthetic process	5	3
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072330	monocarboxylic acid biosynthetic process	6	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016790	thiolester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.511
CLV_C14_Caspase3-7	80	84	PF00656	0.542
CLV_C14_Caspase3-7	93	97	PF00656	0.397
CLV_NRD_NRD_1	253	255	PF00675	0.390
CLV_NRD_NRD_1	310	312	PF00675	0.362
CLV_PCSK_KEX2_1	172	174	PF00082	0.412
CLV_PCSK_KEX2_1	253	255	PF00082	0.410
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.458
CLV_PCSK_SKI1_1	283	287	PF00082	0.388
DEG_APCC_DBOX_1	172	180	PF00400	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.408
DEG_SPOP_SBC_1	357	361	PF00917	0.511
DOC_ANK_TNKS_1	2	9	PF00023	0.505
DOC_CKS1_1	162	167	PF01111	0.556
DOC_CKS1_1	50	55	PF01111	0.542
DOC_CKS1_1	58	63	PF01111	0.613
DOC_MAPK_FxFP_2	331	334	PF00069	0.448
DOC_MAPK_gen_1	396	405	PF00069	0.428
DOC_MAPK_RevD_3	299	312	PF00069	0.507
DOC_PP2B_LxvP_1	227	230	PF13499	0.607
DOC_PP4_FxxP_1	102	105	PF00568	0.606
DOC_PP4_FxxP_1	331	334	PF00568	0.448
DOC_USP7_MATH_1	211	215	PF00917	0.542
DOC_USP7_MATH_1	6	10	PF00917	0.453
DOC_USP7_MATH_2	71	77	PF00917	0.528
DOC_USP7_UBL2_3	182	186	PF12436	0.570
DOC_WW_Pin1_4	161	166	PF00397	0.576
DOC_WW_Pin1_4	222	227	PF00397	0.628
DOC_WW_Pin1_4	369	374	PF00397	0.522
DOC_WW_Pin1_4	49	54	PF00397	0.529
DOC_WW_Pin1_4	57	62	PF00397	0.595
LIG_14-3-3_CanoR_1	197	205	PF00244	0.535
LIG_14-3-3_CanoR_1	398	404	PF00244	0.476
LIG_Actin_WH2_2	244	261	PF00022	0.522
LIG_APCC_Cbox_2	397	403	PF00515	0.488
LIG_BRCT_BRCA1_1	206	210	PF00533	0.430
LIG_Clathr_ClatBox_1	276	280	PF01394	0.382
LIG_Clathr_ClatBox_1	332	336	PF01394	0.400
LIG_EVH1_2	231	235	PF00568	0.376
LIG_FHA_1	272	278	PF00498	0.464
LIG_FHA_1	358	364	PF00498	0.652
LIG_FHA_1	370	376	PF00498	0.649
LIG_FHA_1	382	388	PF00498	0.438
LIG_FHA_1	400	406	PF00498	0.436
LIG_FHA_1	408	414	PF00498	0.499
LIG_FHA_2	133	139	PF00498	0.486
LIG_FHA_2	259	265	PF00498	0.437
LIG_FHA_2	50	56	PF00498	0.519
LIG_FHA_2	78	84	PF00498	0.539
LIG_IBAR_NPY_1	97	99	PF08397	0.448
LIG_LIR_Apic_2	101	105	PF02991	0.525
LIG_LIR_Apic_2	328	334	PF02991	0.458
LIG_LIR_Nem_3	114	120	PF02991	0.353
LIG_LIR_Nem_3	125	130	PF02991	0.349
LIG_LIR_Nem_3	85	91	PF02991	0.366
LIG_LIR_Nem_3	96	102	PF02991	0.415
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.362
LIG_Pex14_2	147	151	PF04695	0.412
LIG_PTB_Apo_2	121	128	PF02174	0.384
LIG_PTB_Apo_2	35	42	PF02174	0.467
LIG_PTB_Phospho_1	121	127	PF10480	0.470
LIG_SH2_CRK	130	134	PF00017	0.383
LIG_SH2_CRK	224	228	PF00017	0.645
LIG_SH2_CRK	293	297	PF00017	0.508
LIG_SH2_STAP1	293	297	PF00017	0.501
LIG_SH2_STAT5	118	121	PF00017	0.434
LIG_SH2_STAT5	134	137	PF00017	0.497
LIG_SH2_STAT5	317	320	PF00017	0.401
LIG_SH2_STAT5	39	42	PF00017	0.491
LIG_SH2_STAT5	79	82	PF00017	0.640
LIG_SH3_1	182	188	PF00018	0.500
LIG_SH3_2	334	339	PF14604	0.499
LIG_SH3_3	13	19	PF00018	0.377
LIG_SH3_3	182	188	PF00018	0.492
LIG_SH3_3	234	240	PF00018	0.477
LIG_SH3_3	296	302	PF00018	0.527
LIG_SH3_3	331	337	PF00018	0.469
LIG_SH3_3	382	388	PF00018	0.459
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.420
LIG_SUMO_SIM_par_1	274	280	PF11976	0.462
LIG_TRFH_1	102	106	PF08558	0.599
LIG_WRC_WIRS_1	148	153	PF05994	0.430
LIG_WW_3	104	108	PF00397	0.529
MOD_CAAXbox	411	414	PF01239	0.528
MOD_CK1_1	109	115	PF00069	0.330
MOD_CK1_1	125	131	PF00069	0.435
MOD_CK1_1	225	231	PF00069	0.623
MOD_CK1_1	82	88	PF00069	0.493
MOD_CK2_1	175	181	PF00069	0.476
MOD_CK2_1	49	55	PF00069	0.445
MOD_GlcNHglycan	111	114	PF01048	0.351
MOD_GlcNHglycan	181	185	PF01048	0.542
MOD_GlcNHglycan	206	209	PF01048	0.423
MOD_GlcNHglycan	213	216	PF01048	0.486
MOD_GlcNHglycan	227	230	PF01048	0.648
MOD_GlcNHglycan	349	352	PF01048	0.617
MOD_GlcNHglycan	7	11	PF01048	0.355
MOD_GSK3_1	147	154	PF00069	0.403
MOD_GSK3_1	171	178	PF00069	0.514
MOD_GSK3_1	211	218	PF00069	0.510
MOD_GSK3_1	321	328	PF00069	0.447
MOD_GSK3_1	342	349	PF00069	0.498
MOD_GSK3_1	73	80	PF00069	0.696
MOD_N-GLC_1	123	128	PF02516	0.382
MOD_N-GLC_1	211	216	PF02516	0.579
MOD_N-GLC_2	38	40	PF02516	0.466
MOD_NEK2_1	147	152	PF00069	0.386
MOD_NEK2_1	204	209	PF00069	0.434
MOD_NEK2_1	235	240	PF00069	0.476
MOD_NEK2_1	399	404	PF00069	0.470
MOD_PIKK_1	171	177	PF00454	0.439
MOD_PKA_2	106	112	PF00069	0.482
MOD_PKA_2	196	202	PF00069	0.544
MOD_PKA_2	258	264	PF00069	0.386
MOD_Plk_1	123	129	PF00069	0.382
MOD_Plk_1	211	217	PF00069	0.478
MOD_Plk_1	28	34	PF00069	0.358
MOD_Plk_1	82	88	PF00069	0.433
MOD_Plk_4	125	131	PF00069	0.488
MOD_Plk_4	132	138	PF00069	0.502
MOD_Plk_4	82	88	PF00069	0.428
MOD_ProDKin_1	161	167	PF00069	0.577
MOD_ProDKin_1	222	228	PF00069	0.628
MOD_ProDKin_1	369	375	PF00069	0.503
MOD_ProDKin_1	49	55	PF00069	0.532
MOD_ProDKin_1	57	63	PF00069	0.603
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.374
TRG_ENDOCYTIC_2	130	133	PF00928	0.380
TRG_ENDOCYTIC_2	134	137	PF00928	0.497
TRG_ENDOCYTIC_2	224	227	PF00928	0.643
TRG_ENDOCYTIC_2	293	296	PF00928	0.507
TRG_ENDOCYTIC_2	99	102	PF00928	0.566
TRG_NES_CRM1_1	376	391	PF08389	0.504
TRG_NLS_MonoExtC_3	310	316	PF00514	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG55	Leptomonas seymouri	58%	97%
A0A0S4JK14	Bodo saltans	25%	93%
A0A1X0NSG4	Trypanosomatidae	36%	100%
A0A3R7M5A1	Trypanosoma rangeli	36%	100%
A4HER8	Leishmania braziliensis	75%	100%
A4I1Z5	Leishmania infantum	100%	100%
C9ZS19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AY42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9D1	Leishmania major	91%	100%
V5B9E8	Trypanosoma cruzi	36%	100%