Alpha/beta hydrolase family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8INV4_LEIDO

TriTrypDb:

LdBPK_343950.1 , LdCL_340048900 , LDHU3_34.6260

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8INV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.402
CLV_NRD_NRD_1	175	177	PF00675	0.451
CLV_PCSK_KEX2_1	139	141	PF00082	0.402
CLV_PCSK_KEX2_1	175	177	PF00082	0.568
CLV_PCSK_SKI1_1	165	169	PF00082	0.487
CLV_PCSK_SKI1_1	235	239	PF00082	0.481
CLV_Separin_Metazoa	136	140	PF03568	0.391
DEG_Nend_UBRbox_2	1	3	PF02207	0.507
DOC_MAPK_gen_1	228	236	PF00069	0.504
DOC_MAPK_MEF2A_6	228	236	PF00069	0.492
DOC_PP2B_LxvP_1	105	108	PF13499	0.406
DOC_PP4_FxxP_1	204	207	PF00568	0.469
DOC_USP7_MATH_1	110	114	PF00917	0.476
DOC_USP7_MATH_1	199	203	PF00917	0.530
DOC_USP7_MATH_1	61	65	PF00917	0.496
DOC_WW_Pin1_4	195	200	PF00397	0.452
DOC_WW_Pin1_4	217	222	PF00397	0.489
DOC_WW_Pin1_4	245	250	PF00397	0.574
DOC_WW_Pin1_4	36	41	PF00397	0.416
LIG_EH1_1	131	139	PF00400	0.382
LIG_eIF4E_1	132	138	PF01652	0.422
LIG_EVH1_2	5	9	PF00568	0.337
LIG_FHA_1	113	119	PF00498	0.339
LIG_FHA_1	39	45	PF00498	0.418
LIG_FHA_2	239	245	PF00498	0.558
LIG_FHA_2	37	43	PF00498	0.418
LIG_LIR_Apic_2	202	207	PF02991	0.445
LIG_LIR_Gen_1	109	118	PF02991	0.343
LIG_LIR_Nem_3	109	114	PF02991	0.369
LIG_LIR_Nem_3	229	234	PF02991	0.472
LIG_NRBOX	21	27	PF00104	0.326
LIG_SH2_NCK_1	190	194	PF00017	0.376
LIG_SH2_STAT5	15	18	PF00017	0.462
LIG_SH2_STAT5	154	157	PF00017	0.425
LIG_SH2_STAT5	190	193	PF00017	0.434
LIG_SH2_STAT5	211	214	PF00017	0.445
LIG_SH2_STAT5	47	50	PF00017	0.488
LIG_SH2_STAT5	68	71	PF00017	0.400
LIG_SH3_1	37	43	PF00018	0.539
LIG_SH3_3	37	43	PF00018	0.411
LIG_TRAF2_1	220	223	PF00917	0.478
MOD_CDK_SPxxK_3	245	252	PF00069	0.406
MOD_CK1_1	112	118	PF00069	0.318
MOD_CK1_1	18	24	PF00069	0.369
MOD_CK1_1	202	208	PF00069	0.357
MOD_CK1_1	36	42	PF00069	0.443
MOD_CK2_1	217	223	PF00069	0.556
MOD_CK2_1	238	244	PF00069	0.557
MOD_CK2_1	36	42	PF00069	0.494
MOD_GlcNHglycan	65	68	PF01048	0.442
MOD_GSK3_1	195	202	PF00069	0.484
MOD_GSK3_1	238	245	PF00069	0.449
MOD_GSK3_1	94	101	PF00069	0.400
MOD_N-GLC_1	143	148	PF02516	0.573
MOD_N-GLC_1	26	31	PF02516	0.564
MOD_N-GLC_1	54	59	PF02516	0.365
MOD_NEK2_1	257	262	PF00069	0.504
MOD_NEK2_1	26	31	PF00069	0.520
MOD_NEK2_1	98	103	PF00069	0.358
MOD_PIKK_1	238	244	PF00454	0.537
MOD_PKA_2	181	187	PF00069	0.360
MOD_Plk_1	143	149	PF00069	0.338
MOD_Plk_1	26	32	PF00069	0.527
MOD_Plk_4	112	118	PF00069	0.178
MOD_Plk_4	150	156	PF00069	0.489
MOD_Plk_4	205	211	PF00069	0.400
MOD_Plk_4	94	100	PF00069	0.408
MOD_ProDKin_1	195	201	PF00069	0.458
MOD_ProDKin_1	217	223	PF00069	0.486
MOD_ProDKin_1	245	251	PF00069	0.567
MOD_ProDKin_1	36	42	PF00069	0.411
TRG_DiLeu_BaEn_1	164	169	PF01217	0.476
TRG_ER_diArg_1	138	140	PF00400	0.396
TRG_ER_diArg_1	174	176	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A3	Leptomonas seymouri	62%	88%
A0A0S4KLY1	Bodo saltans	30%	79%
A0A1X0PB14	Trypanosomatidae	44%	87%
A0A422NVB8	Trypanosoma rangeli	43%	85%
A4HBD5	Leishmania braziliensis	82%	100%
A4IAI3	Leishmania infantum	99%	100%
C9ZLQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	86%
E9B5K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2C9	Leishmania major	91%	100%
V5BLS2	Trypanosoma cruzi	42%	86%