Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INV1_LEIDO

TriTrypDb:

LdBPK_362590.1 , LdCL_360031900 , LDHU3_36.3540

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8INV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.509
CLV_C14_Caspase3-7	323	327	PF00656	0.576
CLV_NRD_NRD_1	106	108	PF00675	0.486
CLV_NRD_NRD_1	349	351	PF00675	0.525
CLV_NRD_NRD_1	360	362	PF00675	0.476
CLV_NRD_NRD_1	385	387	PF00675	0.461
CLV_NRD_NRD_1	420	422	PF00675	0.572
CLV_NRD_NRD_1	488	490	PF00675	0.407
CLV_PCSK_KEX2_1	106	108	PF00082	0.398
CLV_PCSK_KEX2_1	385	387	PF00082	0.461
CLV_PCSK_KEX2_1	392	394	PF00082	0.335
CLV_PCSK_KEX2_1	420	422	PF00082	0.571
CLV_PCSK_KEX2_1	488	490	PF00082	0.407
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.294
CLV_PCSK_PC7_1	381	387	PF00082	0.454
CLV_PCSK_SKI1_1	119	123	PF00082	0.340
CLV_PCSK_SKI1_1	371	375	PF00082	0.492
CLV_PCSK_SKI1_1	386	390	PF00082	0.387
CLV_PCSK_SKI1_1	451	455	PF00082	0.448
CLV_PCSK_SKI1_1	526	530	PF00082	0.374
CLV_PCSK_SKI1_1	558	562	PF00082	0.533
CLV_PCSK_SKI1_1	582	586	PF00082	0.361
CLV_Separin_Metazoa	523	527	PF03568	0.338
DEG_APCC_DBOX_1	525	533	PF00400	0.418
DEG_APCC_DBOX_1	581	589	PF00400	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.399
DOC_ANK_TNKS_1	270	277	PF00023	0.657
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.410
DOC_MAPK_gen_1	134	143	PF00069	0.382
DOC_MAPK_gen_1	392	399	PF00069	0.285
DOC_MAPK_gen_1	655	665	PF00069	0.417
DOC_MAPK_MEF2A_6	137	145	PF00069	0.389
DOC_MAPK_MEF2A_6	477	486	PF00069	0.556
DOC_MAPK_MEF2A_6	582	590	PF00069	0.395
DOC_PP1_RVXF_1	364	371	PF00149	0.436
DOC_PP1_RVXF_1	384	391	PF00149	0.345
DOC_PP2B_LxvP_1	79	82	PF13499	0.461
DOC_PP4_FxxP_1	445	448	PF00568	0.498
DOC_USP7_MATH_1	205	209	PF00917	0.432
DOC_USP7_MATH_1	315	319	PF00917	0.583
DOC_USP7_MATH_1	331	335	PF00917	0.478
DOC_USP7_MATH_1	502	506	PF00917	0.345
DOC_USP7_MATH_1	55	59	PF00917	0.436
DOC_USP7_MATH_1	74	78	PF00917	0.441
DOC_USP7_UBL2_3	362	366	PF12436	0.445
DOC_WW_Pin1_4	223	228	PF00397	0.458
DOC_WW_Pin1_4	259	264	PF00397	0.354
DOC_WW_Pin1_4	265	270	PF00397	0.458
DOC_WW_Pin1_4	404	409	PF00397	0.456
DOC_WW_Pin1_4	454	459	PF00397	0.496
DOC_WW_Pin1_4	558	563	PF00397	0.623
DOC_WW_Pin1_4	88	93	PF00397	0.583
LIG_14-3-3_CanoR_1	111	117	PF00244	0.373
LIG_14-3-3_CanoR_1	22	26	PF00244	0.517
LIG_14-3-3_CanoR_1	220	226	PF00244	0.455
LIG_14-3-3_CanoR_1	385	391	PF00244	0.405
LIG_14-3-3_CanoR_1	451	459	PF00244	0.445
LIG_14-3-3_CanoR_1	517	521	PF00244	0.394
LIG_14-3-3_CanoR_1	618	622	PF00244	0.408
LIG_14-3-3_CanoR_1	633	639	PF00244	0.472
LIG_BIR_III_2	305	309	PF00653	0.552
LIG_CtBP_PxDLS_1	458	462	PF00389	0.452
LIG_FHA_1	341	347	PF00498	0.482
LIG_FHA_1	454	460	PF00498	0.455
LIG_FHA_1	506	512	PF00498	0.401
LIG_FHA_1	58	64	PF00498	0.457
LIG_FHA_1	593	599	PF00498	0.367
LIG_FHA_1	640	646	PF00498	0.375
LIG_FHA_1	675	681	PF00498	0.520
LIG_FHA_2	321	327	PF00498	0.576
LIG_LIR_Apic_2	644	650	PF02991	0.407
LIG_LIR_Gen_1	463	468	PF02991	0.469
LIG_LIR_Nem_3	235	240	PF02991	0.434
LIG_LIR_Nem_3	24	28	PF02991	0.451
LIG_LIR_Nem_3	463	467	PF02991	0.472
LIG_LIR_Nem_3	620	624	PF02991	0.447
LIG_LYPXL_yS_3	670	673	PF13949	0.462
LIG_NRBOX	584	590	PF00104	0.390
LIG_PCNA_yPIPBox_3	172	184	PF02747	0.348
LIG_SH2_NCK_1	298	302	PF00017	0.502
LIG_SH2_NCK_1	536	540	PF00017	0.390
LIG_SH2_SRC	298	301	PF00017	0.509
LIG_SH2_SRC	536	539	PF00017	0.427
LIG_SH2_STAP1	254	258	PF00017	0.357
LIG_SH2_STAP1	479	483	PF00017	0.395
LIG_SH2_STAT5	131	134	PF00017	0.474
LIG_SH2_STAT5	170	173	PF00017	0.368
LIG_SH2_STAT5	237	240	PF00017	0.423
LIG_SH2_STAT5	68	71	PF00017	0.321
LIG_SH3_3	333	339	PF00018	0.494
LIG_SH3_3	440	446	PF00018	0.469
LIG_SH3_3	89	95	PF00018	0.536
LIG_Sin3_3	480	487	PF02671	0.305
LIG_SUMO_SIM_anti_2	512	517	PF11976	0.398
LIG_SUMO_SIM_par_1	454	463	PF11976	0.489
LIG_SUMO_SIM_par_1	58	66	PF11976	0.396
LIG_TRAF2_1	623	626	PF00917	0.429
LIG_TRFH_1	259	263	PF08558	0.456
LIG_UBA3_1	28	32	PF00899	0.450
LIG_WRC_WIRS_1	461	466	PF05994	0.483
MOD_CDC14_SPxK_1	268	271	PF00782	0.509
MOD_CDC14_SPxK_1	91	94	PF00782	0.601
MOD_CDK_SPK_2	404	409	PF00069	0.456
MOD_CDK_SPxK_1	265	271	PF00069	0.477
MOD_CDK_SPxK_1	88	94	PF00069	0.588
MOD_CK1_1	162	168	PF00069	0.516
MOD_CK1_1	208	214	PF00069	0.440
MOD_CK1_1	24	30	PF00069	0.370
MOD_CK1_1	265	271	PF00069	0.525
MOD_CK1_1	430	436	PF00069	0.533
MOD_CK1_1	460	466	PF00069	0.483
MOD_CK1_1	505	511	PF00069	0.348
MOD_CK1_1	632	638	PF00069	0.424
MOD_CK1_1	641	647	PF00069	0.379
MOD_CK1_1	8	14	PF00069	0.452
MOD_CK2_1	102	108	PF00069	0.477
MOD_CK2_1	112	118	PF00069	0.318
MOD_CK2_1	374	380	PF00069	0.458
MOD_Cter_Amidation	418	421	PF01082	0.537
MOD_GlcNHglycan	161	164	PF01048	0.507
MOD_GlcNHglycan	207	210	PF01048	0.388
MOD_GlcNHglycan	255	258	PF01048	0.361
MOD_GlcNHglycan	309	312	PF01048	0.603
MOD_GlcNHglycan	326	329	PF01048	0.496
MOD_GlcNHglycan	416	419	PF01048	0.484
MOD_GlcNHglycan	436	439	PF01048	0.439
MOD_GlcNHglycan	474	477	PF01048	0.441
MOD_GlcNHglycan	651	654	PF01048	0.383
MOD_GlcNHglycan	76	79	PF01048	0.448
MOD_GSK3_1	179	186	PF00069	0.353
MOD_GSK3_1	223	230	PF00069	0.454
MOD_GSK3_1	320	327	PF00069	0.580
MOD_GSK3_1	426	433	PF00069	0.556
MOD_GSK3_1	453	460	PF00069	0.493
MOD_GSK3_1	466	473	PF00069	0.436
MOD_GSK3_1	5	12	PF00069	0.441
MOD_GSK3_1	505	512	PF00069	0.430
MOD_GSK3_1	63	70	PF00069	0.426
MOD_GSK3_1	634	641	PF00069	0.441
MOD_GSK3_1	645	652	PF00069	0.341
MOD_N-GLC_1	502	507	PF02516	0.336
MOD_NEK2_1	136	141	PF00069	0.412
MOD_NEK2_1	21	26	PF00069	0.459
MOD_NEK2_1	412	417	PF00069	0.486
MOD_NEK2_1	453	458	PF00069	0.462
MOD_NEK2_1	545	550	PF00069	0.404
MOD_NEK2_1	598	603	PF00069	0.384
MOD_NEK2_1	638	643	PF00069	0.433
MOD_NEK2_1	675	680	PF00069	0.490
MOD_NEK2_2	502	507	PF00069	0.336
MOD_PIKK_1	208	214	PF00454	0.423
MOD_PIKK_1	262	268	PF00454	0.402
MOD_PIKK_1	545	551	PF00454	0.415
MOD_PKA_2	136	142	PF00069	0.459
MOD_PKA_2	205	211	PF00069	0.392
MOD_PKA_2	21	27	PF00069	0.510
MOD_PKA_2	516	522	PF00069	0.396
MOD_PKA_2	617	623	PF00069	0.410
MOD_PKA_2	632	638	PF00069	0.471
MOD_PKA_2	83	89	PF00069	0.516
MOD_PKA_2	93	99	PF00069	0.566
MOD_Plk_1	426	432	PF00069	0.529
MOD_Plk_1	502	508	PF00069	0.399
MOD_Plk_1	509	515	PF00069	0.402
MOD_Plk_2-3	575	581	PF00069	0.468
MOD_Plk_4	24	30	PF00069	0.596
MOD_Plk_4	331	337	PF00069	0.483
MOD_Plk_4	374	380	PF00069	0.575
MOD_Plk_4	42	48	PF00069	0.283
MOD_Plk_4	427	433	PF00069	0.555
MOD_Plk_4	502	508	PF00069	0.368
MOD_Plk_4	516	522	PF00069	0.362
MOD_Plk_4	617	623	PF00069	0.458
MOD_Plk_4	63	69	PF00069	0.436
MOD_Plk_4	675	681	PF00069	0.481
MOD_ProDKin_1	223	229	PF00069	0.459
MOD_ProDKin_1	259	265	PF00069	0.359
MOD_ProDKin_1	404	410	PF00069	0.457
MOD_ProDKin_1	454	460	PF00069	0.494
MOD_ProDKin_1	558	564	PF00069	0.625
MOD_ProDKin_1	88	94	PF00069	0.588
MOD_SUMO_for_1	31	34	PF00179	0.413
MOD_SUMO_rev_2	355	363	PF00179	0.469
TRG_DiLeu_BaEn_1	243	248	PF01217	0.369
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.348
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.366
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.490
TRG_ENDOCYTIC_2	479	482	PF00928	0.358
TRG_ENDOCYTIC_2	536	539	PF00928	0.475
TRG_ENDOCYTIC_2	670	673	PF00928	0.581
TRG_ER_diArg_1	420	422	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ6	Leptomonas seymouri	37%	100%
A4HPB2	Leishmania braziliensis	75%	100%
A4ICF2	Leishmania infantum	100%	100%
E9AT23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1H5	Leishmania major	91%	100%