Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INS4_LEIDO

TriTrypDb:

LdBPK_343550.1 , LdCL_340044900 , LDHU3_34.5800

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8INS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.457
CLV_C14_Caspase3-7	424	428	PF00656	0.741
CLV_C14_Caspase3-7	49	53	PF00656	0.617
CLV_NRD_NRD_1	287	289	PF00675	0.616
CLV_NRD_NRD_1	334	336	PF00675	0.622
CLV_NRD_NRD_1	35	37	PF00675	0.796
CLV_NRD_NRD_1	363	365	PF00675	0.742
CLV_NRD_NRD_1	402	404	PF00675	0.723
CLV_NRD_NRD_1	509	511	PF00675	0.468
CLV_PCSK_KEX2_1	149	151	PF00082	0.581
CLV_PCSK_KEX2_1	162	164	PF00082	0.436
CLV_PCSK_KEX2_1	287	289	PF00082	0.616
CLV_PCSK_KEX2_1	334	336	PF00082	0.604
CLV_PCSK_KEX2_1	365	367	PF00082	0.748
CLV_PCSK_KEX2_1	508	510	PF00082	0.493
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.617
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.412
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.748
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.493
CLV_PCSK_SKI1_1	209	213	PF00082	0.721
CLV_PCSK_SKI1_1	24	28	PF00082	0.739
CLV_PCSK_SKI1_1	403	407	PF00082	0.567
CLV_PCSK_SKI1_1	509	513	PF00082	0.698
CLV_PCSK_SKI1_1	79	83	PF00082	0.751
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_SPOP_SBC_1	312	316	PF00917	0.754
DEG_SPOP_SBC_1	80	84	PF00917	0.760
DEG_SPOP_SBC_1	93	97	PF00917	0.597
DOC_CKS1_1	25	30	PF01111	0.748
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.739
DOC_MAPK_JIP1_4	326	332	PF00069	0.654
DOC_PP2B_LxvP_1	251	254	PF13499	0.467
DOC_USP7_MATH_1	196	200	PF00917	0.734
DOC_USP7_MATH_1	216	220	PF00917	0.665
DOC_USP7_MATH_1	302	306	PF00917	0.665
DOC_USP7_MATH_1	473	477	PF00917	0.517
DOC_USP7_MATH_1	80	84	PF00917	0.720
DOC_USP7_MATH_1	9	13	PF00917	0.711
DOC_USP7_MATH_1	92	96	PF00917	0.641
DOC_USP7_UBL2_3	400	404	PF12436	0.714
DOC_USP7_UBL2_3	508	512	PF12436	0.580
DOC_WW_Pin1_4	139	144	PF00397	0.517
DOC_WW_Pin1_4	192	197	PF00397	0.788
DOC_WW_Pin1_4	24	29	PF00397	0.705
DOC_WW_Pin1_4	294	299	PF00397	0.734
DOC_WW_Pin1_4	313	318	PF00397	0.766
DOC_WW_Pin1_4	367	372	PF00397	0.733
DOC_WW_Pin1_4	447	452	PF00397	0.521
DOC_WW_Pin1_4	469	474	PF00397	0.661
DOC_WW_Pin1_4	81	86	PF00397	0.623
LIG_14-3-3_CanoR_1	191	196	PF00244	0.742
LIG_14-3-3_CanoR_1	366	371	PF00244	0.595
LIG_14-3-3_CanoR_1	497	503	PF00244	0.520
LIG_14-3-3_CanoR_1	79	85	PF00244	0.709
LIG_BRCT_BRCA1_1	174	178	PF00533	0.475
LIG_BRCT_BRCA1_1	99	103	PF00533	0.623
LIG_FHA_1	115	121	PF00498	0.668
LIG_FHA_1	180	186	PF00498	0.560
LIG_FHA_1	386	392	PF00498	0.809
LIG_FHA_1	94	100	PF00498	0.727
LIG_FHA_2	382	388	PF00498	0.689
LIG_FHA_2	451	457	PF00498	0.644
LIG_FHA_2	491	497	PF00498	0.611
LIG_LIR_Gen_1	100	108	PF02991	0.546
LIG_LIR_Nem_3	100	106	PF02991	0.699
LIG_LIR_Nem_3	142	148	PF02991	0.463
LIG_LIR_Nem_3	39	45	PF02991	0.589
LIG_SH2_CRK	145	149	PF00017	0.424
LIG_SH2_SRC	145	148	PF00017	0.572
LIG_SH2_STAP1	445	449	PF00017	0.493
LIG_SH2_STAT5	105	108	PF00017	0.641
LIG_SH2_STAT5	56	59	PF00017	0.600
LIG_SH3_3	22	28	PF00018	0.749
LIG_SH3_3	306	312	PF00018	0.724
LIG_SH3_3	467	473	PF00018	0.593
LIG_SUMO_SIM_anti_2	277	286	PF11976	0.550
LIG_TRAF2_1	419	422	PF00917	0.751
LIG_TRAF2_1	453	456	PF00917	0.554
LIG_WRC_WIRS_1	482	487	PF05994	0.308
MOD_CDC14_SPxK_1	297	300	PF00782	0.594
MOD_CDC14_SPxK_1	370	373	PF00782	0.627
MOD_CDK_SPK_2	313	318	PF00069	0.729
MOD_CDK_SPK_2	447	452	PF00069	0.606
MOD_CDK_SPK_2	81	86	PF00069	0.591
MOD_CDK_SPxK_1	294	300	PF00069	0.601
MOD_CDK_SPxK_1	367	373	PF00069	0.685
MOD_CDK_SPxxK_3	24	31	PF00069	0.748
MOD_CDK_SPxxK_3	313	320	PF00069	0.732
MOD_CK1_1	14	20	PF00069	0.724
MOD_CK1_1	484	490	PF00069	0.328
MOD_CK1_1	97	103	PF00069	0.657
MOD_CK2_1	109	115	PF00069	0.761
MOD_CK2_1	123	129	PF00069	0.619
MOD_CK2_1	366	372	PF00069	0.551
MOD_CK2_1	450	456	PF00069	0.535
MOD_Cter_Amidation	206	209	PF01082	0.598
MOD_DYRK1A_RPxSP_1	24	28	PF00069	0.752
MOD_GlcNHglycan	125	128	PF01048	0.755
MOD_GlcNHglycan	13	16	PF01048	0.642
MOD_GlcNHglycan	196	199	PF01048	0.703
MOD_GlcNHglycan	214	217	PF01048	0.762
MOD_GlcNHglycan	230	233	PF01048	0.381
MOD_GlcNHglycan	359	362	PF01048	0.721
MOD_GlcNHglycan	408	411	PF01048	0.770
MOD_GlcNHglycan	76	79	PF01048	0.706
MOD_GlcNHglycan	88	91	PF01048	0.734
MOD_GlcNHglycan	96	99	PF01048	0.623
MOD_GSK3_1	190	197	PF00069	0.660
MOD_GSK3_1	20	27	PF00069	0.659
MOD_GSK3_1	212	219	PF00069	0.634
MOD_GSK3_1	381	388	PF00069	0.786
MOD_GSK3_1	469	476	PF00069	0.643
MOD_GSK3_1	477	484	PF00069	0.478
MOD_GSK3_1	59	66	PF00069	0.789
MOD_GSK3_1	67	74	PF00069	0.705
MOD_GSK3_1	7	14	PF00069	0.767
MOD_GSK3_1	80	87	PF00069	0.624
MOD_GSK3_1	93	100	PF00069	0.608
MOD_N-GLC_1	228	233	PF02516	0.456
MOD_N-GLC_1	385	390	PF02516	0.817
MOD_NEK2_1	477	482	PF00069	0.534
MOD_NEK2_1	65	70	PF00069	0.684
MOD_PIKK_1	114	120	PF00454	0.676
MOD_PIKK_1	302	308	PF00454	0.746
MOD_PIKK_1	63	69	PF00454	0.692
MOD_PKA_1	366	372	PF00069	0.551
MOD_PKA_2	17	23	PF00069	0.741
MOD_PKA_2	190	196	PF00069	0.660
MOD_PKA_2	286	292	PF00069	0.685
MOD_PKA_2	345	351	PF00069	0.681
MOD_PKA_2	496	502	PF00069	0.531
MOD_PKA_2	7	13	PF00069	0.693
MOD_PKB_1	364	372	PF00069	0.551
MOD_Plk_1	101	107	PF00069	0.724
MOD_Plk_1	276	282	PF00069	0.635
MOD_Plk_2-3	109	115	PF00069	0.610
MOD_Plk_2-3	244	250	PF00069	0.614
MOD_Plk_4	198	204	PF00069	0.743
MOD_Plk_4	276	282	PF00069	0.538
MOD_ProDKin_1	139	145	PF00069	0.509
MOD_ProDKin_1	192	198	PF00069	0.790
MOD_ProDKin_1	24	30	PF00069	0.702
MOD_ProDKin_1	294	300	PF00069	0.732
MOD_ProDKin_1	313	319	PF00069	0.767
MOD_ProDKin_1	367	373	PF00069	0.737
MOD_ProDKin_1	447	453	PF00069	0.526
MOD_ProDKin_1	469	475	PF00069	0.651
MOD_ProDKin_1	81	87	PF00069	0.624
MOD_SUMO_for_1	419	422	PF00179	0.751
MOD_SUMO_rev_2	47	55	PF00179	0.617
TRG_DiLeu_BaEn_4	115	121	PF01217	0.791
TRG_DiLeu_LyEn_5	129	134	PF01217	0.579
TRG_ENDOCYTIC_2	105	108	PF00928	0.629
TRG_ENDOCYTIC_2	145	148	PF00928	0.412
TRG_ENDOCYTIC_2	168	171	PF00928	0.558
TRG_ENDOCYTIC_2	42	45	PF00928	0.587
TRG_ER_diArg_1	334	336	PF00400	0.606
TRG_ER_diArg_1	509	511	PF00400	0.468
TRG_NLS_MonoCore_2	363	368	PF00514	0.848
TRG_NLS_MonoExtC_3	363	368	PF00514	0.848
TRG_NLS_MonoExtC_3	402	407	PF00514	0.718
TRG_NLS_MonoExtC_3	507	512	PF00514	0.454
TRG_NLS_MonoExtN_4	362	369	PF00514	0.740
TRG_NLS_MonoExtN_4	400	407	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K2	Leptomonas seymouri	36%	89%
A4HB95	Leishmania braziliensis	60%	100%
A4IAE3	Leishmania infantum	98%	100%
E9B5G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2G8	Leishmania major	83%	100%