LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

NOL1/NOP2/sun_family_putative/Pfam:PF01189

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NOL1/NOP2/sun_family_putative/Pfam:PF01189
Gene product:
NOL1/NOP2/sun family, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8INR5_LEIDO
TriTrypDb:
LdBPK_362300.1 , LdCL_360028700 , LDHU3_36.3060
Length:
767

Annotations

Annotations by Jardim et al.

Ribosomal Protein, NOL1/NOP2/sun family, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A0A3Q8INR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INR5

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 9
GO:0006139 nucleobase-containing compound metabolic process 3 9
GO:0006725 cellular aromatic compound metabolic process 3 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009451 RNA modification 5 9
GO:0009987 cellular process 1 9
GO:0016070 RNA metabolic process 5 9
GO:0032259 methylation 2 9
GO:0034641 cellular nitrogen compound metabolic process 3 9
GO:0043170 macromolecule metabolic process 3 9
GO:0043412 macromolecule modification 4 9
GO:0043414 macromolecule methylation 3 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044260 obsolete cellular macromolecule metabolic process 3 9
GO:0046483 heterocycle metabolic process 3 9
GO:0071704 organic substance metabolic process 2 9
GO:0090304 nucleic acid metabolic process 4 9
GO:1901360 organic cyclic compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0008168 methyltransferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016741 transferase activity, transferring one-carbon groups 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0000049 tRNA binding 5 3
GO:0008173 RNA methyltransferase activity 4 3
GO:0008175 tRNA methyltransferase activity 5 3
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 3
GO:0016427 tRNA (cytosine) methyltransferase activity 6 3
GO:0016428 tRNA (cytosine-5-)-methyltransferase activity 7 3
GO:0140098 catalytic activity, acting on RNA 3 3
GO:0140101 catalytic activity, acting on a tRNA 4 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 410 414 PF00656 0.514
CLV_C14_Caspase3-7 69 73 PF00656 0.569
CLV_NRD_NRD_1 15 17 PF00675 0.601
CLV_NRD_NRD_1 158 160 PF00675 0.431
CLV_NRD_NRD_1 322 324 PF00675 0.256
CLV_NRD_NRD_1 655 657 PF00675 0.471
CLV_NRD_NRD_1 765 767 PF00675 0.548
CLV_PCSK_FUR_1 477 481 PF00082 0.376
CLV_PCSK_KEX2_1 15 17 PF00082 0.587
CLV_PCSK_KEX2_1 160 162 PF00082 0.442
CLV_PCSK_KEX2_1 253 255 PF00082 0.221
CLV_PCSK_KEX2_1 263 265 PF00082 0.221
CLV_PCSK_KEX2_1 479 481 PF00082 0.440
CLV_PCSK_KEX2_1 514 516 PF00082 0.635
CLV_PCSK_KEX2_1 655 657 PF00082 0.471
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.461
CLV_PCSK_PC1ET2_1 253 255 PF00082 0.221
CLV_PCSK_PC1ET2_1 263 265 PF00082 0.221
CLV_PCSK_PC1ET2_1 479 481 PF00082 0.440
CLV_PCSK_PC1ET2_1 514 516 PF00082 0.635
CLV_PCSK_SKI1_1 19 23 PF00082 0.592
CLV_PCSK_SKI1_1 266 270 PF00082 0.221
CLV_PCSK_SKI1_1 394 398 PF00082 0.228
CLV_PCSK_SKI1_1 568 572 PF00082 0.434
DEG_APCC_DBOX_1 393 401 PF00400 0.428
DEG_APCC_DBOX_1 691 699 PF00400 0.337
DEG_SCF_FBW7_1 103 110 PF00400 0.381
DEG_SPOP_SBC_1 75 79 PF00917 0.522
DOC_CKS1_1 104 109 PF01111 0.381
DOC_CKS1_1 32 37 PF01111 0.509
DOC_CKS1_1 433 438 PF01111 0.421
DOC_CYCLIN_yCln2_LP_2 267 273 PF00134 0.421
DOC_MAPK_gen_1 253 259 PF00069 0.421
DOC_MAPK_gen_1 263 269 PF00069 0.421
DOC_MAPK_gen_1 383 390 PF00069 0.426
DOC_MAPK_gen_1 615 624 PF00069 0.499
DOC_MAPK_gen_1 655 665 PF00069 0.370
DOC_MAPK_gen_1 692 700 PF00069 0.386
DOC_MAPK_gen_1 723 732 PF00069 0.310
DOC_MAPK_HePTP_8 653 665 PF00069 0.371
DOC_MAPK_MEF2A_6 212 220 PF00069 0.346
DOC_MAPK_MEF2A_6 342 349 PF00069 0.421
DOC_MAPK_MEF2A_6 656 665 PF00069 0.343
DOC_MAPK_MEF2A_6 723 732 PF00069 0.350
DOC_MAPK_NFAT4_5 725 733 PF00069 0.342
DOC_MIT_MIM_1 688 698 PF04212 0.400
DOC_PP1_RVXF_1 264 270 PF00149 0.421
DOC_PP1_RVXF_1 627 634 PF00149 0.456
DOC_PP2B_LxvP_1 430 433 PF13499 0.421
DOC_PP4_FxxP_1 104 107 PF00568 0.336
DOC_PP4_FxxP_1 419 422 PF00568 0.456
DOC_PP4_MxPP_1 188 191 PF00568 0.342
DOC_USP7_MATH_1 227 231 PF00917 0.419
DOC_USP7_MATH_1 283 287 PF00917 0.535
DOC_USP7_MATH_1 522 526 PF00917 0.506
DOC_USP7_MATH_1 643 647 PF00917 0.293
DOC_USP7_MATH_1 73 77 PF00917 0.665
DOC_USP7_UBL2_3 485 489 PF12436 0.537
DOC_USP7_UBL2_3 5 9 PF12436 0.590
DOC_USP7_UBL2_3 514 518 PF12436 0.695
DOC_USP7_UBL2_3 677 681 PF12436 0.497
DOC_WW_Pin1_4 103 108 PF00397 0.386
DOC_WW_Pin1_4 205 210 PF00397 0.325
DOC_WW_Pin1_4 230 235 PF00397 0.407
DOC_WW_Pin1_4 31 36 PF00397 0.516
DOC_WW_Pin1_4 330 335 PF00397 0.415
DOC_WW_Pin1_4 432 437 PF00397 0.421
DOC_WW_Pin1_4 595 600 PF00397 0.524
LIG_14-3-3_CanoR_1 173 180 PF00244 0.445
LIG_14-3-3_CanoR_1 360 370 PF00244 0.433
LIG_14-3-3_CanoR_1 408 418 PF00244 0.501
LIG_14-3-3_CanoR_1 568 577 PF00244 0.480
LIG_14-3-3_CanoR_1 615 624 PF00244 0.464
LIG_14-3-3_CanoR_1 641 650 PF00244 0.332
LIG_14-3-3_CanoR_1 655 663 PF00244 0.277
LIG_Actin_WH2_2 307 325 PF00022 0.487
LIG_Actin_WH2_2 340 358 PF00022 0.454
LIG_BIR_III_2 231 235 PF00653 0.491
LIG_BIR_III_4 413 417 PF00653 0.514
LIG_Clathr_ClatBox_1 704 708 PF01394 0.303
LIG_CSL_BTD_1 331 334 PF09270 0.421
LIG_eIF4E_1 239 245 PF01652 0.260
LIG_FHA_1 104 110 PF00498 0.354
LIG_FHA_1 115 121 PF00498 0.335
LIG_FHA_1 300 306 PF00498 0.501
LIG_FHA_1 363 369 PF00498 0.536
LIG_FHA_1 616 622 PF00498 0.454
LIG_FHA_2 21 27 PF00498 0.538
LIG_FHA_2 273 279 PF00498 0.456
LIG_FHA_2 408 414 PF00498 0.534
LIG_FHA_2 543 549 PF00498 0.587
LIG_FHA_2 67 73 PF00498 0.598
LIG_LIR_Apic_2 102 107 PF02991 0.366
LIG_LIR_Apic_2 571 577 PF02991 0.335
LIG_LIR_Gen_1 49 58 PF02991 0.373
LIG_LIR_Nem_3 140 144 PF02991 0.338
LIG_LIR_Nem_3 49 55 PF02991 0.407
LIG_LIR_Nem_3 571 576 PF02991 0.398
LIG_MAD2 60 68 PF02301 0.413
LIG_PCNA_PIPBox_1 164 173 PF02747 0.395
LIG_PCNA_PIPBox_1 567 576 PF02747 0.467
LIG_PTB_Apo_2 42 49 PF02174 0.558
LIG_SH2_CRK 52 56 PF00017 0.516
LIG_SH2_NCK_1 439 443 PF00017 0.436
LIG_SH2_NCK_1 574 578 PF00017 0.332
LIG_SH2_SRC 25 28 PF00017 0.594
LIG_SH2_SRC 574 577 PF00017 0.336
LIG_SH2_STAP1 439 443 PF00017 0.452
LIG_SH2_STAP1 718 722 PF00017 0.299
LIG_SH2_STAT5 170 173 PF00017 0.470
LIG_SH2_STAT5 281 284 PF00017 0.434
LIG_SH3_1 574 580 PF00018 0.324
LIG_SH3_3 29 35 PF00018 0.576
LIG_SH3_3 398 404 PF00018 0.500
LIG_SH3_3 430 436 PF00018 0.454
LIG_SH3_3 543 549 PF00018 0.577
LIG_SH3_3 557 563 PF00018 0.323
LIG_SH3_3 574 580 PF00018 0.324
LIG_SH3_3 658 664 PF00018 0.468
LIG_SH3_3 745 751 PF00018 0.513
LIG_SUMO_SIM_anti_2 618 625 PF11976 0.392
LIG_SUMO_SIM_par_1 618 625 PF11976 0.350
LIG_SUMO_SIM_par_1 703 708 PF11976 0.328
LIG_TRAF2_1 181 184 PF00917 0.366
LIG_UBA3_1 216 224 PF00899 0.332
LIG_UBA3_1 328 335 PF00899 0.501
LIG_UBA3_1 704 711 PF00899 0.457
LIG_WRC_WIRS_1 109 114 PF05994 0.426
MOD_CDK_SPK_2 330 335 PF00069 0.421
MOD_CDK_SPxxK_3 205 212 PF00069 0.322
MOD_CK1_1 20 26 PF00069 0.584
MOD_CK1_1 208 214 PF00069 0.361
MOD_CK1_1 230 236 PF00069 0.405
MOD_CK1_1 364 370 PF00069 0.439
MOD_CK1_1 493 499 PF00069 0.522
MOD_CK1_1 601 607 PF00069 0.324
MOD_CK1_1 76 82 PF00069 0.746
MOD_CK2_1 131 137 PF00069 0.345
MOD_CK2_1 178 184 PF00069 0.358
MOD_CK2_1 21 27 PF00069 0.544
MOD_CK2_1 330 336 PF00069 0.415
MOD_CK2_1 542 548 PF00069 0.583
MOD_CK2_1 690 696 PF00069 0.339
MOD_GlcNHglycan 19 22 PF01048 0.641
MOD_GlcNHglycan 316 319 PF01048 0.256
MOD_GlcNHglycan 440 443 PF01048 0.301
MOD_GlcNHglycan 524 527 PF01048 0.602
MOD_GlcNHglycan 624 627 PF01048 0.412
MOD_GlcNHglycan 645 648 PF01048 0.343
MOD_GlcNHglycan 718 721 PF01048 0.392
MOD_GlcNHglycan 88 91 PF01048 0.388
MOD_GSK3_1 103 110 PF00069 0.410
MOD_GSK3_1 127 134 PF00069 0.406
MOD_GSK3_1 17 24 PF00069 0.640
MOD_GSK3_1 172 179 PF00069 0.381
MOD_GSK3_1 295 302 PF00069 0.458
MOD_GSK3_1 314 321 PF00069 0.456
MOD_GSK3_1 489 496 PF00069 0.556
MOD_GSK3_1 498 505 PF00069 0.598
MOD_GSK3_1 62 69 PF00069 0.613
MOD_GSK3_1 682 689 PF00069 0.460
MOD_GSK3_1 73 80 PF00069 0.638
MOD_N-GLC_1 114 119 PF02516 0.334
MOD_NEK2_1 108 113 PF00069 0.414
MOD_NEK2_1 361 366 PF00069 0.452
MOD_NEK2_1 447 452 PF00069 0.528
MOD_NEK2_1 585 590 PF00069 0.475
MOD_NEK2_1 622 627 PF00069 0.357
MOD_NEK2_1 654 659 PF00069 0.452
MOD_NEK2_2 318 323 PF00069 0.456
MOD_PIKK_1 299 305 PF00454 0.472
MOD_PIKK_1 686 692 PF00454 0.363
MOD_PKA_1 655 661 PF00069 0.375
MOD_PKA_2 172 178 PF00069 0.470
MOD_PKA_2 407 413 PF00069 0.501
MOD_PKA_2 502 508 PF00069 0.718
MOD_PKA_2 654 660 PF00069 0.404
MOD_Plk_1 184 190 PF00069 0.310
MOD_Plk_1 283 289 PF00069 0.496
MOD_Plk_1 447 453 PF00069 0.518
MOD_Plk_1 686 692 PF00069 0.494
MOD_Plk_4 108 114 PF00069 0.236
MOD_Plk_4 131 137 PF00069 0.372
MOD_Plk_4 184 190 PF00069 0.335
MOD_Plk_4 502 508 PF00069 0.594
MOD_Plk_4 601 607 PF00069 0.338
MOD_Plk_4 663 669 PF00069 0.361
MOD_Plk_4 92 98 PF00069 0.415
MOD_ProDKin_1 103 109 PF00069 0.383
MOD_ProDKin_1 205 211 PF00069 0.325
MOD_ProDKin_1 230 236 PF00069 0.402
MOD_ProDKin_1 31 37 PF00069 0.508
MOD_ProDKin_1 330 336 PF00069 0.415
MOD_ProDKin_1 432 438 PF00069 0.421
MOD_ProDKin_1 595 601 PF00069 0.514
MOD_SUMO_for_1 484 487 PF00179 0.564
MOD_SUMO_for_1 513 516 PF00179 0.709
MOD_SUMO_for_1 755 758 PF00179 0.690
MOD_SUMO_rev_2 249 255 PF00179 0.421
MOD_SUMO_rev_2 482 491 PF00179 0.635
MOD_SUMO_rev_2 537 544 PF00179 0.337
TRG_DiLeu_BaLyEn_6 104 109 PF01217 0.461
TRG_DiLeu_BaLyEn_6 263 268 PF01217 0.421
TRG_ENDOCYTIC_2 52 55 PF00928 0.377
TRG_ER_diArg_1 158 161 PF00400 0.389
TRG_ER_diArg_1 264 267 PF00400 0.421
TRG_ER_diArg_1 382 385 PF00400 0.370
TRG_ER_diArg_1 654 656 PF00400 0.495
TRG_ER_diArg_1 691 694 PF00400 0.383
TRG_ER_diArg_1 722 725 PF00400 0.305
TRG_NLS_Bipartite_1 253 267 PF00514 0.421
TRG_Pf-PMV_PEXEL_1 150 154 PF00026 0.389
TRG_Pf-PMV_PEXEL_1 394 399 PF00026 0.209
TRG_Pf-PMV_PEXEL_1 479 483 PF00026 0.556
TRG_Pf-PMV_PEXEL_1 568 572 PF00026 0.395

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZE7 Leptomonas seymouri 75% 99%
A0A1X0P6Y3 Trypanosomatidae 25% 93%
A0A1X0P7M3 Trypanosomatidae 59% 100%
A0A3Q8IJ07 Leishmania donovani 32% 100%
A0A3R7NNX1 Trypanosoma rangeli 58% 100%
A4HP86 Leishmania braziliensis 85% 100%
A4IDJ1 Leishmania infantum 100% 100%
D0A386 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9AHJ5 Leishmania infantum 32% 100%
E9ASZ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O13935 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
P38205 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
Q08J23 Homo sapiens 31% 100%
Q1HFZ0 Mus musculus 31% 100%
Q28E61 Xenopus tropicalis 31% 96%
Q4Q1K4 Leishmania major 94% 100%
Q4V7N2 Xenopus laevis 31% 100%
Q5ZLV4 Gallus gallus 31% 96%
Q9HGQ2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
V5DCJ5 Trypanosoma cruzi 63% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS