PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3336)/Patatin-like phospholipase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8INR2_LEIDO

TriTrypDb:

LdBPK_343400.1 , LdCL_340043400 , LDHU3_34.5620

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8INR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INR2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004806	triglyceride lipase activity	5	11
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0052689	carboxylic ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.504
CLV_MEL_PAP_1	156	162	PF00089	0.331
CLV_NRD_NRD_1	133	135	PF00675	0.321
CLV_NRD_NRD_1	168	170	PF00675	0.369
CLV_NRD_NRD_1	322	324	PF00675	0.337
CLV_PCSK_FUR_1	266	270	PF00082	0.331
CLV_PCSK_KEX2_1	133	135	PF00082	0.360
CLV_PCSK_KEX2_1	168	170	PF00082	0.441
CLV_PCSK_KEX2_1	268	270	PF00082	0.301
CLV_PCSK_KEX2_1	322	324	PF00082	0.311
CLV_PCSK_KEX2_1	564	566	PF00082	0.397
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.367
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.397
CLV_PCSK_SKI1_1	175	179	PF00082	0.354
CLV_PCSK_SKI1_1	375	379	PF00082	0.389
CLV_PCSK_SKI1_1	419	423	PF00082	0.327
DEG_APCC_DBOX_1	174	182	PF00400	0.543
DEG_APCC_DBOX_1	434	442	PF00400	0.598
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DEG_SIAH_1	351	359	PF03145	0.567
DEG_SPOP_SBC_1	358	362	PF00917	0.684
DOC_CKS1_1	258	263	PF01111	0.402
DOC_CYCLIN_RxL_1	372	381	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	214	217	PF00134	0.331
DOC_MAPK_gen_1	304	313	PF00069	0.473
DOC_MAPK_gen_1	322	329	PF00069	0.543
DOC_MAPK_gen_1	417	426	PF00069	0.588
DOC_MAPK_MEF2A_6	304	313	PF00069	0.534
DOC_MAPK_MEF2A_6	322	331	PF00069	0.543
DOC_MAPK_RevD_3	309	323	PF00069	0.473
DOC_PP1_RVXF_1	476	483	PF00149	0.623
DOC_PP2B_LxvP_1	214	217	PF13499	0.316
DOC_PP2B_LxvP_1	309	312	PF13499	0.536
DOC_PP2B_LxvP_1	41	44	PF13499	0.643
DOC_SPAK_OSR1_1	425	429	PF12202	0.564
DOC_USP7_MATH_1	312	316	PF00917	0.534
DOC_USP7_MATH_1	358	362	PF00917	0.697
DOC_USP7_MATH_1	512	516	PF00917	0.557
DOC_USP7_MATH_1	68	72	PF00917	0.540
DOC_USP7_UBL2_3	139	143	PF12436	0.450
DOC_WW_Pin1_4	257	262	PF00397	0.508
DOC_WW_Pin1_4	314	319	PF00397	0.444
DOC_WW_Pin1_4	334	339	PF00397	0.520
DOC_WW_Pin1_4	489	494	PF00397	0.651
DOC_WW_Pin1_4	522	527	PF00397	0.582
LIG_14-3-3_CanoR_1	380	390	PF00244	0.650
LIG_14-3-3_CanoR_1	462	466	PF00244	0.638
LIG_14-3-3_CanoR_1	550	556	PF00244	0.569
LIG_Actin_WH2_2	93	109	PF00022	0.473
LIG_BRCT_BRCA1_1	199	203	PF00533	0.418
LIG_BRCT_BRCA1_1	27	31	PF00533	0.397
LIG_BRCT_BRCA1_1	87	91	PF00533	0.536
LIG_deltaCOP1_diTrp_1	264	270	PF00928	0.489
LIG_deltaCOP1_diTrp_1	459	465	PF00928	0.581
LIG_eIF4E_1	185	191	PF01652	0.464
LIG_FHA_1	140	146	PF00498	0.442
LIG_FHA_1	17	23	PF00498	0.285
LIG_FHA_1	172	178	PF00498	0.599
LIG_FHA_1	186	192	PF00498	0.472
LIG_FHA_1	274	280	PF00498	0.557
LIG_FHA_1	303	309	PF00498	0.464
LIG_FHA_1	372	378	PF00498	0.628
LIG_FHA_1	382	388	PF00498	0.555
LIG_FHA_1	462	468	PF00498	0.627
LIG_FHA_2	334	340	PF00498	0.531
LIG_FHA_2	496	502	PF00498	0.718
LIG_FHA_2	59	65	PF00498	0.467
LIG_FHA_2	70	76	PF00498	0.536
LIG_FHA_2	97	103	PF00498	0.536
LIG_GBD_Chelix_1	22	30	PF00786	0.397
LIG_LIR_Gen_1	148	157	PF02991	0.448
LIG_LIR_Gen_1	494	504	PF02991	0.541
LIG_LIR_Gen_1	514	524	PF02991	0.605
LIG_LIR_Nem_3	148	152	PF02991	0.448
LIG_LIR_Nem_3	19	24	PF02991	0.420
LIG_LIR_Nem_3	264	270	PF02991	0.472
LIG_LIR_Nem_3	459	463	PF02991	0.568
LIG_LIR_Nem_3	494	500	PF02991	0.577
LIG_LIR_Nem_3	514	520	PF02991	0.602
LIG_LIR_Nem_3	64	69	PF02991	0.450
LIG_LIR_Nem_3	88	93	PF02991	0.459
LIG_MLH1_MIPbox_1	87	91	PF16413	0.536
LIG_NRBOX	437	443	PF00104	0.594
LIG_PCNA_yPIPBox_3	290	304	PF02747	0.342
LIG_Pex14_2	298	302	PF04695	0.567
LIG_Pex14_2	422	426	PF04695	0.575
LIG_PTB_Apo_2	307	314	PF02174	0.447
LIG_SH2_CRK	149	153	PF00017	0.488
LIG_SH2_CRK	27	31	PF00017	0.397
LIG_SH2_CRK	485	489	PF00017	0.642
LIG_SH2_CRK	50	54	PF00017	0.536
LIG_SH2_NCK_1	485	489	PF00017	0.642
LIG_SH2_SRC	390	393	PF00017	0.559
LIG_SH2_STAP1	27	31	PF00017	0.397
LIG_SH2_STAP1	399	403	PF00017	0.642
LIG_SH2_STAP1	463	467	PF00017	0.561
LIG_SH2_STAP1	485	489	PF00017	0.594
LIG_SH2_STAP1	63	67	PF00017	0.462
LIG_SH2_STAT3	437	440	PF00017	0.539
LIG_SH2_STAT5	136	139	PF00017	0.456
LIG_SH2_STAT5	21	24	PF00017	0.418
LIG_SH2_STAT5	334	337	PF00017	0.478
LIG_SH2_STAT5	437	440	PF00017	0.608
LIG_SH2_STAT5	463	466	PF00017	0.570
LIG_SH2_STAT5	519	522	PF00017	0.613
LIG_SH2_STAT5	90	93	PF00017	0.536
LIG_SH3_2	318	323	PF14604	0.473
LIG_SH3_3	276	282	PF00018	0.531
LIG_SH3_3	315	321	PF00018	0.473
LIG_SH3_3	408	414	PF00018	0.600
LIG_SUMO_SIM_par_1	101	108	PF11976	0.501
LIG_SUMO_SIM_par_1	281	287	PF11976	0.497
LIG_SUMO_SIM_par_1	39	46	PF11976	0.612
LIG_SUMO_SIM_par_1	532	537	PF11976	0.528
LIG_TRAF2_1	62	65	PF00917	0.504
LIG_TRAF2_1	99	102	PF00917	0.522
LIG_TYR_ITIM	25	30	PF00017	0.397
LIG_TYR_ITIM	407	412	PF00017	0.632
LIG_UBA3_1	115	121	PF00899	0.513
LIG_WRC_WIRS_1	496	501	PF05994	0.667
LIG_WRC_WIRS_1	90	95	PF05994	0.536
MOD_CK1_1	108	114	PF00069	0.550
MOD_CK1_1	148	154	PF00069	0.515
MOD_CK1_1	179	185	PF00069	0.507
MOD_CK1_1	245	251	PF00069	0.519
MOD_CK1_1	360	366	PF00069	0.684
MOD_CK1_1	430	436	PF00069	0.511
MOD_CK1_1	492	498	PF00069	0.704
MOD_CK1_1	515	521	PF00069	0.618
MOD_CK1_1	525	531	PF00069	0.644
MOD_CK2_1	247	253	PF00069	0.578
MOD_CK2_1	495	501	PF00069	0.701
MOD_CK2_1	58	64	PF00069	0.474
MOD_CK2_1	96	102	PF00069	0.522
MOD_GlcNHglycan	110	113	PF01048	0.311
MOD_GlcNHglycan	199	202	PF01048	0.420
MOD_GlcNHglycan	2	5	PF01048	0.649
MOD_GlcNHglycan	221	224	PF01048	0.401
MOD_GlcNHglycan	245	248	PF01048	0.298
MOD_GlcNHglycan	314	317	PF01048	0.296
MOD_GlcNHglycan	343	346	PF01048	0.278
MOD_GlcNHglycan	384	387	PF01048	0.373
MOD_GlcNHglycan	444	447	PF01048	0.470
MOD_GSK3_1	137	144	PF00069	0.530
MOD_GSK3_1	233	240	PF00069	0.430
MOD_GSK3_1	241	248	PF00069	0.551
MOD_GSK3_1	378	385	PF00069	0.600
MOD_GSK3_1	395	402	PF00069	0.717
MOD_GSK3_1	491	498	PF00069	0.716
MOD_GSK3_1	511	518	PF00069	0.457
MOD_GSK3_1	81	88	PF00069	0.537
MOD_NEK2_1	137	142	PF00069	0.512
MOD_NEK2_1	197	202	PF00069	0.422
MOD_NEK2_1	227	232	PF00069	0.450
MOD_NEK2_1	241	246	PF00069	0.540
MOD_NEK2_1	289	294	PF00069	0.508
MOD_NEK2_1	302	307	PF00069	0.526
MOD_NEK2_1	341	346	PF00069	0.478
MOD_NEK2_1	378	383	PF00069	0.565
MOD_NEK2_1	442	447	PF00069	0.630
MOD_NEK2_1	549	554	PF00069	0.533
MOD_PKA_2	381	387	PF00069	0.609
MOD_PKA_2	461	467	PF00069	0.638
MOD_PKA_2	549	555	PF00069	0.561
MOD_PKB_1	380	388	PF00069	0.553
MOD_Plk_1	179	185	PF00069	0.573
MOD_Plk_1	430	436	PF00069	0.518
MOD_Plk_1	85	91	PF00069	0.536
MOD_Plk_4	11	17	PF00069	0.461
MOD_Plk_4	141	147	PF00069	0.473
MOD_Plk_4	148	154	PF00069	0.440
MOD_Plk_4	227	233	PF00069	0.396
MOD_Plk_4	237	243	PF00069	0.521
MOD_Plk_4	492	498	PF00069	0.683
MOD_Plk_4	512	518	PF00069	0.610
MOD_Plk_4	86	92	PF00069	0.536
MOD_ProDKin_1	257	263	PF00069	0.508
MOD_ProDKin_1	314	320	PF00069	0.444
MOD_ProDKin_1	334	340	PF00069	0.520
MOD_ProDKin_1	489	495	PF00069	0.648
MOD_ProDKin_1	522	528	PF00069	0.583
TRG_DiLeu_BaEn_1	253	258	PF01217	0.450
TRG_DiLeu_BaEn_4	101	107	PF01217	0.536
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.536
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.614
TRG_ENDOCYTIC_2	149	152	PF00928	0.462
TRG_ENDOCYTIC_2	27	30	PF00928	0.397
TRG_ENDOCYTIC_2	409	412	PF00928	0.672
TRG_ENDOCYTIC_2	485	488	PF00928	0.651
TRG_ENDOCYTIC_2	50	53	PF00928	0.605
TRG_ENDOCYTIC_2	519	522	PF00928	0.618
TRG_ENDOCYTIC_2	90	93	PF00928	0.483
TRG_ER_diArg_1	133	135	PF00400	0.521
TRG_ER_diArg_1	168	170	PF00400	0.637
TRG_ER_diArg_1	172	175	PF00400	0.599
TRG_ER_diArg_1	321	323	PF00400	0.536
TRG_ER_diArg_1	380	383	PF00400	0.605
TRG_ER_diArg_1	451	454	PF00400	0.654
TRG_NES_CRM1_1	416	431	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9M9	Leptomonas seymouri	61%	99%
A0A0S4JME6	Bodo saltans	29%	100%
A0A0S4JR20	Bodo saltans	27%	100%
A0A1X0PA17	Trypanosomatidae	33%	100%
A0A422N5R5	Trypanosoma rangeli	34%	100%
A1CRG6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	27%	80%
A4HB80	Leishmania braziliensis	85%	100%
A4HIE6	Leishmania braziliensis	28%	75%
A4IAC8	Leishmania infantum	99%	100%
A4R8V2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	72%
A5DIR3	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	79%
A5DUA8	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	25%	70%
E9B5F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O14115	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	90%
P0CT18	Magnaporthe oryzae (strain Y34)	24%	72%
Q2HA54	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	25%	67%
Q4Q2I2	Leishmania major	94%	100%
Q4Q779	Leishmania major	27%	70%
Q5AM72	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	67%
Q6BXC8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	72%
Q9LZA6	Arabidopsis thaliana	24%	69%
Q9M1I6	Arabidopsis thaliana	25%	71%
Q9Y7P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5BW64	Trypanosoma cruzi	34%	100%