Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INP8_LEIDO

TriTrypDb:

LdBPK_362120.1 , LdCL_360026900 , LDHU3_36.2760

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8INP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.397
CLV_C14_Caspase3-7	64	68	PF00656	0.552
CLV_NRD_NRD_1	116	118	PF00675	0.506
CLV_NRD_NRD_1	134	136	PF00675	0.472
CLV_NRD_NRD_1	254	256	PF00675	0.542
CLV_PCSK_KEX2_1	116	118	PF00082	0.453
CLV_PCSK_KEX2_1	134	136	PF00082	0.477
CLV_PCSK_KEX2_1	194	196	PF00082	0.477
CLV_PCSK_KEX2_1	254	256	PF00082	0.533
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.386
CLV_PCSK_SKI1_1	223	227	PF00082	0.588
CLV_PCSK_SKI1_1	352	356	PF00082	0.523
DEG_APCC_DBOX_1	246	254	PF00400	0.575
DEG_Nend_UBRbox_1	1	4	PF02207	0.573
DOC_MAPK_MEF2A_6	73	80	PF00069	0.571
DOC_USP7_MATH_1	200	204	PF00917	0.412
DOC_USP7_MATH_1	232	236	PF00917	0.614
DOC_USP7_MATH_1	277	281	PF00917	0.518
DOC_USP7_MATH_1	35	39	PF00917	0.690
DOC_WW_Pin1_4	6	11	PF00397	0.542
DOC_WW_Pin1_4	71	76	PF00397	0.519
LIG_14-3-3_CanoR_1	40	44	PF00244	0.765
LIG_14-3-3_CanoR_1	58	63	PF00244	0.660
LIG_14-3-3_CanoR_1	73	79	PF00244	0.717
LIG_14-3-3_CanoR_1	97	105	PF00244	0.637
LIG_Actin_WH2_2	112	129	PF00022	0.424
LIG_Actin_WH2_2	25	42	PF00022	0.496
LIG_BRCT_BRCA1_1	41	45	PF00533	0.573
LIG_deltaCOP1_diTrp_1	146	150	PF00928	0.438
LIG_FHA_1	100	106	PF00498	0.537
LIG_FHA_1	121	127	PF00498	0.568
LIG_FHA_1	179	185	PF00498	0.482
LIG_FHA_1	328	334	PF00498	0.438
LIG_FHA_2	236	242	PF00498	0.578
LIG_FHA_2	346	352	PF00498	0.333
LIG_FHA_2	62	68	PF00498	0.711
LIG_FHA_2	83	89	PF00498	0.503
LIG_LIR_Gen_1	146	153	PF02991	0.448
LIG_LIR_Gen_1	27	37	PF02991	0.514
LIG_LIR_Gen_1	330	340	PF02991	0.414
LIG_LIR_Nem_3	146	150	PF02991	0.462
LIG_LIR_Nem_3	27	32	PF02991	0.697
LIG_LIR_Nem_3	330	335	PF02991	0.469
LIG_MYND_1	317	321	PF01753	0.566
LIG_PCNA_PIPBox_1	279	288	PF02747	0.446
LIG_PCNA_yPIPBox_3	278	286	PF02747	0.412
LIG_Rb_LxCxE_1	167	186	PF01857	0.411
LIG_SH2_CRK	344	348	PF00017	0.355
LIG_SH2_STAT5	285	288	PF00017	0.540
LIG_SH2_STAT5	294	297	PF00017	0.425
LIG_SH3_3	303	309	PF00018	0.390
LIG_SH3_3	311	317	PF00018	0.405
LIG_SH3_3	330	336	PF00018	0.333
LIG_SH3_3	41	47	PF00018	0.657
LIG_SH3_3	63	69	PF00018	0.713
LIG_SH3_3	8	14	PF00018	0.569
LIG_SH3_3	88	94	PF00018	0.580
LIG_SUMO_SIM_par_1	74	79	PF11976	0.552
LIG_SUMO_SIM_par_1	87	95	PF11976	0.488
LIG_TRAF2_1	263	266	PF00917	0.470
LIG_TRAF2_1	85	88	PF00917	0.547
LIG_TRFH_1	332	336	PF08558	0.396
LIG_UBA3_1	183	188	PF00899	0.353
MOD_CDK_SPxxK_3	6	13	PF00069	0.543
MOD_CK1_1	100	106	PF00069	0.577
MOD_CK1_1	151	157	PF00069	0.412
MOD_CK1_1	174	180	PF00069	0.364
MOD_CK1_1	235	241	PF00069	0.605
MOD_CK1_1	38	44	PF00069	0.553
MOD_CK1_1	74	80	PF00069	0.543
MOD_CK2_1	214	220	PF00069	0.400
MOD_CK2_1	235	241	PF00069	0.592
MOD_CK2_1	260	266	PF00069	0.559
MOD_CK2_1	82	88	PF00069	0.504
MOD_GlcNHglycan	234	237	PF01048	0.587
MOD_GlcNHglycan	255	258	PF01048	0.558
MOD_GlcNHglycan	41	44	PF01048	0.550
MOD_GSK3_1	160	167	PF00069	0.547
MOD_GSK3_1	174	181	PF00069	0.392
MOD_GSK3_1	228	235	PF00069	0.596
MOD_GSK3_1	35	42	PF00069	0.558
MOD_GSK3_1	97	104	PF00069	0.594
MOD_N-GLC_1	151	156	PF02516	0.394
MOD_N-GLC_1	6	11	PF02516	0.567
MOD_NEK2_1	253	258	PF00069	0.537
MOD_NEK2_1	268	273	PF00069	0.373
MOD_NEK2_1	39	44	PF00069	0.602
MOD_NEK2_2	35	40	PF00069	0.504
MOD_PIKK_1	225	231	PF00454	0.542
MOD_PIKK_1	268	274	PF00454	0.454
MOD_PIKK_1	321	327	PF00454	0.482
MOD_PKA_2	253	259	PF00069	0.557
MOD_PKA_2	39	45	PF00069	0.761
MOD_PKA_2	98	104	PF00069	0.583
MOD_PKB_1	97	105	PF00069	0.650
MOD_Plk_4	24	30	PF00069	0.510
MOD_Plk_4	61	67	PF00069	0.561
MOD_ProDKin_1	6	12	PF00069	0.543
MOD_ProDKin_1	71	77	PF00069	0.518
MOD_SUMO_rev_2	203	213	PF00179	0.418
MOD_SUMO_rev_2	259	269	PF00179	0.650
MOD_SUMO_rev_2	357	363	PF00179	0.411
TRG_DiLeu_BaEn_2	327	333	PF01217	0.475
TRG_DiLeu_BaEn_4	241	247	PF01217	0.468
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.400
TRG_ENDOCYTIC_2	344	347	PF00928	0.350
TRG_ER_diArg_1	115	117	PF00400	0.589
TRG_ER_diArg_1	253	255	PF00400	0.525
TRG_ER_diArg_1	57	60	PF00400	0.580
TRG_ER_diArg_1	96	99	PF00400	0.621
TRG_ER_diLys_1	362	367	PF00400	0.463
TRG_NLS_MonoExtC_3	192	198	PF00514	0.384
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L0	Leptomonas seymouri	47%	100%
A0A1X0P8R8	Trypanosomatidae	33%	100%
A4HP68	Leishmania braziliensis	74%	100%
A4IDH3	Leishmania infantum	100%	100%
D0A360	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ASX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q1M2	Leishmania major	90%	100%
V5BGD4	Trypanosoma cruzi	33%	100%