HECT-domain (Ubiquitin-transferase), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HECT-domain (ubiquitin-transferase), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8INP3_LEIDO

TriTrypDb:

LdBPK_343180.1 , LdCL_340040700 , LDHU3_34.5350

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8INP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	284	286	PF00675	0.594
CLV_PCSK_KEX2_1	284	286	PF00082	0.594
CLV_PCSK_SKI1_1	115	119	PF00082	0.609
CLV_PCSK_SKI1_1	263	267	PF00082	0.561
CLV_PCSK_SKI1_1	299	303	PF00082	0.514
CLV_Separin_Metazoa	167	171	PF03568	0.613
DEG_Nend_UBRbox_3	1	3	PF02207	0.642
DOC_ANK_TNKS_1	182	189	PF00023	0.628
DOC_MAPK_gen_1	176	184	PF00069	0.623
DOC_PP2B_LxvP_1	311	314	PF13499	0.655
DOC_PP4_FxxP_1	192	195	PF00568	0.611
DOC_USP7_MATH_1	121	125	PF00917	0.686
DOC_USP7_MATH_1	23	27	PF00917	0.494
DOC_USP7_MATH_1	252	256	PF00917	0.635
DOC_WW_Pin1_4	122	127	PF00397	0.651
DOC_WW_Pin1_4	300	305	PF00397	0.644
LIG_14-3-3_CanoR_1	129	137	PF00244	0.572
LIG_14-3-3_CanoR_1	151	158	PF00244	0.563
LIG_14-3-3_CanoR_1	20	29	PF00244	0.494
LIG_14-3-3_CanoR_1	214	219	PF00244	0.588
LIG_14-3-3_CanoR_1	261	269	PF00244	0.680
LIG_14-3-3_CanoR_1	284	288	PF00244	0.642
LIG_14-3-3_CanoR_1	289	295	PF00244	0.545
LIG_14-3-3_CanoR_1	92	99	PF00244	0.397
LIG_APCC_ABBA_1	198	203	PF00400	0.569
LIG_APCC_ABBA_1	312	317	PF00400	0.568
LIG_deltaCOP1_diTrp_1	148	152	PF00928	0.509
LIG_FHA_1	142	148	PF00498	0.693
LIG_FHA_1	197	203	PF00498	0.562
LIG_FHA_1	306	312	PF00498	0.599
LIG_FHA_1	69	75	PF00498	0.312
LIG_FHA_2	138	144	PF00498	0.527
LIG_FHA_2	189	195	PF00498	0.680
LIG_FHA_2	208	214	PF00498	0.392
LIG_Integrin_isoDGR_2	87	89	PF01839	0.403
LIG_LIR_Apic_2	189	195	PF02991	0.621
LIG_LIR_Gen_1	100	109	PF02991	0.183
LIG_LIR_Gen_1	199	209	PF02991	0.513
LIG_LIR_Gen_1	43	51	PF02991	0.323
LIG_LIR_Gen_1	63	72	PF02991	0.228
LIG_LIR_Gen_1	80	86	PF02991	0.356
LIG_LIR_Nem_3	100	105	PF02991	0.183
LIG_LIR_Nem_3	217	222	PF02991	0.551
LIG_LIR_Nem_3	63	68	PF02991	0.321
LIG_LIR_Nem_3	71	75	PF02991	0.340
LIG_LIR_Nem_3	80	85	PF02991	0.356
LIG_NRBOX	204	210	PF00104	0.488
LIG_REV1ctd_RIR_1	99	108	PF16727	0.403
LIG_SH2_CRK	109	113	PF00017	0.436
LIG_SH2_CRK	82	86	PF00017	0.320
LIG_SH2_GRB2like	109	112	PF00017	0.533
LIG_SH2_NCK_1	82	86	PF00017	0.320
LIG_SH3_2	165	170	PF14604	0.626
LIG_SH3_3	162	168	PF00018	0.627
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.564
LIG_TRAF2_1	314	317	PF00917	0.566
LIG_TRFH_1	82	86	PF08558	0.318
MOD_CDK_SPK_2	122	127	PF00069	0.556
MOD_CDK_SPxxK_3	122	129	PF00069	0.553
MOD_CK1_1	239	245	PF00069	0.694
MOD_CK2_1	207	213	PF00069	0.478
MOD_CMANNOS	149	152	PF00535	0.507
MOD_GlcNHglycan	132	135	PF01048	0.648
MOD_GlcNHglycan	227	230	PF01048	0.738
MOD_GlcNHglycan	263	266	PF01048	0.645
MOD_GlcNHglycan	291	294	PF01048	0.587
MOD_GSK3_1	137	144	PF00069	0.692
MOD_GSK3_1	236	243	PF00069	0.615
MOD_GSK3_1	257	264	PF00069	0.600
MOD_GSK3_1	73	80	PF00069	0.368
MOD_N-GLC_1	77	82	PF02516	0.369
MOD_NEK2_1	130	135	PF00069	0.604
MOD_NEK2_1	137	142	PF00069	0.560
MOD_NEK2_1	269	274	PF00069	0.600
MOD_NEK2_1	68	73	PF00069	0.318
MOD_PIKK_1	119	125	PF00454	0.711
MOD_PIKK_1	21	27	PF00454	0.502
MOD_PIKK_1	252	258	PF00454	0.636
MOD_PIKK_1	91	97	PF00454	0.408
MOD_PK_1	214	220	PF00069	0.594
MOD_PKA_2	130	136	PF00069	0.629
MOD_PKA_2	137	143	PF00069	0.592
MOD_PKA_2	150	156	PF00069	0.380
MOD_PKA_2	246	252	PF00069	0.591
MOD_PKA_2	283	289	PF00069	0.640
MOD_PKA_2	91	97	PF00069	0.318
MOD_PKB_1	127	135	PF00069	0.576
MOD_Plk_1	188	194	PF00069	0.618
MOD_Plk_1	236	242	PF00069	0.621
MOD_Plk_1	58	64	PF00069	0.397
MOD_Plk_1	77	83	PF00069	0.268
MOD_Plk_2-3	143	149	PF00069	0.495
MOD_Plk_4	188	194	PF00069	0.618
MOD_Plk_4	196	202	PF00069	0.494
MOD_ProDKin_1	122	128	PF00069	0.649
MOD_ProDKin_1	300	306	PF00069	0.645
TRG_ENDOCYTIC_2	109	112	PF00928	0.448
TRG_ENDOCYTIC_2	82	85	PF00928	0.320
TRG_ER_diArg_1	126	129	PF00400	0.610
TRG_ER_diArg_1	136	139	PF00400	0.556
TRG_ER_diArg_1	175	178	PF00400	0.628
TRG_NES_CRM1_1	66	79	PF08389	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK9	Leptomonas seymouri	49%	97%
A4HB59	Leishmania braziliensis	82%	100%
A4IAA6	Leishmania infantum	100%	100%
E9B5C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2K4	Leishmania major	93%	100%