Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INM1_LEIDO

TriTrypDb:

LdBPK_252020.1 , LdCL_250026000 , LDHU3_25.2490

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8INM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.563
CLV_NRD_NRD_1	323	325	PF00675	0.444
CLV_NRD_NRD_1	419	421	PF00675	0.661
CLV_NRD_NRD_1	487	489	PF00675	0.641
CLV_NRD_NRD_1	84	86	PF00675	0.473
CLV_PCSK_KEX2_1	104	106	PF00082	0.265
CLV_PCSK_KEX2_1	323	325	PF00082	0.444
CLV_PCSK_KEX2_1	419	421	PF00082	0.661
CLV_PCSK_KEX2_1	487	489	PF00082	0.641
CLV_PCSK_KEX2_1	62	64	PF00082	0.473
CLV_PCSK_KEX2_1	84	86	PF00082	0.473
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.482
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.496
CLV_PCSK_SKI1_1	113	117	PF00082	0.448
CLV_PCSK_SKI1_1	166	170	PF00082	0.417
CLV_PCSK_SKI1_1	227	231	PF00082	0.524
CLV_PCSK_SKI1_1	382	386	PF00082	0.552
CLV_PCSK_SKI1_1	452	456	PF00082	0.515
CLV_PCSK_SKI1_1	55	59	PF00082	0.528
CLV_PCSK_SKI1_1	575	579	PF00082	0.624
CLV_PCSK_SKI1_1	84	88	PF00082	0.476
CLV_Separin_Metazoa	146	150	PF03568	0.460
DEG_APCC_DBOX_1	165	173	PF00400	0.413
DEG_APCC_DBOX_1	451	459	PF00400	0.570
DEG_APCC_DBOX_1	520	528	PF00400	0.550
DEG_APCC_DBOX_1	83	91	PF00400	0.459
DEG_Nend_UBRbox_3	1	3	PF02207	0.676
DOC_CKS1_1	172	177	PF01111	0.544
DOC_CYCLIN_RxL_1	149	163	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.502
DOC_MAPK_gen_1	104	111	PF00069	0.453
DOC_MAPK_MEF2A_6	104	111	PF00069	0.524
DOC_MAPK_MEF2A_6	521	529	PF00069	0.650
DOC_MAPK_MEF2A_6	651	659	PF00069	0.534
DOC_PP2B_LxvP_1	316	319	PF13499	0.551
DOC_PP2B_LxvP_1	431	434	PF13499	0.626
DOC_PP2B_LxvP_1	655	658	PF13499	0.527
DOC_PP2B_LxvP_1	76	79	PF13499	0.495
DOC_USP7_MATH_1	274	278	PF00917	0.649
DOC_USP7_MATH_1	299	303	PF00917	0.657
DOC_USP7_MATH_1	401	405	PF00917	0.671
DOC_USP7_MATH_1	439	443	PF00917	0.626
DOC_USP7_MATH_1	474	478	PF00917	0.698
DOC_USP7_MATH_1	516	520	PF00917	0.508
DOC_USP7_MATH_1	658	662	PF00917	0.690
DOC_WW_Pin1_4	171	176	PF00397	0.492
DOC_WW_Pin1_4	397	402	PF00397	0.537
LIG_14-3-3_CanoR_1	117	123	PF00244	0.500
LIG_14-3-3_CanoR_1	155	160	PF00244	0.374
LIG_14-3-3_CanoR_1	338	342	PF00244	0.444
LIG_14-3-3_CanoR_1	488	498	PF00244	0.557
LIG_14-3-3_CanoR_1	521	525	PF00244	0.577
LIG_14-3-3_CanoR_1	560	566	PF00244	0.538
LIG_14-3-3_CterR_2	660	663	PF00244	0.647
LIG_BRCT_BRCA1_1	393	397	PF00533	0.509
LIG_Clathr_ClatBox_1	562	566	PF01394	0.597
LIG_FHA_1	118	124	PF00498	0.470
LIG_FHA_1	154	160	PF00498	0.476
LIG_FHA_1	303	309	PF00498	0.692
LIG_FHA_1	34	40	PF00498	0.541
LIG_FHA_1	356	362	PF00498	0.568
LIG_FHA_1	520	526	PF00498	0.566
LIG_FHA_1	576	582	PF00498	0.524
LIG_FHA_1	654	660	PF00498	0.573
LIG_FHA_1	95	101	PF00498	0.592
LIG_FHA_2	503	509	PF00498	0.697
LIG_FHA_2	94	100	PF00498	0.595
LIG_GBD_Chelix_1	482	490	PF00786	0.669
LIG_LIR_Gen_1	139	148	PF02991	0.452
LIG_LIR_Gen_1	362	373	PF02991	0.559
LIG_LIR_Gen_1	43	53	PF02991	0.503
LIG_LIR_Nem_3	139	144	PF02991	0.431
LIG_LIR_Nem_3	163	168	PF02991	0.390
LIG_LIR_Nem_3	287	291	PF02991	0.428
LIG_LIR_Nem_3	362	368	PF02991	0.576
LIG_LIR_Nem_3	41	45	PF02991	0.571
LIG_LIR_Nem_3	74	80	PF02991	0.471
LIG_NRBOX	53	59	PF00104	0.519
LIG_PCNA_yPIPBox_3	386	397	PF02747	0.493
LIG_Pex14_2	364	368	PF04695	0.559
LIG_SH2_GRB2like	388	391	PF00017	0.581
LIG_SH2_NCK_1	45	49	PF00017	0.592
LIG_SH2_STAP1	502	506	PF00017	0.555
LIG_SH2_STAP1	596	600	PF00017	0.498
LIG_SH2_STAT5	291	294	PF00017	0.550
LIG_SH3_3	169	175	PF00018	0.516
LIG_SUMO_SIM_anti_2	522	531	PF11976	0.523
LIG_SUMO_SIM_par_1	154	161	PF11976	0.511
LIG_SUMO_SIM_par_1	233	240	PF11976	0.432
LIG_TRAF2_1	249	252	PF00917	0.551
LIG_UBA3_1	53	62	PF00899	0.454
LIG_UBA3_1	76	81	PF00899	0.504
LIG_ULM_U2AF65_1	419	424	PF00076	0.615
LIG_WRC_WIRS_1	361	366	PF05994	0.555
LIG_WRC_WIRS_1	600	605	PF05994	0.548
MOD_CK1_1	158	164	PF00069	0.422
MOD_CK1_1	240	246	PF00069	0.517
MOD_CK1_1	302	308	PF00069	0.633
MOD_CK1_1	360	366	PF00069	0.560
MOD_CK1_1	402	408	PF00069	0.622
MOD_CK1_1	519	525	PF00069	0.634
MOD_CK1_1	544	550	PF00069	0.562
MOD_CK2_1	158	164	PF00069	0.481
MOD_CK2_1	281	287	PF00069	0.478
MOD_CK2_1	40	46	PF00069	0.563
MOD_CK2_1	502	508	PF00069	0.703
MOD_CK2_1	93	99	PF00069	0.641
MOD_CMANNOS	514	517	PF00535	0.600
MOD_Cter_Amidation	417	420	PF01082	0.668
MOD_GlcNHglycan	124	127	PF01048	0.478
MOD_GlcNHglycan	160	163	PF01048	0.467
MOD_GlcNHglycan	184	187	PF01048	0.618
MOD_GlcNHglycan	239	242	PF01048	0.605
MOD_GlcNHglycan	246	249	PF01048	0.512
MOD_GlcNHglycan	276	279	PF01048	0.592
MOD_GlcNHglycan	283	286	PF01048	0.559
MOD_GlcNHglycan	296	300	PF01048	0.522
MOD_GlcNHglycan	302	305	PF01048	0.547
MOD_GlcNHglycan	401	404	PF01048	0.734
MOD_GlcNHglycan	407	410	PF01048	0.681
MOD_GlcNHglycan	435	438	PF01048	0.616
MOD_GlcNHglycan	445	448	PF01048	0.545
MOD_GlcNHglycan	536	539	PF01048	0.665
MOD_GlcNHglycan	543	546	PF01048	0.573
MOD_GlcNHglycan	582	585	PF01048	0.576
MOD_GSK3_1	113	120	PF00069	0.347
MOD_GSK3_1	151	158	PF00069	0.430
MOD_GSK3_1	240	247	PF00069	0.562
MOD_GSK3_1	295	302	PF00069	0.546
MOD_GSK3_1	360	367	PF00069	0.563
MOD_GSK3_1	397	404	PF00069	0.635
MOD_GSK3_1	435	442	PF00069	0.634
MOD_GSK3_1	474	481	PF00069	0.640
MOD_GSK3_1	489	496	PF00069	0.558
MOD_GSK3_1	516	523	PF00069	0.536
MOD_GSK3_1	575	582	PF00069	0.534
MOD_GSK3_1	94	101	PF00069	0.618
MOD_LATS_1	489	495	PF00433	0.520
MOD_NEK2_1	153	158	PF00069	0.469
MOD_NEK2_1	16	21	PF00069	0.484
MOD_NEK2_1	230	235	PF00069	0.529
MOD_NEK2_1	237	242	PF00069	0.498
MOD_NEK2_1	244	249	PF00069	0.630
MOD_NEK2_1	364	369	PF00069	0.575
MOD_NEK2_1	396	401	PF00069	0.594
MOD_NEK2_1	478	483	PF00069	0.591
MOD_NEK2_1	53	58	PF00069	0.444
MOD_NEK2_1	536	541	PF00069	0.681
MOD_NEK2_1	580	585	PF00069	0.541
MOD_PIKK_1	133	139	PF00454	0.393
MOD_PIKK_1	176	182	PF00454	0.588
MOD_PIKK_1	302	308	PF00454	0.668
MOD_PKA_2	116	122	PF00069	0.563
MOD_PKA_2	308	314	PF00069	0.494
MOD_PKA_2	337	343	PF00069	0.385
MOD_PKA_2	520	526	PF00069	0.672
MOD_PKA_2	534	540	PF00069	0.569
MOD_PKA_2	570	576	PF00069	0.583
MOD_Plk_1	113	119	PF00069	0.462
MOD_Plk_1	230	236	PF00069	0.471
MOD_Plk_1	426	432	PF00069	0.731
MOD_Plk_1	653	659	PF00069	0.609
MOD_Plk_1	98	104	PF00069	0.498
MOD_Plk_2-3	357	363	PF00069	0.576
MOD_Plk_4	218	224	PF00069	0.416
MOD_Plk_4	360	366	PF00069	0.560
MOD_Plk_4	40	46	PF00069	0.585
MOD_Plk_4	426	432	PF00069	0.749
MOD_Plk_4	474	480	PF00069	0.568
MOD_Plk_4	509	515	PF00069	0.639
MOD_Plk_4	520	526	PF00069	0.563
MOD_Plk_4	53	59	PF00069	0.335
MOD_Plk_4	544	550	PF00069	0.589
MOD_ProDKin_1	171	177	PF00069	0.499
MOD_ProDKin_1	397	403	PF00069	0.543
TRG_DiLeu_BaEn_1	164	169	PF01217	0.381
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.477
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.471
TRG_ENDOCYTIC_2	165	168	PF00928	0.441
TRG_ENDOCYTIC_2	322	325	PF00928	0.495
TRG_ENDOCYTIC_2	353	356	PF00928	0.547
TRG_ENDOCYTIC_2	45	48	PF00928	0.533
TRG_ER_diArg_1	322	324	PF00400	0.451
TRG_ER_diArg_1	486	488	PF00400	0.641
TRG_ER_diArg_1	495	498	PF00400	0.614
TRG_ER_diArg_1	83	85	PF00400	0.536
TRG_NES_CRM1_1	557	570	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9N5	Leptomonas seymouri	38%	100%
A4HE96	Leishmania braziliensis	78%	100%
A4I1P2	Leishmania infantum	99%	100%
C9ZK91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AXS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9P5	Leishmania major	92%	100%