Queuosine salvage protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2419), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8INL6_LEIDO

TriTrypDb:

LdBPK_361750.1 , LdCL_360023000 , LDHU3_36.2310

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8INL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INL6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0101030	tRNA-guanine transglycosylation	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.447
CLV_C14_Caspase3-7	50	54	PF00656	0.547
CLV_NRD_NRD_1	204	206	PF00675	0.391
CLV_PCSK_KEX2_1	204	206	PF00082	0.379
CLV_PCSK_KEX2_1	511	513	PF00082	0.379
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.379
CLV_PCSK_SKI1_1	451	455	PF00082	0.479
CLV_PCSK_SKI1_1	466	470	PF00082	0.294
CLV_PCSK_SKI1_1	528	532	PF00082	0.498
DOC_ANK_TNKS_1	316	323	PF00023	0.562
DOC_CKS1_1	480	485	PF01111	0.445
DOC_CYCLIN_RxL_1	472	482	PF00134	0.445
DOC_MAPK_gen_1	255	264	PF00069	0.401
DOC_MAPK_gen_1	431	440	PF00069	0.393
DOC_MAPK_gen_1	511	519	PF00069	0.445
DOC_MAPK_MEF2A_6	25	32	PF00069	0.505
DOC_MAPK_MEF2A_6	255	264	PF00069	0.368
DOC_MAPK_NFAT4_5	257	265	PF00069	0.386
DOC_PP1_RVXF_1	233	239	PF00149	0.431
DOC_PP1_RVXF_1	473	480	PF00149	0.410
DOC_PP2B_LxvP_1	249	252	PF13499	0.490
DOC_PP2B_LxvP_1	286	289	PF13499	0.442
DOC_PP2B_LxvP_1	454	457	PF13499	0.410
DOC_PP2B_LxvP_1	87	90	PF13499	0.399
DOC_PP4_FxxP_1	168	171	PF00568	0.588
DOC_USP7_MATH_1	126	130	PF00917	0.464
DOC_USP7_MATH_1	229	233	PF00917	0.498
DOC_USP7_MATH_1	365	369	PF00917	0.523
DOC_USP7_MATH_1	383	387	PF00917	0.595
DOC_USP7_MATH_1	407	411	PF00917	0.639
DOC_USP7_MATH_1	45	49	PF00917	0.463
DOC_WW_Pin1_4	244	249	PF00397	0.465
DOC_WW_Pin1_4	331	336	PF00397	0.476
DOC_WW_Pin1_4	370	375	PF00397	0.573
DOC_WW_Pin1_4	479	484	PF00397	0.457
LIG_14-3-3_CanoR_1	271	276	PF00244	0.452
LIG_14-3-3_CanoR_1	403	407	PF00244	0.540
LIG_14-3-3_CanoR_1	466	471	PF00244	0.410
LIG_14-3-3_CanoR_1	486	491	PF00244	0.162
LIG_14-3-3_CanoR_1	512	517	PF00244	0.353
LIG_14-3-3_CanoR_1	77	85	PF00244	0.637
LIG_APCC_ABBA_1	165	170	PF00400	0.454
LIG_APCC_ABBA_1	438	443	PF00400	0.445
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BRCT_BRCA1_1	411	415	PF00533	0.440
LIG_BRCT_BRCA1_1	91	95	PF00533	0.493
LIG_CSL_BTD_1	249	252	PF09270	0.398
LIG_CtBP_PxDLS_1	90	94	PF00389	0.362
LIG_DLG_GKlike_1	271	278	PF00625	0.461
LIG_FHA_1	156	162	PF00498	0.597
LIG_FHA_1	229	235	PF00498	0.399
LIG_FHA_2	331	337	PF00498	0.538
LIG_FHA_2	403	409	PF00498	0.540
LIG_FHA_2	495	501	PF00498	0.398
LIG_Integrin_RGD_1	224	226	PF01839	0.550
LIG_LIR_Apic_2	166	171	PF02991	0.595
LIG_LIR_Apic_2	426	430	PF02991	0.318
LIG_LIR_Gen_1	314	323	PF02991	0.576
LIG_LIR_Nem_3	135	140	PF02991	0.447
LIG_LIR_Nem_3	273	279	PF02991	0.350
LIG_LIR_Nem_3	314	318	PF02991	0.515
LIG_PAM2_1	378	390	PF00658	0.657
LIG_Pex14_2	215	219	PF04695	0.483
LIG_PTAP_UEV_1	379	384	PF05743	0.716
LIG_PTB_Apo_2	58	65	PF02174	0.301
LIG_PTB_Phospho_1	58	64	PF10480	0.288
LIG_RPA_C_Fungi	266	278	PF08784	0.462
LIG_SH2_CRK	276	280	PF00017	0.416
LIG_SH2_CRK	427	431	PF00017	0.318
LIG_SH2_CRK	529	533	PF00017	0.410
LIG_SH2_NCK_1	141	145	PF00017	0.477
LIG_SH2_SRC	427	430	PF00017	0.354
LIG_SH2_SRC	441	444	PF00017	0.354
LIG_SH2_STAP1	312	316	PF00017	0.425
LIG_SH2_STAP1	441	445	PF00017	0.410
LIG_SH2_STAP1	521	525	PF00017	0.410
LIG_SH2_STAT5	103	106	PF00017	0.311
LIG_SH2_STAT5	201	204	PF00017	0.436
LIG_SH2_STAT5	525	528	PF00017	0.365
LIG_SH2_STAT5	9	12	PF00017	0.598
LIG_SH3_1	377	383	PF00018	0.625
LIG_SH3_3	141	147	PF00018	0.528
LIG_SH3_3	317	323	PF00018	0.564
LIG_SH3_3	377	383	PF00018	0.754
LIG_SH3_3	499	505	PF00018	0.432
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.454
LIG_SUMO_SIM_par_1	106	111	PF11976	0.343
LIG_SUMO_SIM_par_1	163	170	PF11976	0.449
LIG_SUMO_SIM_par_1	259	266	PF11976	0.393
LIG_SUMO_SIM_par_1	85	92	PF11976	0.372
LIG_TRAF2_1	459	462	PF00917	0.410
LIG_WW_1	6	9	PF00397	0.439
MOD_CDK_SPxxK_3	370	377	PF00069	0.533
MOD_CDK_SPxxK_3	479	486	PF00069	0.412
MOD_CK1_1	13	19	PF00069	0.462
MOD_CK1_1	148	154	PF00069	0.654
MOD_CK1_1	346	352	PF00069	0.439
MOD_CK1_1	367	373	PF00069	0.631
MOD_CK1_1	386	392	PF00069	0.477
MOD_CK1_1	402	408	PF00069	0.779
MOD_CK1_1	409	415	PF00069	0.396
MOD_CK1_1	65	71	PF00069	0.556
MOD_CK1_1	79	85	PF00069	0.525
MOD_CK2_1	126	132	PF00069	0.526
MOD_CK2_1	395	401	PF00069	0.559
MOD_CK2_1	402	408	PF00069	0.593
MOD_CK2_1	456	462	PF00069	0.445
MOD_CK2_1	494	500	PF00069	0.398
MOD_CK2_1	85	91	PF00069	0.434
MOD_GlcNHglycan	150	153	PF01048	0.597
MOD_GlcNHglycan	172	175	PF01048	0.719
MOD_GlcNHglycan	195	198	PF01048	0.448
MOD_GlcNHglycan	231	234	PF01048	0.499
MOD_GlcNHglycan	367	370	PF01048	0.591
MOD_GlcNHglycan	380	383	PF01048	0.625
MOD_GlcNHglycan	397	400	PF01048	0.575
MOD_GlcNHglycan	411	414	PF01048	0.395
MOD_GlcNHglycan	417	420	PF01048	0.373
MOD_GlcNHglycan	458	461	PF01048	0.379
MOD_GlcNHglycan	67	70	PF01048	0.659
MOD_GlcNHglycan	78	81	PF01048	0.476
MOD_GSK3_1	1	8	PF00069	0.636
MOD_GSK3_1	10	17	PF00069	0.392
MOD_GSK3_1	122	129	PF00069	0.575
MOD_GSK3_1	166	173	PF00069	0.633
MOD_GSK3_1	224	231	PF00069	0.497
MOD_GSK3_1	327	334	PF00069	0.680
MOD_GSK3_1	364	371	PF00069	0.549
MOD_GSK3_1	395	402	PF00069	0.693
MOD_GSK3_1	415	422	PF00069	0.214
MOD_GSK3_1	75	82	PF00069	0.530
MOD_GSK3_1	85	92	PF00069	0.349
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	193	198	PF00069	0.410
MOD_NEK2_1	260	265	PF00069	0.383
MOD_NEK2_1	33	38	PF00069	0.518
MOD_NEK2_1	343	348	PF00069	0.429
MOD_NEK2_1	415	420	PF00069	0.362
MOD_NEK2_1	539	544	PF00069	0.318
MOD_PIKK_1	343	349	PF00454	0.431
MOD_PK_1	512	518	PF00069	0.295
MOD_PKA_2	14	20	PF00069	0.401
MOD_PKA_2	193	199	PF00069	0.371
MOD_PKA_2	270	276	PF00069	0.459
MOD_PKA_2	402	408	PF00069	0.540
MOD_PKA_2	485	491	PF00069	0.399
MOD_PKA_2	76	82	PF00069	0.681
MOD_PKB_1	222	230	PF00069	0.451
MOD_Plk_1	407	413	PF00069	0.678
MOD_Plk_1	461	467	PF00069	0.356
MOD_Plk_4	188	194	PF00069	0.531
MOD_Plk_4	271	277	PF00069	0.371
MOD_Plk_4	28	34	PF00069	0.559
MOD_Plk_4	301	307	PF00069	0.427
MOD_Plk_4	383	389	PF00069	0.555
MOD_Plk_4	466	472	PF00069	0.410
MOD_Plk_4	512	518	PF00069	0.295
MOD_ProDKin_1	244	250	PF00069	0.463
MOD_ProDKin_1	331	337	PF00069	0.462
MOD_ProDKin_1	370	376	PF00069	0.578
MOD_ProDKin_1	479	485	PF00069	0.457
TRG_DiLeu_BaEn_1	256	261	PF01217	0.452
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.410
TRG_ENDOCYTIC_2	103	106	PF00928	0.311
TRG_ENDOCYTIC_2	141	144	PF00928	0.379
TRG_ENDOCYTIC_2	275	278	PF00928	0.423
TRG_ENDOCYTIC_2	312	315	PF00928	0.368
TRG_ER_diArg_1	203	205	PF00400	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P722	Leptomonas seymouri	51%	100%
A0A1X0P849	Trypanosomatidae	34%	100%
A4HP31	Leishmania braziliensis	75%	100%
A4IDD8	Leishmania infantum	99%	100%
D0A314	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AST9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1Q7	Leishmania major	91%	100%