Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8INL3_LEIDO

TriTrypDb:

LdBPK_342890.1 , LdCL_340037000 , LDHU3_34.4910

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8INL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INL3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	1
GO:0005215	transporter activity	1	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	1
GO:0005347	ATP transmembrane transporter activity	5	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015216	purine nucleotide transmembrane transporter activity	5	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.718
CLV_NRD_NRD_1	33	35	PF00675	0.492
CLV_NRD_NRD_1	49	51	PF00675	0.536
CLV_PCSK_KEX2_1	258	260	PF00082	0.597
CLV_PCSK_KEX2_1	33	35	PF00082	0.492
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.597
CLV_PCSK_SKI1_1	255	259	PF00082	0.572
CLV_PCSK_SKI1_1	320	324	PF00082	0.486
CLV_PCSK_SKI1_1	51	55	PF00082	0.642
CLV_Separin_Metazoa	204	208	PF03568	0.436
DEG_APCC_DBOX_1	32	40	PF00400	0.578
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DEG_SCF_FBW7_1	123	128	PF00400	0.644
DEG_SIAH_1	118	126	PF03145	0.582
DOC_CDC14_PxL_1	156	164	PF14671	0.548
DOC_CKS1_1	145	150	PF01111	0.598
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.592
DOC_MAPK_gen_1	133	141	PF00069	0.623
DOC_MAPK_gen_1	46	55	PF00069	0.562
DOC_PP2B_LxvP_1	146	149	PF13499	0.576
DOC_USP7_MATH_1	119	123	PF00917	0.662
DOC_USP7_MATH_1	243	247	PF00917	0.389
DOC_USP7_UBL2_3	48	52	PF12436	0.498
DOC_WW_Pin1_4	112	117	PF00397	0.643
DOC_WW_Pin1_4	121	126	PF00397	0.588
DOC_WW_Pin1_4	144	149	PF00397	0.597
LIG_14-3-3_CanoR_1	103	107	PF00244	0.673
LIG_14-3-3_CanoR_1	137	142	PF00244	0.578
LIG_14-3-3_CanoR_1	34	40	PF00244	0.484
LIG_Actin_WH2_2	322	337	PF00022	0.389
LIG_deltaCOP1_diTrp_1	5	12	PF00928	0.525
LIG_FHA_1	122	128	PF00498	0.668
LIG_FHA_1	186	192	PF00498	0.370
LIG_FHA_1	341	347	PF00498	0.330
LIG_FHA_2	126	132	PF00498	0.718
LIG_GBD_Chelix_1	28	36	PF00786	0.571
LIG_Integrin_isoDGR_2	300	302	PF01839	0.389
LIG_LIR_Gen_1	147	156	PF02991	0.608
LIG_LIR_Gen_1	25	32	PF02991	0.472
LIG_LIR_Gen_1	343	350	PF02991	0.330
LIG_LIR_Gen_1	75	86	PF02991	0.611
LIG_LIR_Nem_3	147	153	PF02991	0.606
LIG_LIR_Nem_3	217	222	PF02991	0.389
LIG_LIR_Nem_3	25	29	PF02991	0.244
LIG_LIR_Nem_3	323	329	PF02991	0.389
LIG_LIR_Nem_3	343	347	PF02991	0.161
LIG_LIR_Nem_3	5	11	PF02991	0.524
LIG_LIR_Nem_3	75	81	PF02991	0.591
LIG_PCNA_yPIPBox_3	315	326	PF02747	0.389
LIG_Pex14_2	218	222	PF04695	0.389
LIG_Pex14_2	26	30	PF04695	0.477
LIG_SH2_NCK_1	240	244	PF00017	0.389
LIG_SH2_STAP1	40	44	PF00017	0.520
LIG_SH2_STAT3	250	253	PF00017	0.510
LIG_SH2_STAT5	333	336	PF00017	0.352
LIG_SH2_STAT5	35	38	PF00017	0.572
LIG_SH3_3	113	119	PF00018	0.702
LIG_SH3_3	280	286	PF00018	0.389
LIG_TYR_ITIM	230	235	PF00017	0.389
LIG_UBA3_1	179	187	PF00899	0.341
LIG_UBA3_1	248	256	PF00899	0.563
MOD_CK1_1	115	121	PF00069	0.706
MOD_CK1_1	144	150	PF00069	0.593
MOD_CK1_1	263	269	PF00069	0.562
MOD_CK1_1	324	330	PF00069	0.336
MOD_CK1_1	340	346	PF00069	0.303
MOD_CK2_1	125	131	PF00069	0.629
MOD_CK2_1	35	41	PF00069	0.488
MOD_GlcNHglycan	241	244	PF01048	0.486
MOD_GlcNHglycan	265	268	PF01048	0.569
MOD_GlcNHglycan	306	309	PF01048	0.486
MOD_GlcNHglycan	326	329	PF01048	0.161
MOD_GlcNHglycan	339	342	PF01048	0.389
MOD_GlcNHglycan	62	67	PF01048	0.621
MOD_GSK3_1	115	122	PF00069	0.612
MOD_GSK3_1	137	144	PF00069	0.562
MOD_GSK3_1	239	246	PF00069	0.389
MOD_GSK3_1	275	282	PF00069	0.389
MOD_GSK3_1	289	296	PF00069	0.389
MOD_GSK3_1	320	327	PF00069	0.389
MOD_GSK3_1	90	97	PF00069	0.770
MOD_N-GLC_1	164	169	PF02516	0.389
MOD_NEK2_1	239	244	PF00069	0.389
MOD_NEK2_1	274	279	PF00069	0.389
MOD_NEK2_2	321	326	PF00069	0.389
MOD_NEK2_2	35	40	PF00069	0.481
MOD_PIKK_1	293	299	PF00454	0.389
MOD_PIKK_1	69	75	PF00454	0.508
MOD_PK_1	137	143	PF00069	0.622
MOD_PK_1	64	70	PF00069	0.588
MOD_PKA_1	304	310	PF00069	0.411
MOD_PKA_2	102	108	PF00069	0.732
MOD_PKB_1	135	143	PF00069	0.579
MOD_PKB_1	291	299	PF00069	0.389
MOD_Plk_1	141	147	PF00069	0.584
MOD_Plk_1	164	170	PF00069	0.389
MOD_Plk_1	260	266	PF00069	0.536
MOD_Plk_4	109	115	PF00069	0.558
MOD_Plk_4	141	147	PF00069	0.587
MOD_Plk_4	243	249	PF00069	0.330
MOD_Plk_4	321	327	PF00069	0.389
MOD_Plk_4	340	346	PF00069	0.295
MOD_Plk_4	35	41	PF00069	0.488
MOD_Plk_4	94	100	PF00069	0.711
MOD_ProDKin_1	112	118	PF00069	0.641
MOD_ProDKin_1	121	127	PF00069	0.582
MOD_ProDKin_1	144	150	PF00069	0.597
TRG_DiLeu_BaEn_2	73	79	PF01217	0.527
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.367
TRG_ENDOCYTIC_2	219	222	PF00928	0.389
TRG_ENDOCYTIC_2	232	235	PF00928	0.359
TRG_ENDOCYTIC_2	306	309	PF00928	0.389
TRG_ER_diArg_1	132	135	PF00400	0.627
TRG_ER_diArg_1	290	293	PF00400	0.389
TRG_ER_diArg_1	32	34	PF00400	0.479
TRG_ER_diArg_1	86	89	PF00400	0.648
TRG_NLS_Bipartite_1	33	54	PF00514	0.611
TRG_NLS_MonoExtC_3	254	259	PF00514	0.569
TRG_NLS_MonoExtN_4	48	54	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG6	Leptomonas seymouri	71%	68%
A4H8E6	Leishmania braziliensis	24%	100%
A4HB25	Leishmania braziliensis	80%	100%
A4IA82	Leishmania infantum	100%	100%
A5PJZ1	Bos taurus	28%	75%
B8ZHC9	Rattus norvegicus	26%	100%
E9B595	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2N8	Leishmania major	94%	100%
Q5PQ27	Xenopus laevis	27%	100%
Q6DHC3	Danio rerio	21%	100%
Q86AV5	Dictyostelium discoideum	25%	100%
Q9BV35	Homo sapiens	31%	76%
Q9FI43	Arabidopsis thaliana	24%	74%
Q9P6L7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	99%