DNA polymerase delta subunit 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase delta subunit 2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ING8_LEIDO

TriTrypDb:

LdBPK_251450.1 , LdCL_250020100 , LDHU3_25.1790

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0043625	delta DNA polymerase complex	3	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

A0A3Q8ING8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ING8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0022616	DNA strand elongation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	8
GO:0003887	DNA-directed DNA polymerase activity	5	8
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034061	DNA polymerase activity	4	8
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.398
CLV_C14_Caspase3-7	430	434	PF00656	0.497
CLV_NRD_NRD_1	76	78	PF00675	0.382
CLV_PCSK_KEX2_1	76	78	PF00082	0.384
CLV_PCSK_SKI1_1	184	188	PF00082	0.339
CLV_PCSK_SKI1_1	217	221	PF00082	0.458
CLV_PCSK_SKI1_1	25	29	PF00082	0.411
CLV_PCSK_SKI1_1	314	318	PF00082	0.321
CLV_PCSK_SKI1_1	509	513	PF00082	0.507
CLV_PCSK_SKI1_1	522	526	PF00082	0.651
CLV_PCSK_SKI1_1	76	80	PF00082	0.382
CLV_PCSK_SKI1_1	95	99	PF00082	0.441
CLV_Separin_Metazoa	110	114	PF03568	0.339
DEG_APCC_DBOX_1	183	191	PF00400	0.321
DEG_APCC_DBOX_1	24	32	PF00400	0.435
DEG_APCC_DBOX_1	267	275	PF00400	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.514
DOC_CKS1_1	492	497	PF01111	0.420
DOC_CYCLIN_RxL_1	21	32	PF00134	0.444
DOC_MAPK_FxFP_2	479	482	PF00069	0.321
DOC_MAPK_gen_1	266	275	PF00069	0.339
DOC_MAPK_gen_1	290	299	PF00069	0.425
DOC_MAPK_gen_1	311	318	PF00069	0.305
DOC_MAPK_gen_1	351	360	PF00069	0.452
DOC_MAPK_gen_1	384	393	PF00069	0.316
DOC_MAPK_gen_1	425	431	PF00069	0.555
DOC_MAPK_gen_1	74	81	PF00069	0.364
DOC_MAPK_HePTP_8	348	360	PF00069	0.321
DOC_MAPK_MEF2A_6	194	203	PF00069	0.425
DOC_MAPK_MEF2A_6	266	275	PF00069	0.322
DOC_MAPK_MEF2A_6	351	360	PF00069	0.321
DOC_MAPK_MEF2A_6	566	575	PF00069	0.421
DOC_MAPK_NFAT4_5	268	276	PF00069	0.362
DOC_PP1_RVXF_1	27	34	PF00149	0.450
DOC_PP2B_LxvP_1	380	383	PF13499	0.339
DOC_PP4_FxxP_1	479	482	PF00568	0.321
DOC_PP4_FxxP_1	587	590	PF00568	0.577
DOC_USP7_MATH_1	132	136	PF00917	0.312
DOC_USP7_MATH_1	209	213	PF00917	0.409
DOC_USP7_MATH_1	243	247	PF00917	0.391
DOC_USP7_MATH_1	253	257	PF00917	0.547
DOC_USP7_MATH_1	267	271	PF00917	0.357
DOC_USP7_MATH_1	331	335	PF00917	0.423
DOC_USP7_MATH_1	449	453	PF00917	0.425
DOC_USP7_UBL2_3	311	315	PF12436	0.311
DOC_WW_Pin1_4	235	240	PF00397	0.483
DOC_WW_Pin1_4	491	496	PF00397	0.390
DOC_WW_Pin1_4	574	579	PF00397	0.397
LIG_14-3-3_CanoR_1	225	229	PF00244	0.400
LIG_14-3-3_CanoR_1	266	272	PF00244	0.341
LIG_14-3-3_CanoR_1	351	357	PF00244	0.367
LIG_14-3-3_CanoR_1	509	514	PF00244	0.520
LIG_Actin_WH2_2	209	227	PF00022	0.431
LIG_AP2alpha_2	487	489	PF02296	0.305
LIG_BRCT_BRCA1_1	29	33	PF00533	0.545
LIG_BRCT_BRCA1_1	367	371	PF00533	0.339
LIG_BRCT_BRCA1_1	394	398	PF00533	0.436
LIG_BRCT_BRCA1_1	479	483	PF00533	0.309
LIG_Clathr_ClatBox_1	111	115	PF01394	0.305
LIG_Clathr_ClatBox_1	570	574	PF01394	0.373
LIG_EH_1	395	399	PF12763	0.425
LIG_EH1_1	53	61	PF00400	0.277
LIG_eIF4E_1	94	100	PF01652	0.339
LIG_FHA_1	195	201	PF00498	0.305
LIG_FHA_1	305	311	PF00498	0.317
LIG_FHA_1	353	359	PF00498	0.341
LIG_FHA_1	388	394	PF00498	0.396
LIG_FHA_1	407	413	PF00498	0.389
LIG_FHA_1	48	54	PF00498	0.374
LIG_FHA_1	580	586	PF00498	0.464
LIG_FHA_2	345	351	PF00498	0.434
LIG_FHA_2	454	460	PF00498	0.330
LIG_FHA_2	510	516	PF00498	0.462
LIG_LIR_Apic_2	477	482	PF02991	0.321
LIG_LIR_Apic_2	586	590	PF02991	0.479
LIG_LIR_Gen_1	223	234	PF02991	0.450
LIG_LIR_Gen_1	238	248	PF02991	0.416
LIG_LIR_Gen_1	507	516	PF02991	0.457
LIG_LIR_Nem_3	223	229	PF02991	0.446
LIG_LIR_Nem_3	238	244	PF02991	0.424
LIG_LIR_Nem_3	507	513	PF02991	0.384
LIG_LIR_Nem_3	523	527	PF02991	0.533
LIG_MYND_1	379	383	PF01753	0.321
LIG_NRBOX	344	350	PF00104	0.425
LIG_Pex14_2	479	483	PF04695	0.321
LIG_PTAP_UEV_1	471	476	PF05743	0.305
LIG_SH2_CRK	204	208	PF00017	0.425
LIG_SH2_STAP1	49	53	PF00017	0.418
LIG_SH2_STAT5	241	244	PF00017	0.413
LIG_SH2_STAT5	49	52	PF00017	0.376
LIG_SH3_3	226	232	PF00018	0.434
LIG_SH3_3	370	376	PF00018	0.291
LIG_SH3_3	391	397	PF00018	0.320
LIG_SH3_3	469	475	PF00018	0.305
LIG_SH3_3	572	578	PF00018	0.395
LIG_SH3_3	80	86	PF00018	0.388
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.342
LIG_SUMO_SIM_anti_2	357	362	PF11976	0.321
LIG_SUMO_SIM_par_1	354	359	PF11976	0.340
LIG_SUMO_SIM_par_1	462	467	PF11976	0.452
LIG_SUMO_SIM_par_1	569	574	PF11976	0.386
LIG_TRAF2_1	257	260	PF00917	0.564
LIG_TRAF2_1	512	515	PF00917	0.566
LIG_WRC_WIRS_1	561	566	PF05994	0.372
LIG_WRC_WIRS_1	584	589	PF05994	0.504
MOD_CK1_1	246	252	PF00069	0.470
MOD_CK1_1	3	9	PF00069	0.654
MOD_CK1_1	334	340	PF00069	0.398
MOD_CK1_1	531	537	PF00069	0.695
MOD_CK1_1	539	545	PF00069	0.736
MOD_CK1_1	583	589	PF00069	0.515
MOD_CK2_1	169	175	PF00069	0.362
MOD_CK2_1	253	259	PF00069	0.530
MOD_CK2_1	344	350	PF00069	0.440
MOD_CK2_1	509	515	PF00069	0.462
MOD_CK2_1	539	545	PF00069	0.749
MOD_DYRK1A_RPxSP_1	235	239	PF00069	0.466
MOD_GlcNHglycan	121	126	PF01048	0.419
MOD_GlcNHglycan	14	17	PF01048	0.524
MOD_GlcNHglycan	171	174	PF01048	0.340
MOD_GlcNHglycan	179	184	PF01048	0.287
MOD_GlcNHglycan	220	223	PF01048	0.517
MOD_GlcNHglycan	245	248	PF01048	0.369
MOD_GlcNHglycan	337	340	PF01048	0.302
MOD_GlcNHglycan	440	443	PF01048	0.341
MOD_GlcNHglycan	466	469	PF01048	0.348
MOD_GlcNHglycan	5	8	PF01048	0.649
MOD_GlcNHglycan	50	53	PF01048	0.403
MOD_GlcNHglycan	538	541	PF01048	0.705
MOD_GlcNHglycan	566	569	PF01048	0.449
MOD_GSK3_1	165	172	PF00069	0.353
MOD_GSK3_1	27	34	PF00069	0.515
MOD_GSK3_1	279	286	PF00069	0.395
MOD_GSK3_1	300	307	PF00069	0.347
MOD_GSK3_1	331	338	PF00069	0.381
MOD_GSK3_1	449	456	PF00069	0.328
MOD_GSK3_1	470	477	PF00069	0.303
MOD_GSK3_1	505	512	PF00069	0.421
MOD_GSK3_1	522	529	PF00069	0.483
MOD_GSK3_1	560	567	PF00069	0.373
MOD_GSK3_1	576	583	PF00069	0.410
MOD_N-GLC_1	209	214	PF02516	0.420
MOD_N-GLC_1	283	288	PF02516	0.461
MOD_N-GLC_1	3	8	PF02516	0.540
MOD_NEK2_1	178	183	PF00069	0.375
MOD_NEK2_1	224	229	PF00069	0.398
MOD_NEK2_1	31	36	PF00069	0.465
MOD_NEK2_1	398	403	PF00069	0.398
MOD_NEK2_1	437	442	PF00069	0.306
MOD_NEK2_1	564	569	PF00069	0.347
MOD_NEK2_1	580	585	PF00069	0.373
MOD_NEK2_2	209	214	PF00069	0.355
MOD_NEK2_2	283	288	PF00069	0.374
MOD_PIKK_1	31	37	PF00454	0.429
MOD_PKA_2	224	230	PF00069	0.456
MOD_PKA_2	253	259	PF00069	0.590
MOD_PKA_2	267	273	PF00069	0.367
MOD_PKA_2	449	455	PF00069	0.296
MOD_Plk_1	283	289	PF00069	0.461
MOD_Plk_1	580	586	PF00069	0.464
MOD_Plk_2-3	413	419	PF00069	0.521
MOD_Plk_4	203	209	PF00069	0.395
MOD_Plk_4	344	350	PF00069	0.440
MOD_Plk_4	474	480	PF00069	0.383
MOD_Plk_4	580	586	PF00069	0.449
MOD_ProDKin_1	235	241	PF00069	0.472
MOD_ProDKin_1	491	497	PF00069	0.390
MOD_ProDKin_1	574	580	PF00069	0.392
MOD_SUMO_rev_2	303	312	PF00179	0.390
MOD_SUMO_rev_2	322	331	PF00179	0.425
MOD_SUMO_rev_2	542	550	PF00179	0.701
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.450
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.321
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.394
TRG_ENDOCYTIC_2	204	207	PF00928	0.395
TRG_ENDOCYTIC_2	241	244	PF00928	0.327
TRG_ENDOCYTIC_2	37	40	PF00928	0.323
TRG_ENDOCYTIC_2	510	513	PF00928	0.507
TRG_ENDOCYTIC_2	94	97	PF00928	0.326
TRG_ER_diArg_1	41	44	PF00400	0.379
TRG_ER_diArg_1	75	77	PF00400	0.352
TRG_NES_CRM1_1	346	359	PF08389	0.425
TRG_NLS_MonoExtC_3	312	317	PF00514	0.321
TRG_NLS_MonoExtC_3	424	430	PF00514	0.663
TRG_NLS_MonoExtN_4	311	318	PF00514	0.321
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P663	Leptomonas seymouri	71%	100%
A0A0S4IRV7	Bodo saltans	40%	100%
A0A1X0NMG0	Trypanosomatidae	48%	100%
A0A422P247	Trypanosoma rangeli	47%	100%
A4HEE9	Leishmania braziliensis	86%	100%
A4I1I5	Leishmania infantum	99%	100%
C9ZJY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AXM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O35654	Mus musculus	27%	100%
O48520	Arabidopsis thaliana	25%	100%
O93610	Xenopus laevis	26%	100%
P46957	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P49004	Bos taurus	27%	100%
P49005	Homo sapiens	27%	100%
P87324	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4Q9V2	Leishmania major	94%	100%
Q6AXY4	Rattus norvegicus	26%	100%
Q9LRE5	Oryza sativa subsp. japonica	26%	100%
Q9W088	Drosophila melanogaster	26%	100%
V5B3K0	Trypanosoma cruzi	46%	100%