Phospholipid-transporting ATPase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipid-transporting ATPase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ING5_LEIDO

TriTrypDb:

LdBPK_342460.1 , LdCL_340032200 , LDHU3_34.4040

Length:

1491

Annotations

LeishMANIAdb annotations

Eukaryotic P-ATPase protein, its closest animal relatives (ATP11A) are involved in phospholipid transport.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

A0A3Q8ING5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006869	lipid transport	5	2
GO:0009987	cellular process	1	1
GO:0015748	organophosphate ester transport	5	2
GO:0015914	phospholipid transport	6	2
GO:0016043	cellular component organization	3	1
GO:0034204	lipid translocation	4	1
GO:0045332	phospholipid translocation	5	1
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0000287	magnesium ion binding	5	1
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	8
GO:0005319	lipid transporter activity	2	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.578
CLV_C14_Caspase3-7	173	177	PF00656	0.608
CLV_C14_Caspase3-7	217	221	PF00656	0.573
CLV_C14_Caspase3-7	785	789	PF00656	0.473
CLV_NRD_NRD_1	1061	1063	PF00675	0.340
CLV_NRD_NRD_1	107	109	PF00675	0.393
CLV_NRD_NRD_1	1144	1146	PF00675	0.346
CLV_NRD_NRD_1	246	248	PF00675	0.367
CLV_NRD_NRD_1	705	707	PF00675	0.226
CLV_NRD_NRD_1	730	732	PF00675	0.273

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKQ9	Leptomonas seymouri	68%	99%
A0A0S4J0T6	Bodo saltans	26%	100%
A4HAY0	Leishmania braziliensis	78%	100%
A4IA39	Leishmania infantum	100%	100%
E9B554	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q2T2	Leishmania major	95%	100%

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