Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INF5_LEIDO

TriTrypDb:

LdBPK_342290.1 , LdCL_340030600 , LDHU3_34.3810

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005634	nucleus	5	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8INF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.677
CLV_NRD_NRD_1	154	156	PF00675	0.378
CLV_NRD_NRD_1	251	253	PF00675	0.476
CLV_NRD_NRD_1	279	281	PF00675	0.419
CLV_NRD_NRD_1	346	348	PF00675	0.631
CLV_NRD_NRD_1	88	90	PF00675	0.496
CLV_PCSK_KEX2_1	154	156	PF00082	0.378
CLV_PCSK_KEX2_1	251	253	PF00082	0.435
CLV_PCSK_KEX2_1	279	281	PF00082	0.419
CLV_PCSK_KEX2_1	348	350	PF00082	0.590
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.581
CLV_PCSK_SKI1_1	16	20	PF00082	0.671
CLV_PCSK_SKI1_1	298	302	PF00082	0.529
CLV_PCSK_SKI1_1	85	89	PF00082	0.416
CLV_Separin_Metazoa	107	111	PF03568	0.514
CLV_Separin_Metazoa	86	90	PF03568	0.390
DEG_APCC_DBOX_1	159	167	PF00400	0.347
DEG_SPOP_SBC_1	221	225	PF00917	0.529
DEG_SPOP_SBC_1	46	50	PF00917	0.640
DEG_SPOP_SBC_1	62	66	PF00917	0.587
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.533
DOC_PP1_RVXF_1	162	169	PF00149	0.401
DOC_PP4_FxxP_1	113	116	PF00568	0.496
DOC_USP7_MATH_1	208	212	PF00917	0.657
DOC_USP7_MATH_1	217	221	PF00917	0.637
DOC_USP7_MATH_1	300	304	PF00917	0.642
DOC_USP7_MATH_1	343	347	PF00917	0.497
DOC_USP7_MATH_1	37	41	PF00917	0.714
DOC_USP7_MATH_1	42	46	PF00917	0.741
DOC_USP7_MATH_1	47	51	PF00917	0.682
DOC_USP7_MATH_1	81	85	PF00917	0.557
DOC_USP7_UBL2_3	16	20	PF12436	0.661
DOC_WW_Pin1_4	201	206	PF00397	0.629
DOC_WW_Pin1_4	289	294	PF00397	0.648
LIG_14-3-3_CanoR_1	15	19	PF00244	0.669
LIG_14-3-3_CanoR_1	160	164	PF00244	0.389
LIG_14-3-3_CanoR_1	170	180	PF00244	0.343
LIG_14-3-3_CanoR_1	298	307	PF00244	0.584
LIG_Actin_WH2_2	149	166	PF00022	0.402
LIG_Actin_WH2_2	246	264	PF00022	0.365
LIG_EH1_1	93	101	PF00400	0.426
LIG_FHA_1	160	166	PF00498	0.404
LIG_FHA_1	182	188	PF00498	0.361
LIG_FHA_1	319	325	PF00498	0.470
LIG_FHA_1	56	62	PF00498	0.672
LIG_LIR_Apic_2	111	116	PF02991	0.502
LIG_LIR_Gen_1	147	158	PF02991	0.457
LIG_LIR_Gen_1	305	316	PF02991	0.371
LIG_LIR_Nem_3	147	153	PF02991	0.448
LIG_LIR_Nem_3	305	311	PF02991	0.383
LIG_NRP_CendR_1	358	359	PF00754	0.608
LIG_REV1ctd_RIR_1	150	159	PF16727	0.420
LIG_RPA_C_Fungi	167	179	PF08784	0.352
LIG_SH2_GRB2like	308	311	PF00017	0.464
LIG_SH2_PTP2	331	334	PF00017	0.475
LIG_SH2_STAT5	124	127	PF00017	0.330
LIG_SH2_STAT5	150	153	PF00017	0.434
LIG_SH2_STAT5	308	311	PF00017	0.474
LIG_SH2_STAT5	315	318	PF00017	0.505
LIG_SH2_STAT5	331	334	PF00017	0.365
LIG_SUMO_SIM_anti_2	103	111	PF11976	0.382
LIG_SUMO_SIM_anti_2	223	231	PF11976	0.273
LIG_SUMO_SIM_par_1	228	233	PF11976	0.284
LIG_TRAF2_1	66	69	PF00917	0.488
LIG_UBA3_1	229	237	PF00899	0.479
MOD_CK1_1	211	217	PF00069	0.630
MOD_CK1_1	220	226	PF00069	0.405
MOD_CK1_1	289	295	PF00069	0.652
MOD_CK1_1	40	46	PF00069	0.651
MOD_CK1_1	49	55	PF00069	0.657
MOD_CK2_1	108	114	PF00069	0.583
MOD_CK2_1	222	228	PF00069	0.289
MOD_CK2_1	61	67	PF00069	0.569
MOD_GlcNHglycan	173	176	PF01048	0.359
MOD_GlcNHglycan	219	222	PF01048	0.591
MOD_GlcNHglycan	289	292	PF01048	0.672
MOD_GlcNHglycan	302	305	PF01048	0.570
MOD_GlcNHglycan	39	42	PF01048	0.686
MOD_GlcNHglycan	49	52	PF01048	0.729
MOD_GlcNHglycan	81	84	PF01048	0.567
MOD_GSK3_1	14	21	PF00069	0.684
MOD_GSK3_1	197	204	PF00069	0.625
MOD_GSK3_1	208	215	PF00069	0.598
MOD_GSK3_1	217	224	PF00069	0.662
MOD_GSK3_1	298	305	PF00069	0.593
MOD_GSK3_1	343	350	PF00069	0.588
MOD_GSK3_1	42	49	PF00069	0.643
MOD_GSK3_1	75	82	PF00069	0.511
MOD_NEK2_1	125	130	PF00069	0.373
MOD_NEK2_1	181	186	PF00069	0.446
MOD_NEK2_1	230	235	PF00069	0.284
MOD_NEK2_2	14	19	PF00069	0.586
MOD_PK_1	252	258	PF00069	0.416
MOD_PKA_1	347	353	PF00069	0.583
MOD_PKA_2	14	20	PF00069	0.707
MOD_PKA_2	159	165	PF00069	0.439
MOD_PKA_2	171	177	PF00069	0.345
MOD_PKA_2	318	324	PF00069	0.501
MOD_PKB_1	345	353	PF00069	0.508
MOD_Plk_1	125	131	PF00069	0.375
MOD_Plk_1	209	215	PF00069	0.757
MOD_Plk_1	230	236	PF00069	0.297
MOD_Plk_4	125	131	PF00069	0.375
MOD_ProDKin_1	201	207	PF00069	0.629
MOD_ProDKin_1	289	295	PF00069	0.644
TRG_ENDOCYTIC_2	124	127	PF00928	0.424
TRG_ENDOCYTIC_2	150	153	PF00928	0.434
TRG_ENDOCYTIC_2	308	311	PF00928	0.464
TRG_ENDOCYTIC_2	331	334	PF00928	0.475
TRG_ENDOCYTIC_2	94	97	PF00928	0.346
TRG_ER_diArg_1	109	112	PF00400	0.540
TRG_ER_diArg_1	153	155	PF00400	0.532
TRG_ER_diArg_1	170	173	PF00400	0.337
TRG_ER_diArg_1	250	252	PF00400	0.425
TRG_ER_diArg_1	278	280	PF00400	0.408
TRG_NLS_MonoExtC_3	346	351	PF00514	0.450
TRG_NLS_MonoExtN_4	345	351	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC4	Leptomonas seymouri	63%	97%
A0A0S4JWU2	Bodo saltans	36%	100%
A0A1X0P9N6	Trypanosomatidae	46%	100%
A0A3R7NT18	Trypanosoma rangeli	48%	100%
A4HAW3	Leishmania braziliensis	78%	100%
A4IA23	Leishmania infantum	100%	100%
C9ZMJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B538	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2U8	Leishmania major	91%	100%
V5B0E5	Trypanosoma cruzi	50%	97%