LeishMANIAdb
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MGT2 magnesium transporter

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MGT2 magnesium transporter
Gene product:
magnesium transporter protein 2
Species:
Leishmania donovani
UniProt:
A0A3Q8IND2_LEIDO
TriTrypDb:
LdBPK_251130.1 , LdCL_250016700 , LDHU3_25.1450
Length:
413

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Annotations by Jardim et al.

Transporters, MGT2 magnesium transporter MGT2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Amastigote: 20

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IND2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IND2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 7
GO:0006811 monoatomic ion transport 4 7
GO:0006812 monoatomic cation transport 5 7
GO:0051179 localization 1 7
GO:0051234 establishment of localization 2 7
GO:0015693 magnesium ion transport 7 6
GO:0030001 metal ion transport 6 6
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 16
GO:0008324 monoatomic cation transmembrane transporter activity 4 16
GO:0015075 monoatomic ion transmembrane transporter activity 3 16
GO:0015095 magnesium ion transmembrane transporter activity 6 10
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 16
GO:0022857 transmembrane transporter activity 2 16
GO:0022890 inorganic cation transmembrane transporter activity 4 16
GO:0046873 metal ion transmembrane transporter activity 5 16
GO:0015562 efflux transmembrane transporter activity 3 1
GO:0046583 monoatomic cation efflux transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 4 8 PF00656 0.727
CLV_NRD_NRD_1 244 246 PF00675 0.262
CLV_NRD_NRD_1 251 253 PF00675 0.262
CLV_NRD_NRD_1 41 43 PF00675 0.415
CLV_NRD_NRD_1 70 72 PF00675 0.330
CLV_PCSK_KEX2_1 165 167 PF00082 0.377
CLV_PCSK_KEX2_1 244 246 PF00082 0.268
CLV_PCSK_KEX2_1 250 252 PF00082 0.271
CLV_PCSK_KEX2_1 70 72 PF00082 0.319
CLV_PCSK_PC1ET2_1 165 167 PF00082 0.377
CLV_PCSK_SKI1_1 165 169 PF00082 0.324
CLV_PCSK_SKI1_1 245 249 PF00082 0.311
CLV_PCSK_SKI1_1 257 261 PF00082 0.305
CLV_PCSK_SKI1_1 27 31 PF00082 0.379
CLV_PCSK_SKI1_1 292 296 PF00082 0.300
CLV_PCSK_SKI1_1 309 313 PF00082 0.170
CLV_PCSK_SKI1_1 397 401 PF00082 0.425
CLV_PCSK_SKI1_1 71 75 PF00082 0.274
CLV_Separin_Metazoa 172 176 PF03568 0.529
DEG_APCC_DBOX_1 2 10 PF00400 0.640
DEG_APCC_DBOX_1 70 78 PF00400 0.485
DOC_CKS1_1 193 198 PF01111 0.521
DOC_CKS1_1 270 275 PF01111 0.572
DOC_PP1_RVXF_1 361 367 PF00149 0.344
DOC_PP2B_LxvP_1 231 234 PF13499 0.509
DOC_USP7_MATH_1 205 209 PF00917 0.559
DOC_USP7_MATH_1 94 98 PF00917 0.565
DOC_WW_Pin1_4 17 22 PF00397 0.716
DOC_WW_Pin1_4 192 197 PF00397 0.552
DOC_WW_Pin1_4 269 274 PF00397 0.556
DOC_WW_Pin1_4 63 68 PF00397 0.563
LIG_14-3-3_CanoR_1 250 260 PF00244 0.485
LIG_14-3-3_CanoR_1 27 32 PF00244 0.558
LIG_14-3-3_CanoR_1 326 336 PF00244 0.529
LIG_APCC_ABBA_1 288 293 PF00400 0.572
LIG_BRCT_BRCA1_1 196 200 PF00533 0.521
LIG_BRCT_BRCA1_1 36 40 PF00533 0.612
LIG_DLG_GKlike_1 252 259 PF00625 0.572
LIG_eIF4E_1 261 267 PF01652 0.509
LIG_FHA_1 126 132 PF00498 0.580
LIG_FHA_1 153 159 PF00498 0.544
LIG_FHA_1 184 190 PF00498 0.577
LIG_FHA_1 193 199 PF00498 0.552
LIG_FHA_1 214 220 PF00498 0.492
LIG_FHA_1 55 61 PF00498 0.565
LIG_FHA_1 8 14 PF00498 0.751
LIG_FHA_2 122 128 PF00498 0.580
LIG_FHA_2 159 165 PF00498 0.572
LIG_FHA_2 64 70 PF00498 0.550
LIG_FHA_2 93 99 PF00498 0.538
LIG_GBD_Chelix_1 173 181 PF00786 0.294
LIG_LIR_Gen_1 197 206 PF02991 0.521
LIG_LIR_Gen_1 56 67 PF02991 0.519
LIG_LIR_Nem_3 164 170 PF02991 0.511
LIG_LIR_Nem_3 197 203 PF02991 0.577
LIG_LIR_Nem_3 254 259 PF02991 0.572
LIG_LIR_Nem_3 369 374 PF02991 0.263
LIG_LIR_Nem_3 37 41 PF02991 0.598
LIG_LIR_Nem_3 56 62 PF02991 0.519
LIG_LYPXL_yS_3 371 374 PF13949 0.326
LIG_PTB_Apo_2 116 123 PF02174 0.567
LIG_PTB_Phospho_1 116 122 PF10480 0.567
LIG_Rb_pABgroove_1 116 124 PF01858 0.494
LIG_SH2_SRC 109 112 PF00017 0.500
LIG_SH2_STAP1 206 210 PF00017 0.548
LIG_SH2_STAT5 28 31 PF00017 0.606
LIG_SH3_3 190 196 PF00018 0.582
LIG_SH3_3 78 84 PF00018 0.554
LIG_SH3_3 88 94 PF00018 0.518
LIG_SUMO_SIM_anti_2 226 233 PF11976 0.497
LIG_SUMO_SIM_anti_2 342 348 PF11976 0.471
LIG_SUMO_SIM_par_1 155 161 PF11976 0.503
LIG_TRAF2_1 66 69 PF00917 0.552
LIG_UBA3_1 158 165 PF00899 0.557
LIG_UBA3_1 259 265 PF00899 0.577
LIG_UBA3_1 357 363 PF00899 0.319
LIG_WRC_WIRS_1 253 258 PF05994 0.556
MOD_CDK_SPxxK_3 269 276 PF00069 0.556
MOD_CDK_SPxxK_3 63 70 PF00069 0.577
MOD_CK1_1 192 198 PF00069 0.532
MOD_CK1_1 328 334 PF00069 0.511
MOD_CK1_1 34 40 PF00069 0.595
MOD_CK1_1 392 398 PF00069 0.464
MOD_CK1_1 53 59 PF00069 0.567
MOD_CK2_1 121 127 PF00069 0.529
MOD_CK2_1 63 69 PF00069 0.517
MOD_GlcNHglycan 10 13 PF01048 0.525
MOD_GlcNHglycan 136 139 PF01048 0.381
MOD_GlcNHglycan 33 36 PF01048 0.400
MOD_GlcNHglycan 330 333 PF01048 0.305
MOD_GlcNHglycan 84 87 PF01048 0.378
MOD_GSK3_1 121 128 PF00069 0.497
MOD_GSK3_1 148 155 PF00069 0.482
MOD_GSK3_1 185 192 PF00069 0.542
MOD_GSK3_1 213 220 PF00069 0.517
MOD_GSK3_1 27 34 PF00069 0.606
MOD_GSK3_1 271 278 PF00069 0.504
MOD_GSK3_1 321 328 PF00069 0.523
MOD_GSK3_1 50 57 PF00069 0.627
MOD_N-GLC_1 134 139 PF02516 0.377
MOD_N-GLC_1 31 36 PF02516 0.445
MOD_NEK2_1 1 6 PF00069 0.759
MOD_NEK2_1 158 163 PF00069 0.503
MOD_NEK2_1 184 189 PF00069 0.575
MOD_NEK2_1 275 280 PF00069 0.479
MOD_NEK2_1 325 330 PF00069 0.502
MOD_NEK2_1 353 358 PF00069 0.407
MOD_NEK2_1 389 394 PF00069 0.445
MOD_PIKK_1 325 331 PF00454 0.517
MOD_PIKK_1 339 345 PF00454 0.306
MOD_PIKK_1 50 56 PF00454 0.632
MOD_PKA_1 251 257 PF00069 0.509
MOD_PKA_2 251 257 PF00069 0.486
MOD_PKA_2 275 281 PF00069 0.485
MOD_PKA_2 325 331 PF00069 0.529
MOD_PKA_2 92 98 PF00069 0.544
MOD_PKB_1 25 33 PF00069 0.629
MOD_PKB_1 250 258 PF00069 0.542
MOD_Plk_1 184 190 PF00069 0.565
MOD_Plk_1 54 60 PF00069 0.542
MOD_Plk_4 148 154 PF00069 0.498
MOD_Plk_4 189 195 PF00069 0.552
MOD_Plk_4 199 205 PF00069 0.483
MOD_Plk_4 214 220 PF00069 0.472
MOD_Plk_4 275 281 PF00069 0.481
MOD_Plk_4 34 40 PF00069 0.600
MOD_Plk_4 353 359 PF00069 0.378
MOD_Plk_4 54 60 PF00069 0.530
MOD_ProDKin_1 17 23 PF00069 0.715
MOD_ProDKin_1 192 198 PF00069 0.552
MOD_ProDKin_1 269 275 PF00069 0.556
MOD_ProDKin_1 63 69 PF00069 0.563
MOD_SUMO_rev_2 330 338 PF00179 0.511
TRG_DiLeu_BaEn_1 227 232 PF01217 0.483
TRG_DiLeu_BaEn_3 68 74 PF01217 0.573
TRG_ENDOCYTIC_2 28 31 PF00928 0.606
TRG_ENDOCYTIC_2 371 374 PF00928 0.291
TRG_ER_diArg_1 243 245 PF00400 0.462
TRG_ER_diArg_1 249 252 PF00400 0.462
TRG_ER_diArg_1 25 28 PF00400 0.660
TRG_Pf-PMV_PEXEL_1 166 171 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 265 269 PF00026 0.303

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3I5 Leptomonas seymouri 73% 100%
A0A1X0NLW5 Trypanosomatidae 43% 96%
A0A1X0NLX5 Trypanosomatidae 37% 100%
A0A1X0NUD3 Trypanosomatidae 29% 100%
A0A3R7KXL6 Trypanosoma rangeli 37% 100%
A0A3R7R8A9 Trypanosoma rangeli 43% 97%
A0A422N320 Trypanosoma rangeli 28% 76%
A4HE45 Leishmania braziliensis 84% 100%
A4I1F1 Leishmania infantum 100% 100%
C9ZK17 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZK26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 97%
C9ZXP3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AXI8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q9Y4 Leishmania major 97% 100%
V5B7S4 Trypanosoma cruzi 42% 100%
V5D3L0 Trypanosoma cruzi 44% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS