Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INC5_LEIDO

TriTrypDb:

LdBPK_341920.1 , LdCL_340026900 , LDHU3_34.3260

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8INC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.756
CLV_C14_Caspase3-7	165	169	PF00656	0.540
CLV_MEL_PAP_1	407	413	PF00089	0.587
CLV_NRD_NRD_1	251	253	PF00675	0.563
CLV_NRD_NRD_1	63	65	PF00675	0.451
CLV_NRD_NRD_1	80	82	PF00675	0.414
CLV_NRD_NRD_1	86	88	PF00675	0.621
CLV_PCSK_FUR_1	61	65	PF00082	0.561
CLV_PCSK_KEX2_1	115	117	PF00082	0.472
CLV_PCSK_KEX2_1	251	253	PF00082	0.678
CLV_PCSK_KEX2_1	425	427	PF00082	0.645
CLV_PCSK_KEX2_1	63	65	PF00082	0.451
CLV_PCSK_KEX2_1	79	81	PF00082	0.431
CLV_PCSK_KEX2_1	86	88	PF00082	0.568
CLV_PCSK_KEX2_1	99	101	PF00082	0.447
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.472
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.574
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.706
CLV_PCSK_SKI1_1	404	408	PF00082	0.600
CLV_PCSK_SKI1_1	425	429	PF00082	0.546
CLV_PCSK_SKI1_1	432	436	PF00082	0.524
CLV_Separin_Metazoa	446	450	PF03568	0.482
DEG_APCC_DBOX_1	186	194	PF00400	0.607
DEG_APCC_DBOX_1	340	348	PF00400	0.621
DEG_SPOP_SBC_1	152	156	PF00917	0.583
DEG_SPOP_SBC_1	472	476	PF00917	0.679
DOC_CYCLIN_RxL_1	183	195	PF00134	0.608
DOC_CYCLIN_RxL_1	401	408	PF00134	0.606
DOC_MAPK_FxFP_2	216	219	PF00069	0.569
DOC_MAPK_gen_1	173	181	PF00069	0.518
DOC_MAPK_gen_1	251	260	PF00069	0.665
DOC_MAPK_gen_1	79	85	PF00069	0.591
DOC_MAPK_MEF2A_6	14	22	PF00069	0.602
DOC_PP4_FxxP_1	216	219	PF00568	0.569
DOC_USP7_MATH_1	152	156	PF00917	0.743
DOC_USP7_MATH_1	2	6	PF00917	0.612
DOC_USP7_MATH_1	297	301	PF00917	0.601
DOC_USP7_MATH_1	473	477	PF00917	0.570
DOC_USP7_MATH_2	122	128	PF00917	0.716
DOC_USP7_UBL2_3	197	201	PF12436	0.518
DOC_WW_Pin1_4	103	108	PF00397	0.667
DOC_WW_Pin1_4	115	120	PF00397	0.638
DOC_WW_Pin1_4	228	233	PF00397	0.688
DOC_WW_Pin1_4	405	410	PF00397	0.579
DOC_WW_Pin1_4	468	473	PF00397	0.683
LIG_14-3-3_CanoR_1	100	107	PF00244	0.666
LIG_14-3-3_CanoR_1	110	115	PF00244	0.676
LIG_14-3-3_CanoR_1	183	187	PF00244	0.593
LIG_14-3-3_CanoR_1	353	357	PF00244	0.585
LIG_14-3-3_CanoR_1	410	414	PF00244	0.564
LIG_14-3-3_CanoR_1	426	430	PF00244	0.595
LIG_AP2alpha_2	214	216	PF02296	0.560
LIG_APCC_ABBA_1	20	25	PF00400	0.610
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	407	411	PF00533	0.649
LIG_Clathr_ClatBox_1	190	194	PF01394	0.608
LIG_DLG_GKlike_1	110	118	PF00625	0.674
LIG_FHA_1	144	150	PF00498	0.659
LIG_FHA_1	480	486	PF00498	0.635
LIG_FHA_2	158	164	PF00498	0.642
LIG_FHA_2	272	278	PF00498	0.605
LIG_FHA_2	41	47	PF00498	0.574
LIG_FHA_2	426	432	PF00498	0.506
LIG_IRF3_LxIS_1	12	19	PF10401	0.515
LIG_LIR_Apic_2	214	219	PF02991	0.524
LIG_LIR_Gen_1	377	386	PF02991	0.584
LIG_LIR_Gen_1	408	419	PF02991	0.665
LIG_LIR_Nem_3	377	381	PF02991	0.528
LIG_LIR_Nem_3	408	414	PF02991	0.676
LIG_MAD2	211	219	PF02301	0.614
LIG_NRBOX	432	438	PF00104	0.501
LIG_NRBOX	54	60	PF00104	0.420
LIG_PCNA_yPIPBox_3	425	437	PF02747	0.643
LIG_Rb_pABgroove_1	342	350	PF01858	0.612
LIG_SH2_STAP1	318	322	PF00017	0.474
LIG_SH2_STAP1	348	352	PF00017	0.661
LIG_SH3_1	116	122	PF00018	0.622
LIG_SH3_3	116	122	PF00018	0.715
LIG_SH3_3	209	215	PF00018	0.551
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.658
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.633
LIG_SUMO_SIM_par_1	37	43	PF11976	0.567
LIG_SUMO_SIM_par_1	482	490	PF11976	0.591
LIG_SUMO_SIM_par_1	70	75	PF11976	0.640
LIG_TRAF2_1	135	138	PF00917	0.718
LIG_TRAF2_1	428	431	PF00917	0.559
LIG_UBA3_1	190	197	PF00899	0.581
MOD_CDK_SPK_2	115	120	PF00069	0.740
MOD_CDK_SPK_2	228	233	PF00069	0.500
MOD_CDK_SPK_2	405	410	PF00069	0.554
MOD_CDK_SPxxK_3	103	110	PF00069	0.654
MOD_CK1_1	108	114	PF00069	0.693
MOD_CK1_1	150	156	PF00069	0.706
MOD_CK1_1	228	234	PF00069	0.701
MOD_CK1_1	237	243	PF00069	0.658
MOD_CK1_1	304	310	PF00069	0.555
MOD_CK1_1	324	330	PF00069	0.608
MOD_CK1_1	471	477	PF00069	0.630
MOD_CK1_1	5	11	PF00069	0.567
MOD_CK2_1	128	134	PF00069	0.734
MOD_CK2_1	352	358	PF00069	0.645
MOD_CK2_1	40	46	PF00069	0.570
MOD_CK2_1	425	431	PF00069	0.553
MOD_CK2_1	72	78	PF00069	0.506
MOD_GlcNHglycan	110	113	PF01048	0.667
MOD_GlcNHglycan	129	133	PF01048	0.749
MOD_GlcNHglycan	141	144	PF01048	0.679
MOD_GlcNHglycan	227	230	PF01048	0.637
MOD_GlcNHglycan	254	257	PF01048	0.742
MOD_GlcNHglycan	287	290	PF01048	0.533
MOD_GlcNHglycan	305	309	PF01048	0.599
MOD_GlcNHglycan	323	327	PF01048	0.666
MOD_GlcNHglycan	475	478	PF01048	0.687
MOD_GlcNHglycan	7	10	PF01048	0.642
MOD_GSK3_1	101	108	PF00069	0.665
MOD_GSK3_1	124	131	PF00069	0.667
MOD_GSK3_1	139	146	PF00069	0.672
MOD_GSK3_1	147	154	PF00069	0.642
MOD_GSK3_1	159	166	PF00069	0.605
MOD_GSK3_1	228	235	PF00069	0.686
MOD_GSK3_1	246	253	PF00069	0.793
MOD_GSK3_1	297	304	PF00069	0.593
MOD_GSK3_1	321	328	PF00069	0.584
MOD_GSK3_1	385	392	PF00069	0.623
MOD_GSK3_1	405	412	PF00069	0.382
MOD_GSK3_1	468	475	PF00069	0.617
MOD_LATS_1	250	256	PF00433	0.539
MOD_N-GLC_1	271	276	PF02516	0.563
MOD_N-GLC_1	301	306	PF02516	0.605
MOD_NEK2_1	16	21	PF00069	0.565
MOD_NEK2_1	225	230	PF00069	0.725
MOD_NEK2_1	298	303	PF00069	0.620
MOD_NEK2_1	322	327	PF00069	0.508
MOD_NEK2_1	65	70	PF00069	0.544
MOD_PIKK_1	192	198	PF00454	0.502
MOD_PIKK_1	2	8	PF00454	0.473
MOD_PIKK_1	234	240	PF00454	0.657
MOD_PIKK_1	385	391	PF00454	0.601
MOD_PIKK_1	451	457	PF00454	0.622
MOD_PIKK_1	72	78	PF00454	0.576
MOD_PIKK_1	90	96	PF00454	0.671
MOD_PKA_1	425	431	PF00069	0.447
MOD_PKA_2	182	188	PF00069	0.560
MOD_PKA_2	232	238	PF00069	0.570
MOD_PKA_2	250	256	PF00069	0.719
MOD_PKA_2	285	291	PF00069	0.514
MOD_PKA_2	340	346	PF00069	0.645
MOD_PKA_2	352	358	PF00069	0.522
MOD_PKA_2	368	374	PF00069	0.615
MOD_PKA_2	409	415	PF00069	0.554
MOD_PKA_2	425	431	PF00069	0.524
MOD_PKA_2	89	95	PF00069	0.684
MOD_Plk_1	256	262	PF00069	0.698
MOD_Plk_2-3	124	130	PF00069	0.680
MOD_Plk_2-3	163	169	PF00069	0.553
MOD_Plk_4	368	374	PF00069	0.519
MOD_Plk_4	479	485	PF00069	0.671
MOD_ProDKin_1	103	109	PF00069	0.668
MOD_ProDKin_1	115	121	PF00069	0.637
MOD_ProDKin_1	228	234	PF00069	0.691
MOD_ProDKin_1	405	411	PF00069	0.582
MOD_ProDKin_1	468	474	PF00069	0.680
MOD_SUMO_rev_2	355	361	PF00179	0.633
MOD_SUMO_rev_2	412	422	PF00179	0.561
TRG_DiLeu_BaEn_1	54	59	PF01217	0.544
TRG_ER_diArg_1	251	254	PF00400	0.544
TRG_ER_diArg_1	61	64	PF00400	0.455
TRG_ER_diArg_1	79	81	PF00400	0.389
TRG_ER_diArg_1	85	87	PF00400	0.610
TRG_NES_CRM1_1	11	25	PF08389	0.624
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED0	Leptomonas seymouri	57%	100%
A0A1X0P9K0	Trypanosomatidae	30%	100%
A0A422NY19	Trypanosoma rangeli	29%	100%
A4HAS8	Leishmania braziliensis	75%	100%
A4I9Y8	Leishmania infantum	100%	100%
C9ZMP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B502	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2Y4	Leishmania major	92%	100%
V5BPZ9	Trypanosoma cruzi	29%	97%