UAA transporter family/EamA-like transporter family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8INC1_LEIDO

TriTrypDb:

LdBPK_360730.1 , LdCL_360012200 , LDHU3_36.0920

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0000139	Golgi membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

A0A3Q8INC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INC1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0009987	cellular process	1	4
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	4
GO:0008643	carbohydrate transport	5	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	4
GO:0022857	transmembrane transporter activity	2	4
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.292
CLV_NRD_NRD_1	432	434	PF00675	0.356
CLV_NRD_NRD_1	99	101	PF00675	0.355
CLV_PCSK_SKI1_1	100	104	PF00082	0.306
CLV_PCSK_SKI1_1	368	372	PF00082	0.286
DOC_CDC14_PxL_1	243	251	PF14671	0.444
DOC_CYCLIN_RxL_1	198	209	PF00134	0.224
DOC_MAPK_DCC_7	242	251	PF00069	0.427
DOC_MAPK_gen_1	433	442	PF00069	0.544
DOC_MAPK_MEF2A_6	242	251	PF00069	0.427
DOC_MAPK_MEF2A_6	332	339	PF00069	0.386
DOC_PP1_RVXF_1	199	206	PF00149	0.231
DOC_PP2B_LxvP_1	311	314	PF13499	0.359
DOC_PP2B_LxvP_1	377	380	PF13499	0.329
DOC_PP4_FxxP_1	40	43	PF00568	0.446
DOC_PP4_FxxP_1	61	64	PF00568	0.258
DOC_USP7_MATH_1	105	109	PF00917	0.497
DOC_USP7_MATH_1	4	8	PF00917	0.442
DOC_USP7_MATH_1	74	78	PF00917	0.250
LIG_14-3-3_CanoR_1	100	107	PF00244	0.517
LIG_14-3-3_CanoR_1	368	373	PF00244	0.317
LIG_14-3-3_CanoR_1	56	62	PF00244	0.329
LIG_Actin_WH2_2	16	31	PF00022	0.404
LIG_BIR_III_2	423	427	PF00653	0.504
LIG_BRCT_BRCA1_1	340	344	PF00533	0.328
LIG_BRCT_BRCA1_1	36	40	PF00533	0.396
LIG_BRCT_BRCA1_1	6	10	PF00533	0.309
LIG_EH1_1	386	394	PF00400	0.167
LIG_FHA_1	23	29	PF00498	0.357
LIG_FHA_1	252	258	PF00498	0.471
LIG_FHA_1	357	363	PF00498	0.474
LIG_FHA_1	369	375	PF00498	0.239
LIG_FHA_1	74	80	PF00498	0.362
LIG_FHA_2	174	180	PF00498	0.475
LIG_FHA_2	409	415	PF00498	0.635
LIG_FHA_2	447	453	PF00498	0.609
LIG_LIR_Apic_2	115	120	PF02991	0.549
LIG_LIR_Apic_2	124	129	PF02991	0.273
LIG_LIR_Apic_2	37	43	PF02991	0.431
LIG_LIR_Apic_2	60	64	PF02991	0.278
LIG_LIR_Gen_1	145	155	PF02991	0.216
LIG_LIR_Gen_1	159	169	PF02991	0.241
LIG_LIR_Gen_1	384	395	PF02991	0.228
LIG_LIR_Gen_1	411	421	PF02991	0.536
LIG_LIR_Gen_1	7	18	PF02991	0.276
LIG_LIR_Nem_3	145	151	PF02991	0.223
LIG_LIR_Nem_3	159	165	PF02991	0.281
LIG_LIR_Nem_3	167	173	PF02991	0.321
LIG_LIR_Nem_3	384	390	PF02991	0.300
LIG_LIR_Nem_3	411	416	PF02991	0.605
LIG_LIR_Nem_3	66	72	PF02991	0.298
LIG_LIR_Nem_3	7	13	PF02991	0.362
LIG_LIR_Nem_3	85	91	PF02991	0.364
LIG_MLH1_MIPbox_1	340	344	PF16413	0.328
LIG_NRBOX	194	200	PF00104	0.309
LIG_NRBOX	217	223	PF00104	0.382
LIG_NRBOX	335	341	PF00104	0.250
LIG_NRBOX	373	379	PF00104	0.464
LIG_PCNA_yPIPBox_3	212	222	PF02747	0.253
LIG_Pex14_2	383	387	PF04695	0.294
LIG_Pex14_2	61	65	PF04695	0.268
LIG_PTB_Apo_2	399	406	PF02174	0.382
LIG_SH2_CRK	117	121	PF00017	0.588
LIG_SH2_CRK	148	152	PF00017	0.215
LIG_SH2_CRK	232	236	PF00017	0.260
LIG_SH2_CRK	244	248	PF00017	0.405
LIG_SH2_NCK_1	148	152	PF00017	0.227
LIG_SH2_PTP2	91	94	PF00017	0.500
LIG_SH2_SRC	315	318	PF00017	0.320
LIG_SH2_STAP1	148	152	PF00017	0.227
LIG_SH2_STAP1	315	319	PF00017	0.351
LIG_SH2_STAT5	338	341	PF00017	0.294
LIG_SH2_STAT5	355	358	PF00017	0.486
LIG_SH2_STAT5	91	94	PF00017	0.543
LIG_SH3_1	117	123	PF00018	0.563
LIG_SH3_3	117	123	PF00018	0.561
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.329
LIG_SUMO_SIM_par_1	359	366	PF11976	0.547
LIG_TRAF2_1	284	287	PF00917	0.347
LIG_TRAF2_2	418	423	PF00917	0.494
LIG_TYR_ITIM	146	151	PF00017	0.227
LIG_TYR_ITIM	313	318	PF00017	0.325
LIG_UBA3_1	240	245	PF00899	0.431
LIG_WRC_WIRS_1	58	63	PF05994	0.303
MOD_CK2_1	173	179	PF00069	0.444
MOD_CK2_1	378	384	PF00069	0.331
MOD_CK2_1	446	452	PF00069	0.709
MOD_GlcNHglycan	107	110	PF01048	0.404
MOD_GlcNHglycan	129	132	PF01048	0.354
MOD_GlcNHglycan	290	293	PF01048	0.635
MOD_GlcNHglycan	340	343	PF01048	0.374
MOD_GlcNHglycan	356	359	PF01048	0.197
MOD_GlcNHglycan	44	47	PF01048	0.695
MOD_GlcNHglycan	6	9	PF01048	0.399
MOD_GSK3_1	30	37	PF00069	0.369
MOD_GSK3_1	354	361	PF00069	0.493
MOD_GSK3_1	38	45	PF00069	0.411
MOD_GSK3_1	96	103	PF00069	0.513
MOD_N-GLC_1	299	304	PF02516	0.588
MOD_N-GLC_1	368	373	PF02516	0.341
MOD_N-GLC_2	346	348	PF02516	0.294
MOD_NEK2_1	134	139	PF00069	0.240
MOD_NEK2_1	144	149	PF00069	0.227
MOD_NEK2_1	155	160	PF00069	0.269
MOD_NEK2_1	19	24	PF00069	0.304
MOD_NEK2_1	205	210	PF00069	0.304
MOD_NEK2_1	262	267	PF00069	0.336
MOD_NEK2_1	288	293	PF00069	0.342
MOD_NEK2_1	363	368	PF00069	0.340
MOD_NEK2_1	57	62	PF00069	0.345
MOD_NEK2_1	82	87	PF00069	0.421
MOD_NEK2_1	96	101	PF00069	0.445
MOD_OFUCOSY	73	78	PF10250	0.250
MOD_PIKK_1	63	69	PF00454	0.337
MOD_PKA_1	100	106	PF00069	0.519
MOD_PKA_2	173	179	PF00069	0.450
MOD_PKA_2	325	331	PF00069	0.364
MOD_PKA_2	446	452	PF00069	0.673
MOD_PKB_1	445	453	PF00069	0.587
MOD_Plk_1	299	305	PF00069	0.389
MOD_Plk_1	368	374	PF00069	0.362
MOD_Plk_1	447	453	PF00069	0.620
MOD_Plk_1	74	80	PF00069	0.250
MOD_Plk_4	121	127	PF00069	0.460
MOD_Plk_4	134	140	PF00069	0.224
MOD_Plk_4	147	153	PF00069	0.194
MOD_Plk_4	156	162	PF00069	0.269
MOD_Plk_4	262	268	PF00069	0.334
MOD_Plk_4	299	305	PF00069	0.398
MOD_Plk_4	348	354	PF00069	0.388
MOD_Plk_4	358	364	PF00069	0.449
MOD_Plk_4	368	374	PF00069	0.120
MOD_Plk_4	378	384	PF00069	0.120
MOD_Plk_4	82	88	PF00069	0.315
MOD_SUMO_for_1	440	443	PF00179	0.568
MOD_SUMO_rev_2	327	334	PF00179	0.231
TRG_DiLeu_BaEn_1	75	80	PF01217	0.329
TRG_DiLeu_BaEn_2	329	335	PF01217	0.276
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.490
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.341
TRG_ENDOCYTIC_2	148	151	PF00928	0.217
TRG_ENDOCYTIC_2	152	155	PF00928	0.259
TRG_ENDOCYTIC_2	232	235	PF00928	0.269
TRG_ENDOCYTIC_2	315	318	PF00928	0.364
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC3	Leptomonas seymouri	59%	99%
A0A0S4JLV3	Bodo saltans	32%	100%
A0A0S4JVX5	Bodo saltans	32%	100%
A0A1X0P938	Trypanosomatidae	48%	100%
A0A3R7N2L5	Trypanosoma rangeli	48%	100%
A4HNS7	Leishmania braziliensis	74%	100%
A4ICR7	Leishmania infantum	100%	100%
E9ASI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q209	Leishmania major	93%	100%
Q5RFT1	Pongo abelii	30%	100%
Q5RKH7	Rattus norvegicus	30%	100%
Q8N357	Homo sapiens	30%	100%
Q8VE96	Mus musculus	29%	100%