ATPase, AAA family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INB5_LEIDO

TriTrypDb:

LdBPK_250970.1 , LdCL_250015000 , LDHU3_25.1240

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8INB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.656
CLV_C14_Caspase3-7	46	50	PF00656	0.816
CLV_C14_Caspase3-7	475	479	PF00656	0.628
CLV_NRD_NRD_1	140	142	PF00675	0.747
CLV_NRD_NRD_1	145	147	PF00675	0.854
CLV_NRD_NRD_1	361	363	PF00675	0.614
CLV_NRD_NRD_1	368	370	PF00675	0.592
CLV_NRD_NRD_1	380	382	PF00675	0.494
CLV_NRD_NRD_1	394	396	PF00675	0.726
CLV_NRD_NRD_1	468	470	PF00675	0.718
CLV_NRD_NRD_1	472	474	PF00675	0.740
CLV_NRD_NRD_1	547	549	PF00675	0.751
CLV_NRD_NRD_1	97	99	PF00675	0.731
CLV_PCSK_FUR_1	464	468	PF00082	0.710
CLV_PCSK_KEX2_1	140	142	PF00082	0.797
CLV_PCSK_KEX2_1	145	147	PF00082	0.858
CLV_PCSK_KEX2_1	361	363	PF00082	0.614
CLV_PCSK_KEX2_1	370	372	PF00082	0.587
CLV_PCSK_KEX2_1	393	395	PF00082	0.830
CLV_PCSK_KEX2_1	466	468	PF00082	0.713
CLV_PCSK_KEX2_1	472	474	PF00082	0.740
CLV_PCSK_KEX2_1	584	586	PF00082	0.747
CLV_PCSK_KEX2_1	86	88	PF00082	0.841
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.642
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.713
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.747
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.755
CLV_PCSK_PC7_1	141	147	PF00082	0.725
CLV_PCSK_PC7_1	464	470	PF00082	0.713
CLV_PCSK_PC7_1	580	586	PF00082	0.727
CLV_PCSK_PC7_1	82	88	PF00082	0.758
CLV_PCSK_SKI1_1	302	306	PF00082	0.656
CLV_PCSK_SKI1_1	485	489	PF00082	0.713
CLV_PCSK_SKI1_1	87	91	PF00082	0.760
DEG_APCC_DBOX_1	264	272	PF00400	0.595
DEG_COP1_1	508	515	PF00400	0.790
DEG_Nend_UBRbox_2	1	3	PF02207	0.678
DEG_SCF_FBW7_1	316	321	PF00400	0.738
DEG_SPOP_SBC_1	500	504	PF00917	0.600
DOC_ANK_TNKS_1	393	400	PF00023	0.752
DOC_CKS1_1	222	227	PF01111	0.710
DOC_CKS1_1	456	461	PF01111	0.672
DOC_CKS1_1	542	547	PF01111	0.751
DOC_MAPK_gen_1	262	271	PF00069	0.599
DOC_MAPK_MEF2A_6	327	336	PF00069	0.622
DOC_PP1_RVXF_1	578	584	PF00149	0.608
DOC_PP2B_LxvP_1	417	420	PF13499	0.819
DOC_USP7_MATH_1	105	109	PF00917	0.719
DOC_USP7_MATH_1	231	235	PF00917	0.808
DOC_USP7_MATH_1	383	387	PF00917	0.770
DOC_USP7_MATH_1	474	478	PF00917	0.762
DOC_USP7_MATH_1	5	9	PF00917	0.621
DOC_USP7_MATH_1	500	504	PF00917	0.712
DOC_USP7_MATH_1	506	510	PF00917	0.695
DOC_USP7_UBL2_3	378	382	PF12436	0.638
DOC_WW_Pin1_4	19	24	PF00397	0.635
DOC_WW_Pin1_4	221	226	PF00397	0.772
DOC_WW_Pin1_4	314	319	PF00397	0.699
DOC_WW_Pin1_4	326	331	PF00397	0.570
DOC_WW_Pin1_4	455	460	PF00397	0.665
DOC_WW_Pin1_4	477	482	PF00397	0.760
DOC_WW_Pin1_4	541	546	PF00397	0.740
DOC_WW_Pin1_4	58	63	PF00397	0.821
DOC_WW_Pin1_4	67	72	PF00397	0.784
LIG_14-3-3_CanoR_1	153	159	PF00244	0.559
LIG_14-3-3_CanoR_1	214	222	PF00244	0.742
LIG_14-3-3_CanoR_1	265	269	PF00244	0.538
LIG_14-3-3_CanoR_1	361	367	PF00244	0.732
LIG_14-3-3_CanoR_1	371	377	PF00244	0.667
LIG_14-3-3_CanoR_1	381	388	PF00244	0.544
LIG_14-3-3_CanoR_1	467	474	PF00244	0.702
LIG_14-3-3_CanoR_1	553	561	PF00244	0.642
LIG_14-3-3_CanoR_1	87	92	PF00244	0.711
LIG_Actin_WH2_2	250	267	PF00022	0.672
LIG_BIR_III_2	478	482	PF00653	0.622
LIG_deltaCOP1_diTrp_1	421	431	PF00928	0.730
LIG_FHA_1	172	178	PF00498	0.628
LIG_FHA_1	222	228	PF00498	0.834
LIG_FHA_1	315	321	PF00498	0.702
LIG_FHA_1	36	42	PF00498	0.623
LIG_FHA_2	164	170	PF00498	0.609
LIG_FHA_2	28	34	PF00498	0.708
LIG_FHA_2	473	479	PF00498	0.628
LIG_FHA_2	542	548	PF00498	0.649
LIG_LIR_Gen_1	496	506	PF02991	0.690
LIG_LIR_Gen_1	567	576	PF02991	0.615
LIG_LIR_Nem_3	458	463	PF02991	0.621
LIG_LIR_Nem_3	496	501	PF02991	0.696
LIG_LIR_Nem_3	567	572	PF02991	0.621
LIG_PTB_Apo_2	226	233	PF02174	0.602
LIG_Rb_LxCxE_1	514	529	PF01857	0.711
LIG_SH2_CRK	569	573	PF00017	0.621
LIG_SH2_SRC	346	349	PF00017	0.618
LIG_SH2_STAP1	354	358	PF00017	0.616
LIG_SH2_STAP1	551	555	PF00017	0.648
LIG_SH2_STAP1	569	573	PF00017	0.621
LIG_SH2_STAT5	346	349	PF00017	0.618
LIG_SH2_STAT5	554	557	PF00017	0.635
LIG_SH3_1	305	311	PF00018	0.647
LIG_SH3_2	308	313	PF14604	0.606
LIG_SH3_3	219	225	PF00018	0.754
LIG_SH3_3	268	274	PF00018	0.641
LIG_SH3_3	305	311	PF00018	0.724
LIG_SH3_3	329	335	PF00018	0.637
LIG_SH3_3	422	428	PF00018	0.718
LIG_SH3_3	518	524	PF00018	0.675
LIG_SH3_3	536	542	PF00018	0.684
LIG_Sin3_3	536	543	PF02671	0.781
LIG_SUMO_SIM_anti_2	534	541	PF11976	0.670
LIG_TRAF2_1	104	107	PF00917	0.750
LIG_TRAF2_1	241	244	PF00917	0.759
LIG_TRAF2_1	544	547	PF00917	0.747
LIG_UBA3_1	333	338	PF00899	0.583
MOD_CDK_SPxK_1	455	461	PF00069	0.669
MOD_CDK_SPxxK_3	541	548	PF00069	0.756
MOD_CK1_1	19	25	PF00069	0.756
MOD_CK1_1	217	223	PF00069	0.823
MOD_CK1_1	234	240	PF00069	0.622
MOD_CK1_1	386	392	PF00069	0.773
MOD_CK1_1	477	483	PF00069	0.735
MOD_CK1_1	499	505	PF00069	0.732
MOD_CK1_1	61	67	PF00069	0.736
MOD_CK1_1	80	86	PF00069	0.624
MOD_CK2_1	101	107	PF00069	0.614
MOD_CK2_1	127	133	PF00069	0.772
MOD_CK2_1	153	159	PF00069	0.620
MOD_CK2_1	163	169	PF00069	0.551
MOD_CK2_1	190	196	PF00069	0.814
MOD_CK2_1	27	33	PF00069	0.705
MOD_CK2_1	291	297	PF00069	0.629
MOD_CK2_1	402	408	PF00069	0.755
MOD_CK2_1	47	53	PF00069	0.825
MOD_CK2_1	541	547	PF00069	0.655
MOD_CMANNOS	457	460	PF00535	0.677
MOD_Cter_Amidation	379	382	PF01082	0.692
MOD_Cter_Amidation	96	99	PF01082	0.735
MOD_GlcNHglycan	103	106	PF01048	0.716
MOD_GlcNHglycan	117	120	PF01048	0.671
MOD_GlcNHglycan	2	5	PF01048	0.605
MOD_GlcNHglycan	236	239	PF01048	0.794
MOD_GlcNHglycan	27	30	PF01048	0.661
MOD_GlcNHglycan	293	296	PF01048	0.598
MOD_GlcNHglycan	385	388	PF01048	0.738
MOD_GlcNHglycan	401	407	PF01048	0.678
MOD_GlcNHglycan	440	443	PF01048	0.789
MOD_GlcNHglycan	448	451	PF01048	0.620
MOD_GlcNHglycan	482	485	PF01048	0.785
MOD_GlcNHglycan	490	493	PF01048	0.740
MOD_GlcNHglycan	498	501	PF01048	0.772
MOD_GlcNHglycan	503	506	PF01048	0.660
MOD_GlcNHglycan	508	511	PF01048	0.620
MOD_GlcNHglycan	534	537	PF01048	0.780
MOD_GlcNHglycan	557	560	PF01048	0.646
MOD_GlcNHglycan	79	82	PF01048	0.764
MOD_GSK3_1	101	108	PF00069	0.774
MOD_GSK3_1	121	128	PF00069	0.802
MOD_GSK3_1	131	138	PF00069	0.684
MOD_GSK3_1	141	148	PF00069	0.528
MOD_GSK3_1	210	217	PF00069	0.807
MOD_GSK3_1	314	321	PF00069	0.732
MOD_GSK3_1	382	389	PF00069	0.742
MOD_GSK3_1	468	475	PF00069	0.730
MOD_GSK3_1	496	503	PF00069	0.758
MOD_GSK3_1	511	518	PF00069	0.579
MOD_GSK3_1	56	63	PF00069	0.789
MOD_GSK3_1	66	73	PF00069	0.687
MOD_N-GLC_1	153	158	PF02516	0.696
MOD_N-GLC_1	56	61	PF02516	0.730
MOD_NEK2_1	232	237	PF00069	0.594
MOD_NEK2_1	264	269	PF00069	0.572
MOD_NEK2_1	27	32	PF00069	0.706
MOD_NEK2_1	319	324	PF00069	0.698
MOD_NEK2_1	571	576	PF00069	0.611
MOD_PIKK_1	306	312	PF00454	0.785
MOD_PIKK_1	360	366	PF00454	0.642
MOD_PKA_1	145	151	PF00069	0.725
MOD_PKA_1	381	387	PF00069	0.648
MOD_PKA_1	467	473	PF00069	0.724
MOD_PKA_2	126	132	PF00069	0.638
MOD_PKA_2	145	151	PF00069	0.808
MOD_PKA_2	16	22	PF00069	0.737
MOD_PKA_2	210	216	PF00069	0.738
MOD_PKA_2	264	270	PF00069	0.552
MOD_PKA_2	360	366	PF00069	0.670
MOD_PKA_2	372	378	PF00069	0.572
MOD_PKA_2	467	473	PF00069	0.724
MOD_PKA_2	92	98	PF00069	0.757
MOD_PKB_1	214	222	PF00069	0.840
MOD_Plk_1	105	111	PF00069	0.833
MOD_Plk_1	153	159	PF00069	0.696
MOD_Plk_2-3	47	53	PF00069	0.787
MOD_Plk_4	106	112	PF00069	0.834
MOD_Plk_4	264	270	PF00069	0.573
MOD_ProDKin_1	19	25	PF00069	0.633
MOD_ProDKin_1	221	227	PF00069	0.769
MOD_ProDKin_1	314	320	PF00069	0.697
MOD_ProDKin_1	326	332	PF00069	0.566
MOD_ProDKin_1	455	461	PF00069	0.669
MOD_ProDKin_1	477	483	PF00069	0.759
MOD_ProDKin_1	541	547	PF00069	0.737
MOD_ProDKin_1	58	64	PF00069	0.822
MOD_ProDKin_1	67	73	PF00069	0.785
MOD_SUMO_for_1	241	244	PF00179	0.661
TRG_DiLeu_BaEn_1	106	111	PF01217	0.834
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.593
TRG_ENDOCYTIC_2	569	572	PF00928	0.626
TRG_ER_diArg_1	360	362	PF00400	0.613
TRG_ER_diArg_1	393	395	PF00400	0.759
TRG_ER_diArg_1	467	469	PF00400	0.718
TRG_ER_diArg_1	472	474	PF00400	0.740
TRG_NLS_Bipartite_1	84	102	PF00514	0.762
TRG_NLS_MonoCore_2	83	88	PF00514	0.755
TRG_NLS_MonoExtC_3	368	373	PF00514	0.641
TRG_NLS_MonoExtC_3	97	102	PF00514	0.763
TRG_NLS_MonoExtN_4	369	374	PF00514	0.646
TRG_NLS_MonoExtN_4	82	89	PF00514	0.758
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P735	Leptomonas seymouri	43%	100%
A4HE29	Leishmania braziliensis	67%	98%
A4I1D5	Leishmania infantum	99%	100%
E9AXH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QA00	Leishmania major	86%	100%