Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8INA6_LEIDO

TriTrypDb:

LdBPK_360480.1 , LdCL_360009700 , LDHU3_36.0630

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8INA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8INA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.693
CLV_C14_Caspase3-7	309	313	PF00656	0.678
CLV_C14_Caspase3-7	508	512	PF00656	0.568
CLV_NRD_NRD_1	278	280	PF00675	0.621
CLV_NRD_NRD_1	379	381	PF00675	0.625
CLV_NRD_NRD_1	492	494	PF00675	0.571
CLV_PCSK_KEX2_1	278	280	PF00082	0.621
CLV_PCSK_KEX2_1	379	381	PF00082	0.625
CLV_PCSK_KEX2_1	492	494	PF00082	0.583
CLV_PCSK_SKI1_1	123	127	PF00082	0.612
CLV_PCSK_SKI1_1	449	453	PF00082	0.655
CLV_PCSK_SKI1_1	81	85	PF00082	0.433
DEG_APCC_DBOX_1	80	88	PF00400	0.429
DEG_SPOP_SBC_1	235	239	PF00917	0.614
DEG_SPOP_SBC_1	27	31	PF00917	0.589
DEG_SPOP_SBC_1	294	298	PF00917	0.698
DEG_SPOP_SBC_1	432	436	PF00917	0.634
DOC_MAPK_gen_1	461	471	PF00069	0.560
DOC_MAPK_gen_1	78	86	PF00069	0.512
DOC_MAPK_MEF2A_6	78	86	PF00069	0.512
DOC_USP7_MATH_1	130	134	PF00917	0.582
DOC_USP7_MATH_1	142	146	PF00917	0.669
DOC_USP7_MATH_1	198	202	PF00917	0.606
DOC_USP7_MATH_1	204	208	PF00917	0.616
DOC_USP7_MATH_1	234	238	PF00917	0.615
DOC_USP7_MATH_1	28	32	PF00917	0.598
DOC_USP7_MATH_1	320	324	PF00917	0.808
DOC_USP7_MATH_1	361	365	PF00917	0.611
DOC_USP7_MATH_1	431	435	PF00917	0.720
DOC_USP7_MATH_1	465	469	PF00917	0.754
DOC_USP7_MATH_1	470	474	PF00917	0.629
DOC_USP7_MATH_1	501	505	PF00917	0.635
DOC_WW_Pin1_4	165	170	PF00397	0.671
DOC_WW_Pin1_4	213	218	PF00397	0.614
DOC_WW_Pin1_4	350	355	PF00397	0.624
DOC_WW_Pin1_4	405	410	PF00397	0.710
DOC_WW_Pin1_4	66	71	PF00397	0.663
LIG_14-3-3_CanoR_1	111	116	PF00244	0.437
LIG_14-3-3_CanoR_1	197	203	PF00244	0.610
LIG_14-3-3_CanoR_1	268	276	PF00244	0.625
LIG_14-3-3_CanoR_1	449	457	PF00244	0.645
LIG_14-3-3_CanoR_1	464	470	PF00244	0.587
LIG_14-3-3_CanoR_1	62	70	PF00244	0.542
LIG_BIR_III_4	445	449	PF00653	0.655
LIG_DLG_GKlike_1	111	118	PF00625	0.517
LIG_FHA_1	120	126	PF00498	0.632
LIG_FHA_1	129	135	PF00498	0.692
LIG_FHA_1	27	33	PF00498	0.596
LIG_FHA_1	271	277	PF00498	0.623
LIG_FHA_1	406	412	PF00498	0.552
LIG_FHA_1	452	458	PF00498	0.740
LIG_FHA_1	464	470	PF00498	0.541
LIG_FHA_2	327	333	PF00498	0.706
LIG_FHA_2	367	373	PF00498	0.746
LIG_FHA_2	453	459	PF00498	0.627
LIG_FHA_2	75	81	PF00498	0.519
LIG_FHA_2	98	104	PF00498	0.432
LIG_Integrin_RGD_1	474	476	PF01839	0.554
LIG_LIR_Nem_3	150	155	PF02991	0.745
LIG_LIR_Nem_3	364	368	PF02991	0.523
LIG_LIR_Nem_3	510	516	PF02991	0.533
LIG_NRBOX	82	88	PF00104	0.428
LIG_SH2_CRK	152	156	PF00017	0.614
LIG_SH2_CRK	378	382	PF00017	0.571
LIG_SH2_NCK_1	368	372	PF00017	0.629
LIG_SH2_STAP1	516	520	PF00017	0.463
LIG_SH2_STAT3	189	192	PF00017	0.698
LIG_SH2_STAT3	88	91	PF00017	0.468
LIG_SH2_STAT5	362	365	PF00017	0.601
LIG_SH2_STAT5	368	371	PF00017	0.606
LIG_SH2_STAT5	39	42	PF00017	0.698
LIG_SH3_1	379	385	PF00018	0.620
LIG_SH3_3	246	252	PF00018	0.601
LIG_SH3_3	348	354	PF00018	0.706
LIG_SH3_3	360	366	PF00018	0.638
LIG_SH3_3	371	377	PF00018	0.660
LIG_SH3_3	379	385	PF00018	0.595
LIG_SH3_3	9	15	PF00018	0.696
LIG_SUMO_SIM_anti_2	468	473	PF11976	0.554
MOD_CK1_1	119	125	PF00069	0.524
MOD_CK1_1	132	138	PF00069	0.599
MOD_CK1_1	143	149	PF00069	0.593
MOD_CK1_1	219	225	PF00069	0.629
MOD_CK1_1	241	247	PF00069	0.611
MOD_CK1_1	256	262	PF00069	0.629
MOD_CK1_1	26	32	PF00069	0.649
MOD_CK1_1	267	273	PF00069	0.625
MOD_CK1_1	285	291	PF00069	0.627
MOD_CK1_1	314	320	PF00069	0.765
MOD_CK1_1	323	329	PF00069	0.622
MOD_CK1_1	330	336	PF00069	0.636
MOD_CK1_1	353	359	PF00069	0.617
MOD_CK1_1	37	43	PF00069	0.572
MOD_CK1_1	370	376	PF00069	0.574
MOD_CK1_1	401	407	PF00069	0.652
MOD_CK1_1	436	442	PF00069	0.637
MOD_CK1_1	515	521	PF00069	0.468
MOD_CK1_1	65	71	PF00069	0.703
MOD_CK2_1	144	150	PF00069	0.679
MOD_CK2_1	204	210	PF00069	0.611
MOD_CK2_1	420	426	PF00069	0.646
MOD_CK2_1	452	458	PF00069	0.629
MOD_CK2_1	5	11	PF00069	0.658
MOD_CK2_1	66	72	PF00069	0.663
MOD_CK2_1	97	103	PF00069	0.434
MOD_Cter_Amidation	276	279	PF01082	0.626
MOD_DYRK1A_RPxSP_1	213	217	PF00069	0.590
MOD_GlcNHglycan	136	139	PF01048	0.722
MOD_GlcNHglycan	146	149	PF01048	0.595
MOD_GlcNHglycan	16	19	PF01048	0.675
MOD_GlcNHglycan	171	174	PF01048	0.674
MOD_GlcNHglycan	182	185	PF01048	0.633
MOD_GlcNHglycan	200	203	PF01048	0.517
MOD_GlcNHglycan	232	235	PF01048	0.615
MOD_GlcNHglycan	243	246	PF01048	0.635
MOD_GlcNHglycan	258	261	PF01048	0.637
MOD_GlcNHglycan	273	276	PF01048	0.540
MOD_GlcNHglycan	316	319	PF01048	0.672
MOD_GlcNHglycan	325	328	PF01048	0.702
MOD_GlcNHglycan	369	372	PF01048	0.694
MOD_GlcNHglycan	400	403	PF01048	0.573
MOD_GlcNHglycan	412	415	PF01048	0.653
MOD_GlcNHglycan	422	425	PF01048	0.620
MOD_GlcNHglycan	45	48	PF01048	0.595
MOD_GlcNHglycan	501	504	PF01048	0.621
MOD_GlcNHglycan	64	67	PF01048	0.576
MOD_GlcNHglycan	7	10	PF01048	0.630
MOD_GSK3_1	119	126	PF00069	0.534
MOD_GSK3_1	128	135	PF00069	0.618
MOD_GSK3_1	140	147	PF00069	0.645
MOD_GSK3_1	165	172	PF00069	0.618
MOD_GSK3_1	180	187	PF00069	0.503
MOD_GSK3_1	204	211	PF00069	0.680
MOD_GSK3_1	219	226	PF00069	0.630
MOD_GSK3_1	23	30	PF00069	0.639
MOD_GSK3_1	230	237	PF00069	0.557
MOD_GSK3_1	252	259	PF00069	0.613
MOD_GSK3_1	264	271	PF00069	0.626
MOD_GSK3_1	282	289	PF00069	0.621
MOD_GSK3_1	316	323	PF00069	0.807
MOD_GSK3_1	326	333	PF00069	0.631
MOD_GSK3_1	366	373	PF00069	0.609
MOD_GSK3_1	37	44	PF00069	0.515
MOD_GSK3_1	396	403	PF00069	0.725
MOD_GSK3_1	412	419	PF00069	0.536
MOD_GSK3_1	432	439	PF00069	0.554
MOD_GSK3_1	495	502	PF00069	0.625
MOD_GSK3_1	62	69	PF00069	0.727
MOD_LATS_1	121	127	PF00433	0.571
MOD_LATS_1	195	201	PF00433	0.611
MOD_LATS_1	266	272	PF00433	0.628
MOD_N-GLC_1	253	258	PF02516	0.615
MOD_N-GLC_1	441	446	PF02516	0.599
MOD_NEK2_1	134	139	PF00069	0.729
MOD_NEK2_1	164	169	PF00069	0.737
MOD_NEK2_1	209	214	PF00069	0.595
MOD_NEK2_1	283	288	PF00069	0.622
MOD_NEK2_1	311	316	PF00069	0.714
MOD_NEK2_1	35	40	PF00069	0.582
MOD_NEK2_1	420	425	PF00069	0.645
MOD_NEK2_1	437	442	PF00069	0.578
MOD_PIKK_1	330	336	PF00454	0.708
MOD_PKA_2	116	122	PF00069	0.481
MOD_PKA_2	196	202	PF00069	0.661
MOD_PKA_2	267	273	PF00069	0.625
MOD_PKA_2	41	47	PF00069	0.592
MOD_PKA_2	463	469	PF00069	0.742
MOD_PKB_1	447	455	PF00069	0.704
MOD_Plk_1	253	259	PF00069	0.690
MOD_Plk_1	311	317	PF00069	0.693
MOD_Plk_1	416	422	PF00069	0.641
MOD_Plk_1	452	458	PF00069	0.629
MOD_Plk_1	505	511	PF00069	0.572
MOD_Plk_4	184	190	PF00069	0.689
MOD_Plk_4	204	210	PF00069	0.484
MOD_Plk_4	370	376	PF00069	0.566
MOD_Plk_4	433	439	PF00069	0.587
MOD_ProDKin_1	165	171	PF00069	0.674
MOD_ProDKin_1	213	219	PF00069	0.615
MOD_ProDKin_1	350	356	PF00069	0.624
MOD_ProDKin_1	405	411	PF00069	0.711
MOD_ProDKin_1	66	72	PF00069	0.663
MOD_SUMO_rev_2	298	308	PF00179	0.696
TRG_DiLeu_BaEn_1	79	84	PF01217	0.433
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.613
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.429
TRG_ENDOCYTIC_2	152	155	PF00928	0.571
TRG_ENDOCYTIC_2	362	365	PF00928	0.662
TRG_ENDOCYTIC_2	378	381	PF00928	0.598
TRG_ER_diArg_1	378	380	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL9	Leptomonas seymouri	49%	100%
A4HNQ3	Leishmania braziliensis	78%	100%
A4ICU2	Leishmania infantum	100%	100%
E9ASG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%