Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IN72_LEIDO

TriTrypDb:

LdBPK_360170.1 , LdCL_360006500 , LDHU3_36.0240

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 1
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IN72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IN72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.431
CLV_NRD_NRD_1	137	139	PF00675	0.630
CLV_NRD_NRD_1	234	236	PF00675	0.445
CLV_PCSK_KEX2_1	137	139	PF00082	0.596
CLV_PCSK_KEX2_1	281	283	PF00082	0.478
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.433
CLV_PCSK_SKI1_1	230	234	PF00082	0.415
DEG_Nend_UBRbox_3	1	3	PF02207	0.577
DEG_SPOP_SBC_1	96	100	PF00917	0.383
DOC_CKS1_1	154	159	PF01111	0.406
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.405
DOC_MAPK_RevD_3	220	236	PF00069	0.496
DOC_USP7_MATH_1	200	204	PF00917	0.493
DOC_USP7_MATH_1	273	277	PF00917	0.600
DOC_USP7_MATH_1	96	100	PF00917	0.407
DOC_WW_Pin1_4	119	124	PF00397	0.390
DOC_WW_Pin1_4	153	158	PF00397	0.395
DOC_WW_Pin1_4	250	255	PF00397	0.665
LIG_14-3-3_CanoR_1	94	103	PF00244	0.507
LIG_Actin_WH2_2	88	104	PF00022	0.475
LIG_FHA_1	174	180	PF00498	0.482
LIG_FHA_1	253	259	PF00498	0.596
LIG_FHA_1	29	35	PF00498	0.472
LIG_FHA_1	98	104	PF00498	0.419
LIG_FHA_2	56	62	PF00498	0.464
LIG_Integrin_isoDGR_2	150	152	PF01839	0.571
LIG_Integrin_isoDGR_2	64	66	PF01839	0.559
LIG_LIR_Apic_2	118	123	PF02991	0.399
LIG_NRBOX	11	17	PF00104	0.432
LIG_PCNA_yPIPBox_3	60	71	PF02747	0.361
LIG_PDZ_Class_1	280	285	PF00595	0.691
LIG_Rb_pABgroove_1	65	73	PF01858	0.421
LIG_SH2_CRK	82	86	PF00017	0.481
LIG_SH2_STAP1	48	52	PF00017	0.425
LIG_SH2_STAT5	164	167	PF00017	0.466
LIG_SH2_STAT5	231	234	PF00017	0.564
LIG_SH3_1	138	144	PF00018	0.401
LIG_SH3_3	138	144	PF00018	0.403
LIG_TYR_ITIM	80	85	PF00017	0.607
LIG_UBA3_1	267	272	PF00899	0.427
LIG_WRC_WIRS_1	126	131	PF05994	0.500
LIG_WW_1	45	48	PF00397	0.546
MOD_CDK_SPxK_1	153	159	PF00069	0.511
MOD_CDK_SPxxK_3	250	257	PF00069	0.578
MOD_CK1_1	207	213	PF00069	0.563
MOD_CK1_1	97	103	PF00069	0.481
MOD_CK2_1	55	61	PF00069	0.593
MOD_GlcNHglycan	146	149	PF01048	0.517
MOD_GlcNHglycan	202	205	PF01048	0.660
MOD_GlcNHglycan	209	212	PF01048	0.547
MOD_GlcNHglycan	23	26	PF01048	0.580
MOD_GlcNHglycan	274	278	PF01048	0.584
MOD_GlcNHglycan	6	9	PF01048	0.519
MOD_GSK3_1	115	122	PF00069	0.623
MOD_GSK3_1	169	176	PF00069	0.454
MOD_GSK3_1	17	24	PF00069	0.486
MOD_GSK3_1	200	207	PF00069	0.583
MOD_GSK3_1	248	255	PF00069	0.585
MOD_GSK3_1	28	35	PF00069	0.437
MOD_NEK2_1	16	21	PF00069	0.411
MOD_NEK2_1	239	244	PF00069	0.550
MOD_NEK2_1	4	9	PF00069	0.616
MOD_NEK2_2	17	22	PF00069	0.500
MOD_NEK2_2	55	60	PF00069	0.631
MOD_PIKK_1	183	189	PF00454	0.623
MOD_PIKK_1	252	258	PF00454	0.552
MOD_PKA_2	21	27	PF00069	0.685
MOD_Plk_1	239	245	PF00069	0.533
MOD_Plk_1	32	38	PF00069	0.459
MOD_Plk_1	48	54	PF00069	0.553
MOD_Plk_4	115	121	PF00069	0.520
MOD_Plk_4	169	175	PF00069	0.391
MOD_Plk_4	209	215	PF00069	0.419
MOD_Plk_4	33	39	PF00069	0.566
MOD_ProDKin_1	119	125	PF00069	0.474
MOD_ProDKin_1	153	159	PF00069	0.482
MOD_ProDKin_1	250	256	PF00069	0.579
MOD_SUMO_for_1	271	274	PF00179	0.460
TRG_DiLeu_BaEn_1	130	135	PF01217	0.476
TRG_DiLeu_BaEn_1	170	175	PF01217	0.476
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.376
TRG_ENDOCYTIC_2	82	85	PF00928	0.608
TRG_ER_diArg_1	136	138	PF00400	0.501
TRG_ER_diArg_1	158	161	PF00400	0.428
TRG_ER_diArg_1	196	199	PF00400	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B3	Leptomonas seymouri	44%	99%
A0A1X0P8Q0	Trypanosomatidae	25%	100%
A4HNM3	Leishmania braziliensis	79%	100%
A4ICX1	Leishmania infantum	100%	100%
E9ASD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q262	Leishmania major	90%	100%