LeishMANIAdb
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Amino acid permease, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amino acid permease, putative
Gene product:
amino acid permease, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IN54_LEIDO
TriTrypDb:
LdBPK_355070.1 * , LdCL_350059100 , LDHU3_35.7100
Length:
320

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 32
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0016020 membrane 2 30
GO:0110165 cellular anatomical entity 1 30

Expansion

Sequence features

A0A3Q8IN54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IN54

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 3
GO:0006810 transport 3 3
GO:0006865 amino acid transport 5 3
GO:0009987 cellular process 1 3
GO:0015849 organic acid transport 5 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071702 organic substance transport 4 3
GO:0071705 nitrogen compound transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016787 hydrolase activity 2 11
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0015171 amino acid transmembrane transporter activity 5 3
GO:0015179 L-amino acid transmembrane transporter activity 6 3
GO:0022857 transmembrane transporter activity 2 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 108 110 PF00675 0.468
CLV_PCSK_KEX2_1 108 110 PF00082 0.476
CLV_PCSK_SKI1_1 109 113 PF00082 0.501
CLV_PCSK_SKI1_1 144 148 PF00082 0.304
DEG_APCC_DBOX_1 107 115 PF00400 0.313
DEG_APCC_DBOX_1 183 191 PF00400 0.189
DEG_APCC_DBOX_1 279 287 PF00400 0.490
DEG_Nend_Nbox_1 1 3 PF02207 0.137
DEG_ODPH_VHL_1 288 299 PF01847 0.525
DOC_ANK_TNKS_1 185 192 PF00023 0.176
DOC_CKS1_1 20 25 PF01111 0.301
DOC_CYCLIN_yCln2_LP_2 112 118 PF00134 0.308
DOC_MAPK_DCC_7 109 119 PF00069 0.247
DOC_MAPK_FxFP_2 273 276 PF00069 0.298
DOC_MAPK_gen_1 108 116 PF00069 0.271
DOC_MAPK_gen_1 280 288 PF00069 0.455
DOC_MAPK_HePTP_8 106 118 PF00069 0.296
DOC_MAPK_MEF2A_6 108 116 PF00069 0.247
DOC_MAPK_MEF2A_6 144 152 PF00069 0.466
DOC_MAPK_NFAT4_5 109 117 PF00069 0.278
DOC_PP2B_LxvP_1 112 115 PF13499 0.308
DOC_PP2B_LxvP_1 228 231 PF13499 0.525
DOC_PP2B_LxvP_1 251 254 PF13499 0.240
DOC_PP2B_LxvP_1 30 33 PF13499 0.350
DOC_PP4_FxxP_1 273 276 PF00568 0.271
DOC_USP7_MATH_1 135 139 PF00917 0.489
DOC_USP7_MATH_1 146 150 PF00917 0.317
DOC_USP7_MATH_1 231 235 PF00917 0.464
DOC_USP7_MATH_1 265 269 PF00917 0.375
DOC_USP7_MATH_1 57 61 PF00917 0.465
DOC_USP7_MATH_1 87 91 PF00917 0.318
DOC_USP7_MATH_1 94 98 PF00917 0.300
DOC_WW_Pin1_4 166 171 PF00397 0.322
DOC_WW_Pin1_4 19 24 PF00397 0.270
LIG_14-3-3_CanoR_1 108 112 PF00244 0.339
LIG_14-3-3_CanoR_1 95 103 PF00244 0.315
LIG_BRCT_BRCA1_1 124 128 PF00533 0.302
LIG_EH1_1 73 81 PF00400 0.309
LIG_FHA_1 145 151 PF00498 0.315
LIG_FHA_1 167 173 PF00498 0.267
LIG_FHA_1 196 202 PF00498 0.312
LIG_FHA_1 20 26 PF00498 0.341
LIG_FHA_1 63 69 PF00498 0.455
LIG_FHA_1 71 77 PF00498 0.292
LIG_FHA_2 176 182 PF00498 0.269
LIG_LIR_Apic_2 270 276 PF02991 0.283
LIG_LIR_Gen_1 45 53 PF02991 0.315
LIG_LIR_Gen_1 65 75 PF02991 0.222
LIG_LIR_Nem_3 100 106 PF02991 0.301
LIG_LIR_Nem_3 154 160 PF02991 0.320
LIG_LIR_Nem_3 192 197 PF02991 0.326
LIG_LIR_Nem_3 243 247 PF02991 0.370
LIG_LIR_Nem_3 274 278 PF02991 0.334
LIG_LIR_Nem_3 45 49 PF02991 0.301
LIG_LIR_Nem_3 65 70 PF02991 0.255
LIG_LYPXL_yS_3 275 278 PF13949 0.293
LIG_PCNA_PIPBox_1 24 33 PF02747 0.268
LIG_Pex14_1 300 304 PF04695 0.242
LIG_SH2_CRK 157 161 PF00017 0.353
LIG_SH2_PTP2 13 16 PF00017 0.353
LIG_SH2_PTP2 203 206 PF00017 0.308
LIG_SH2_STAP1 195 199 PF00017 0.345
LIG_SH2_STAP1 294 298 PF00017 0.439
LIG_SH2_STAT5 103 106 PF00017 0.287
LIG_SH2_STAT5 13 16 PF00017 0.295
LIG_SH2_STAT5 203 206 PF00017 0.299
LIG_SH2_STAT5 258 261 PF00017 0.212
LIG_SH2_STAT5 303 306 PF00017 0.285
LIG_SH2_STAT5 31 34 PF00017 0.239
LIG_SH2_STAT5 63 66 PF00017 0.544
LIG_SH2_STAT5 84 87 PF00017 0.299
LIG_SH3_3 20 26 PF00018 0.236
LIG_SH3_3 46 52 PF00018 0.323
LIG_SUMO_SIM_anti_2 147 154 PF11976 0.342
LIG_SUMO_SIM_par_1 13 19 PF11976 0.260
LIG_TYR_ITIM 101 106 PF00017 0.296
LIG_TYR_ITIM 11 16 PF00017 0.265
LIG_TYR_ITIM 155 160 PF00017 0.392
LIG_TYR_ITIM 201 206 PF00017 0.357
LIG_UBA3_1 50 58 PF00899 0.288
LIG_WRC_WIRS_1 241 246 PF05994 0.414
LIG_WRC_WIRS_1 64 69 PF05994 0.328
MOD_CK1_1 107 113 PF00069 0.245
MOD_CK1_1 138 144 PF00069 0.418
MOD_CK1_1 36 42 PF00069 0.304
MOD_GlcNHglycan 307 310 PF01048 0.299
MOD_GlcNHglycan 76 79 PF01048 0.321
MOD_GlcNHglycan 89 92 PF01048 0.491
MOD_GSK3_1 146 153 PF00069 0.296
MOD_GSK3_1 236 243 PF00069 0.289
MOD_GSK3_1 267 274 PF00069 0.342
MOD_GSK3_1 70 77 PF00069 0.326
MOD_NEK2_1 104 109 PF00069 0.241
MOD_NEK2_1 151 156 PF00069 0.368
MOD_NEK2_1 236 241 PF00069 0.270
MOD_NEK2_1 266 271 PF00069 0.338
MOD_NEK2_1 305 310 PF00069 0.363
MOD_NEK2_1 35 40 PF00069 0.298
MOD_NEK2_1 42 47 PF00069 0.304
MOD_NEK2_1 62 67 PF00069 0.380
MOD_NEK2_1 74 79 PF00069 0.279
MOD_PKA_2 107 113 PF00069 0.329
MOD_PKA_2 138 144 PF00069 0.409
MOD_PKA_2 94 100 PF00069 0.172
MOD_Plk_4 122 128 PF00069 0.290
MOD_Plk_4 146 152 PF00069 0.289
MOD_Plk_4 190 196 PF00069 0.356
MOD_Plk_4 236 242 PF00069 0.335
MOD_Plk_4 63 69 PF00069 0.428
MOD_Plk_4 70 76 PF00069 0.284
MOD_ProDKin_1 166 172 PF00069 0.322
MOD_ProDKin_1 19 25 PF00069 0.270
MOD_SUMO_rev_2 97 104 PF00179 0.320
TRG_ENDOCYTIC_2 103 106 PF00928 0.299
TRG_ENDOCYTIC_2 13 16 PF00928 0.316
TRG_ENDOCYTIC_2 157 160 PF00928 0.330
TRG_ENDOCYTIC_2 180 183 PF00928 0.284
TRG_ENDOCYTIC_2 203 206 PF00928 0.339
TRG_ENDOCYTIC_2 275 278 PF00928 0.284
TRG_ENDOCYTIC_2 294 297 PF00928 0.450
TRG_ENDOCYTIC_2 82 85 PF00928 0.376
TRG_ER_diArg_1 279 282 PF00400 0.450

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5D2 Leptomonas seymouri 23% 67%
A0A0N0P613 Leptomonas seymouri 78% 79%
A0A0N0P6F5 Leptomonas seymouri 52% 78%
A0A0N0P6F6 Leptomonas seymouri 27% 66%
A0A0N0P955 Leptomonas seymouri 23% 67%
A0A0N1I2L5 Leptomonas seymouri 25% 67%
A0A0N1I9T3 Leptomonas seymouri 27% 66%
A0A0N1IAJ0 Leptomonas seymouri 27% 67%
A0A0N1IJ81 Leptomonas seymouri 36% 67%
A0A0S4JEJ9 Bodo saltans 25% 100%
A0A0S4JHM8 Bodo saltans 24% 68%
A0A0S4JQ87 Bodo saltans 29% 71%
A0A1X0NKS5 Trypanosomatidae 26% 67%
A0A1X0NKW7 Trypanosomatidae 24% 68%
A0A1X0NLA5 Trypanosomatidae 26% 69%
A0A1X0NNX9 Trypanosomatidae 28% 71%
A0A1X0NPV3 Trypanosomatidae 29% 70%
A0A1X0NQH3 Trypanosomatidae 25% 72%
A0A1X0NR26 Trypanosomatidae 24% 70%
A0A1X0NRL3 Trypanosomatidae 27% 69%
A0A1X0NRL7 Trypanosomatidae 27% 67%
A0A1X0P1N2 Trypanosomatidae 40% 70%
A0A1X0P4S1 Trypanosomatidae 55% 78%
A0A1X0P9N8 Trypanosomatidae 23% 70%
A0A3Q8IDG8 Leishmania donovani 26% 67%
A0A3Q8IG00 Leishmania donovani 24% 68%
A0A3Q8IJX8 Leishmania donovani 25% 67%
A0A3R7JSA0 Trypanosoma rangeli 22% 67%
A0A3R7KDS3 Trypanosoma rangeli 23% 78%
A0A3R7MQD8 Trypanosoma rangeli 27% 68%
A0A3R7MWF1 Trypanosoma rangeli 44% 74%
A0A3R7N2A2 Trypanosoma rangeli 27% 73%
A0A3R7R2W8 Trypanosoma rangeli 27% 69%
A0A3R7RQX3 Trypanosoma rangeli 25% 67%
A0A3S7X4A1 Leishmania donovani 25% 67%
A0A3S7XA86 Leishmania donovani 51% 78%
A0A3S7XCE3 Leishmania donovani 28% 67%
A0A422N5W8 Trypanosoma rangeli 53% 78%
A0A422NBM3 Trypanosoma rangeli 24% 68%
A0A422NBQ2 Trypanosoma rangeli 26% 73%
A0A422NZS1 Trypanosoma rangeli 28% 68%
A0A451EJH9 Leishmania donovani 28% 100%
A2VCW5 Rattus norvegicus 25% 67%
A4HC75 Leishmania braziliensis 27% 66%
A4HFT5 Leishmania braziliensis 26% 67%
A4HJ35 Leishmania braziliensis 23% 68%
A4HJ63 Leishmania braziliensis 22% 67%
A4HKQ7 Leishmania braziliensis 27% 68%
A4HNJ6 Leishmania braziliensis 52% 100%
A4HNJ7 Leishmania braziliensis 88% 100%
A4HNQ0 Leishmania braziliensis 23% 66%
A4I6I1 Leishmania infantum 24% 67%
A4I6L3 Leishmania infantum 24% 68%
A4I6L4 Leishmania infantum 24% 67%
A4IC53 Leishmania infantum 51% 100%
A4IC66 Leishmania infantum 100% 100%
A4ICC3 Leishmania infantum 28% 100%
A6NNN8 Homo sapiens 21% 74%
A7E3U5 Bos taurus 21% 69%
C9ZMB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 68%
C9ZMD2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 68%
C9ZMD4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 68%
C9ZN51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 71%
C9ZN59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 66%
C9ZN60 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 68%
C9ZWQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 69%
C9ZWQ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 69%
C9ZWQ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 69%
C9ZWR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 69%
C9ZWR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 69%
C9ZWX2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 70%
C9ZWX3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 69%
C9ZWX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 69%
C9ZWX5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 70%
C9ZWX6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 69%
C9ZWX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 70%
C9ZWY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 68%
C9ZWY1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 68%
D0A362 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 78%
D0AAF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 69%
D0AAF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 69%
D3Z813 Rattus norvegicus 23% 71%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9ADD7 Leishmania major 26% 67%
E9AG08 Leishmania major 50% 100%
E9AG09 Leishmania major 95% 100%
E9AHD8 Leishmania infantum 25% 100%
E9AUB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AVK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 66%
E9AZ62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 66%
E9B1I3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B1I4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 69%
E9B1K7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 68%
E9B1N8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 67%
E9B1N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 67%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
G3UVW3 Mus musculus 25% 70%
O74327 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 76%
P38176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 70%
Q08AI6 Homo sapiens 23% 79%
Q28HE5 Xenopus tropicalis 27% 71%
Q28I47 Xenopus tropicalis 24% 73%
Q3USY0 Mus musculus 24% 71%
Q4Q072 Leishmania major 28% 100%
Q4Q6H5 Leishmania major 25% 67%
Q4Q6K6 Leishmania major 24% 68%
Q503G8 Danio rerio 26% 71%
Q5E9S9 Bos taurus 23% 67%
Q5EA97 Bos taurus 24% 69%
Q5HZH7 Mus musculus 23% 74%
Q5R9F5 Pongo abelii 21% 69%
Q6DEL1 Danio rerio 22% 69%
Q6DFE7 Xenopus laevis 22% 71%
Q6JWR2 Rattus norvegicus 20% 69%
Q6WWW3 Rattus norvegicus 26% 70%
Q8BWH0 Mus musculus 21% 69%
Q8HXI3 Macaca fascicularis 22% 70%
Q8IZM9 Homo sapiens 23% 70%
Q8WUX1 Homo sapiens 23% 68%
Q9NVC3 Homo sapiens 21% 69%
V5AXD0 Trypanosoma cruzi 44% 74%
V5B9A6 Trypanosoma cruzi 24% 70%
V5BA72 Trypanosoma cruzi 25% 69%
V5BH70 Trypanosoma cruzi 24% 71%
V5BMG4 Trypanosoma cruzi 25% 68%
V5D7K9 Trypanosoma cruzi 29% 71%
V5DCG4 Trypanosoma cruzi 26% 70%
V5DKR4 Trypanosoma cruzi 27% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS