Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IN51_LEIDO

TriTrypDb:

LdBPK_250250.1 , LdCL_250007600 , LDHU3_25.0310

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IN51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IN51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.485
CLV_C14_Caspase3-7	697	701	PF00656	0.587
CLV_NRD_NRD_1	49	51	PF00675	0.399
CLV_NRD_NRD_1	502	504	PF00675	0.619
CLV_NRD_NRD_1	650	652	PF00675	0.474
CLV_NRD_NRD_1	718	720	PF00675	0.523
CLV_NRD_NRD_1	842	844	PF00675	0.586
CLV_NRD_NRD_1	870	872	PF00675	0.661
CLV_NRD_NRD_1	97	99	PF00675	0.457
CLV_PCSK_KEX2_1	502	504	PF00082	0.518
CLV_PCSK_KEX2_1	650	652	PF00082	0.474
CLV_PCSK_KEX2_1	717	719	PF00082	0.484
CLV_PCSK_KEX2_1	842	844	PF00082	0.586
CLV_PCSK_KEX2_1	869	871	PF00082	0.662
CLV_PCSK_KEX2_1	97	99	PF00082	0.457
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.553
CLV_PCSK_PC7_1	498	504	PF00082	0.486
CLV_PCSK_SKI1_1	19	23	PF00082	0.557
CLV_PCSK_SKI1_1	229	233	PF00082	0.552
CLV_PCSK_SKI1_1	533	537	PF00082	0.579
CLV_PCSK_SKI1_1	696	700	PF00082	0.502
CLV_PCSK_SKI1_1	748	752	PF00082	0.582
CLV_PCSK_SKI1_1	763	767	PF00082	0.544
CLV_Separin_Metazoa	734	738	PF03568	0.480
CLV_Separin_Metazoa	760	764	PF03568	0.520
DEG_APCC_DBOX_1	586	594	PF00400	0.486
DEG_APCC_DBOX_1	695	703	PF00400	0.521
DEG_APCC_DBOX_1	708	716	PF00400	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.346
DEG_SPOP_SBC_1	57	61	PF00917	0.341
DEG_SPOP_SBC_1	670	674	PF00917	0.533
DOC_CDC14_PxL_1	862	870	PF14671	0.608
DOC_CKS1_1	399	404	PF01111	0.669
DOC_CKS1_1	77	82	PF01111	0.480
DOC_CKS1_1	781	786	PF01111	0.789
DOC_CKS1_1	872	877	PF01111	0.645
DOC_CYCLIN_RxL_1	255	266	PF00134	0.399
DOC_CYCLIN_RxL_1	619	631	PF00134	0.490
DOC_MAPK_gen_1	584	592	PF00069	0.527
DOC_MAPK_gen_1	620	628	PF00069	0.496
DOC_USP7_MATH_1	237	241	PF00917	0.425
DOC_USP7_MATH_1	359	363	PF00917	0.682
DOC_USP7_MATH_1	388	392	PF00917	0.592
DOC_USP7_MATH_1	422	426	PF00917	0.638
DOC_USP7_MATH_1	450	454	PF00917	0.725
DOC_USP7_MATH_1	517	521	PF00917	0.567
DOC_USP7_MATH_1	524	528	PF00917	0.556
DOC_USP7_MATH_1	542	546	PF00917	0.534
DOC_USP7_MATH_1	550	554	PF00917	0.483
DOC_USP7_MATH_1	555	559	PF00917	0.421
DOC_USP7_MATH_1	560	564	PF00917	0.566
DOC_USP7_MATH_1	670	674	PF00917	0.545
DOC_USP7_MATH_1	701	705	PF00917	0.435
DOC_USP7_MATH_1	727	731	PF00917	0.510
DOC_USP7_MATH_1	810	814	PF00917	0.676
DOC_USP7_UBL2_3	643	647	PF12436	0.542
DOC_WW_Pin1_4	246	251	PF00397	0.413
DOC_WW_Pin1_4	277	282	PF00397	0.429
DOC_WW_Pin1_4	398	403	PF00397	0.645
DOC_WW_Pin1_4	417	422	PF00397	0.518
DOC_WW_Pin1_4	76	81	PF00397	0.414
DOC_WW_Pin1_4	780	785	PF00397	0.660
DOC_WW_Pin1_4	799	804	PF00397	0.625
DOC_WW_Pin1_4	834	839	PF00397	0.604
DOC_WW_Pin1_4	871	876	PF00397	0.639
LIG_14-3-3_CanoR_1	16	22	PF00244	0.525
LIG_14-3-3_CanoR_1	187	195	PF00244	0.458
LIG_14-3-3_CanoR_1	229	238	PF00244	0.483
LIG_14-3-3_CanoR_1	28	33	PF00244	0.463
LIG_14-3-3_CanoR_1	305	314	PF00244	0.401
LIG_14-3-3_CanoR_1	408	416	PF00244	0.595
LIG_14-3-3_CanoR_1	48	54	PF00244	0.270
LIG_14-3-3_CanoR_1	519	523	PF00244	0.524
LIG_14-3-3_CanoR_1	584	593	PF00244	0.597
LIG_14-3-3_CanoR_1	668	676	PF00244	0.480
LIG_14-3-3_CanoR_1	687	695	PF00244	0.447
LIG_14-3-3_CanoR_1	82	90	PF00244	0.437
LIG_14-3-3_CanoR_1	842	850	PF00244	0.659
LIG_14-3-3_CanoR_1	97	102	PF00244	0.428
LIG_Actin_WH2_2	480	497	PF00022	0.536
LIG_BIR_III_2	445	449	PF00653	0.553
LIG_BIR_III_2	833	837	PF00653	0.622
LIG_BRCT_BRCA1_1	200	204	PF00533	0.386
LIG_BRCT_BRCA1_1	390	394	PF00533	0.661
LIG_BRCT_BRCA1_1	813	817	PF00533	0.639
LIG_FHA_1	255	261	PF00498	0.419
LIG_FHA_1	327	333	PF00498	0.599
LIG_FHA_1	469	475	PF00498	0.499
LIG_FHA_1	599	605	PF00498	0.663
LIG_FHA_1	705	711	PF00498	0.550
LIG_FHA_2	129	135	PF00498	0.453
LIG_FHA_2	153	159	PF00498	0.432
LIG_FHA_2	163	169	PF00498	0.391
LIG_FHA_2	221	227	PF00498	0.438
LIG_FHA_2	290	296	PF00498	0.390
LIG_FHA_2	38	44	PF00498	0.426
LIG_FHA_2	495	501	PF00498	0.473
LIG_FHA_2	687	693	PF00498	0.429
LIG_FHA_2	781	787	PF00498	0.595
LIG_FHA_2	98	104	PF00498	0.443
LIG_GBD_Chelix_1	582	590	PF00786	0.435
LIG_HCF-1_HBM_1	618	621	PF13415	0.529
LIG_LIR_Gen_1	162	172	PF02991	0.401
LIG_LIR_Gen_1	189	200	PF02991	0.389
LIG_LIR_Gen_1	216	227	PF02991	0.370
LIG_LIR_Gen_1	63	74	PF02991	0.423
LIG_LIR_Gen_1	849	858	PF02991	0.678
LIG_LIR_Nem_3	162	167	PF02991	0.399
LIG_LIR_Nem_3	169	175	PF02991	0.390
LIG_LIR_Nem_3	178	184	PF02991	0.400
LIG_LIR_Nem_3	189	195	PF02991	0.258
LIG_LIR_Nem_3	216	222	PF02991	0.345
LIG_LIR_Nem_3	23	29	PF02991	0.443
LIG_LIR_Nem_3	278	282	PF02991	0.454
LIG_LIR_Nem_3	470	475	PF02991	0.476
LIG_LIR_Nem_3	52	58	PF02991	0.408
LIG_LIR_Nem_3	63	69	PF02991	0.336
LIG_LIR_Nem_3	849	853	PF02991	0.583
LIG_NRBOX	258	264	PF00104	0.400
LIG_Pex14_1	275	279	PF04695	0.333
LIG_Pex14_2	202	206	PF04695	0.399
LIG_Pex14_2	293	297	PF04695	0.389
LIG_RPA_C_Fungi	230	242	PF08784	0.459
LIG_RPA_C_Fungi	645	657	PF08784	0.527
LIG_SH2_CRK	472	476	PF00017	0.462
LIG_SH2_CRK	66	70	PF00017	0.416
LIG_SH2_PTP2	172	175	PF00017	0.350
LIG_SH2_STAP1	307	311	PF00017	0.374
LIG_SH2_STAP1	522	526	PF00017	0.642
LIG_SH2_STAP1	66	70	PF00017	0.470
LIG_SH2_STAP1	743	747	PF00017	0.481
LIG_SH2_STAT3	743	746	PF00017	0.545
LIG_SH2_STAT5	172	175	PF00017	0.377
LIG_SH2_STAT5	261	264	PF00017	0.403
LIG_SH2_STAT5	30	33	PF00017	0.356
LIG_SH2_STAT5	780	783	PF00017	0.563
LIG_SH2_STAT5	99	102	PF00017	0.352
LIG_SH3_1	869	875	PF00018	0.683
LIG_SH3_3	114	120	PF00018	0.488
LIG_SH3_3	396	402	PF00018	0.679
LIG_SH3_3	415	421	PF00018	0.688
LIG_SH3_3	66	72	PF00018	0.398
LIG_SH3_3	74	80	PF00018	0.363
LIG_SH3_3	765	771	PF00018	0.590
LIG_SH3_3	778	784	PF00018	0.735
LIG_SH3_3	869	875	PF00018	0.683
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.453
LIG_SUMO_SIM_anti_2	308	317	PF11976	0.481
LIG_SUMO_SIM_anti_2	35	43	PF11976	0.432
LIG_SUMO_SIM_anti_2	588	594	PF11976	0.493
LIG_SUMO_SIM_par_1	280	286	PF11976	0.453
LIG_SUMO_SIM_par_1	40	47	PF11976	0.478
LIG_SUMO_SIM_par_1	624	629	PF11976	0.538
LIG_SUMO_SIM_par_1	86	91	PF11976	0.360
LIG_TRAF2_1	292	295	PF00917	0.463
LIG_TRAF2_1	458	461	PF00917	0.616
LIG_TRFH_1	261	265	PF08558	0.341
LIG_UBA3_1	259	264	PF00899	0.398
LIG_WRC_WIRS_1	199	204	PF05994	0.325
LIG_WRC_WIRS_1	219	224	PF05994	0.221
LIG_WRC_WIRS_1	276	281	PF05994	0.420
LIG_WW_3	802	806	PF00397	0.657
MOD_CDC14_SPxK_1	802	805	PF00782	0.563
MOD_CDK_SPxK_1	76	82	PF00069	0.475
MOD_CDK_SPxK_1	799	805	PF00069	0.661
MOD_CDK_SPxxK_3	780	787	PF00069	0.658
MOD_CK1_1	11	17	PF00069	0.607
MOD_CK1_1	128	134	PF00069	0.439
MOD_CK1_1	177	183	PF00069	0.473
MOD_CK1_1	20	26	PF00069	0.516
MOD_CK1_1	280	286	PF00069	0.399
MOD_CK1_1	368	374	PF00069	0.721
MOD_CK1_1	376	382	PF00069	0.682
MOD_CK1_1	426	432	PF00069	0.752
MOD_CK1_1	553	559	PF00069	0.506
MOD_CK1_1	60	66	PF00069	0.497
MOD_CK1_1	704	710	PF00069	0.502
MOD_CK1_1	752	758	PF00069	0.510
MOD_CK1_1	825	831	PF00069	0.658
MOD_CK1_1	846	852	PF00069	0.637
MOD_CK2_1	152	158	PF00069	0.443
MOD_CK2_1	162	168	PF00069	0.398
MOD_CK2_1	220	226	PF00069	0.423
MOD_CK2_1	280	286	PF00069	0.453
MOD_CK2_1	289	295	PF00069	0.408
MOD_CK2_1	510	516	PF00069	0.650
MOD_CK2_1	671	677	PF00069	0.619
MOD_CK2_1	686	692	PF00069	0.394
MOD_DYRK1A_RPxSP_1	871	875	PF00069	0.637
MOD_GlcNHglycan	12	16	PF01048	0.492
MOD_GlcNHglycan	127	130	PF01048	0.419
MOD_GlcNHglycan	239	242	PF01048	0.442
MOD_GlcNHglycan	321	324	PF01048	0.587
MOD_GlcNHglycan	378	382	PF01048	0.660
MOD_GlcNHglycan	390	393	PF01048	0.700
MOD_GlcNHglycan	411	414	PF01048	0.692
MOD_GlcNHglycan	460	465	PF01048	0.517
MOD_GlcNHglycan	552	555	PF01048	0.527
MOD_GlcNHglycan	557	560	PF01048	0.557
MOD_GlcNHglycan	673	676	PF01048	0.511
MOD_GlcNHglycan	753	757	PF01048	0.423
MOD_GlcNHglycan	824	827	PF01048	0.745
MOD_GlcNHglycan	845	848	PF01048	0.757
MOD_GlcNHglycan	93	96	PF01048	0.394
MOD_GSK3_1	121	128	PF00069	0.438
MOD_GSK3_1	246	253	PF00069	0.422
MOD_GSK3_1	28	35	PF00069	0.571
MOD_GSK3_1	373	380	PF00069	0.705
MOD_GSK3_1	407	414	PF00069	0.648
MOD_GSK3_1	422	429	PF00069	0.581
MOD_GSK3_1	456	463	PF00069	0.558
MOD_GSK3_1	56	63	PF00069	0.404
MOD_GSK3_1	735	742	PF00069	0.615
MOD_GSK3_1	776	783	PF00069	0.694
MOD_GSK3_1	811	818	PF00069	0.599
MOD_LATS_1	17	23	PF00433	0.486
MOD_N-GLC_1	134	139	PF02516	0.480
MOD_N-GLC_1	213	218	PF02516	0.369
MOD_N-GLC_1	314	319	PF02516	0.529
MOD_NEK2_1	109	114	PF00069	0.425
MOD_NEK2_1	206	211	PF00069	0.428
MOD_NEK2_1	231	236	PF00069	0.443
MOD_NEK2_1	252	257	PF00069	0.410
MOD_NEK2_1	306	311	PF00069	0.426
MOD_NEK2_1	314	319	PF00069	0.561
MOD_NEK2_1	409	414	PF00069	0.594
MOD_NEK2_1	58	63	PF00069	0.531
MOD_NEK2_1	73	78	PF00069	0.320
MOD_NEK2_1	735	740	PF00069	0.553
MOD_NEK2_1	798	803	PF00069	0.755
MOD_PIKK_1	20	26	PF00454	0.431
MOD_PIKK_1	365	371	PF00454	0.787
MOD_PIKK_1	60	66	PF00454	0.415
MOD_PIKK_1	704	710	PF00454	0.523
MOD_PIKK_1	81	87	PF00454	0.463
MOD_PKA_1	97	103	PF00069	0.447
MOD_PKA_2	186	192	PF00069	0.465
MOD_PKA_2	376	382	PF00069	0.705
MOD_PKA_2	407	413	PF00069	0.654
MOD_PKA_2	429	435	PF00069	0.569
MOD_PKA_2	49	55	PF00069	0.447
MOD_PKA_2	494	500	PF00069	0.518
MOD_PKA_2	518	524	PF00069	0.545
MOD_PKA_2	686	692	PF00069	0.485
MOD_PKA_2	81	87	PF00069	0.463
MOD_PKA_2	97	103	PF00069	0.431
MOD_Plk_1	134	140	PF00069	0.460
MOD_Plk_1	177	183	PF00069	0.475
MOD_Plk_1	213	219	PF00069	0.365
MOD_Plk_1	314	320	PF00069	0.455
MOD_Plk_1	35	41	PF00069	0.453
MOD_Plk_1	775	781	PF00069	0.648
MOD_Plk_2-3	134	140	PF00069	0.480
MOD_Plk_2-3	152	158	PF00069	0.503
MOD_Plk_2-3	289	295	PF00069	0.501
MOD_Plk_2-3	510	516	PF00069	0.579
MOD_Plk_2-3	686	692	PF00069	0.500
MOD_Plk_4	152	158	PF00069	0.499
MOD_Plk_4	263	269	PF00069	0.412
MOD_Plk_4	28	34	PF00069	0.395
MOD_Plk_4	280	286	PF00069	0.495
MOD_Plk_4	314	320	PF00069	0.479
MOD_Plk_4	37	43	PF00069	0.376
MOD_Plk_4	73	79	PF00069	0.436
MOD_Plk_4	776	782	PF00069	0.559
MOD_Plk_4	97	103	PF00069	0.431
MOD_ProDKin_1	246	252	PF00069	0.408
MOD_ProDKin_1	277	283	PF00069	0.434
MOD_ProDKin_1	398	404	PF00069	0.646
MOD_ProDKin_1	417	423	PF00069	0.519
MOD_ProDKin_1	76	82	PF00069	0.424
MOD_ProDKin_1	780	786	PF00069	0.659
MOD_ProDKin_1	799	805	PF00069	0.627
MOD_ProDKin_1	834	840	PF00069	0.602
MOD_ProDKin_1	871	877	PF00069	0.643
MOD_SUMO_for_1	750	753	PF00179	0.499
MOD_SUMO_rev_2	744	752	PF00179	0.499
TRG_DiLeu_BaEn_1	599	604	PF01217	0.521
TRG_DiLeu_BaEn_2	678	684	PF01217	0.495
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.406
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.429
TRG_DiLeu_BaLyEn_6	863	868	PF01217	0.534
TRG_ENDOCYTIC_2	172	175	PF00928	0.377
TRG_ENDOCYTIC_2	29	32	PF00928	0.362
TRG_ENDOCYTIC_2	472	475	PF00928	0.464
TRG_ENDOCYTIC_2	55	58	PF00928	0.452
TRG_ENDOCYTIC_2	66	69	PF00928	0.336
TRG_ENDOCYTIC_2	99	102	PF00928	0.352
TRG_ER_diArg_1	360	363	PF00400	0.663
TRG_ER_diArg_1	501	503	PF00400	0.451
TRG_ER_diArg_1	621	624	PF00400	0.493
TRG_ER_diArg_1	693	696	PF00400	0.496
TRG_ER_diArg_1	709	712	PF00400	0.458
TRG_ER_diArg_1	842	845	PF00400	0.685
TRG_ER_diArg_1	868	871	PF00400	0.657
TRG_ER_diArg_1	97	99	PF00400	0.372
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	584	589	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	748	753	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP5	Leptomonas seymouri	48%	97%
A0A3R7KB27	Trypanosoma rangeli	30%	96%
A4HDX2	Leishmania braziliensis	73%	100%
A4I167	Leishmania infantum	100%	100%
E9AXA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QA71	Leishmania major	89%	100%