Dihydrouridine synthase (Dus), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase (Dus), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IN46_LEIDO

TriTrypDb:

LdBPK_341220.1 , LdCL_340018100 , LDHU3_34.1940

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A0A3Q8IN46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IN46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0016491	oxidoreductase activity	2	16
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	16
GO:0017150	tRNA dihydrouridine synthase activity	5	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0050660	flavin adenine dinucleotide binding	4	16
GO:0097159	organic cyclic compound binding	2	16
GO:0106413	dihydrouridine synthase activity	4	16
GO:0140098	catalytic activity, acting on RNA	3	16
GO:0140101	catalytic activity, acting on a tRNA	4	16
GO:0140640	catalytic activity, acting on a nucleic acid	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.675
CLV_NRD_NRD_1	257	259	PF00675	0.282
CLV_NRD_NRD_1	361	363	PF00675	0.660
CLV_PCSK_KEX2_1	257	259	PF00082	0.280
CLV_PCSK_KEX2_1	361	363	PF00082	0.660
CLV_PCSK_SKI1_1	108	112	PF00082	0.265
DEG_APCC_DBOX_1	468	476	PF00400	0.445
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.459
DOC_MAPK_gen_1	295	305	PF00069	0.472
DOC_MAPK_MEF2A_6	298	307	PF00069	0.448
DOC_PP1_RVXF_1	256	263	PF00149	0.460
DOC_PP2B_LxvP_1	301	304	PF13499	0.515
DOC_PP2B_LxvP_1	397	400	PF13499	0.628
DOC_PP2B_LxvP_1	440	443	PF13499	0.513
DOC_USP7_MATH_1	120	124	PF00917	0.404
DOC_USP7_MATH_1	158	162	PF00917	0.448
DOC_USP7_MATH_1	218	222	PF00917	0.561
DOC_USP7_MATH_1	269	273	PF00917	0.523
DOC_USP7_MATH_1	353	357	PF00917	0.644
DOC_USP7_MATH_1	400	404	PF00917	0.721
DOC_USP7_MATH_1	460	464	PF00917	0.516
DOC_USP7_MATH_2	424	430	PF00917	0.354
DOC_USP7_UBL2_3	249	253	PF12436	0.564
DOC_WW_Pin1_4	133	138	PF00397	0.551
DOC_WW_Pin1_4	277	282	PF00397	0.437
DOC_WW_Pin1_4	371	376	PF00397	0.761
DOC_WW_Pin1_4	386	391	PF00397	0.614
DOC_WW_Pin1_4	420	425	PF00397	0.615
DOC_WW_Pin1_4	455	460	PF00397	0.418
DOC_WW_Pin1_4	77	82	PF00397	0.544
LIG_14-3-3_CanoR_1	121	129	PF00244	0.551
LIG_14-3-3_CanoR_1	257	261	PF00244	0.475
LIG_14-3-3_CanoR_1	411	415	PF00244	0.619
LIG_14-3-3_CanoR_1	469	475	PF00244	0.424
LIG_Actin_WH2_2	241	259	PF00022	0.477
LIG_Actin_WH2_2	307	325	PF00022	0.551
LIG_APCC_ABBA_1	172	177	PF00400	0.472
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	258	262	PF00533	0.448
LIG_BRCT_BRCA1_1	384	388	PF00533	0.590
LIG_deltaCOP1_diTrp_1	3	12	PF00928	0.652
LIG_eIF4E_1	93	99	PF01652	0.459
LIG_FHA_1	123	129	PF00498	0.481
LIG_FHA_1	235	241	PF00498	0.440
LIG_FHA_2	314	320	PF00498	0.552
LIG_FHA_2	411	417	PF00498	0.685
LIG_FHA_2	421	427	PF00498	0.479
LIG_FHA_2	63	69	PF00498	0.589
LIG_LIR_Gen_1	123	130	PF02991	0.453
LIG_LIR_Gen_1	272	281	PF02991	0.551
LIG_LIR_LC3C_4	150	155	PF02991	0.440
LIG_LIR_Nem_3	143	147	PF02991	0.491
LIG_LIR_Nem_3	2	8	PF02991	0.655
LIG_LIR_Nem_3	272	276	PF02991	0.521
LIG_LIR_Nem_3	385	391	PF02991	0.615
LIG_LIR_Nem_3	86	92	PF02991	0.433
LIG_Pex14_1	89	93	PF04695	0.523
LIG_Pex14_2	384	388	PF04695	0.590
LIG_SH2_CRK	93	97	PF00017	0.400
LIG_SH2_NCK_1	412	416	PF00017	0.590
LIG_SH2_PTP2	456	459	PF00017	0.426
LIG_SH2_SRC	484	487	PF00017	0.416
LIG_SH2_STAP1	124	128	PF00017	0.448
LIG_SH2_STAP1	47	51	PF00017	0.652
LIG_SH2_STAP1	8	12	PF00017	0.575
LIG_SH2_STAT5	124	127	PF00017	0.448
LIG_SH2_STAT5	175	178	PF00017	0.459
LIG_SH2_STAT5	343	346	PF00017	0.548
LIG_SH2_STAT5	412	415	PF00017	0.615
LIG_SH2_STAT5	456	459	PF00017	0.401
LIG_SH2_STAT5	484	487	PF00017	0.391
LIG_SH2_STAT5	93	96	PF00017	0.492
LIG_SH3_3	131	137	PF00018	0.553
LIG_SH3_3	239	245	PF00018	0.477
LIG_SH3_3	384	390	PF00018	0.638
LIG_SH3_3	75	81	PF00018	0.554
LIG_SUMO_SIM_anti_2	463	470	PF11976	0.527
LIG_TRAF2_1	477	480	PF00917	0.428
LIG_WW_3	364	368	PF00397	0.579
MOD_CDK_SPK_2	420	425	PF00069	0.584
MOD_CDK_SPxxK_3	133	140	PF00069	0.551
MOD_CDK_SPxxK_3	455	462	PF00069	0.386
MOD_CK1_1	221	227	PF00069	0.430
MOD_CK1_1	235	241	PF00069	0.500
MOD_CK1_1	272	278	PF00069	0.556
MOD_CK1_1	356	362	PF00069	0.763
MOD_CK1_1	470	476	PF00069	0.366
MOD_CK1_1	80	86	PF00069	0.589
MOD_CK2_1	313	319	PF00069	0.540
MOD_CK2_1	371	377	PF00069	0.671
MOD_CK2_1	400	406	PF00069	0.645
MOD_CK2_1	420	426	PF00069	0.604
MOD_CK2_1	455	461	PF00069	0.392
MOD_CK2_1	62	68	PF00069	0.759
MOD_GlcNHglycan	160	163	PF01048	0.245
MOD_GlcNHglycan	196	199	PF01048	0.218
MOD_GlcNHglycan	25	28	PF01048	0.566
MOD_GlcNHglycan	285	288	PF01048	0.254
MOD_GlcNHglycan	330	333	PF01048	0.272
MOD_GlcNHglycan	486	489	PF01048	0.577
MOD_GlcNHglycan	65	68	PF01048	0.665
MOD_GSK3_1	129	136	PF00069	0.449
MOD_GSK3_1	19	26	PF00069	0.581
MOD_GSK3_1	218	225	PF00069	0.483
MOD_GSK3_1	232	239	PF00069	0.475
MOD_GSK3_1	279	286	PF00069	0.465
MOD_GSK3_1	309	316	PF00069	0.463
MOD_GSK3_1	353	360	PF00069	0.693
MOD_GSK3_1	371	378	PF00069	0.661
MOD_GSK3_1	382	389	PF00069	0.619
MOD_LATS_1	277	283	PF00433	0.515
MOD_N-GLC_1	299	304	PF02516	0.393
MOD_N-GLC_1	41	46	PF02516	0.515
MOD_N-GLC_1	470	475	PF02516	0.478
MOD_N-GLC_1	83	88	PF02516	0.495
MOD_N-GLC_2	229	231	PF02516	0.204
MOD_NEK2_1	19	24	PF00069	0.456
MOD_NEK2_1	209	214	PF00069	0.462
MOD_NEK2_1	357	362	PF00069	0.744
MOD_NEK2_1	410	415	PF00069	0.641
MOD_NEK2_1	467	472	PF00069	0.379
MOD_NEK2_1	52	57	PF00069	0.758
MOD_NEK2_1	92	97	PF00069	0.499
MOD_OFUCOSY	231	236	PF10250	0.204
MOD_PKA_2	104	110	PF00069	0.441
MOD_PKA_2	120	126	PF00069	0.360
MOD_PKA_2	256	262	PF00069	0.462
MOD_PKA_2	410	416	PF00069	0.605
MOD_Plk_1	299	305	PF00069	0.477
MOD_Plk_1	353	359	PF00069	0.691
MOD_Plk_1	460	466	PF00069	0.403
MOD_Plk_1	47	53	PF00069	0.567
MOD_Plk_1	470	476	PF00069	0.413
MOD_Plk_1	83	89	PF00069	0.522
MOD_Plk_4	129	135	PF00069	0.551
MOD_Plk_4	222	228	PF00069	0.418
MOD_Plk_4	269	275	PF00069	0.551
MOD_Plk_4	392	398	PF00069	0.699
MOD_Plk_4	47	53	PF00069	0.544
MOD_Plk_4	470	476	PF00069	0.434
MOD_ProDKin_1	133	139	PF00069	0.551
MOD_ProDKin_1	277	283	PF00069	0.437
MOD_ProDKin_1	371	377	PF00069	0.760
MOD_ProDKin_1	386	392	PF00069	0.614
MOD_ProDKin_1	420	426	PF00069	0.604
MOD_ProDKin_1	455	461	PF00069	0.412
MOD_ProDKin_1	77	83	PF00069	0.541
TRG_DiLeu_BaEn_1	292	297	PF01217	0.489
TRG_ENDOCYTIC_2	124	127	PF00928	0.448
TRG_ENDOCYTIC_2	93	96	PF00928	0.348
TRG_ER_diArg_1	256	258	PF00400	0.483
TRG_ER_diArg_1	361	364	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT7	Leptomonas seymouri	69%	96%
A0A0S4JTG4	Bodo saltans	44%	100%
A0A1X0PAA8	Trypanosomatidae	45%	100%
A0A3Q8IJ00	Leishmania donovani	23%	100%
A0A3R7KZP3	Trypanosoma rangeli	46%	100%
A4HAN2	Leishmania braziliensis	78%	100%
A4HNQ5	Leishmania braziliensis	24%	100%
A4I9S4	Leishmania infantum	99%	100%
A4ICU0	Leishmania infantum	23%	100%
C9ZMV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ASG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B4T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q391	Leishmania major	92%	100%
V5DJT2	Trypanosoma cruzi	46%	100%