Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IN33_LEIDO

TriTrypDb:

LdBPK_250110.1 , LdCL_250006200 , LDHU3_25.0160

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IN33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IN33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.740
CLV_C14_Caspase3-7	442	446	PF00656	0.541
CLV_NRD_NRD_1	189	191	PF00675	0.591
CLV_NRD_NRD_1	2	4	PF00675	0.595
CLV_NRD_NRD_1	305	307	PF00675	0.666
CLV_NRD_NRD_1	376	378	PF00675	0.530
CLV_NRD_NRD_1	458	460	PF00675	0.383
CLV_NRD_NRD_1	67	69	PF00675	0.398
CLV_PCSK_KEX2_1	189	191	PF00082	0.591
CLV_PCSK_KEX2_1	2	4	PF00082	0.515
CLV_PCSK_KEX2_1	305	307	PF00082	0.661
CLV_PCSK_KEX2_1	376	378	PF00082	0.583
CLV_PCSK_KEX2_1	414	416	PF00082	0.410
CLV_PCSK_KEX2_1	458	460	PF00082	0.357
CLV_PCSK_KEX2_1	67	69	PF00082	0.398
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.409
CLV_PCSK_SKI1_1	116	120	PF00082	0.322
CLV_PCSK_SKI1_1	182	186	PF00082	0.628
CLV_PCSK_SKI1_1	29	33	PF00082	0.401
CLV_PCSK_SKI1_1	34	38	PF00082	0.355
CLV_PCSK_SKI1_1	407	411	PF00082	0.528
CLV_Separin_Metazoa	260	264	PF03568	0.438
DEG_APCC_DBOX_1	97	105	PF00400	0.372
DEG_COP1_1	288	297	PF00400	0.537
DEG_Nend_UBRbox_1	1	4	PF02207	0.495
DOC_CKS1_1	227	232	PF01111	0.392
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.486
DOC_MAPK_DCC_7	224	233	PF00069	0.238
DOC_MAPK_gen_1	186	195	PF00069	0.584
DOC_MAPK_gen_1	414	422	PF00069	0.356
DOC_MAPK_gen_1	48	56	PF00069	0.398
DOC_MAPK_MEF2A_6	116	123	PF00069	0.538
DOC_MAPK_MEF2A_6	189	197	PF00069	0.469
DOC_MAPK_MEF2A_6	376	385	PF00069	0.441
DOC_MAPK_MEF2A_6	50	58	PF00069	0.312
DOC_PP4_FxxP_1	334	337	PF00568	0.426
DOC_PP4_FxxP_1	418	421	PF00568	0.376
DOC_USP7_MATH_1	180	184	PF00917	0.594
DOC_USP7_MATH_1	19	23	PF00917	0.437
DOC_USP7_MATH_1	304	308	PF00917	0.558
DOC_USP7_MATH_1	361	365	PF00917	0.582
DOC_USP7_MATH_1	468	472	PF00917	0.667
DOC_WW_Pin1_4	226	231	PF00397	0.425
LIG_14-3-3_CanoR_1	137	144	PF00244	0.372
LIG_14-3-3_CanoR_1	2	7	PF00244	0.466
LIG_14-3-3_CanoR_1	208	215	PF00244	0.548
LIG_14-3-3_CanoR_1	34	39	PF00244	0.377
LIG_14-3-3_CanoR_1	458	464	PF00244	0.515
LIG_14-3-3_CanoR_1	50	55	PF00244	0.257
LIG_APCC_ABBA_1	195	200	PF00400	0.351
LIG_APCC_ABBA_1	235	240	PF00400	0.379
LIG_BRCT_BRCA1_1	298	302	PF00533	0.455
LIG_BRCT_BRCA1_1	38	42	PF00533	0.364
LIG_Clathr_ClatBox_1	120	124	PF01394	0.368
LIG_deltaCOP1_diTrp_1	89	95	PF00928	0.339
LIG_DLG_GKlike_1	50	57	PF00625	0.383
LIG_FAT_LD_1	54	62	PF03623	0.468
LIG_FHA_1	159	165	PF00498	0.425
LIG_FHA_1	2	8	PF00498	0.514
LIG_FHA_1	223	229	PF00498	0.431
LIG_FHA_1	341	347	PF00498	0.626
LIG_FHA_1	353	359	PF00498	0.433
LIG_FHA_1	404	410	PF00498	0.522
LIG_FHA_1	75	81	PF00498	0.529
LIG_FHA_2	310	316	PF00498	0.711
LIG_FHA_2	42	48	PF00498	0.537
LIG_FHA_2	50	56	PF00498	0.465
LIG_LIR_Apic_2	330	336	PF02991	0.335
LIG_LIR_Gen_1	200	211	PF02991	0.520
LIG_LIR_Gen_1	39	47	PF02991	0.380
LIG_LIR_Gen_1	89	96	PF02991	0.393
LIG_LIR_Nem_3	200	206	PF02991	0.517
LIG_LIR_Nem_3	360	365	PF02991	0.397
LIG_LIR_Nem_3	39	45	PF02991	0.384
LIG_LIR_Nem_3	81	86	PF02991	0.406
LIG_LIR_Nem_3	89	93	PF02991	0.340
LIG_MYND_1	347	351	PF01753	0.443
LIG_NRBOX	100	106	PF00104	0.445
LIG_NRBOX	53	59	PF00104	0.383
LIG_Pex14_2	418	422	PF04695	0.368
LIG_RPA_C_Fungi	454	466	PF08784	0.273
LIG_SH2_CRK	30	34	PF00017	0.413
LIG_SH2_NCK_1	298	302	PF00017	0.445
LIG_SH2_STAP1	298	302	PF00017	0.445
LIG_SH2_STAP1	412	416	PF00017	0.376
LIG_SH2_STAT5	165	168	PF00017	0.371
LIG_SH2_STAT5	425	428	PF00017	0.292
LIG_SH2_STAT5	6	9	PF00017	0.456
LIG_SH2_STAT5	64	67	PF00017	0.483
LIG_SH3_1	236	242	PF00018	0.411
LIG_SH3_2	336	341	PF14604	0.356
LIG_SH3_3	224	230	PF00018	0.397
LIG_SH3_3	236	242	PF00018	0.415
LIG_SH3_3	289	295	PF00018	0.473
LIG_SH3_3	333	339	PF00018	0.448
LIG_SH3_3	348	354	PF00018	0.349
LIG_SH3_4	331	338	PF00018	0.393
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.462
LIG_SUMO_SIM_anti_2	99	106	PF11976	0.416
LIG_SUMO_SIM_par_1	119	124	PF11976	0.489
LIG_SUMO_SIM_par_1	354	360	PF11976	0.469
LIG_SUMO_SIM_par_1	381	386	PF11976	0.427
LIG_SUMO_SIM_par_1	99	106	PF11976	0.401
LIG_TRAF2_1	399	402	PF00917	0.561
LIG_UBA3_1	119	126	PF00899	0.378
LIG_WW_2	336	339	PF00397	0.359
MOD_CK1_1	307	313	PF00069	0.598
MOD_CK1_1	41	47	PF00069	0.450
MOD_CK1_1	74	80	PF00069	0.420
MOD_CK2_1	314	320	PF00069	0.714
MOD_CK2_1	324	330	PF00069	0.667
MOD_Cter_Amidation	65	68	PF01082	0.387
MOD_GlcNHglycan	105	108	PF01048	0.579
MOD_GlcNHglycan	182	185	PF01048	0.526
MOD_GlcNHglycan	209	212	PF01048	0.641
MOD_GlcNHglycan	299	302	PF01048	0.496
MOD_GlcNHglycan	324	327	PF01048	0.597
MOD_GlcNHglycan	359	362	PF01048	0.493
MOD_GlcNHglycan	429	432	PF01048	0.491
MOD_GlcNHglycan	61	64	PF01048	0.305
MOD_GSK3_1	132	139	PF00069	0.384
MOD_GSK3_1	222	229	PF00069	0.429
MOD_GSK3_1	305	312	PF00069	0.576
MOD_GSK3_1	34	41	PF00069	0.517
MOD_GSK3_1	357	364	PF00069	0.537
MOD_LATS_1	303	309	PF00433	0.576
MOD_N-GLC_2	392	394	PF02516	0.415
MOD_NEK2_1	1	6	PF00069	0.482
MOD_NEK2_1	324	329	PF00069	0.613
MOD_NEK2_1	36	41	PF00069	0.373
MOD_NEK2_2	19	24	PF00069	0.598
MOD_PIKK_1	307	313	PF00454	0.568
MOD_PIKK_1	74	80	PF00454	0.420
MOD_PK_1	459	465	PF00069	0.301
MOD_PK_1	9	15	PF00069	0.352
MOD_PKA_1	2	8	PF00069	0.526
MOD_PKA_1	305	311	PF00069	0.601
MOD_PKA_2	1	7	PF00069	0.473
MOD_PKA_2	132	138	PF00069	0.380
MOD_PKA_2	207	213	PF00069	0.592
MOD_PKA_2	304	310	PF00069	0.627
MOD_PKA_2	340	346	PF00069	0.658
MOD_PKA_2	403	409	PF00069	0.452
MOD_PKA_2	443	449	PF00069	0.451
MOD_PKA_2	49	55	PF00069	0.399
MOD_Plk_1	201	207	PF00069	0.476
MOD_Plk_1	383	389	PF00069	0.361
MOD_Plk_4	2	8	PF00069	0.553
MOD_Plk_4	352	358	PF00069	0.327
MOD_Plk_4	443	449	PF00069	0.436
MOD_ProDKin_1	226	232	PF00069	0.425
MOD_SUMO_rev_2	89	96	PF00179	0.322
TRG_DiLeu_BaEn_1	100	105	PF01217	0.411
TRG_DiLeu_BaEn_1	115	120	PF01217	0.277
TRG_DiLeu_BaEn_1	443	448	PF01217	0.507
TRG_DiLeu_BaEn_2	221	227	PF01217	0.440
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.523
TRG_ENDOCYTIC_2	425	428	PF00928	0.292
TRG_ER_diArg_1	1	3	PF00400	0.534
TRG_ER_diArg_1	376	378	PF00400	0.662
TRG_ER_diArg_1	457	459	PF00400	0.401
TRG_NES_CRM1_1	260	276	PF08389	0.286
TRG_NES_CRM1_1	78	92	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X3	Leptomonas seymouri	70%	100%
A0A0S4IT89	Bodo saltans	42%	82%
A0A1X0P4R6	Trypanosomatidae	57%	100%
A0A3R7MKC3	Trypanosoma rangeli	56%	100%
A4HDV8	Leishmania braziliensis	86%	100%
A4I153	Leishmania infantum	99%	100%
D0A5D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A5D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AX87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QA85	Leishmania major	93%	100%
V5BSX0	Trypanosoma cruzi	56%	100%