LeishMANIAdb
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Ribosomal protein L13

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal protein L13
Gene product:
60S ribosomal protein L13a, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A3Q8IN17_LEIDO
TriTrypDb:
LdBPK_340910.1 * , LdCL_150007100 , LdCL_340014600 , LDHU3_15.0300
Length:
222

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L13a

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0015934 large ribosomal subunit 4 16
GO:0032991 protein-containing complex 1 16
GO:0044391 ribosomal subunit 3 16
GO:1990904 ribonucleoprotein complex 2 16
GO:0005730 nucleolus 5 2
GO:0005737 cytoplasm 2 2
GO:0005840 ribosome 5 2
GO:0022625 cytosolic large ribosomal subunit 5 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

A0A3Q8IN17
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IN17

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 16
GO:0006518 peptide metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009058 biosynthetic process 2 16
GO:0009059 macromolecule biosynthetic process 4 16
GO:0009987 cellular process 1 16
GO:0019538 protein metabolic process 3 16
GO:0034641 cellular nitrogen compound metabolic process 3 16
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 16
GO:0043043 peptide biosynthetic process 5 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043603 amide metabolic process 3 16
GO:0043604 amide biosynthetic process 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0044249 cellular biosynthetic process 3 16
GO:0044260 obsolete cellular macromolecule metabolic process 3 16
GO:0044271 cellular nitrogen compound biosynthetic process 4 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:1901566 organonitrogen compound biosynthetic process 4 16
GO:1901576 organic substance biosynthetic process 3 16
GO:0006417 regulation of translation 6 2
GO:0009889 regulation of biosynthetic process 4 2
GO:0009890 negative regulation of biosynthetic process 5 2
GO:0009892 negative regulation of metabolic process 4 2
GO:0010468 regulation of gene expression 5 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0010558 negative regulation of macromolecule biosynthetic process 6 2
GO:0010605 negative regulation of macromolecule metabolic process 5 2
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0010629 negative regulation of gene expression 6 2
GO:0017148 negative regulation of translation 7 2
GO:0019222 regulation of metabolic process 3 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031324 negative regulation of cellular metabolic process 5 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0031327 negative regulation of cellular biosynthetic process 6 2
GO:0034248 regulation of amide metabolic process 5 2
GO:0034249 negative regulation of amide metabolic process 6 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051172 negative regulation of nitrogen compound metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051248 negative regulation of protein metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0080090 regulation of primary metabolic process 4 2
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 2
GO:2000113 obsolete negative regulation of cellular macromolecule biosynthetic process 7 2
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 16
GO:0005198 structural molecule activity 1 16
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0003729 mRNA binding 5 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 5 9 PF00656 0.670
CLV_NRD_NRD_1 13 15 PF00675 0.611
CLV_NRD_NRD_1 200 202 PF00675 0.521
CLV_NRD_NRD_1 5 7 PF00675 0.642
CLV_NRD_NRD_1 76 78 PF00675 0.392
CLV_PCSK_KEX2_1 111 113 PF00082 0.392
CLV_PCSK_KEX2_1 78 80 PF00082 0.392
CLV_PCSK_PC1ET2_1 111 113 PF00082 0.392
CLV_PCSK_PC1ET2_1 78 80 PF00082 0.392
CLV_PCSK_SKI1_1 103 107 PF00082 0.392
CLV_PCSK_SKI1_1 112 116 PF00082 0.392
CLV_PCSK_SKI1_1 15 19 PF00082 0.698
CLV_PCSK_SKI1_1 189 193 PF00082 0.596
CLV_PCSK_SKI1_1 202 206 PF00082 0.437
CLV_PCSK_SKI1_1 43 47 PF00082 0.382
CLV_PCSK_SKI1_1 49 53 PF00082 0.382
CLV_PCSK_SKI1_1 79 83 PF00082 0.496
DOC_MAPK_gen_1 18 27 PF00069 0.552
DOC_MAPK_gen_1 207 215 PF00069 0.517
DOC_MAPK_MEF2A_6 18 26 PF00069 0.574
DOC_PP1_RVXF_1 160 167 PF00149 0.461
DOC_PP2B_PxIxI_1 21 27 PF00149 0.432
DOC_USP7_MATH_1 116 120 PF00917 0.462
DOC_USP7_MATH_1 2 6 PF00917 0.778
DOC_USP7_UBL2_3 111 115 PF12436 0.373
DOC_USP7_UBL2_3 15 19 PF12436 0.623
DOC_USP7_UBL2_3 198 202 PF12436 0.550
LIG_14-3-3_CanoR_1 100 106 PF00244 0.392
LIG_14-3-3_CanoR_1 14 22 PF00244 0.749
LIG_14-3-3_CanoR_1 152 157 PF00244 0.468
LIG_BIR_II_1 1 5 PF00653 0.782
LIG_BIR_III_1 1 5 PF00653 0.782
LIG_BIR_III_3 1 5 PF00653 0.782
LIG_BRCT_BRCA1_1 94 98 PF00533 0.417
LIG_LIR_Gen_1 151 160 PF02991 0.469
LIG_LIR_Nem_3 151 157 PF02991 0.477
LIG_SH2_CRK 154 158 PF00017 0.456
LIG_SH2_STAP1 168 172 PF00017 0.488
LIG_SH2_STAT5 109 112 PF00017 0.392
LIG_SH2_STAT5 154 157 PF00017 0.506
LIG_SH2_STAT5 72 75 PF00017 0.392
LIG_SH3_3 134 140 PF00018 0.521
LIG_SUMO_SIM_anti_2 23 28 PF11976 0.417
LIG_SUMO_SIM_par_1 23 28 PF11976 0.392
LIG_TYR_ITIM 121 126 PF00017 0.384
LIG_UBA3_1 24 30 PF00899 0.526
MOD_Cter_Amidation 47 50 PF01082 0.392
MOD_GlcNHglycan 15 18 PF01048 0.625
MOD_LATS_1 90 96 PF00433 0.417
MOD_N-GLC_2 159 161 PF02516 0.447
MOD_NEK2_1 98 103 PF00069 0.361
MOD_PKA_1 49 55 PF00069 0.392
MOD_PKA_1 79 85 PF00069 0.392
MOD_PKA_2 107 113 PF00069 0.392
MOD_PKA_2 13 19 PF00069 0.616
MOD_PKB_1 77 85 PF00069 0.392
MOD_Plk_4 116 122 PF00069 0.555
MOD_Plk_4 152 158 PF00069 0.475
TRG_ENDOCYTIC_2 123 126 PF00928 0.384
TRG_ENDOCYTIC_2 154 157 PF00928 0.459
TRG_ENDOCYTIC_2 168 171 PF00928 0.388
TRG_ER_diArg_1 76 79 PF00400 0.392
TRG_NLS_Bipartite_1 6 22 PF00514 0.703
TRG_NLS_MonoCore_2 76 81 PF00514 0.392
TRG_NLS_MonoExtC_3 17 22 PF00514 0.619
TRG_NLS_MonoExtN_4 15 22 PF00514 0.628
TRG_NLS_MonoExtN_4 77 82 PF00514 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JFU0 Bodo saltans 77% 100%
A0A0S4KJ25 Bodo saltans 76% 93%
A0A1X0P9I5 Trypanosomatidae 82% 100%
A0A3S5IQR0 Trypanosoma rangeli 81% 100%
A0A422NS83 Trypanosoma rangeli 81% 100%
A4H7Z1 Leishmania braziliensis 93% 100%
A4HAJ9 Leishmania braziliensis 93% 100%
A4HWB9 Leishmania infantum 100% 100%
C9ZNV6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 78% 100%
E9AQ19 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O42848 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 100%
O42991 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 49% 100%
O43004 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 100%
O49885 Lupinus luteus 44% 100%
O65055 Picea mariana 44% 100%
P0DJ15 Tetrahymena thermophila (strain SB210) 41% 100%
P19253 Mus musculus 48% 100%
P26784 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 49% 100%
P26785 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 48% 100%
P35427 Rattus norvegicus 49% 100%
P40429 Homo sapiens 49% 100%
P93099 Cyanophora paradoxa 42% 100%
Q27389 Caenorhabditis elegans 42% 100%
Q3SZ90 Bos taurus 49% 100%
Q4Q3B9 Leishmania major 99% 100%
Q4QFG2 Leishmania major 98% 100%
Q4R8Z2 Macaca fascicularis 48% 100%
Q553M7 Dictyostelium discoideum 47% 100%
Q5AB87 Candida albicans (strain SC5314 / ATCC MYA-2876) 46% 100%
Q5RA38 Pongo abelii 48% 100%
Q8MUR4 Choristoneura parallela 46% 100%
Q8ZYQ1 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 33% 100%
Q91487 Salmo trutta 46% 100%
Q962U0 Spodoptera frugiperda 46% 100%
Q9FKC0 Arabidopsis thaliana 41% 100%
Q9LRX8 Arabidopsis thaliana 39% 100%
Q9P720 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 45% 100%
Q9SFU1 Arabidopsis thaliana 42% 100%
Q9SVR0 Arabidopsis thaliana 42% 100%
Q9VNE9 Drosophila melanogaster 46% 100%
Q9XSU0 Canis lupus familiaris 48% 100%
Q9YB50 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 33% 100%
V5BAB2 Trypanosoma cruzi 81% 79%
V5DCT1 Trypanosoma cruzi 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS