Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMW3_LEIDO

TriTrypDb:

LdBPK_242000.1 , LdCL_240025700 , LDHU3_24.2440

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IMW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.469
CLV_NRD_NRD_1	281	283	PF00675	0.490
CLV_NRD_NRD_1	453	455	PF00675	0.466
CLV_NRD_NRD_1	510	512	PF00675	0.478
CLV_PCSK_FUR_1	508	512	PF00082	0.553
CLV_PCSK_KEX2_1	281	283	PF00082	0.495
CLV_PCSK_KEX2_1	453	455	PF00082	0.483
CLV_PCSK_KEX2_1	510	512	PF00082	0.482
CLV_PCSK_PC7_1	277	283	PF00082	0.446
CLV_PCSK_PC7_1	506	512	PF00082	0.547
CLV_PCSK_SKI1_1	21	25	PF00082	0.606
CLV_PCSK_SKI1_1	251	255	PF00082	0.553
CLV_PCSK_SKI1_1	334	338	PF00082	0.413
CLV_PCSK_SKI1_1	457	461	PF00082	0.557
CLV_Separin_Metazoa	472	476	PF03568	0.439
DEG_SPOP_SBC_1	83	87	PF00917	0.649
DOC_CKS1_1	399	404	PF01111	0.547
DOC_CKS1_1	6	11	PF01111	0.639
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.430
DOC_MAPK_MEF2A_6	319	326	PF00069	0.402
DOC_MAPK_MEF2A_6	334	341	PF00069	0.413
DOC_MAPK_NFAT4_5	334	342	PF00069	0.438
DOC_PP1_RVXF_1	441	447	PF00149	0.452
DOC_PP4_FxxP_1	342	345	PF00568	0.472
DOC_USP7_MATH_1	309	313	PF00917	0.623
DOC_USP7_MATH_1	315	319	PF00917	0.599
DOC_USP7_MATH_1	365	369	PF00917	0.699
DOC_USP7_MATH_1	84	88	PF00917	0.618
DOC_USP7_UBL2_3	162	166	PF12436	0.549
DOC_WW_Pin1_4	14	19	PF00397	0.741
DOC_WW_Pin1_4	30	35	PF00397	0.721
DOC_WW_Pin1_4	318	323	PF00397	0.566
DOC_WW_Pin1_4	398	403	PF00397	0.708
DOC_WW_Pin1_4	44	49	PF00397	0.676
DOC_WW_Pin1_4	5	10	PF00397	0.720
DOC_WW_Pin1_4	94	99	PF00397	0.729
LIG_14-3-3_CanoR_1	13	17	PF00244	0.748
LIG_14-3-3_CanoR_1	240	248	PF00244	0.541
LIG_14-3-3_CanoR_1	508	516	PF00244	0.555
LIG_Actin_WH2_2	134	151	PF00022	0.611
LIG_Actin_WH2_2	203	219	PF00022	0.399
LIG_APCC_ABBA_1	339	344	PF00400	0.475
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_Clathr_ClatBox_1	323	327	PF01394	0.501
LIG_Clathr_ClatBox_1	347	351	PF01394	0.524
LIG_deltaCOP1_diTrp_1	340	350	PF00928	0.403
LIG_FHA_1	140	146	PF00498	0.593
LIG_FHA_1	250	256	PF00498	0.544
LIG_FHA_1	265	271	PF00498	0.309
LIG_FHA_1	36	42	PF00498	0.750
LIG_FHA_1	399	405	PF00498	0.542
LIG_FHA_1	439	445	PF00498	0.307
LIG_FHA_1	58	64	PF00498	0.636
LIG_FHA_2	108	114	PF00498	0.545
LIG_FHA_2	404	410	PF00498	0.586
LIG_GBD_Chelix_1	237	245	PF00786	0.348
LIG_LIR_Apic_2	340	345	PF02991	0.443
LIG_LIR_Nem_3	340	346	PF02991	0.462
LIG_PCNA_yPIPBox_3	328	342	PF02747	0.483
LIG_SH2_SRC	470	473	PF00017	0.519
LIG_SH2_SRC	496	499	PF00017	0.463
LIG_SH2_STAP1	470	474	PF00017	0.513
LIG_SH2_STAT5	126	129	PF00017	0.466
LIG_SH2_STAT5	479	482	PF00017	0.523
LIG_SH3_3	3	9	PF00018	0.633
LIG_SH3_3	371	377	PF00018	0.712
LIG_SH3_3	396	402	PF00018	0.608
LIG_SH3_3	45	51	PF00018	0.650
LIG_SH3_3	69	75	PF00018	0.795
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.490
LIG_SUMO_SIM_par_1	269	274	PF11976	0.512
LIG_SUMO_SIM_par_1	35	42	PF11976	0.625
LIG_TRAF2_1	177	180	PF00917	0.642
LIG_TRAF2_1	34	37	PF00917	0.718
LIG_TRAF2_1	369	372	PF00917	0.748
LIG_UBA3_1	480	485	PF00899	0.514
MOD_CDK_SPK_2	14	19	PF00069	0.713
MOD_CDK_SPxxK_3	14	21	PF00069	0.644
MOD_CDK_SPxxK_3	318	325	PF00069	0.410
MOD_CK1_1	239	245	PF00069	0.499
MOD_CK1_1	29	35	PF00069	0.621
MOD_CK1_1	318	324	PF00069	0.671
MOD_CK1_1	509	515	PF00069	0.580
MOD_CK1_1	86	92	PF00069	0.668
MOD_CK2_1	30	36	PF00069	0.731
MOD_GlcNHglycan	10	13	PF01048	0.658
MOD_GlcNHglycan	154	157	PF01048	0.618
MOD_GlcNHglycan	170	173	PF01048	0.657
MOD_GlcNHglycan	20	24	PF01048	0.554
MOD_GlcNHglycan	3	6	PF01048	0.726
MOD_GlcNHglycan	306	309	PF01048	0.514
MOD_GlcNHglycan	359	362	PF01048	0.486
MOD_GlcNHglycan	367	370	PF01048	0.725
MOD_GlcNHglycan	86	89	PF01048	0.727
MOD_GSK3_1	1	8	PF00069	0.666
MOD_GSK3_1	122	129	PF00069	0.484
MOD_GSK3_1	152	159	PF00069	0.568
MOD_GSK3_1	19	26	PF00069	0.539
MOD_GSK3_1	247	254	PF00069	0.483
MOD_GSK3_1	418	425	PF00069	0.378
MOD_GSK3_1	42	49	PF00069	0.725
MOD_GSK3_1	502	509	PF00069	0.600
MOD_GSK3_1	57	64	PF00069	0.570
MOD_GSK3_1	82	89	PF00069	0.678
MOD_N-GLC_1	57	62	PF02516	0.754
MOD_NEK2_1	1	6	PF00069	0.729
MOD_NEK2_1	141	146	PF00069	0.514
MOD_NEK2_1	187	192	PF00069	0.642
MOD_NEK2_1	357	362	PF00069	0.480
MOD_PIKK_1	126	132	PF00454	0.543
MOD_PIKK_1	261	267	PF00454	0.509
MOD_PIKK_1	310	316	PF00454	0.580
MOD_PIKK_1	418	424	PF00454	0.426
MOD_PIKK_1	509	515	PF00454	0.555
MOD_PIKK_1	76	82	PF00454	0.608
MOD_PKA_2	12	18	PF00069	0.678
MOD_PKA_2	239	245	PF00069	0.560
MOD_PKA_2	452	458	PF00069	0.385
MOD_PKA_2	509	515	PF00069	0.515
MOD_Plk_1	19	25	PF00069	0.700
MOD_Plk_1	35	41	PF00069	0.718
MOD_Plk_1	418	424	PF00069	0.557
MOD_Plk_4	295	301	PF00069	0.560
MOD_Plk_4	352	358	PF00069	0.540
MOD_ProDKin_1	14	20	PF00069	0.740
MOD_ProDKin_1	30	36	PF00069	0.723
MOD_ProDKin_1	318	324	PF00069	0.558
MOD_ProDKin_1	398	404	PF00069	0.704
MOD_ProDKin_1	44	50	PF00069	0.671
MOD_ProDKin_1	5	11	PF00069	0.721
MOD_ProDKin_1	94	100	PF00069	0.729
MOD_SUMO_for_1	177	180	PF00179	0.494
MOD_SUMO_for_1	484	487	PF00179	0.509
TRG_DiLeu_BaEn_2	441	447	PF01217	0.452
TRG_DiLeu_BaEn_4	243	249	PF01217	0.499
TRG_DiLeu_BaEn_4	418	424	PF01217	0.511
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.469
TRG_ENDOCYTIC_2	470	473	PF00928	0.519
TRG_ER_diArg_1	117	120	PF00400	0.486
TRG_ER_diArg_1	281	283	PF00400	0.488
TRG_ER_diArg_1	423	426	PF00400	0.534
TRG_ER_diArg_1	433	436	PF00400	0.472
TRG_ER_diArg_1	452	454	PF00400	0.456
TRG_ER_diArg_1	508	511	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P7	Leptomonas seymouri	58%	95%
A0A0S4J1F8	Bodo saltans	26%	95%
A0A1X0NW49	Trypanosomatidae	33%	100%
A0A422NWS4	Trypanosoma rangeli	34%	100%
A4HDQ4	Leishmania braziliensis	87%	100%
A4I100	Leishmania infantum	100%	100%
C9ZWA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AX38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAD8	Leishmania major	96%	100%