LeishMANIAdb
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Polyadenylate-binding protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Polyadenylate-binding protein
Gene product:
polyadenylate-binding protein 2
Species:
Leishmania donovani
UniProt:
A0A3Q8IMW2_LEIDO
TriTrypDb:
LdBPK_354200.1 , LdCL_350047100 , LDHU3_35.5420
Length:
585

Annotations

Annotations by Jardim et al.

RNA Processing, Polyadenylate-binding PABP2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0000932 P-body 5 1
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0032991 protein-containing complex 1 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0097165 nuclear stress granule 4 1
GO:0099080 supramolecular complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IMW2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMW2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003727 single-stranded RNA binding 5 1
GO:0003729 mRNA binding 5 1
GO:0003730 mRNA 3'-UTR binding 6 1
GO:0005515 protein binding 2 1
GO:0008143 poly(A) binding 7 1
GO:0008187 poly-pyrimidine tract binding 6 1
GO:0008266 poly(U) RNA binding 7 1
GO:0031369 translation initiation factor binding 3 1
GO:0031370 eukaryotic initiation factor 4G binding 4 1
GO:0070717 poly-purine tract binding 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 147 151 PF00656 0.540
CLV_C14_Caspase3-7 566 570 PF00656 0.547
CLV_NRD_NRD_1 277 279 PF00675 0.551
CLV_NRD_NRD_1 366 368 PF00675 0.525
CLV_NRD_NRD_1 371 373 PF00675 0.527
CLV_NRD_NRD_1 90 92 PF00675 0.508
CLV_PCSK_FUR_1 275 279 PF00082 0.542
CLV_PCSK_KEX2_1 277 279 PF00082 0.549
CLV_PCSK_KEX2_1 371 373 PF00082 0.528
CLV_PCSK_KEX2_1 89 91 PF00082 0.509
CLV_PCSK_PC1ET2_1 89 91 PF00082 0.525
CLV_PCSK_PC7_1 273 279 PF00082 0.544
CLV_PCSK_PC7_1 367 373 PF00082 0.541
CLV_PCSK_PC7_1 85 91 PF00082 0.520
CLV_PCSK_SKI1_1 112 116 PF00082 0.263
CLV_PCSK_SKI1_1 180 184 PF00082 0.488
CLV_PCSK_SKI1_1 200 204 PF00082 0.132
CLV_PCSK_SKI1_1 358 362 PF00082 0.417
CLV_PCSK_SKI1_1 524 528 PF00082 0.263
CLV_PCSK_SKI1_1 79 83 PF00082 0.426
DOC_ANK_TNKS_1 119 126 PF00023 0.474
DOC_MAPK_gen_1 117 126 PF00069 0.458
DOC_MAPK_HePTP_8 307 319 PF00069 0.487
DOC_MAPK_MEF2A_6 310 319 PF00069 0.474
DOC_MAPK_MEF2A_6 545 553 PF00069 0.463
DOC_PP1_RVXF_1 137 143 PF00149 0.523
DOC_PP2B_PxIxI_1 7 13 PF00149 0.331
DOC_PP4_FxxP_1 3 6 PF00568 0.627
DOC_PP4_FxxP_1 354 357 PF00568 0.552
DOC_PP4_FxxP_1 402 405 PF00568 0.597
DOC_PP4_FxxP_1 415 418 PF00568 0.615
DOC_PP4_FxxP_1 56 59 PF00568 0.463
DOC_USP7_MATH_1 219 223 PF00917 0.563
DOC_USP7_MATH_1 33 37 PF00917 0.459
DOC_USP7_MATH_1 492 496 PF00917 0.715
DOC_USP7_MATH_1 6 10 PF00917 0.441
DOC_USP7_UBL2_3 100 104 PF12436 0.549
DOC_WW_Pin1_4 253 258 PF00397 0.475
DOC_WW_Pin1_4 353 358 PF00397 0.648
DOC_WW_Pin1_4 561 566 PF00397 0.503
LIG_14-3-3_CanoR_1 120 126 PF00244 0.463
LIG_14-3-3_CanoR_1 139 143 PF00244 0.463
LIG_14-3-3_CanoR_1 530 535 PF00244 0.549
LIG_14-3-3_CterR_2 581 585 PF00244 0.627
LIG_BIR_II_1 1 5 PF00653 0.534
LIG_BRCT_BRCA1_1 327 331 PF00533 0.463
LIG_BRCT_BRCA1_1 378 382 PF00533 0.679
LIG_Clathr_ClatBox_1 550 554 PF01394 0.463
LIG_EVH1_2 398 402 PF00568 0.714
LIG_FHA_1 106 112 PF00498 0.474
LIG_FHA_1 312 318 PF00498 0.463
LIG_FHA_1 361 367 PF00498 0.468
LIG_FHA_1 545 551 PF00498 0.463
LIG_FHA_2 564 570 PF00498 0.512
LIG_GBD_Chelix_1 542 550 PF00786 0.349
LIG_LIR_Apic_2 352 357 PF02991 0.627
LIG_LIR_Gen_1 113 123 PF02991 0.523
LIG_LIR_Gen_1 134 142 PF02991 0.474
LIG_LIR_Gen_1 26 34 PF02991 0.459
LIG_LIR_Gen_1 529 540 PF02991 0.453
LIG_LIR_Gen_1 75 83 PF02991 0.621
LIG_LIR_Nem_3 113 118 PF02991 0.463
LIG_LIR_Nem_3 134 140 PF02991 0.474
LIG_LIR_Nem_3 26 31 PF02991 0.459
LIG_LIR_Nem_3 285 290 PF02991 0.462
LIG_LIR_Nem_3 305 311 PF02991 0.332
LIG_LIR_Nem_3 328 334 PF02991 0.463
LIG_LIR_Nem_3 48 54 PF02991 0.459
LIG_LIR_Nem_3 529 535 PF02991 0.453
LIG_LIR_Nem_3 75 80 PF02991 0.535
LIG_LYPXL_yS_3 287 290 PF13949 0.432
LIG_REV1ctd_RIR_1 200 209 PF16727 0.523
LIG_SH2_CRK 137 141 PF00017 0.501
LIG_SH2_CRK 51 55 PF00017 0.463
LIG_SH2_CRK 532 536 PF00017 0.487
LIG_SH2_GRB2like 53 56 PF00017 0.463
LIG_SH2_NCK_1 137 141 PF00017 0.474
LIG_SH2_STAP1 25 29 PF00017 0.463
LIG_SH2_STAP1 532 536 PF00017 0.549
LIG_SH2_STAT3 170 173 PF00017 0.600
LIG_SH2_STAT5 186 189 PF00017 0.479
LIG_SH2_STAT5 228 231 PF00017 0.463
LIG_SH2_STAT5 27 30 PF00017 0.543
LIG_SH2_STAT5 291 294 PF00017 0.463
LIG_SH2_STAT5 53 56 PF00017 0.463
LIG_SH2_STAT5 534 537 PF00017 0.487
LIG_SH2_STAT5 77 80 PF00017 0.639
LIG_SH3_1 485 491 PF00018 0.698
LIG_SH3_3 408 414 PF00018 0.660
LIG_SH3_3 415 421 PF00018 0.560
LIG_SH3_3 470 476 PF00018 0.617
LIG_SH3_3 485 491 PF00018 0.660
LIG_SH3_4 490 497 PF00018 0.774
LIG_SUMO_SIM_anti_2 316 322 PF11976 0.482
LIG_SUMO_SIM_par_1 256 261 PF11976 0.546
LIG_SUMO_SIM_par_1 313 318 PF11976 0.487
LIG_TRAF2_1 240 243 PF00917 0.466
LIG_TRAF2_1 265 268 PF00917 0.578
LIG_TRAF2_1 345 348 PF00917 0.474
LIG_TYR_ITIM 49 54 PF00017 0.463
MOD_CDK_SPK_2 353 358 PF00069 0.648
MOD_CK1_1 105 111 PF00069 0.483
MOD_CK1_1 538 544 PF00069 0.568
MOD_CK2_1 262 268 PF00069 0.514
MOD_GlcNHglycan 145 149 PF01048 0.263
MOD_GlcNHglycan 210 213 PF01048 0.288
MOD_GlcNHglycan 42 45 PF01048 0.344
MOD_GlcNHglycan 91 94 PF01048 0.485
MOD_GSK3_1 249 256 PF00069 0.566
MOD_GSK3_1 258 265 PF00069 0.585
MOD_GSK3_1 311 318 PF00069 0.501
MOD_GSK3_1 349 356 PF00069 0.540
MOD_GSK3_1 477 484 PF00069 0.746
MOD_GSK3_1 563 570 PF00069 0.541
MOD_GSK3_1 68 75 PF00069 0.525
MOD_GSK3_1 85 92 PF00069 0.321
MOD_N-GLC_1 349 354 PF02516 0.349
MOD_NEK2_1 1 6 PF00069 0.637
MOD_NEK2_1 258 263 PF00069 0.457
MOD_NEK2_1 295 300 PF00069 0.470
MOD_NEK2_1 349 354 PF00069 0.463
MOD_NEK2_1 360 365 PF00069 0.422
MOD_NEK2_1 567 572 PF00069 0.523
MOD_NEK2_2 33 38 PF00069 0.463
MOD_NEK2_2 332 337 PF00069 0.463
MOD_PIKK_1 340 346 PF00454 0.568
MOD_PIKK_1 42 48 PF00454 0.474
MOD_PIKK_1 477 483 PF00454 0.736
MOD_PKA_1 89 95 PF00069 0.499
MOD_PKA_2 119 125 PF00069 0.463
MOD_PKA_2 138 144 PF00069 0.463
MOD_PKA_2 89 95 PF00069 0.483
MOD_Plk_1 144 150 PF00069 0.463
MOD_Plk_1 258 264 PF00069 0.562
MOD_Plk_1 295 301 PF00069 0.474
MOD_Plk_2-3 563 569 PF00069 0.547
MOD_Plk_4 315 321 PF00069 0.482
MOD_Plk_4 350 356 PF00069 0.487
MOD_Plk_4 492 498 PF00069 0.692
MOD_Plk_4 530 536 PF00069 0.549
MOD_Plk_4 563 569 PF00069 0.547
MOD_Plk_4 6 12 PF00069 0.430
MOD_ProDKin_1 253 259 PF00069 0.473
MOD_ProDKin_1 353 359 PF00069 0.648
MOD_ProDKin_1 561 567 PF00069 0.503
MOD_SUMO_rev_2 16 24 PF00179 0.457
MOD_SUMO_rev_2 191 199 PF00179 0.487
MOD_SUMO_rev_2 563 573 PF00179 0.453
TRG_ENDOCYTIC_2 137 140 PF00928 0.501
TRG_ENDOCYTIC_2 206 209 PF00928 0.566
TRG_ENDOCYTIC_2 228 231 PF00928 0.514
TRG_ENDOCYTIC_2 25 28 PF00928 0.463
TRG_ENDOCYTIC_2 287 290 PF00928 0.432
TRG_ENDOCYTIC_2 51 54 PF00928 0.463
TRG_ENDOCYTIC_2 532 535 PF00928 0.453
TRG_ENDOCYTIC_2 77 80 PF00928 0.639
TRG_ER_diArg_1 263 266 PF00400 0.512
TRG_ER_diArg_1 275 278 PF00400 0.527
TRG_ER_diArg_1 382 385 PF00400 0.591
TRG_ER_diArg_1 482 485 PF00400 0.661
TRG_NES_CRM1_1 176 191 PF08389 0.502
TRG_NLS_MonoExtN_4 87 93 PF00514 0.511

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5A9 Leptomonas seymouri 91% 100%
A0A0N1I0F0 Leptomonas seymouri 35% 100%
A0A0S4IKZ4 Bodo saltans 57% 100%
A0A0S4JPT3 Bodo saltans 38% 100%
A0A1X0P4T3 Trypanosomatidae 37% 100%
A0A1X0P4V5 Trypanosomatidae 37% 100%
A0A1X0P525 Trypanosomatidae 67% 100%
A0A3Q8IF40 Leishmania donovani 36% 100%
A0A3Q8IGR8 Leishmania donovani 37% 100%
A0A3R7NAH9 Trypanosoma rangeli 37% 100%
A0A422NK82 Trypanosoma rangeli 67% 100%
A1CRM1 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 33% 78%
A1D4K4 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 32% 78%
A2Q848 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 33% 80%
A3LXL0 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 34% 93%
A4HDV5 Leishmania braziliensis 36% 100%
A4HN85 Leishmania braziliensis 93% 99%
A4HNG6 Leishmania braziliensis 37% 100%
A4I150 Leishmania infantum 35% 100%
A4IBV3 Leishmania infantum 100% 100%
A4IC57 Leishmania infantum 37% 100%
A4QUF0 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 33% 77%
A5DM21 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 35% 93%
A5DW14 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 36% 89%
C9ZYQ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9AFP0 Leishmania major 99% 100%
E9AFX7 Leishmania major 36% 100%
E9AX84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B6U3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
E9B730 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
F1QB54 Danio rerio 41% 92%
O22173 Arabidopsis thaliana 38% 88%
P04147 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
P0CP46 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 37% 87%
P0CP47 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 37% 87%
P11940 Homo sapiens 40% 92%
P20965 Xenopus laevis 40% 92%
P29341 Mus musculus 40% 92%
P31209 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 90%
P42731 Arabidopsis thaliana 38% 93%
P61286 Bos taurus 40% 92%
Q05196 Arabidopsis thaliana 36% 86%
Q0CR95 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 32% 78%
Q0U1G2 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 32% 79%
Q13310 Homo sapiens 40% 91%
Q1DXH0 Coccidioides immitis (strain RS) 34% 76%
Q1ZXC2 Dictyostelium discoideum 31% 72%
Q2GSX8 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 32% 75%
Q2UK72 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 28% 76%
Q4QA88 Leishmania major 34% 100%
Q4VXU2 Homo sapiens 39% 95%
Q4WK03 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 32% 78%
Q54BM2 Dictyostelium discoideum 33% 100%
Q5AI15 Candida albicans (strain SC5314 / ATCC MYA-2876) 33% 93%
Q5B630 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 35% 80%
Q5R8F7 Pongo abelii 40% 92%
Q6BI95 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 35% 93%
Q6CDH3 Yarrowia lipolytica (strain CLIB 122 / E 150) 33% 93%
Q6CSV3 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 34% 99%
Q6DEY7 Xenopus tropicalis 38% 93%
Q6FKG4 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 33% 100%
Q6GR16 Xenopus laevis 38% 93%
Q6IP09 Xenopus laevis 35% 92%
Q74ZS6 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 38% 100%
Q7S6N6 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 35% 77%
Q8SR30 Encephalitozoon cuniculi (strain GB-M1) 25% 100%
Q98SP8 Xenopus laevis 38% 93%
Q9EPH8 Rattus norvegicus 40% 92%
Q9FXA2 Arabidopsis thaliana 37% 87%
Q9ZQA8 Arabidopsis thaliana 32% 96%
V5BYR2 Trypanosoma cruzi 36% 100%
V5DUJ1 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS