Pyridine nucleotide-disulfide oxidoreductase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyridine nucleotide-disulphide oxidoreductase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IMW0_LEIDO

TriTrypDb:

LdBPK_340290.1 , LdCL_340008000 , LDHU3_34.0430

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IMW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMW0

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019418	sulfide oxidation	4	1
GO:0044237	cellular metabolic process	2	1
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0070224	sulfide:quinone oxidoreductase activity	5	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.453
CLV_C14_Caspase3-7	366	370	PF00656	0.491
CLV_NRD_NRD_1	198	200	PF00675	0.577
CLV_NRD_NRD_1	2	4	PF00675	0.752
CLV_NRD_NRD_1	546	548	PF00675	0.641
CLV_NRD_NRD_1	558	560	PF00675	0.646
CLV_NRD_NRD_1	563	565	PF00675	0.648
CLV_NRD_NRD_1	566	568	PF00675	0.648
CLV_NRD_NRD_1	591	593	PF00675	0.589
CLV_NRD_NRD_1	67	69	PF00675	0.518
CLV_PCSK_KEX2_1	198	200	PF00082	0.577
CLV_PCSK_KEX2_1	2	4	PF00082	0.752
CLV_PCSK_KEX2_1	546	548	PF00082	0.641
CLV_PCSK_KEX2_1	558	560	PF00082	0.635
CLV_PCSK_KEX2_1	591	593	PF00082	0.589
CLV_PCSK_KEX2_1	69	71	PF00082	0.486
CLV_PCSK_KEX2_1	714	716	PF00082	0.669
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.443
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.669
CLV_PCSK_SKI1_1	163	167	PF00082	0.541
CLV_PCSK_SKI1_1	171	175	PF00082	0.554
CLV_PCSK_SKI1_1	64	68	PF00082	0.542
CLV_PCSK_SKI1_1	740	744	PF00082	0.707
CLV_Separin_Metazoa	154	158	PF03568	0.346
CLV_Separin_Metazoa	644	648	PF03568	0.544
CLV_Separin_Metazoa	65	69	PF03568	0.734
DEG_APCC_DBOX_1	2	10	PF00400	0.555
DEG_APCC_DBOX_1	267	275	PF00400	0.452
DEG_APCC_DBOX_1	739	747	PF00400	0.509
DEG_COP1_1	768	777	PF00400	0.449
DEG_Nend_UBRbox_1	1	4	PF02207	0.552
DEG_SCF_FBW7_1	324	330	PF00400	0.580
DOC_CKS1_1	324	329	PF01111	0.649
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.370
DOC_MAPK_gen_1	105	112	PF00069	0.419
DOC_MAPK_gen_1	188	196	PF00069	0.349
DOC_MAPK_gen_1	198	206	PF00069	0.287
DOC_MAPK_gen_1	2	11	PF00069	0.554
DOC_MAPK_gen_1	68	78	PF00069	0.613
DOC_MAPK_HePTP_8	196	208	PF00069	0.363
DOC_MAPK_MEF2A_6	198	206	PF00069	0.363
DOC_MAPK_MEF2A_6	502	509	PF00069	0.336
DOC_PP2B_LxvP_1	516	519	PF13499	0.366
DOC_PP2B_LxvP_1	520	523	PF13499	0.373
DOC_PP4_FxxP_1	345	348	PF00568	0.563
DOC_PP4_FxxP_1	772	775	PF00568	0.440
DOC_USP7_MATH_1	239	243	PF00917	0.419
DOC_USP7_MATH_1	306	310	PF00917	0.603
DOC_USP7_MATH_1	82	86	PF00917	0.416
DOC_USP7_MATH_2	329	335	PF00917	0.437
DOC_USP7_UBL2_3	13	17	PF12436	0.489
DOC_USP7_UBL2_3	662	666	PF12436	0.502
DOC_WW_Pin1_4	135	140	PF00397	0.346
DOC_WW_Pin1_4	318	323	PF00397	0.511
DOC_WW_Pin1_4	335	340	PF00397	0.547
DOC_WW_Pin1_4	361	366	PF00397	0.608
DOC_WW_Pin1_4	389	394	PF00397	0.519
DOC_WW_Pin1_4	701	706	PF00397	0.572
DOC_WW_Pin1_4	765	770	PF00397	0.464
DOC_WW_Pin1_4	775	780	PF00397	0.425
LIG_14-3-3_CanoR_1	205	213	PF00244	0.336
LIG_14-3-3_CanoR_1	297	303	PF00244	0.480
LIG_14-3-3_CanoR_1	58	67	PF00244	0.666
LIG_14-3-3_CanoR_1	697	705	PF00244	0.524
LIG_Actin_WH2_2	344	361	PF00022	0.502
LIG_Actin_WH2_2	37	55	PF00022	0.416
LIG_Actin_WH2_2	530	548	PF00022	0.321
LIG_Actin_WH2_2	83	101	PF00022	0.513
LIG_BRCT_BRCA1_1	28	32	PF00533	0.489
LIG_CaM_NSCaTE_8	354	361	PF13499	0.486
LIG_Clathr_ClatBox_1	513	517	PF01394	0.364
LIG_EVH1_2	285	289	PF00568	0.386
LIG_FHA_1	208	214	PF00498	0.404
LIG_FHA_1	255	261	PF00498	0.535
LIG_FHA_1	33	39	PF00498	0.359
LIG_FHA_1	342	348	PF00498	0.561
LIG_FHA_1	41	47	PF00498	0.345
LIG_FHA_1	781	787	PF00498	0.446
LIG_FHA_2	129	135	PF00498	0.419
LIG_FHA_2	264	270	PF00498	0.457
LIG_FHA_2	495	501	PF00498	0.410
LIG_FHA_2	564	570	PF00498	0.433
LIG_FHA_2	786	792	PF00498	0.528
LIG_FHA_2	99	105	PF00498	0.346
LIG_LIR_Apic_2	344	348	PF02991	0.560
LIG_LIR_Apic_2	686	692	PF02991	0.501
LIG_LIR_Apic_2	770	775	PF02991	0.456
LIG_LIR_Gen_1	229	237	PF02991	0.346
LIG_LIR_Gen_1	47	55	PF02991	0.436
LIG_LIR_Gen_1	476	486	PF02991	0.451
LIG_LIR_Gen_1	577	588	PF02991	0.390
LIG_LIR_Gen_1	668	677	PF02991	0.396
LIG_LIR_LC3C_4	231	235	PF02991	0.419
LIG_LIR_Nem_3	229	233	PF02991	0.346
LIG_LIR_Nem_3	419	424	PF02991	0.386
LIG_LIR_Nem_3	47	52	PF02991	0.420
LIG_LIR_Nem_3	476	481	PF02991	0.461
LIG_LIR_Nem_3	577	583	PF02991	0.381
LIG_LIR_Nem_3	610	614	PF02991	0.406
LIG_LIR_Nem_3	668	673	PF02991	0.391
LIG_LIR_Nem_3	733	739	PF02991	0.466
LIG_LIR_Nem_3	754	760	PF02991	0.415
LIG_LIR_Nem_3	768	774	PF02991	0.462
LIG_LIR_Nem_3	776	780	PF02991	0.427
LIG_LIR_Nem_3	788	792	PF02991	0.326
LIG_PALB2_WD40_1	350	358	PF16756	0.484
LIG_PCNA_TLS_4	567	574	PF02747	0.462
LIG_PCNA_yPIPBox_3	450	460	PF02747	0.419
LIG_PDZ_Class_3	788	793	PF00595	0.570
LIG_Pex14_1	400	404	PF04695	0.401
LIG_Pex14_2	478	482	PF04695	0.439
LIG_PTB_Apo_2	741	748	PF02174	0.436
LIG_Rb_pABgroove_1	493	501	PF01858	0.453
LIG_SH2_CRK	230	234	PF00017	0.346
LIG_SH2_CRK	427	431	PF00017	0.414
LIG_SH2_CRK	435	439	PF00017	0.372
LIG_SH2_CRK	511	515	PF00017	0.412
LIG_SH2_CRK	611	615	PF00017	0.407
LIG_SH2_GRB2like	426	429	PF00017	0.494
LIG_SH2_NCK_1	125	129	PF00017	0.419
LIG_SH2_NCK_1	593	597	PF00017	0.382
LIG_SH2_NCK_1	689	693	PF00017	0.540
LIG_SH2_NCK_1	777	781	PF00017	0.499
LIG_SH2_SRC	125	128	PF00017	0.419
LIG_SH2_SRC	593	596	PF00017	0.460
LIG_SH2_SRC	689	692	PF00017	0.402
LIG_SH2_STAP1	230	234	PF00017	0.346
LIG_SH2_STAP1	593	597	PF00017	0.382
LIG_SH2_STAP1	753	757	PF00017	0.453
LIG_SH2_STAT5	10	13	PF00017	0.555
LIG_SH2_STAT5	423	426	PF00017	0.397
LIG_SH2_STAT5	485	488	PF00017	0.371
LIG_SH2_STAT5	536	539	PF00017	0.400
LIG_SH2_STAT5	667	670	PF00017	0.394
LIG_SH2_STAT5	757	760	PF00017	0.419
LIG_SH2_STAT5	773	776	PF00017	0.441
LIG_SH3_2	12	17	PF14604	0.543
LIG_SH3_3	133	139	PF00018	0.419
LIG_SH3_3	279	285	PF00018	0.447
LIG_SH3_3	441	447	PF00018	0.393
LIG_SH3_3	504	510	PF00018	0.392
LIG_SH3_3	640	646	PF00018	0.423
LIG_SH3_3	655	661	PF00018	0.588
LIG_SH3_3	716	722	PF00018	0.443
LIG_SH3_3	781	787	PF00018	0.436
LIG_SH3_3	9	15	PF00018	0.553
LIG_SUMO_SIM_anti_2	129	138	PF11976	0.419
LIG_SUMO_SIM_par_1	42	47	PF11976	0.436
LIG_SUMO_SIM_par_1	512	517	PF11976	0.371
LIG_TYR_ITIM	509	514	PF00017	0.450
LIG_TYR_ITIM	755	760	PF00017	0.441
LIG_WRC_WIRS_1	670	675	PF05994	0.392
MOD_CDK_SPK_2	780	785	PF00069	0.428
MOD_CDK_SPxxK_3	318	325	PF00069	0.564
MOD_CK1_1	209	215	PF00069	0.394
MOD_CK1_1	222	228	PF00069	0.282
MOD_CK1_1	242	248	PF00069	0.183
MOD_CK1_1	346	352	PF00069	0.527
MOD_CK1_1	416	422	PF00069	0.375
MOD_CK1_1	59	65	PF00069	0.676
MOD_CK1_1	607	613	PF00069	0.474
MOD_CK1_1	648	654	PF00069	0.563
MOD_CK1_1	700	706	PF00069	0.572
MOD_CK2_1	335	341	PF00069	0.589
MOD_CK2_1	563	569	PF00069	0.512
MOD_CK2_1	59	65	PF00069	0.676
MOD_CK2_1	98	104	PF00069	0.329
MOD_GlcNHglycan	275	278	PF01048	0.637
MOD_GlcNHglycan	306	309	PF01048	0.811
MOD_GlcNHglycan	384	387	PF01048	0.812
MOD_GlcNHglycan	470	473	PF01048	0.702
MOD_GlcNHglycan	528	531	PF01048	0.587
MOD_GlcNHglycan	614	617	PF01048	0.613
MOD_GlcNHglycan	649	653	PF01048	0.759
MOD_GlcNHglycan	84	87	PF01048	0.513
MOD_GlcNHglycan	93	96	PF01048	0.513
MOD_GSK3_1	175	182	PF00069	0.286
MOD_GSK3_1	215	222	PF00069	0.389
MOD_GSK3_1	306	313	PF00069	0.561
MOD_GSK3_1	323	330	PF00069	0.507
MOD_GSK3_1	331	338	PF00069	0.623
MOD_GSK3_1	343	350	PF00069	0.596
MOD_GSK3_1	382	389	PF00069	0.545
MOD_GSK3_1	40	47	PF00069	0.467
MOD_GSK3_1	408	415	PF00069	0.392
MOD_GSK3_1	665	672	PF00069	0.390
MOD_GSK3_1	697	704	PF00069	0.580
MOD_N-GLC_1	142	147	PF02516	0.546
MOD_N-GLC_1	219	224	PF02516	0.543
MOD_NEK2_1	1	6	PF00069	0.551
MOD_NEK2_1	166	171	PF00069	0.363
MOD_NEK2_1	206	211	PF00069	0.363
MOD_NEK2_1	316	321	PF00069	0.535
MOD_NEK2_1	32	37	PF00069	0.346
MOD_NEK2_1	387	392	PF00069	0.536
MOD_NEK2_1	402	407	PF00069	0.419
MOD_NEK2_1	413	418	PF00069	0.439
MOD_NEK2_1	481	486	PF00069	0.369
MOD_NEK2_1	563	568	PF00069	0.442
MOD_NEK2_1	730	735	PF00069	0.429
MOD_NEK2_1	759	764	PF00069	0.445
MOD_NEK2_1	98	103	PF00069	0.331
MOD_NEK2_2	354	359	PF00069	0.486
MOD_NEK2_2	669	674	PF00069	0.392
MOD_PIKK_1	26	32	PF00454	0.529
MOD_PIKK_1	628	634	PF00454	0.482
MOD_PIKK_1	697	703	PF00454	0.530
MOD_PKA_2	1	7	PF00069	0.550
MOD_PKA_2	167	173	PF00069	0.419
MOD_PKA_2	526	532	PF00069	0.384
MOD_PKA_2	563	569	PF00069	0.457
MOD_PKA_2	59	65	PF00069	0.681
MOD_PKB_1	380	388	PF00069	0.572
MOD_Plk_1	409	415	PF00069	0.393
MOD_Plk_1	576	582	PF00069	0.384
MOD_Plk_2-3	576	582	PF00069	0.384
MOD_Plk_4	223	229	PF00069	0.339
MOD_Plk_4	285	291	PF00069	0.444
MOD_Plk_4	40	46	PF00069	0.436
MOD_Plk_4	409	415	PF00069	0.393
MOD_Plk_4	416	422	PF00069	0.382
MOD_Plk_4	481	487	PF00069	0.370
MOD_Plk_4	494	500	PF00069	0.376
MOD_Plk_4	521	527	PF00069	0.422
MOD_Plk_4	576	582	PF00069	0.384
MOD_Plk_4	767	773	PF00069	0.454
MOD_ProDKin_1	135	141	PF00069	0.346
MOD_ProDKin_1	318	324	PF00069	0.513
MOD_ProDKin_1	335	341	PF00069	0.550
MOD_ProDKin_1	361	367	PF00069	0.609
MOD_ProDKin_1	389	395	PF00069	0.511
MOD_ProDKin_1	701	707	PF00069	0.570
MOD_ProDKin_1	765	771	PF00069	0.467
MOD_ProDKin_1	775	781	PF00069	0.427
MOD_SUMO_rev_2	159	165	PF00179	0.330
MOD_SUMO_rev_2	94	101	PF00179	0.363
TRG_DiLeu_BaEn_1	476	481	PF01217	0.461
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.420
TRG_ENDOCYTIC_2	230	233	PF00928	0.346
TRG_ENDOCYTIC_2	427	430	PF00928	0.409
TRG_ENDOCYTIC_2	435	438	PF00928	0.371
TRG_ENDOCYTIC_2	511	514	PF00928	0.415
TRG_ENDOCYTIC_2	593	596	PF00928	0.387
TRG_ENDOCYTIC_2	611	614	PF00928	0.408
TRG_ENDOCYTIC_2	670	673	PF00928	0.388
TRG_ENDOCYTIC_2	753	756	PF00928	0.415
TRG_ENDOCYTIC_2	757	760	PF00928	0.430
TRG_ENDOCYTIC_2	777	780	PF00928	0.260
TRG_ER_diArg_1	1	3	PF00400	0.553
TRG_ER_diArg_1	197	199	PF00400	0.381
TRG_ER_diArg_1	380	383	PF00400	0.502
TRG_ER_diArg_1	533	536	PF00400	0.404
TRG_ER_diArg_1	545	547	PF00400	0.421
TRG_ER_diArg_1	557	559	PF00400	0.437
TRG_ER_diArg_1	58	61	PF00400	0.676
TRG_ER_diArg_1	591	593	PF00400	0.389
TRG_ER_diArg_1	67	70	PF00400	0.655
TRG_NLS_Bipartite_1	546	568	PF00514	0.457
TRG_NLS_MonoCore_2	67	72	PF00514	0.594
TRG_NLS_MonoExtC_3	563	568	PF00514	0.459
TRG_NLS_MonoExtN_4	561	568	PF00514	0.455
TRG_NLS_MonoExtN_4	68	73	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A2	Leptomonas seymouri	56%	95%
A4HAE5	Leishmania braziliensis	83%	100%
A4I9J7	Leishmania infantum	100%	100%
E9B4J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3I1	Leishmania major	93%	100%