RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IMV3_LEIDO

TriTrypDb:

LdBPK_241860.1 , LdCL_240024200 , LDHU3_24.2290

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IMV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMV3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	133	137	PF00082	0.411
CLV_PCSK_SKI1_1	228	232	PF00082	0.527
DEG_Nend_UBRbox_2	1	3	PF02207	0.684
DOC_CKS1_1	87	92	PF01111	0.806
DOC_MAPK_MEF2A_6	206	214	PF00069	0.619
DOC_USP7_MATH_1	105	109	PF00917	0.758
DOC_WW_Pin1_4	117	122	PF00397	0.776
DOC_WW_Pin1_4	144	149	PF00397	0.557
DOC_WW_Pin1_4	214	219	PF00397	0.639
DOC_WW_Pin1_4	81	86	PF00397	0.803
LIG_BRCT_BRCA1_1	216	220	PF00533	0.673
LIG_BRCT_BRCA1_1	75	79	PF00533	0.814
LIG_CtBP_PxDLS_1	152	156	PF00389	0.546
LIG_EH_1	76	80	PF12763	0.816
LIG_FHA_1	118	124	PF00498	0.686
LIG_FHA_1	180	186	PF00498	0.513
LIG_FHA_1	207	213	PF00498	0.546
LIG_FHA_1	214	220	PF00498	0.546
LIG_FHA_2	148	154	PF00498	0.546
LIG_LIR_Gen_1	182	192	PF02991	0.516
LIG_LIR_Nem_3	182	187	PF02991	0.516
LIG_PAM2_1	77	89	PF00658	0.805
LIG_RPA_C_Fungi	6	18	PF08784	0.708
LIG_SH2_STAT3	95	98	PF00017	0.810
LIG_SH2_STAT5	184	187	PF00017	0.411
LIG_SH2_STAT5	190	193	PF00017	0.411
LIG_SH2_STAT5	221	224	PF00017	0.538
LIG_SH3_3	50	56	PF00018	0.744
LIG_SH3_3	65	71	PF00018	0.621
LIG_SH3_3	72	78	PF00018	0.702
LIG_SH3_3	82	88	PF00018	0.519
LIG_TRAF2_1	151	154	PF00917	0.411
LIG_TYR_ITIM	219	224	PF00017	0.490
LIG_WRC_WIRS_1	123	128	PF05994	0.654
MOD_CK1_1	127	133	PF00069	0.547
MOD_CK1_1	3	9	PF00069	0.720
MOD_CK2_1	147	153	PF00069	0.411
MOD_GlcNHglycan	107	110	PF01048	0.675
MOD_GlcNHglycan	4	8	PF01048	0.717
MOD_GSK3_1	127	134	PF00069	0.542
MOD_GSK3_1	144	151	PF00069	0.411
MOD_N-GLC_1	166	171	PF02516	0.411
MOD_N-GLC_1	81	86	PF02516	0.803
MOD_NEK2_1	166	171	PF00069	0.411
MOD_NEK2_1	205	210	PF00069	0.411
MOD_NEK2_1	222	227	PF00069	0.621
MOD_NEK2_1	48	53	PF00069	0.819
MOD_NEK2_1	63	68	PF00069	0.557
MOD_PIKK_1	35	41	PF00454	0.571
MOD_PIKK_1	63	69	PF00454	0.727
MOD_PIKK_1	93	99	PF00454	0.734
MOD_PKA_2	141	147	PF00069	0.490
MOD_PKA_2	173	179	PF00069	0.411
MOD_Plk_1	166	172	PF00069	0.411
MOD_Plk_1	188	194	PF00069	0.513
MOD_Plk_4	166	172	PF00069	0.407
MOD_Plk_4	206	212	PF00069	0.411
MOD_Plk_4	41	47	PF00069	0.695
MOD_ProDKin_1	117	123	PF00069	0.775
MOD_ProDKin_1	144	150	PF00069	0.426
MOD_ProDKin_1	214	220	PF00069	0.648
MOD_ProDKin_1	81	87	PF00069	0.802
MOD_SUMO_rev_2	173	182	PF00179	0.411
TRG_ENDOCYTIC_2	184	187	PF00928	0.360
TRG_ENDOCYTIC_2	190	193	PF00928	0.344
TRG_ENDOCYTIC_2	221	224	PF00928	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7NAM0	Trypanosoma rangeli	50%	100%
A4HDP0	Leishmania braziliensis	80%	100%
E9AH86	Leishmania infantum	98%	100%
E9AX24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAF2	Leishmania major	91%	99%