AP complex subunit sigma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adaptor complex AP-3 small subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IMU4_LEIDO

TriTrypDb:

LdBPK_241610.1 , LdCL_240021200 , LDHU3_24.1950

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IMU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMU4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0016192	vesicle-mediated transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.354
CLV_NRD_NRD_1	67	69	PF00675	0.383
CLV_PCSK_KEX2_1	42	44	PF00082	0.332
CLV_PCSK_KEX2_1	67	69	PF00082	0.383
CLV_PCSK_PC7_1	38	44	PF00082	0.333
CLV_PCSK_PC7_1	63	69	PF00082	0.383
CLV_PCSK_SKI1_1	3	7	PF00082	0.418
CLV_PCSK_SKI1_1	68	72	PF00082	0.383
CLV_Separin_Metazoa	31	35	PF03568	0.383
DEG_Nend_Nbox_1	1	3	PF02207	0.298
DOC_CKS1_1	57	62	PF01111	0.298
DOC_CYCLIN_RxL_1	12	23	PF00134	0.445
DOC_MAPK_gen_1	67	74	PF00069	0.383
DOC_PP1_RVXF_1	13	20	PF00149	0.445
DOC_USP7_MATH_1	154	158	PF00917	0.655
DOC_WW_Pin1_4	56	61	PF00397	0.284
LIG_14-3-3_CanoR_1	147	153	PF00244	0.597
LIG_14-3-3_CanoR_1	15	20	PF00244	0.418
LIG_14-3-3_CanoR_1	67	73	PF00244	0.298
LIG_AP2alpha_1	50	54	PF02296	0.298
LIG_APCC_ABBA_1	91	96	PF00400	0.314
LIG_FHA_1	21	27	PF00498	0.445
LIG_FHA_1	60	66	PF00498	0.298
LIG_FHA_2	118	124	PF00498	0.310
LIG_FHA_2	150	156	PF00498	0.662
LIG_Integrin_RGD_1	43	45	PF01839	0.383
LIG_LIR_Apic_2	56	60	PF02991	0.299
LIG_LIR_Gen_1	71	79	PF02991	0.298
LIG_LIR_Gen_1	99	110	PF02991	0.293
LIG_LIR_Nem_3	71	77	PF02991	0.298
LIG_LIR_Nem_3	99	105	PF02991	0.293
LIG_PCNA_yPIPBox_3	116	125	PF02747	0.333
LIG_Pex14_2	50	54	PF04695	0.298
LIG_SH2_CRK	69	73	PF00017	0.298
LIG_SH2_STAP1	20	24	PF00017	0.314
LIG_SH2_STAT5	119	122	PF00017	0.378
LIG_SUMO_SIM_anti_2	107	112	PF11976	0.298
LIG_SUMO_SIM_anti_2	78	89	PF11976	0.301
LIG_SUMO_SIM_par_1	4	10	PF11976	0.299
LIG_WRC_WIRS_1	16	21	PF05994	0.445
MOD_CDK_SPxxK_3	56	63	PF00069	0.298
MOD_CK1_1	149	155	PF00069	0.632
MOD_CK1_1	80	86	PF00069	0.285
MOD_CK2_1	117	123	PF00069	0.324
MOD_CK2_1	131	137	PF00069	0.271
MOD_CK2_1	138	144	PF00069	0.383
MOD_CK2_1	149	155	PF00069	0.633
MOD_CK2_1	15	21	PF00069	0.418
MOD_GlcNHglycan	148	151	PF01048	0.615
MOD_GlcNHglycan	162	165	PF01048	0.602
MOD_GSK3_1	154	161	PF00069	0.664
MOD_GSK3_1	94	101	PF00069	0.403
MOD_N-GLC_1	155	160	PF02516	0.706
MOD_N-GLC_2	104	106	PF02516	0.298
MOD_NEK2_1	32	37	PF00069	0.418
MOD_PIKK_1	80	86	PF00454	0.298
MOD_PKA_2	146	152	PF00069	0.681
MOD_Plk_1	20	26	PF00069	0.445
MOD_Plk_1	98	104	PF00069	0.314
MOD_Plk_4	117	123	PF00069	0.353
MOD_Plk_4	15	21	PF00069	0.431
MOD_ProDKin_1	56	62	PF00069	0.284
TRG_DiLeu_BaEn_2	45	51	PF01217	0.403
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.298
TRG_ENDOCYTIC_2	119	122	PF00928	0.418
TRG_ENDOCYTIC_2	69	72	PF00928	0.298
TRG_ER_diArg_1	66	68	PF00400	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V4	Leptomonas seymouri	89%	100%
A0A0N1I965	Leptomonas seymouri	37%	100%
A0A0N1PDE8	Leptomonas seymouri	33%	100%
A0A0N1PDX0	Leptomonas seymouri	37%	100%
A0A0S4J0F7	Bodo saltans	73%	100%
A0A0S4J161	Bodo saltans	36%	99%
A0A0S4JQI5	Bodo saltans	38%	100%
A0A1X0NVQ0	Trypanosomatidae	72%	100%
A0A1X0P093	Trypanosomatidae	35%	99%
A0A1X0P9M2	Trypanosomatidae	37%	100%
A0A3Q8INE3	Leishmania donovani	39%	100%
A0A3R7MTZ7	Trypanosoma rangeli	37%	100%
A0A3R7N944	Trypanosoma rangeli	74%	100%
A0A3R7NTN2	Trypanosoma rangeli	27%	89%
A0A3S7X2E9	Leishmania donovani	36%	100%
A0A422N1J3	Trypanosoma rangeli	36%	99%
A4HAU5	Leishmania braziliensis	37%	99%
A4HDI7	Leishmania braziliensis	93%	100%
A4HHF6	Leishmania braziliensis	35%	100%
A4I4K2	Leishmania infantum	36%	100%
A4IA12	Leishmania infantum	39%	99%
B0G185	Dictyostelium discoideum	35%	100%
C9ZL88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZWF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
D0A005	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
E9AE03	Leishmania major	33%	100%
E9AH61	Leishmania infantum	100%	100%
E9ALS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AWZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B519	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	99%
O23685	Arabidopsis thaliana	35%	100%
O50016	Zea mays	39%	100%
O82201	Arabidopsis thaliana	37%	100%
P35181	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P47064	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	86%
P53680	Homo sapiens	38%	100%
P56377	Homo sapiens	30%	100%
P59780	Homo sapiens	53%	86%
P61966	Homo sapiens	32%	100%
P61967	Mus musculus	32%	100%
P62743	Mus musculus	38%	100%
P62744	Rattus norvegicus	38%	100%
Q00381	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
Q09905	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
Q17QC5	Bos taurus	38%	100%
Q1JQ98	Bos taurus	32%	100%
Q1JQA3	Bos taurus	53%	86%
Q2YDH6	Bos taurus	53%	86%
Q3ZBB6	Bos taurus	33%	100%
Q3ZBS3	Bos taurus	30%	100%
Q4ICG5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	36%	100%
Q4Q2W7	Leishmania major	39%	99%
Q4QAH7	Leishmania major	99%	100%
Q4WS49	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	100%
Q54H39	Dictyostelium discoideum	36%	100%
Q54NZ4	Dictyostelium discoideum	37%	100%
Q54WW3	Dictyostelium discoideum	35%	100%
Q553S2	Dictyostelium discoideum	50%	97%
Q59QC5	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	95%
Q5BFF8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q5R940	Pongo abelii	38%	100%
Q5RDP9	Pongo abelii	53%	86%
Q75F71	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	90%
Q7SAQ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
Q7TN05	Mus musculus	32%	100%
Q84WL9	Arabidopsis thaliana	38%	100%
Q8BSZ2	Mus musculus	53%	86%
Q8LEZ8	Arabidopsis thaliana	34%	100%
Q8VZ37	Arabidopsis thaliana	42%	100%
Q92572	Homo sapiens	53%	86%
Q96PC3	Homo sapiens	32%	100%
Q9DB50	Mus musculus	30%	100%
Q9DCR2	Mus musculus	53%	86%
Q9P7N2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9WVL1	Mus musculus	34%	100%
Q9Y587	Homo sapiens	33%	100%
Q9Y7L6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
V5DBK5	Trypanosoma cruzi	70%	100%