GAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMT0_LEIDO

TriTrypDb:

LdBPK_333320.1 , LdCL_330040800 , LDHU3_33.4800

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IMT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.588
CLV_C14_Caspase3-7	310	314	PF00656	0.539
CLV_C14_Caspase3-7	82	86	PF00656	0.596
CLV_NRD_NRD_1	120	122	PF00675	0.526
CLV_NRD_NRD_1	509	511	PF00675	0.539
CLV_PCSK_KEX2_1	120	122	PF00082	0.481
CLV_PCSK_KEX2_1	296	298	PF00082	0.537
CLV_PCSK_KEX2_1	300	302	PF00082	0.551
CLV_PCSK_KEX2_1	509	511	PF00082	0.607
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.588
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.600
CLV_PCSK_SKI1_1	120	124	PF00082	0.512
CLV_PCSK_SKI1_1	230	234	PF00082	0.457
CLV_PCSK_SKI1_1	297	301	PF00082	0.530
CLV_PCSK_SKI1_1	332	336	PF00082	0.433
CLV_PCSK_SKI1_1	343	347	PF00082	0.461
CLV_PCSK_SKI1_1	355	359	PF00082	0.353
CLV_PCSK_SKI1_1	73	77	PF00082	0.592
DEG_APCC_DBOX_1	354	362	PF00400	0.427
DEG_MDM2_SWIB_1	28	36	PF02201	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.614
DOC_CDC14_PxL_1	512	520	PF14671	0.611
DOC_CYCLIN_RxL_1	117	125	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.601
DOC_MAPK_gen_1	309	317	PF00069	0.543
DOC_MAPK_MEF2A_6	217	224	PF00069	0.487
DOC_PP2B_LxvP_1	315	318	PF13499	0.604
DOC_USP7_MATH_1	103	107	PF00917	0.432
DOC_USP7_MATH_1	20	24	PF00917	0.448
DOC_USP7_MATH_1	349	353	PF00917	0.542
DOC_USP7_MATH_1	427	431	PF00917	0.633
DOC_USP7_MATH_1	461	465	PF00917	0.706
DOC_USP7_MATH_1	483	487	PF00917	0.741
DOC_USP7_MATH_1	501	505	PF00917	0.431
DOC_USP7_MATH_1	59	63	PF00917	0.525
DOC_USP7_MATH_1	87	91	PF00917	0.537
DOC_USP7_UBL2_3	292	296	PF12436	0.534
DOC_WW_Pin1_4	215	220	PF00397	0.594
DOC_WW_Pin1_4	477	482	PF00397	0.717
DOC_WW_Pin1_4	490	495	PF00397	0.519
LIG_14-3-3_CanoR_1	130	134	PF00244	0.580
LIG_14-3-3_CanoR_1	158	168	PF00244	0.562
LIG_14-3-3_CanoR_1	225	229	PF00244	0.552
LIG_14-3-3_CanoR_1	235	240	PF00244	0.475
LIG_14-3-3_CanoR_1	425	434	PF00244	0.734
LIG_14-3-3_CanoR_1	510	516	PF00244	0.626
LIG_14-3-3_CanoR_1	70	80	PF00244	0.708
LIG_Actin_WH2_2	115	132	PF00022	0.477
LIG_APCC_Cbox_2	97	103	PF00515	0.509
LIG_BRCT_BRCA1_1	243	247	PF00533	0.553
LIG_CaM_IQ_9	277	292	PF13499	0.581
LIG_Clathr_ClatBox_1	13	17	PF01394	0.631
LIG_FHA_1	107	113	PF00498	0.572
LIG_FHA_1	135	141	PF00498	0.583
LIG_FHA_1	149	155	PF00498	0.607
LIG_FHA_1	16	22	PF00498	0.532
LIG_FHA_1	170	176	PF00498	0.542
LIG_FHA_1	192	198	PF00498	0.758
LIG_FHA_1	231	237	PF00498	0.523
LIG_FHA_1	263	269	PF00498	0.679
LIG_FHA_1	90	96	PF00498	0.592
LIG_FHA_2	100	106	PF00498	0.547
LIG_FHA_2	308	314	PF00498	0.490
LIG_FHA_2	325	331	PF00498	0.607
LIG_FHA_2	452	458	PF00498	0.697
LIG_FHA_2	466	472	PF00498	0.471
LIG_LIR_Apic_2	456	461	PF02991	0.620
LIG_LIR_Gen_1	302	312	PF02991	0.560
LIG_LIR_Nem_3	302	307	PF02991	0.558
LIG_LIR_Nem_3	352	357	PF02991	0.438
LIG_Pex14_2	28	32	PF04695	0.532
LIG_SH2_CRK	434	438	PF00017	0.631
LIG_SH2_CRK	458	462	PF00017	0.628
LIG_SH2_NCK_1	520	524	PF00017	0.532
LIG_SH2_STAP1	499	503	PF00017	0.515
LIG_SH2_STAT5	267	270	PF00017	0.608
LIG_SH3_3	408	414	PF00018	0.694
LIG_SH3_3	513	519	PF00018	0.516
LIG_SUMO_SIM_par_1	218	223	PF11976	0.562
LIG_TRAF2_1	376	379	PF00917	0.618
LIG_WRC_WIRS_1	221	226	PF05994	0.459
LIG_WRC_WIRS_1	60	65	PF05994	0.526
MOD_CDK_SPK_2	477	482	PF00069	0.645
MOD_CK1_1	106	112	PF00069	0.612
MOD_CK1_1	132	138	PF00069	0.635
MOD_CK1_1	141	147	PF00069	0.525
MOD_CK1_1	187	193	PF00069	0.534
MOD_CK1_1	201	207	PF00069	0.664
MOD_CK1_1	210	216	PF00069	0.456
MOD_CK1_1	440	446	PF00069	0.677
MOD_CK1_1	5	11	PF00069	0.641
MOD_CK2_1	16	22	PF00069	0.575
MOD_CK2_1	324	330	PF00069	0.475
MOD_CK2_1	373	379	PF00069	0.689
MOD_CK2_1	451	457	PF00069	0.697
MOD_CK2_1	465	471	PF00069	0.718
MOD_CK2_1	5	11	PF00069	0.666
MOD_CK2_1	99	105	PF00069	0.540
MOD_GlcNHglycan	105	108	PF01048	0.647
MOD_GlcNHglycan	134	137	PF01048	0.561
MOD_GlcNHglycan	164	167	PF01048	0.580
MOD_GlcNHglycan	17	21	PF01048	0.555
MOD_GlcNHglycan	186	189	PF01048	0.597
MOD_GlcNHglycan	198	201	PF01048	0.588
MOD_GlcNHglycan	203	206	PF01048	0.575
MOD_GlcNHglycan	272	275	PF01048	0.576
MOD_GlcNHglycan	4	7	PF01048	0.713
MOD_GlcNHglycan	427	430	PF01048	0.639
MOD_GlcNHglycan	45	48	PF01048	0.494
MOD_GlcNHglycan	451	454	PF01048	0.592
MOD_GlcNHglycan	89	92	PF01048	0.643
MOD_GSK3_1	1	8	PF00069	0.597
MOD_GSK3_1	134	141	PF00069	0.557
MOD_GSK3_1	158	165	PF00069	0.562
MOD_GSK3_1	16	23	PF00069	0.477
MOD_GSK3_1	187	194	PF00069	0.582
MOD_GSK3_1	220	227	PF00069	0.560
MOD_GSK3_1	230	237	PF00069	0.440
MOD_GSK3_1	303	310	PF00069	0.480
MOD_GSK3_1	357	364	PF00069	0.550
MOD_GSK3_1	421	428	PF00069	0.632
MOD_GSK3_1	436	443	PF00069	0.612
MOD_GSK3_1	449	456	PF00069	0.578
MOD_GSK3_1	461	468	PF00069	0.498
MOD_GSK3_1	501	508	PF00069	0.590
MOD_GSK3_1	59	66	PF00069	0.476
MOD_GSK3_1	99	106	PF00069	0.550
MOD_N-GLC_1	191	196	PF02516	0.476
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	16	21	PF00069	0.512
MOD_NEK2_1	167	172	PF00069	0.460
MOD_NEK2_1	196	201	PF00069	0.633
MOD_NEK2_1	220	225	PF00069	0.529
MOD_NEK2_1	247	252	PF00069	0.499
MOD_NEK2_1	280	285	PF00069	0.594
MOD_NEK2_1	307	312	PF00069	0.527
MOD_NEK2_1	357	362	PF00069	0.530
MOD_NEK2_1	437	442	PF00069	0.765
MOD_NEK2_1	63	68	PF00069	0.559
MOD_NEK2_1	99	104	PF00069	0.535
MOD_PIKK_1	159	165	PF00454	0.515
MOD_PIKK_1	361	367	PF00454	0.636
MOD_PIKK_1	427	433	PF00454	0.691
MOD_PIKK_1	451	457	PF00454	0.766
MOD_PIKK_1	465	471	PF00454	0.471
MOD_PIKK_1	492	498	PF00454	0.563
MOD_PIKK_1	89	95	PF00454	0.547
MOD_PK_1	235	241	PF00069	0.552
MOD_PKA_2	1	7	PF00069	0.600
MOD_PKA_2	129	135	PF00069	0.505
MOD_PKA_2	224	230	PF00069	0.526
MOD_PKA_2	234	240	PF00069	0.445
MOD_PKA_2	393	399	PF00069	0.730
MOD_PKB_1	423	431	PF00069	0.532
MOD_Plk_1	16	22	PF00069	0.575
MOD_Plk_1	483	489	PF00069	0.656
MOD_Plk_2-3	207	213	PF00069	0.619
MOD_Plk_4	192	198	PF00069	0.686
MOD_Plk_4	210	216	PF00069	0.622
MOD_Plk_4	224	230	PF00069	0.449
MOD_Plk_4	235	241	PF00069	0.511
MOD_Plk_4	303	309	PF00069	0.547
MOD_Plk_4	311	317	PF00069	0.599
MOD_Plk_4	393	399	PF00069	0.657
MOD_Plk_4	483	489	PF00069	0.725
MOD_Plk_4	59	65	PF00069	0.576
MOD_ProDKin_1	215	221	PF00069	0.588
MOD_ProDKin_1	477	483	PF00069	0.715
MOD_ProDKin_1	490	496	PF00069	0.513
TRG_DiLeu_BaEn_1	303	308	PF01217	0.502
TRG_DiLeu_BaEn_1	353	358	PF01217	0.518
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.491
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.533
TRG_ENDOCYTIC_2	434	437	PF00928	0.633
TRG_ENDOCYTIC_2	499	502	PF00928	0.585
TRG_ER_diArg_1	120	122	PF00400	0.520
TRG_ER_diArg_1	422	425	PF00400	0.637
TRG_NES_CRM1_1	169	184	PF08389	0.508
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K5	Leptomonas seymouri	46%	96%
A0A0S4J1S4	Bodo saltans	25%	68%
A0A422N0Y7	Trypanosoma rangeli	27%	100%
A4HM24	Leishmania braziliensis	66%	100%
A4I9F8	Leishmania infantum	98%	100%
C9ZJT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	99%
E9B4F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q3L9	Leishmania major	89%	100%