Tyrosyl-DNA phosphodiesterase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosyl-DNA phosphodiesterase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IMS2_LEIDO

TriTrypDb:

LdBPK_333210.1 , LdCL_330039400 , LDHU3_33.4680

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

A0A3Q8IMS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMS2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000012	single strand break repair	6	1
GO:0006302	double-strand break repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	5	1
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.373
CLV_C14_Caspase3-7	209	213	PF00656	0.561
CLV_C14_Caspase3-7	366	370	PF00656	0.412
CLV_NRD_NRD_1	186	188	PF00675	0.247
CLV_NRD_NRD_1	320	322	PF00675	0.259
CLV_NRD_NRD_1	512	514	PF00675	0.323
CLV_NRD_NRD_1	675	677	PF00675	0.673
CLV_NRD_NRD_1	98	100	PF00675	0.294
CLV_PCSK_KEX2_1	320	322	PF00082	0.259
CLV_PCSK_KEX2_1	428	430	PF00082	0.297
CLV_PCSK_KEX2_1	677	679	PF00082	0.576
CLV_PCSK_KEX2_1	98	100	PF00082	0.294
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.349
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.587
CLV_PCSK_SKI1_1	161	165	PF00082	0.269
CLV_PCSK_SKI1_1	200	204	PF00082	0.297
CLV_PCSK_SKI1_1	321	325	PF00082	0.327
CLV_PCSK_SKI1_1	42	46	PF00082	0.304
CLV_PCSK_SKI1_1	428	432	PF00082	0.228
CLV_PCSK_SKI1_1	494	498	PF00082	0.318
CLV_PCSK_SKI1_1	565	569	PF00082	0.308
CLV_PCSK_SKI1_1	84	88	PF00082	0.207
CLV_Separin_Metazoa	317	321	PF03568	0.508
DEG_APCC_DBOX_1	140	148	PF00400	0.459
DEG_APCC_DBOX_1	308	316	PF00400	0.508
DEG_Nend_UBRbox_3	1	3	PF02207	0.561
DEG_SCF_FBW7_1	589	596	PF00400	0.459
DEG_SPOP_SBC_1	219	223	PF00917	0.426
DOC_CDC14_PxL_1	72	80	PF14671	0.444
DOC_CKS1_1	569	574	PF01111	0.494
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	582	588	PF00134	0.444
DOC_MAPK_gen_1	187	194	PF00069	0.406
DOC_MAPK_gen_1	633	642	PF00069	0.502
DOC_MAPK_MEF2A_6	395	404	PF00069	0.444
DOC_MAPK_NFAT4_5	395	403	PF00069	0.447
DOC_PP2B_LxvP_1	147	150	PF13499	0.423
DOC_PP2B_LxvP_1	582	585	PF13499	0.374
DOC_PP2B_LxvP_1	628	631	PF13499	0.502
DOC_PP4_FxxP_1	431	434	PF00568	0.412
DOC_PP4_FxxP_1	475	478	PF00568	0.459
DOC_USP7_MATH_1	219	223	PF00917	0.434
DOC_USP7_MATH_1	440	444	PF00917	0.472
DOC_USP7_MATH_1	488	492	PF00917	0.570
DOC_USP7_MATH_1	507	511	PF00917	0.416
DOC_USP7_MATH_1	542	546	PF00917	0.479
DOC_USP7_MATH_1	561	565	PF00917	0.475
DOC_USP7_MATH_1	593	597	PF00917	0.468
DOC_USP7_MATH_1	645	649	PF00917	0.578
DOC_USP7_MATH_1	668	672	PF00917	0.693
DOC_WW_Pin1_4	109	114	PF00397	0.536
DOC_WW_Pin1_4	257	262	PF00397	0.506
DOC_WW_Pin1_4	326	331	PF00397	0.446
DOC_WW_Pin1_4	568	573	PF00397	0.491
DOC_WW_Pin1_4	589	594	PF00397	0.548
DOC_WW_Pin1_4	648	653	PF00397	0.411
LIG_14-3-3_CanoR_1	130	139	PF00244	0.389
LIG_14-3-3_CanoR_1	187	194	PF00244	0.524
LIG_14-3-3_CanoR_1	320	326	PF00244	0.523
LIG_14-3-3_CanoR_1	388	392	PF00244	0.491
LIG_14-3-3_CanoR_1	395	401	PF00244	0.486
LIG_Actin_WH2_2	159	174	PF00022	0.459
LIG_BIR_III_4	636	640	PF00653	0.401
LIG_BRCT_BRCA1_1	229	233	PF00533	0.437
LIG_BRCT_BRCA1_1	544	548	PF00533	0.526
LIG_BRCT_BRCA1_2	229	235	PF00533	0.412
LIG_EH_1	118	122	PF12763	0.508
LIG_eIF4E_1	583	589	PF01652	0.545
LIG_EVH1_1	431	435	PF00568	0.358
LIG_FHA_1	130	136	PF00498	0.459
LIG_FHA_1	175	181	PF00498	0.459
LIG_FHA_1	199	205	PF00498	0.454
LIG_FHA_1	274	280	PF00498	0.474
LIG_FHA_1	460	466	PF00498	0.420
LIG_FHA_1	575	581	PF00498	0.499
LIG_FHA_1	595	601	PF00498	0.391
LIG_FHA_1	664	670	PF00498	0.645
LIG_FHA_1	80	86	PF00498	0.494
LIG_FHA_1	92	98	PF00498	0.473
LIG_FHA_2	212	218	PF00498	0.457
LIG_FHA_2	381	387	PF00498	0.426
LIG_FHA_2	72	78	PF00498	0.530
LIG_FHA_2	98	104	PF00498	0.459
LIG_Integrin_isoDGR_2	167	169	PF01839	0.173
LIG_LIR_Apic_2	472	478	PF02991	0.373
LIG_LIR_Gen_1	22	32	PF02991	0.486
LIG_LIR_Gen_1	482	488	PF02991	0.413
LIG_LIR_Gen_1	54	64	PF02991	0.413
LIG_LIR_Gen_1	545	556	PF02991	0.533
LIG_LIR_Gen_1	620	628	PF02991	0.322
LIG_LIR_Gen_1	643	654	PF02991	0.373
LIG_LIR_Nem_3	22	27	PF02991	0.469
LIG_LIR_Nem_3	482	486	PF02991	0.420
LIG_LIR_Nem_3	54	59	PF02991	0.413
LIG_LIR_Nem_3	545	551	PF02991	0.482
LIG_LIR_Nem_3	620	624	PF02991	0.326
LIG_LIR_Nem_3	643	649	PF02991	0.422
LIG_Pex14_2	274	278	PF04695	0.508
LIG_PTB_Apo_2	343	350	PF02174	0.412
LIG_Rb_pABgroove_1	528	536	PF01858	0.501
LIG_SH2_CRK	483	487	PF00017	0.432
LIG_SH2_CRK	586	590	PF00017	0.444
LIG_SH2_NCK_1	108	112	PF00017	0.412
LIG_SH2_NCK_1	208	212	PF00017	0.334
LIG_SH2_NCK_1	483	487	PF00017	0.459
LIG_SH2_SRC	299	302	PF00017	0.412
LIG_SH2_STAP1	483	487	PF00017	0.459
LIG_SH2_STAP1	594	598	PF00017	0.398
LIG_SH2_STAT3	246	249	PF00017	0.489
LIG_SH2_STAT3	339	342	PF00017	0.469
LIG_SH2_STAT5	108	111	PF00017	0.508
LIG_SH2_STAT5	193	196	PF00017	0.413
LIG_SH2_STAT5	246	249	PF00017	0.426
LIG_SH2_STAT5	583	586	PF00017	0.534
LIG_SH2_STAT5	64	67	PF00017	0.437
LIG_SH3_1	429	435	PF00018	0.358
LIG_SH3_3	143	149	PF00018	0.420
LIG_SH3_3	376	382	PF00018	0.444
LIG_SH3_3	429	435	PF00018	0.358
LIG_SH3_3	46	52	PF00018	0.484
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.508
LIG_SUMO_SIM_par_1	84	89	PF11976	0.480
LIG_TRAF2_1	382	385	PF00917	0.550
LIG_TRAF2_1	420	423	PF00917	0.389
LIG_TRAF2_1	613	616	PF00917	0.445
LIG_TYR_ITIM	584	589	PF00017	0.451
LIG_WRC_WIRS_1	21	26	PF05994	0.400
LIG_WW_2	149	152	PF00397	0.469
MOD_CK1_1	174	180	PF00069	0.484
MOD_CK1_1	221	227	PF00069	0.562
MOD_CK1_1	23	29	PF00069	0.528
MOD_CK1_1	322	328	PF00069	0.459
MOD_CK1_1	329	335	PF00069	0.425
MOD_CK1_1	341	347	PF00069	0.441
MOD_CK1_1	543	549	PF00069	0.428
MOD_CK1_1	63	69	PF00069	0.484
MOD_CK1_1	648	654	PF00069	0.410
MOD_CK1_1	79	85	PF00069	0.508
MOD_CK2_1	211	217	PF00069	0.376
MOD_CK2_1	380	386	PF00069	0.426
MOD_CK2_1	417	423	PF00069	0.420
MOD_CK2_1	551	557	PF00069	0.519
MOD_CK2_1	71	77	PF00069	0.516
MOD_CMANNOS	391	394	PF00535	0.259
MOD_GlcNHglycan	132	135	PF01048	0.342
MOD_GlcNHglycan	209	212	PF01048	0.270
MOD_GlcNHglycan	265	268	PF01048	0.339
MOD_GlcNHglycan	283	287	PF01048	0.239
MOD_GlcNHglycan	321	324	PF01048	0.297
MOD_GlcNHglycan	360	363	PF01048	0.275
MOD_GlcNHglycan	366	369	PF01048	0.286
MOD_GlcNHglycan	499	502	PF01048	0.220
MOD_GlcNHglycan	537	540	PF01048	0.288
MOD_GlcNHglycan	542	545	PF01048	0.271
MOD_GlcNHglycan	77	81	PF01048	0.248
MOD_GlcNHglycan	88	91	PF01048	0.179
MOD_GSK3_1	102	109	PF00069	0.478
MOD_GSK3_1	130	137	PF00069	0.518
MOD_GSK3_1	203	210	PF00069	0.476
MOD_GSK3_1	211	218	PF00069	0.492
MOD_GSK3_1	219	226	PF00069	0.365
MOD_GSK3_1	227	234	PF00069	0.419
MOD_GSK3_1	259	266	PF00069	0.454
MOD_GSK3_1	273	280	PF00069	0.452
MOD_GSK3_1	291	298	PF00069	0.362
MOD_GSK3_1	322	329	PF00069	0.476
MOD_GSK3_1	333	340	PF00069	0.429
MOD_GSK3_1	461	468	PF00069	0.458
MOD_GSK3_1	497	504	PF00069	0.420
MOD_GSK3_1	542	549	PF00069	0.438
MOD_GSK3_1	589	596	PF00069	0.518
MOD_GSK3_1	59	66	PF00069	0.462
MOD_GSK3_1	648	655	PF00069	0.420
MOD_GSK3_1	93	100	PF00069	0.486
MOD_N-GLC_1	227	232	PF02516	0.367
MOD_N-GLC_1	501	506	PF02516	0.213
MOD_N-GLC_1	652	657	PF02516	0.495
MOD_NEK2_1	135	140	PF00069	0.558
MOD_NEK2_1	171	176	PF00069	0.459
MOD_NEK2_1	215	220	PF00069	0.504
MOD_NEK2_1	291	296	PF00069	0.463
MOD_NEK2_1	319	324	PF00069	0.431
MOD_NEK2_1	34	39	PF00069	0.524
MOD_NEK2_1	349	354	PF00069	0.505
MOD_NEK2_1	465	470	PF00069	0.459
MOD_NEK2_1	496	501	PF00069	0.445
MOD_NEK2_1	533	538	PF00069	0.443
MOD_NEK2_1	60	65	PF00069	0.490
MOD_NEK2_1	71	76	PF00069	0.409
MOD_NEK2_1	97	102	PF00069	0.563
MOD_NEK2_2	93	98	PF00069	0.508
MOD_PIKK_1	186	192	PF00454	0.428
MOD_PIKK_1	338	344	PF00454	0.413
MOD_PIKK_1	501	507	PF00454	0.463
MOD_PIKK_1	574	580	PF00454	0.519
MOD_PKA_1	98	104	PF00069	0.428
MOD_PKA_2	129	135	PF00069	0.389
MOD_PKA_2	171	177	PF00069	0.508
MOD_PKA_2	186	192	PF00069	0.508
MOD_PKA_2	319	325	PF00069	0.428
MOD_PKA_2	387	393	PF00069	0.474
MOD_PKA_2	517	523	PF00069	0.558
MOD_PKA_2	561	567	PF00069	0.389
MOD_PKA_2	97	103	PF00069	0.459
MOD_Plk_1	211	217	PF00069	0.415
MOD_Plk_1	333	339	PF00069	0.466
MOD_Plk_1	488	494	PF00069	0.508
MOD_Plk_1	76	82	PF00069	0.508
MOD_Plk_4	171	177	PF00069	0.566
MOD_Plk_4	211	217	PF00069	0.482
MOD_Plk_4	34	40	PF00069	0.484
MOD_Plk_4	543	549	PF00069	0.497
MOD_Plk_4	60	66	PF00069	0.482
MOD_Plk_4	645	651	PF00069	0.372
MOD_ProDKin_1	109	115	PF00069	0.536
MOD_ProDKin_1	257	263	PF00069	0.506
MOD_ProDKin_1	326	332	PF00069	0.488
MOD_ProDKin_1	568	574	PF00069	0.491
MOD_ProDKin_1	589	595	PF00069	0.548
MOD_ProDKin_1	648	654	PF00069	0.410
MOD_SUMO_rev_2	549	556	PF00179	0.472
TRG_ENDOCYTIC_2	483	486	PF00928	0.390
TRG_ENDOCYTIC_2	586	589	PF00928	0.454
TRG_ER_diArg_1	319	321	PF00400	0.459
TRG_ER_diArg_1	39	42	PF00400	0.459
TRG_ER_diArg_1	659	662	PF00400	0.529
TRG_ER_diArg_1	675	678	PF00400	0.532
TRG_ER_diArg_1	97	99	PF00400	0.494
TRG_NES_CRM1_1	77	91	PF08389	0.508
TRG_NLS_MonoExtC_3	675	680	PF00514	0.689
TRG_NLS_MonoExtN_4	675	680	PF00514	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C9	Leptomonas seymouri	50%	98%
A0A0S4JE96	Bodo saltans	30%	97%
A0A1X0NRE8	Trypanosomatidae	36%	100%
A0A3R7RCR4	Trypanosoma rangeli	32%	100%
A4HM15	Leishmania braziliensis	75%	100%
A4I9E7	Leishmania infantum	99%	100%
C9ZJR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B4E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3N1	Leishmania major	90%	100%
Q8H1D9	Arabidopsis thaliana	26%	100%
Q9VQM4	Drosophila melanogaster	23%	100%