NET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMQ4_LEIDO

TriTrypDb:

LdBPK_353690.1 , LdCL_350041900 , LDHU3_35.4840

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IMQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.517
CLV_C14_Caspase3-7	6	10	PF00656	0.467
CLV_NRD_NRD_1	126	128	PF00675	0.503
CLV_NRD_NRD_1	198	200	PF00675	0.641
CLV_NRD_NRD_1	7	9	PF00675	0.471
CLV_PCSK_FUR_1	196	200	PF00082	0.505
CLV_PCSK_KEX2_1	126	128	PF00082	0.503
CLV_PCSK_KEX2_1	196	198	PF00082	0.664
CLV_PCSK_KEX2_1	7	9	PF00082	0.471
CLV_PCSK_PC7_1	3	9	PF00082	0.479
DOC_PP2B_LxvP_1	113	116	PF13499	0.509
DOC_USP7_MATH_1	102	106	PF00917	0.466
DOC_USP7_MATH_1	49	53	PF00917	0.536
DOC_WW_Pin1_4	140	145	PF00397	0.600
LIG_14-3-3_CanoR_1	153	162	PF00244	0.717
LIG_14-3-3_CanoR_1	18	23	PF00244	0.473
LIG_14-3-3_CanoR_1	25	30	PF00244	0.539
LIG_14-3-3_CanoR_1	38	47	PF00244	0.446
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_EH1_1	16	24	PF00400	0.458
LIG_eIF4E_1	17	23	PF01652	0.476
LIG_FHA_1	39	45	PF00498	0.405
LIG_FHA_1	83	89	PF00498	0.514
LIG_LIR_Gen_1	45	55	PF02991	0.465
LIG_PTAP_UEV_1	143	148	PF05743	0.531
LIG_SH3_3	141	147	PF00018	0.578
LIG_SUMO_SIM_anti_2	169	179	PF11976	0.687
LIG_SUMO_SIM_anti_2	75	82	PF11976	0.494
LIG_SUMO_SIM_par_1	105	111	PF11976	0.418
LIG_SUMO_SIM_par_1	134	140	PF11976	0.399
LIG_TRAF2_1	119	122	PF00917	0.445
MOD_CK1_1	140	146	PF00069	0.600
MOD_CK1_1	2	8	PF00069	0.633
MOD_CK1_1	68	74	PF00069	0.634
MOD_CK2_1	69	75	PF00069	0.727
MOD_GlcNHglycan	103	107	PF01048	0.557
MOD_GlcNHglycan	139	142	PF01048	0.529
MOD_GlcNHglycan	144	147	PF01048	0.624
MOD_GlcNHglycan	164	167	PF01048	0.484
MOD_GlcNHglycan	67	70	PF01048	0.710
MOD_GlcNHglycan	71	74	PF01048	0.663
MOD_GSK3_1	102	109	PF00069	0.606
MOD_GSK3_1	33	40	PF00069	0.619
MOD_GSK3_1	65	72	PF00069	0.698
MOD_GSK3_1	82	89	PF00069	0.676
MOD_NEK2_1	37	42	PF00069	0.638
MOD_NEK2_1	86	91	PF00069	0.466
MOD_PKA_2	2	8	PF00069	0.677
MOD_PKA_2	37	43	PF00069	0.573
MOD_Plk_1	75	81	PF00069	0.664
MOD_Plk_2-3	186	192	PF00069	0.671
MOD_Plk_2-3	75	81	PF00069	0.606
MOD_Plk_4	18	24	PF00069	0.457
MOD_Plk_4	75	81	PF00069	0.663
MOD_Plk_4	86	92	PF00069	0.452
MOD_ProDKin_1	140	146	PF00069	0.605
TRG_DiLeu_BaEn_1	75	80	PF01217	0.502
TRG_ER_diArg_1	196	199	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI1	Leptomonas seymouri	46%	92%
A0A1X0P5H7	Trypanosomatidae	33%	100%
A0A422NR35	Trypanosoma rangeli	38%	100%
A4HN35	Leishmania braziliensis	72%	99%
A4IBQ3	Leishmania infantum	99%	100%
C9ZYX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	81%
E9AFI8	Leishmania major	88%	99%
E9B6P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5BD49	Trypanosoma cruzi	34%	100%