Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMM0_LEIDO

TriTrypDb:

LdBPK_353460.1 , LdCL_350039600 , LDHU3_35.4540

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IMM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.724
CLV_NRD_NRD_1	476	478	PF00675	0.411
CLV_NRD_NRD_1	669	671	PF00675	0.500
CLV_NRD_NRD_1	713	715	PF00675	0.691
CLV_NRD_NRD_1	90	92	PF00675	0.643
CLV_PCSK_FUR_1	473	477	PF00082	0.427
CLV_PCSK_FUR_1	667	671	PF00082	0.546
CLV_PCSK_KEX2_1	188	190	PF00082	0.725
CLV_PCSK_KEX2_1	475	477	PF00082	0.425
CLV_PCSK_KEX2_1	478	480	PF00082	0.385
CLV_PCSK_KEX2_1	669	671	PF00082	0.467
CLV_PCSK_KEX2_1	713	715	PF00082	0.656
CLV_PCSK_KEX2_1	90	92	PF00082	0.643
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.395
CLV_PCSK_SKI1_1	153	157	PF00082	0.347
CLV_PCSK_SKI1_1	349	353	PF00082	0.324
CLV_PCSK_SKI1_1	52	56	PF00082	0.520
CLV_PCSK_SKI1_1	670	674	PF00082	0.467
CLV_PCSK_SKI1_1	696	700	PF00082	0.573
DEG_APCC_DBOX_1	541	549	PF00400	0.499
DEG_APCC_DBOX_1	609	617	PF00400	0.378
DEG_MDM2_SWIB_1	678	686	PF02201	0.491
DEG_SPOP_SBC_1	203	207	PF00917	0.526
DOC_CDC14_PxL_1	375	383	PF14671	0.339
DOC_CDC14_PxL_1	602	610	PF14671	0.521
DOC_CKS1_1	29	34	PF01111	0.456
DOC_CYCLIN_RxL_1	346	356	PF00134	0.323
DOC_CYCLIN_yCln2_LP_2	364	367	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.343
DOC_MAPK_DCC_7	637	646	PF00069	0.461
DOC_MAPK_gen_1	667	676	PF00069	0.437
DOC_MAPK_RevD_3	77	91	PF00069	0.512
DOC_PP1_RVXF_1	347	354	PF00149	0.321
DOC_PP2B_LxvP_1	363	366	PF13499	0.476
DOC_PP2B_LxvP_1	376	379	PF13499	0.360
DOC_PP4_FxxP_1	200	203	PF00568	0.568
DOC_PP4_FxxP_1	29	32	PF00568	0.454
DOC_PP4_FxxP_1	672	675	PF00568	0.419
DOC_USP7_MATH_1	196	200	PF00917	0.725
DOC_USP7_MATH_1	203	207	PF00917	0.716
DOC_USP7_MATH_1	282	286	PF00917	0.658
DOC_USP7_MATH_1	405	409	PF00917	0.757
DOC_USP7_MATH_1	566	570	PF00917	0.633
DOC_USP7_MATH_1	635	639	PF00917	0.609
DOC_USP7_MATH_1	650	654	PF00917	0.640
DOC_USP7_MATH_1	698	702	PF00917	0.624
DOC_USP7_UBL2_3	685	689	PF12436	0.522
DOC_USP7_UBL2_3	692	696	PF12436	0.571
DOC_WW_Pin1_4	103	108	PF00397	0.621
DOC_WW_Pin1_4	116	121	PF00397	0.474
DOC_WW_Pin1_4	262	267	PF00397	0.498
DOC_WW_Pin1_4	28	33	PF00397	0.455
DOC_WW_Pin1_4	319	324	PF00397	0.683
DOC_WW_Pin1_4	417	422	PF00397	0.542
DOC_WW_Pin1_4	489	494	PF00397	0.406
DOC_WW_Pin1_4	639	644	PF00397	0.599
DOC_WW_Pin1_4	646	651	PF00397	0.585
DOC_WW_Pin1_4	81	86	PF00397	0.636
DOC_WW_Pin1_4	95	100	PF00397	0.665
LIG_14-3-3_CanoR_1	16	22	PF00244	0.470
LIG_14-3-3_CanoR_1	269	275	PF00244	0.514
LIG_14-3-3_CanoR_1	463	470	PF00244	0.530
LIG_14-3-3_CanoR_1	7	13	PF00244	0.545
LIG_Actin_WH2_2	497	513	PF00022	0.426
LIG_APCC_ABBA_1	624	629	PF00400	0.502
LIG_BIR_III_2	418	422	PF00653	0.534
LIG_CtBP_PxDLS_1	643	647	PF00389	0.488
LIG_EH1_1	613	621	PF00400	0.431
LIG_FHA_1	106	112	PF00498	0.576
LIG_FHA_1	28	34	PF00498	0.540
LIG_FHA_1	292	298	PF00498	0.519
LIG_FHA_1	360	366	PF00498	0.523
LIG_FHA_1	534	540	PF00498	0.475
LIG_FHA_2	244	250	PF00498	0.564
LIG_FHA_2	284	290	PF00498	0.678
LIG_FHA_2	345	351	PF00498	0.484
LIG_FHA_2	572	578	PF00498	0.480
LIG_GBD_Chelix_1	500	508	PF00786	0.405
LIG_HCF-1_HBM_1	298	301	PF13415	0.448
LIG_LIR_Apic_2	199	203	PF02991	0.567
LIG_LIR_Apic_2	235	239	PF02991	0.333
LIG_LIR_Apic_2	28	32	PF02991	0.454
LIG_LIR_Apic_2	383	389	PF02991	0.484
LIG_LIR_Apic_2	671	675	PF02991	0.462
LIG_LIR_Gen_1	125	132	PF02991	0.398
LIG_LIR_Gen_1	298	309	PF02991	0.500
LIG_LIR_Gen_1	370	380	PF02991	0.469
LIG_LIR_Gen_1	428	435	PF02991	0.418
LIG_LIR_Gen_1	8	18	PF02991	0.462
LIG_LIR_Nem_3	125	129	PF02991	0.416
LIG_LIR_Nem_3	231	236	PF02991	0.293
LIG_LIR_Nem_3	298	304	PF02991	0.453
LIG_LIR_Nem_3	336	340	PF02991	0.378
LIG_LIR_Nem_3	370	375	PF02991	0.457
LIG_LIR_Nem_3	428	433	PF02991	0.417
LIG_LIR_Nem_3	8	13	PF02991	0.585
LIG_MAD2	258	266	PF02301	0.441
LIG_PCNA_yPIPBox_3	610	624	PF02747	0.429
LIG_Pex14_1	25	29	PF04695	0.442
LIG_Pex14_2	672	676	PF04695	0.457
LIG_Pex14_2	678	682	PF04695	0.483
LIG_REV1ctd_RIR_1	10	20	PF16727	0.460
LIG_SH2_CRK	386	390	PF00017	0.456
LIG_SH2_NCK_1	386	390	PF00017	0.456
LIG_SH2_PTP2	301	304	PF00017	0.429
LIG_SH2_STAP1	159	163	PF00017	0.493
LIG_SH2_STAT3	690	693	PF00017	0.546
LIG_SH2_STAT5	236	239	PF00017	0.500
LIG_SH2_STAT5	301	304	PF00017	0.429
LIG_SH2_STAT5	430	433	PF00017	0.408
LIG_SH2_STAT5	487	490	PF00017	0.418
LIG_SH2_STAT5	494	497	PF00017	0.332
LIG_SH2_STAT5	690	693	PF00017	0.546
LIG_SH3_1	600	606	PF00018	0.475
LIG_SH3_3	104	110	PF00018	0.548
LIG_SH3_3	117	123	PF00018	0.334
LIG_SH3_3	141	147	PF00018	0.489
LIG_SH3_3	317	323	PF00018	0.550
LIG_SH3_3	39	45	PF00018	0.469
LIG_SH3_3	600	606	PF00018	0.535
LIG_SUMO_SIM_anti_2	622	627	PF11976	0.406
LIG_SUMO_SIM_anti_2	629	636	PF11976	0.370
LIG_SUMO_SIM_par_1	642	649	PF11976	0.486
LIG_SxIP_EBH_1	122	134	PF03271	0.412
LIG_TRAF2_1	447	450	PF00917	0.465
LIG_TRAF2_1	574	577	PF00917	0.434
LIG_TRFH_1	505	509	PF08558	0.426
LIG_WRC_WIRS_1	26	31	PF05994	0.453
MOD_CDK_SPxxK_3	262	269	PF00069	0.472
MOD_CDK_SPxxK_3	319	326	PF00069	0.582
MOD_CK1_1	106	112	PF00069	0.559
MOD_CK1_1	283	289	PF00069	0.687
MOD_CK1_1	322	328	PF00069	0.583
MOD_CK1_1	569	575	PF00069	0.459
MOD_CK1_1	584	590	PF00069	0.508
MOD_CK1_1	639	645	PF00069	0.679
MOD_CK1_1	649	655	PF00069	0.656
MOD_CK1_1	708	714	PF00069	0.625
MOD_CK1_1	97	103	PF00069	0.683
MOD_CK2_1	243	249	PF00069	0.548
MOD_CK2_1	284	290	PF00069	0.609
MOD_CK2_1	344	350	PF00069	0.477
MOD_CK2_1	571	577	PF00069	0.446
MOD_Cter_Amidation	667	670	PF01082	0.522
MOD_GlcNHglycan	206	209	PF01048	0.671
MOD_GlcNHglycan	286	289	PF01048	0.613
MOD_GlcNHglycan	33	36	PF01048	0.464
MOD_GlcNHglycan	353	356	PF01048	0.468
MOD_GlcNHglycan	376	379	PF01048	0.374
MOD_GlcNHglycan	393	396	PF01048	0.598
MOD_GlcNHglycan	403	406	PF01048	0.711
MOD_GlcNHglycan	409	412	PF01048	0.692
MOD_GlcNHglycan	465	468	PF01048	0.578
MOD_GlcNHglycan	49	52	PF01048	0.441
MOD_GlcNHglycan	516	519	PF01048	0.472
MOD_GSK3_1	101	108	PF00069	0.632
MOD_GSK3_1	210	217	PF00069	0.707
MOD_GSK3_1	27	34	PF00069	0.454
MOD_GSK3_1	280	287	PF00069	0.620
MOD_GSK3_1	387	394	PF00069	0.553
MOD_GSK3_1	401	408	PF00069	0.620
MOD_GSK3_1	413	420	PF00069	0.709
MOD_GSK3_1	421	428	PF00069	0.657
MOD_GSK3_1	594	601	PF00069	0.574
MOD_GSK3_1	635	642	PF00069	0.675
MOD_GSK3_1	645	652	PF00069	0.659
MOD_GSK3_1	684	691	PF00069	0.531
MOD_GSK3_1	77	84	PF00069	0.735
MOD_GSK3_1	93	100	PF00069	0.608
MOD_N-GLC_1	533	538	PF02516	0.436
MOD_N-GLC_1	639	644	PF02516	0.460
MOD_NEK2_1	204	209	PF00069	0.587
MOD_NEK2_1	243	248	PF00069	0.523
MOD_NEK2_1	27	32	PF00069	0.453
MOD_NEK2_1	425	430	PF00069	0.559
MOD_NEK2_1	519	524	PF00069	0.508
MOD_NEK2_1	644	649	PF00069	0.719
MOD_NEK2_2	270	275	PF00069	0.419
MOD_NEK2_2	698	703	PF00069	0.606
MOD_NEK2_2	85	90	PF00069	0.600
MOD_PK_1	216	222	PF00069	0.526
MOD_PKA_2	180	186	PF00069	0.677
MOD_PKA_2	283	289	PF00069	0.720
MOD_PKA_2	6	12	PF00069	0.470
MOD_PKA_2	636	642	PF00069	0.540
MOD_PKB_1	179	187	PF00069	0.514
MOD_PKB_1	703	711	PF00069	0.657
MOD_Plk_1	291	297	PF00069	0.496
MOD_Plk_1	448	454	PF00069	0.557
MOD_Plk_4	232	238	PF00069	0.338
MOD_Plk_4	359	365	PF00069	0.461
MOD_Plk_4	425	431	PF00069	0.464
MOD_Plk_4	448	454	PF00069	0.476
MOD_Plk_4	77	83	PF00069	0.484
MOD_ProDKin_1	103	109	PF00069	0.603
MOD_ProDKin_1	116	122	PF00069	0.471
MOD_ProDKin_1	262	268	PF00069	0.495
MOD_ProDKin_1	28	34	PF00069	0.455
MOD_ProDKin_1	319	325	PF00069	0.677
MOD_ProDKin_1	417	423	PF00069	0.536
MOD_ProDKin_1	489	495	PF00069	0.401
MOD_ProDKin_1	639	645	PF00069	0.603
MOD_ProDKin_1	646	652	PF00069	0.579
MOD_ProDKin_1	81	87	PF00069	0.635
MOD_ProDKin_1	95	101	PF00069	0.667
MOD_SUMO_rev_2	161	168	PF00179	0.526
TRG_DiLeu_BaEn_1	359	364	PF01217	0.439
TRG_DiLeu_BaEn_2	116	122	PF01217	0.380
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.371
TRG_ENDOCYTIC_2	301	304	PF00928	0.440
TRG_ENDOCYTIC_2	430	433	PF00928	0.408
TRG_ER_diArg_1	174	177	PF00400	0.391
TRG_ER_diArg_1	178	181	PF00400	0.532
TRG_ER_diArg_1	255	258	PF00400	0.564
TRG_ER_diArg_1	473	476	PF00400	0.505
TRG_ER_diArg_1	666	669	PF00400	0.524
TRG_ER_diArg_1	702	705	PF00400	0.655
TRG_ER_diArg_1	713	715	PF00400	0.640
TRG_ER_diArg_1	89	91	PF00400	0.638
TRG_NLS_MonoCore_2	476	481	PF00514	0.418
TRG_NLS_MonoExtN_4	475	482	PF00514	0.403
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUU2	Leptomonas seymouri	53%	100%
A0A1X0P6R1	Trypanosomatidae	29%	100%
A0A3R7L599	Trypanosoma rangeli	31%	100%
A4HN08	Leishmania braziliensis	81%	100%
A4IBN1	Leishmania infantum	99%	100%
C9ZZ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AFG5	Leishmania major	93%	100%
E9B6M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BY91	Trypanosoma cruzi	32%	100%