Succinyl-CoA:3-ketoacid-coenzyme A transferase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IMK1_LEIDO

TriTrypDb:

LdBPK_332470.1 , LdCL_330031700 , LDHU3_33.3530

Length:

489

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinyl-CoA:3-ketoacid-coenzyme A transferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IMK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMK1

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0016042	lipid catabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046950	cellular ketone body metabolic process	3	12
GO:0046952	ketone body catabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901568	fatty acid derivative metabolic process	4	12
GO:1901569	fatty acid derivative catabolic process	5	12
GO:1901575	organic substance catabolic process	3	12
GO:1902224	ketone body metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008260	succinyl-CoA:3-oxo-acid CoA-transferase activity	5	12
GO:0008410	CoA-transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016782	transferase activity, transferring sulphur-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.583
CLV_C14_Caspase3-7	281	285	PF00656	0.489
CLV_NRD_NRD_1	211	213	PF00675	0.327
CLV_NRD_NRD_1	276	278	PF00675	0.278
CLV_NRD_NRD_1	3	5	PF00675	0.505
CLV_NRD_NRD_1	81	83	PF00675	0.340
CLV_NRD_NRD_1	96	98	PF00675	0.343
CLV_PCSK_KEX2_1	211	213	PF00082	0.378
CLV_PCSK_KEX2_1	252	254	PF00082	0.509
CLV_PCSK_KEX2_1	276	278	PF00082	0.278
CLV_PCSK_KEX2_1	3	5	PF00082	0.505
CLV_PCSK_KEX2_1	414	416	PF00082	0.389
CLV_PCSK_KEX2_1	81	83	PF00082	0.338
CLV_PCSK_KEX2_1	95	97	PF00082	0.338
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.509
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.389
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.356
CLV_PCSK_SKI1_1	183	187	PF00082	0.350
CLV_PCSK_SKI1_1	277	281	PF00082	0.278
CLV_PCSK_SKI1_1	436	440	PF00082	0.278
CLV_PCSK_SKI1_1	441	445	PF00082	0.278
CLV_PCSK_SKI1_1	52	56	PF00082	0.284
CLV_PCSK_SKI1_1	92	96	PF00082	0.320
DEG_MDM2_SWIB_1	164	171	PF02201	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_MAPK_gen_1	186	195	PF00069	0.489
DOC_MAPK_gen_1	273	282	PF00069	0.484
DOC_MAPK_gen_1	51	59	PF00069	0.533
DOC_MAPK_MEF2A_6	359	367	PF00069	0.478
DOC_PP4_FxxP_1	202	205	PF00568	0.478
DOC_USP7_MATH_1	187	191	PF00917	0.502
DOC_USP7_MATH_1	260	264	PF00917	0.717
DOC_USP7_MATH_1	400	404	PF00917	0.564
DOC_USP7_UBL2_3	51	55	PF12436	0.549
LIG_14-3-3_CanoR_1	404	410	PF00244	0.594
LIG_14-3-3_CanoR_1	423	427	PF00244	0.417
LIG_14-3-3_CanoR_1	436	444	PF00244	0.422
LIG_14-3-3_CanoR_1	82	88	PF00244	0.538
LIG_Actin_WH2_2	439	456	PF00022	0.488
LIG_APCC_ABBA_1	308	313	PF00400	0.554
LIG_APCC_ABBA_1	57	62	PF00400	0.502
LIG_EH1_1	431	439	PF00400	0.564
LIG_FHA_1	24	30	PF00498	0.573
LIG_FHA_1	305	311	PF00498	0.552
LIG_FHA_1	433	439	PF00498	0.566
LIG_FHA_1	75	81	PF00498	0.582
LIG_FHA_2	110	116	PF00498	0.518
LIG_FHA_2	459	465	PF00498	0.502
LIG_Integrin_RGD_1	415	417	PF01839	0.327
LIG_LIR_Apic_2	245	249	PF02991	0.520
LIG_LIR_Gen_1	178	187	PF02991	0.474
LIG_LIR_Gen_1	284	295	PF02991	0.479
LIG_LIR_Gen_1	353	363	PF02991	0.484
LIG_LIR_Nem_3	178	182	PF02991	0.472
LIG_LIR_Nem_3	284	290	PF02991	0.479
LIG_LIR_Nem_3	353	358	PF02991	0.474
LIG_Pex14_2	164	168	PF04695	0.538
LIG_PTB_Apo_2	163	170	PF02174	0.499
LIG_PTB_Phospho_1	163	169	PF10480	0.499
LIG_SH2_CRK	179	183	PF00017	0.564
LIG_SH2_CRK	287	291	PF00017	0.562
LIG_SH2_CRK	483	487	PF00017	0.590
LIG_SH2_GRB2like	287	290	PF00017	0.478
LIG_SH2_SRC	179	182	PF00017	0.583
LIG_SH2_SRC	98	101	PF00017	0.518
LIG_SH2_STAP1	128	132	PF00017	0.583
LIG_SH2_STAP1	60	64	PF00017	0.518
LIG_SH2_STAT3	133	136	PF00017	0.564
LIG_SH2_STAT5	128	131	PF00017	0.468
LIG_SH2_STAT5	169	172	PF00017	0.489
LIG_SH2_STAT5	237	240	PF00017	0.478
LIG_SH2_STAT5	60	63	PF00017	0.564
LIG_SH2_STAT5	98	101	PF00017	0.524
LIG_SH3_3	228	234	PF00018	0.484
LIG_SH3_3	386	392	PF00018	0.502
LIG_SUMO_SIM_par_1	306	313	PF11976	0.549
LIG_TRAF2_1	17	20	PF00917	0.527
MOD_CK1_1	351	357	PF00069	0.478
MOD_CK2_1	109	115	PF00069	0.478
MOD_CK2_1	14	20	PF00069	0.369
MOD_CK2_1	255	261	PF00069	0.599
MOD_Cter_Amidation	209	212	PF01082	0.327
MOD_GlcNHglycan	188	192	PF01048	0.289
MOD_GlcNHglycan	255	258	PF01048	0.627
MOD_GlcNHglycan	328	331	PF01048	0.355
MOD_GlcNHglycan	350	353	PF01048	0.283
MOD_GlcNHglycan	38	41	PF01048	0.355
MOD_GlcNHglycan	400	403	PF01048	0.280
MOD_GlcNHglycan	46	49	PF01048	0.348
MOD_GlcNHglycan	62	65	PF01048	0.326
MOD_GSK3_1	128	135	PF00069	0.478
MOD_GSK3_1	23	30	PF00069	0.586
MOD_GSK3_1	251	258	PF00069	0.538
MOD_GSK3_1	422	429	PF00069	0.538
MOD_GSK3_1	432	439	PF00069	0.538
MOD_N-GLC_1	363	368	PF02516	0.326
MOD_NEK2_1	171	176	PF00069	0.593
MOD_NEK2_1	195	200	PF00069	0.478
MOD_NEK2_1	36	41	PF00069	0.544
MOD_NEK2_1	363	368	PF00069	0.510
MOD_NEK2_1	371	376	PF00069	0.478
MOD_NEK2_1	398	403	PF00069	0.472
MOD_NEK2_1	74	79	PF00069	0.506
MOD_NEK2_1	83	88	PF00069	0.445
MOD_PIKK_1	132	138	PF00454	0.564
MOD_PKA_1	466	472	PF00069	0.505
MOD_PKA_2	136	142	PF00069	0.549
MOD_PKA_2	195	201	PF00069	0.478
MOD_PKA_2	422	428	PF00069	0.558
MOD_Plk_1	171	177	PF00069	0.499
MOD_Plk_1	363	369	PF00069	0.478
MOD_Plk_2-3	458	464	PF00069	0.478
MOD_Plk_4	363	369	PF00069	0.502
MOD_Plk_4	83	89	PF00069	0.478
MOD_SUMO_rev_2	156	161	PF00179	0.536
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.564
TRG_ENDOCYTIC_2	179	182	PF00928	0.564
TRG_ENDOCYTIC_2	287	290	PF00928	0.470
TRG_ER_diArg_1	2	4	PF00400	0.513
TRG_ER_diArg_1	211	213	PF00400	0.527
TRG_ER_diArg_1	80	82	PF00400	0.564
TRG_ER_diArg_1	96	98	PF00400	0.564
TRG_NLS_Bipartite_1	81	99	PF00514	0.583
TRG_NLS_MonoExtC_3	94	100	PF00514	0.583
TRG_NLS_MonoExtN_4	92	99	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P584	Leptomonas seymouri	41%	100%
A0A0N1I0F3	Leptomonas seymouri	84%	100%
A0A0S4JH09	Bodo saltans	62%	99%
A0A1X0NIU4	Trypanosomatidae	42%	98%
A0A1X0P425	Trypanosomatidae	64%	99%
A0A3Q8IC07	Leishmania donovani	45%	100%
A0A3R7LBN6	Trypanosoma rangeli	64%	99%
A0A3S7X3G0	Leishmania donovani	46%	98%
A4HLU7	Leishmania braziliensis	89%	100%
A4I5L8	Leishmania infantum	45%	100%
A4I5L9	Leishmania infantum	46%	100%
B2GV06	Rattus norvegicus	53%	94%
D0A680	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	99%
E9AHQ2	Leishmania infantum	100%	100%
E9B0W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B0W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B473	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F1CYZ5	Acetobacterium woodii	25%	93%
P37766	Escherichia coli (strain K12)	25%	92%
P55809	Homo sapiens	53%	94%
Q09450	Caenorhabditis elegans	53%	94%
Q29551	Sus scrofa	55%	94%
Q4Q3V3	Leishmania major	98%	100%
Q4Q7A2	Leishmania major	47%	100%
Q4Q7A3	Leishmania major	45%	99%
Q54JD9	Dictyostelium discoideum	52%	96%
Q5XIJ9	Rattus norvegicus	52%	94%
Q8X5X6	Escherichia coli O157:H7	25%	92%
Q9BYC2	Homo sapiens	54%	95%
Q9D0K2	Mus musculus	53%	94%
Q9ESL0	Mus musculus	53%	94%
Q9JJN4	Mus musculus	53%	94%
Q9W058	Drosophila melanogaster	50%	95%
V5DQB8	Trypanosoma cruzi	64%	100%