Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMJ3_LEIDO

TriTrypDb:

LdBPK_240390.1 , LdCL_240008800 , LDHU3_24.0490

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IMJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.547
CLV_C14_Caspase3-7	113	117	PF00656	0.477
CLV_C14_Caspase3-7	118	122	PF00656	0.428
CLV_C14_Caspase3-7	335	339	PF00656	0.565
CLV_MEL_PAP_1	569	575	PF00089	0.734
CLV_NRD_NRD_1	296	298	PF00675	0.733
CLV_NRD_NRD_1	481	483	PF00675	0.669
CLV_NRD_NRD_1	582	584	PF00675	0.657
CLV_PCSK_KEX2_1	296	298	PF00082	0.706
CLV_PCSK_KEX2_1	399	401	PF00082	0.705
CLV_PCSK_KEX2_1	582	584	PF00082	0.657
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.695
CLV_PCSK_SKI1_1	155	159	PF00082	0.638
CLV_PCSK_SKI1_1	497	501	PF00082	0.735
CLV_PCSK_SKI1_1	565	569	PF00082	0.679
DEG_APCC_DBOX_1	198	206	PF00400	0.465
DEG_APCC_DBOX_1	460	468	PF00400	0.498
DEG_APCC_DBOX_1	5	13	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.706
DEG_SPOP_SBC_1	422	426	PF00917	0.460
DOC_ANK_TNKS_1	315	322	PF00023	0.576
DOC_CDC14_PxL_1	159	167	PF14671	0.539
DOC_CKS1_1	134	139	PF01111	0.576
DOC_CKS1_1	69	74	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.482
DOC_MAPK_gen_1	565	575	PF00069	0.478
DOC_MAPK_JIP1_4	284	290	PF00069	0.604
DOC_MAPK_MEF2A_6	6	14	PF00069	0.563
DOC_PP1_RVXF_1	434	441	PF00149	0.558
DOC_PP1_RVXF_1	570	576	PF00149	0.562
DOC_PP1_RVXF_1	613	619	PF00149	0.485
DOC_PP2B_LxvP_1	500	503	PF13499	0.441
DOC_PP2B_LxvP_1	532	535	PF13499	0.591
DOC_PP4_FxxP_1	495	498	PF00568	0.581
DOC_PP4_FxxP_1	530	533	PF00568	0.515
DOC_USP7_MATH_1	106	110	PF00917	0.584
DOC_USP7_MATH_1	141	145	PF00917	0.459
DOC_USP7_MATH_1	172	176	PF00917	0.447
DOC_USP7_MATH_1	232	236	PF00917	0.560
DOC_USP7_MATH_1	237	241	PF00917	0.559
DOC_USP7_MATH_1	276	280	PF00917	0.455
DOC_USP7_MATH_1	421	425	PF00917	0.517
DOC_USP7_MATH_1	524	528	PF00917	0.582
DOC_USP7_MATH_1	561	565	PF00917	0.493
DOC_USP7_MATH_1	593	597	PF00917	0.502
DOC_WW_Pin1_4	133	138	PF00397	0.501
DOC_WW_Pin1_4	251	256	PF00397	0.596
DOC_WW_Pin1_4	68	73	PF00397	0.523
LIG_14-3-3_CanoR_1	107	112	PF00244	0.589
LIG_14-3-3_CanoR_1	231	237	PF00244	0.625
LIG_14-3-3_CanoR_1	284	289	PF00244	0.523
LIG_14-3-3_CanoR_1	303	311	PF00244	0.572
LIG_14-3-3_CanoR_1	329	333	PF00244	0.654
LIG_14-3-3_CanoR_1	423	432	PF00244	0.545
LIG_14-3-3_CanoR_1	572	576	PF00244	0.486
LIG_14-3-3_CanoR_1	6	10	PF00244	0.527
LIG_14-3-3_CanoR_1	615	619	PF00244	0.483
LIG_Actin_WH2_2	467	484	PF00022	0.537
LIG_BIR_III_2	121	125	PF00653	0.529
LIG_BRCT_BRCA1_1	526	530	PF00533	0.579
LIG_deltaCOP1_diTrp_1	437	443	PF00928	0.501
LIG_FHA_1	14	20	PF00498	0.390
LIG_FHA_1	204	210	PF00498	0.535
LIG_FHA_1	228	234	PF00498	0.610
LIG_FHA_1	36	42	PF00498	0.548
LIG_FHA_1	47	53	PF00498	0.474
LIG_FHA_1	550	556	PF00498	0.507
LIG_FHA_1	69	75	PF00498	0.526
LIG_FHA_2	116	122	PF00498	0.565
LIG_FHA_2	32	38	PF00498	0.575
LIG_FHA_2	333	339	PF00498	0.599
LIG_LIR_Apic_2	131	137	PF02991	0.494
LIG_LIR_Apic_2	198	203	PF02991	0.499
LIG_LIR_Apic_2	362	368	PF02991	0.553
LIG_LIR_Apic_2	527	533	PF02991	0.583
LIG_LIR_Gen_1	574	581	PF02991	0.483
LIG_LIR_Gen_1	599	608	PF02991	0.541
LIG_LIR_Gen_1	617	624	PF02991	0.344
LIG_LIR_Nem_3	547	551	PF02991	0.488
LIG_LIR_Nem_3	574	579	PF02991	0.486
LIG_LIR_Nem_3	599	604	PF02991	0.548
LIG_LIR_Nem_3	617	621	PF02991	0.356
LIG_MYND_1	510	514	PF01753	0.602
LIG_NBox_RRM_1	119	129	PF00076	0.577
LIG_NRBOX	265	271	PF00104	0.519
LIG_PCNA_TLS_4	582	589	PF02747	0.472
LIG_PCNA_yPIPBox_3	139	149	PF02747	0.485
LIG_Pex14_1	584	588	PF04695	0.472
LIG_SH2_CRK	156	160	PF00017	0.439
LIG_SH2_CRK	88	92	PF00017	0.435
LIG_SH2_GRB2like	578	581	PF00017	0.475
LIG_SH2_SRC	597	600	PF00017	0.482
LIG_SH2_STAP1	146	150	PF00017	0.440
LIG_SH2_STAP1	273	277	PF00017	0.518
LIG_SH2_STAP1	62	66	PF00017	0.589
LIG_SH2_STAP1	77	81	PF00017	0.414
LIG_SH2_STAT5	22	25	PF00017	0.411
LIG_SH2_STAT5	551	554	PF00017	0.468
LIG_SH2_STAT5	578	581	PF00017	0.449
LIG_SH2_STAT5	88	91	PF00017	0.535
LIG_SH3_3	322	328	PF00018	0.597
LIG_SH3_3	381	387	PF00018	0.613
LIG_SH3_3	495	501	PF00018	0.586
LIG_SH3_3	504	510	PF00018	0.539
LIG_SH3_3	528	534	PF00018	0.541
LIG_SH3_3	66	72	PF00018	0.517
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.371
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.578
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.510
LIG_SUMO_SIM_par_1	388	394	PF11976	0.532
LIG_SUMO_SIM_par_1	410	415	PF11976	0.538
LIG_TRFH_1	530	534	PF08558	0.515
LIG_UBA3_1	464	468	PF00899	0.501
LIG_WW_1	533	536	PF00397	0.538
MOD_CK1_1	110	116	PF00069	0.608
MOD_CK1_1	239	245	PF00069	0.617
MOD_CK1_1	261	267	PF00069	0.559
MOD_CK1_1	271	277	PF00069	0.454
MOD_CK1_1	304	310	PF00069	0.578
MOD_CK1_1	424	430	PF00069	0.496
MOD_CK1_1	5	11	PF00069	0.470
MOD_CK2_1	167	173	PF00069	0.473
MOD_CK2_1	192	198	PF00069	0.499
MOD_CMANNOS	440	443	PF00535	0.684
MOD_CMANNOS	584	587	PF00535	0.675
MOD_GlcNHglycan	109	112	PF01048	0.811
MOD_GlcNHglycan	159	162	PF01048	0.718
MOD_GlcNHglycan	167	170	PF01048	0.652
MOD_GlcNHglycan	270	273	PF01048	0.793
MOD_GlcNHglycan	278	281	PF01048	0.712
MOD_GlcNHglycan	306	309	PF01048	0.773
MOD_GlcNHglycan	361	364	PF01048	0.782
MOD_GlcNHglycan	428	431	PF01048	0.763
MOD_GlcNHglycan	514	517	PF01048	0.751
MOD_GSK3_1	106	113	PF00069	0.589
MOD_GSK3_1	129	136	PF00069	0.563
MOD_GSK3_1	232	239	PF00069	0.616
MOD_GSK3_1	258	265	PF00069	0.553
MOD_GSK3_1	271	278	PF00069	0.470
MOD_GSK3_1	302	309	PF00069	0.562
MOD_GSK3_1	31	38	PF00069	0.492
MOD_GSK3_1	328	335	PF00069	0.588
MOD_GSK3_1	421	428	PF00069	0.520
MOD_GSK3_1	602	609	PF00069	0.462
MOD_LATS_1	282	288	PF00433	0.559
MOD_N-GLC_1	10	15	PF02516	0.513
MOD_N-GLC_1	375	380	PF02516	0.717
MOD_N-GLC_1	549	554	PF02516	0.697
MOD_N-GLC_1	86	91	PF02516	0.728
MOD_NEK2_1	10	15	PF00069	0.416
MOD_NEK2_1	165	170	PF00069	0.548
MOD_NEK2_1	211	216	PF00069	0.513
MOD_NEK2_1	262	267	PF00069	0.526
MOD_NEK2_1	275	280	PF00069	0.530
MOD_NEK2_1	31	36	PF00069	0.484
MOD_NEK2_1	488	493	PF00069	0.517
MOD_NEK2_1	588	593	PF00069	0.471
MOD_NEK2_2	141	146	PF00069	0.482
MOD_NEK2_2	328	333	PF00069	0.585
MOD_NEK2_2	571	576	PF00069	0.563
MOD_PIKK_1	243	249	PF00454	0.619
MOD_PIKK_1	264	270	PF00454	0.568
MOD_PIKK_1	474	480	PF00454	0.580
MOD_PIKK_1	98	104	PF00454	0.577
MOD_PKA_2	106	112	PF00069	0.586
MOD_PKA_2	211	217	PF00069	0.463
MOD_PKA_2	243	249	PF00069	0.561
MOD_PKA_2	302	308	PF00069	0.653
MOD_PKA_2	328	334	PF00069	0.619
MOD_PKA_2	422	428	PF00069	0.543
MOD_PKA_2	5	11	PF00069	0.536
MOD_PKA_2	571	577	PF00069	0.489
MOD_PKA_2	614	620	PF00069	0.486
MOD_Plk_1	10	16	PF00069	0.513
MOD_Plk_1	115	121	PF00069	0.606
MOD_Plk_1	130	136	PF00069	0.434
MOD_Plk_1	172	178	PF00069	0.460
MOD_Plk_1	412	418	PF00069	0.547
MOD_Plk_1	561	567	PF00069	0.491
MOD_Plk_4	130	136	PF00069	0.486
MOD_Plk_4	141	147	PF00069	0.460
MOD_Plk_4	192	198	PF00069	0.465
MOD_Plk_4	284	290	PF00069	0.604
MOD_Plk_4	328	334	PF00069	0.569
MOD_Plk_4	412	418	PF00069	0.495
MOD_Plk_4	448	454	PF00069	0.483
MOD_Plk_4	5	11	PF00069	0.553
MOD_Plk_4	571	577	PF00069	0.562
MOD_ProDKin_1	133	139	PF00069	0.500
MOD_ProDKin_1	251	257	PF00069	0.595
MOD_ProDKin_1	68	74	PF00069	0.524
MOD_SUMO_for_1	346	349	PF00179	0.506
MOD_SUMO_for_1	544	547	PF00179	0.599
MOD_SUMO_rev_2	340	348	PF00179	0.499
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.438
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.475
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.531
TRG_ENDOCYTIC_2	156	159	PF00928	0.440
TRG_ENDOCYTIC_2	218	221	PF00928	0.463
TRG_ENDOCYTIC_2	536	539	PF00928	0.528
TRG_ENDOCYTIC_2	55	58	PF00928	0.465
TRG_ER_diArg_1	295	297	PF00400	0.534
TRG_ER_diArg_1	526	529	PF00400	0.578
TRG_ER_diArg_1	581	583	PF00400	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L4	Leptomonas seymouri	46%	97%
A4HD95	Leishmania braziliensis	77%	95%
E9AH50	Leishmania infantum	99%	100%
E9AWM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAU2	Leishmania major	94%	100%