WD repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

WD repeat protein

Gene product:

WD repeat protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IMH5_LEIDO

TriTrypDb:

LdBPK_240230.1 , LdCL_240007200 , LDHU3_24.0270

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IMH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMH5

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.220
CLV_NRD_NRD_1	25	27	PF00675	0.510
CLV_NRD_NRD_1	267	269	PF00675	0.335
CLV_NRD_NRD_1	357	359	PF00675	0.536
CLV_NRD_NRD_1	58	60	PF00675	0.485
CLV_NRD_NRD_1	74	76	PF00675	0.468
CLV_PCSK_KEX2_1	24	26	PF00082	0.502
CLV_PCSK_KEX2_1	267	269	PF00082	0.335
CLV_PCSK_KEX2_1	340	342	PF00082	0.394
CLV_PCSK_KEX2_1	357	359	PF00082	0.452
CLV_PCSK_KEX2_1	58	60	PF00082	0.485
CLV_PCSK_KEX2_1	74	76	PF00082	0.468
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.421
CLV_PCSK_PC7_1	20	26	PF00082	0.370
CLV_PCSK_SKI1_1	267	271	PF00082	0.371
CLV_PCSK_SKI1_1	523	527	PF00082	0.312
CLV_PCSK_SKI1_1	544	548	PF00082	0.308
CLV_PCSK_SKI1_1	585	589	PF00082	0.334
DEG_COP1_1	79	89	PF00400	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.397
DEG_SPOP_SBC_1	289	293	PF00917	0.438
DEG_SPOP_SBC_1	442	446	PF00917	0.443
DOC_ANK_TNKS_1	356	363	PF00023	0.582
DOC_CYCLIN_RxL_1	520	528	PF00134	0.317
DOC_CYCLIN_yClb5_NLxxxL_5	174	180	PF00134	0.500
DOC_MAPK_DCC_7	279	288	PF00069	0.323
DOC_MAPK_DCC_7	33	42	PF00069	0.381
DOC_MAPK_gen_1	340	349	PF00069	0.530
DOC_MAPK_MEF2A_6	340	349	PF00069	0.406
DOC_PP1_RVXF_1	57	64	PF00149	0.327
DOC_PP2B_LxvP_1	40	43	PF13499	0.373
DOC_PP2B_LxvP_1	84	87	PF13499	0.419
DOC_PP4_FxxP_1	47	50	PF00568	0.383
DOC_USP7_MATH_1	289	293	PF00917	0.328
DOC_USP7_MATH_1	389	393	PF00917	0.359
DOC_USP7_MATH_1	442	446	PF00917	0.447
DOC_USP7_MATH_1	468	472	PF00917	0.425
DOC_USP7_MATH_1	487	491	PF00917	0.439
DOC_USP7_MATH_1	53	57	PF00917	0.374
DOC_USP7_MATH_1	89	93	PF00917	0.475
DOC_USP7_MATH_1	97	101	PF00917	0.386
DOC_USP7_MATH_2	323	329	PF00917	0.547
DOC_USP7_UBL2_3	544	548	PF12436	0.468
DOC_WW_Pin1_4	120	125	PF00397	0.407
DOC_WW_Pin1_4	186	191	PF00397	0.410
DOC_WW_Pin1_4	33	38	PF00397	0.383
DOC_WW_Pin1_4	433	438	PF00397	0.398
DOC_WW_Pin1_4	472	477	PF00397	0.327
DOC_WW_Pin1_4	85	90	PF00397	0.543
LIG_14-3-3_CanoR_1	115	125	PF00244	0.669
LIG_14-3-3_CanoR_1	165	170	PF00244	0.378
LIG_14-3-3_CanoR_1	18	23	PF00244	0.430
LIG_14-3-3_CanoR_1	24	32	PF00244	0.496
LIG_14-3-3_CanoR_1	426	434	PF00244	0.327
LIG_14-3-3_CanoR_1	455	465	PF00244	0.490
LIG_14-3-3_CanoR_1	497	505	PF00244	0.403
LIG_14-3-3_CanoR_1	542	547	PF00244	0.323
LIG_14-3-3_CanoR_1	74	79	PF00244	0.426
LIG_Actin_WH2_2	481	499	PF00022	0.443
LIG_BIR_III_4	486	490	PF00653	0.325
LIG_BRCT_BRCA1_1	47	51	PF00533	0.383
LIG_BRCT_BRCA1_1	489	493	PF00533	0.287
LIG_Clathr_ClatBox_1	180	184	PF01394	0.434
LIG_deltaCOP1_diTrp_1	184	194	PF00928	0.435
LIG_deltaCOP1_diTrp_1	558	563	PF00928	0.285
LIG_FHA_1	133	139	PF00498	0.693
LIG_FHA_1	204	210	PF00498	0.410
LIG_FHA_1	232	238	PF00498	0.525
LIG_FHA_1	246	252	PF00498	0.390
LIG_FHA_1	391	397	PF00498	0.359
LIG_FHA_1	444	450	PF00498	0.390
LIG_FHA_1	457	463	PF00498	0.382
LIG_FHA_1	551	557	PF00498	0.313
LIG_FHA_2	329	335	PF00498	0.437
LIG_FHA_2	348	354	PF00498	0.410
LIG_FHA_2	380	386	PF00498	0.411
LIG_FHA_2	433	439	PF00498	0.470
LIG_LIR_Apic_2	184	190	PF02991	0.410
LIG_LIR_Apic_2	431	437	PF02991	0.319
LIG_LIR_Gen_1	219	230	PF02991	0.410
LIG_LIR_Gen_1	301	310	PF02991	0.391
LIG_LIR_Nem_3	108	114	PF02991	0.496
LIG_LIR_Nem_3	219	225	PF02991	0.433
LIG_LIR_Nem_3	27	32	PF02991	0.417
LIG_LIR_Nem_3	301	305	PF02991	0.347
LIG_LIR_Nem_3	36	41	PF02991	0.465
LIG_LIR_Nem_3	413	418	PF02991	0.369
LIG_LIR_Nem_3	490	496	PF02991	0.349
LIG_LYPXL_SIV_4	196	204	PF13949	0.391
LIG_PDZ_Class_2	586	591	PF00595	0.445
LIG_Pex14_2	47	51	PF04695	0.383
LIG_REV1ctd_RIR_1	491	501	PF16727	0.379
LIG_SH2_CRK	111	115	PF00017	0.396
LIG_SH2_CRK	280	284	PF00017	0.327
LIG_SH2_GRB2like	450	453	PF00017	0.367
LIG_SH2_NCK_1	244	248	PF00017	0.540
LIG_SH2_NCK_1	280	284	PF00017	0.349
LIG_SH2_PTP2	222	225	PF00017	0.477
LIG_SH2_SRC	280	283	PF00017	0.342
LIG_SH2_STAP1	107	111	PF00017	0.388
LIG_SH2_STAT5	107	110	PF00017	0.450
LIG_SH2_STAT5	197	200	PF00017	0.484
LIG_SH2_STAT5	222	225	PF00017	0.410
LIG_SH2_STAT5	298	301	PF00017	0.297
LIG_SH2_STAT5	450	453	PF00017	0.367
LIG_SH3_1	279	285	PF00018	0.470
LIG_SH3_2	311	316	PF14604	0.458
LIG_SH3_3	135	141	PF00018	0.587
LIG_SH3_3	279	285	PF00018	0.494
LIG_SH3_3	308	314	PF00018	0.455
LIG_SH3_3	317	323	PF00018	0.463
LIG_SH3_3	47	53	PF00018	0.381
LIG_SH3_3	61	67	PF00018	0.289
LIG_SH3_3	83	89	PF00018	0.519
LIG_SUMO_SIM_par_1	284	293	PF11976	0.314
LIG_TRAF2_1	153	156	PF00917	0.553
LIG_TRAF2_1	159	162	PF00917	0.348
LIG_TRAF2_1	330	333	PF00917	0.438
LIG_TRAF2_1	562	565	PF00917	0.467
LIG_TRFH_1	63	67	PF08558	0.296
LIG_TYR_ITIM	109	114	PF00017	0.391
LIG_UBA3_1	492	501	PF00899	0.330
LIG_WRC_WIRS_1	98	103	PF05994	0.382
MOD_CK1_1	119	125	PF00069	0.406
MOD_CK1_1	146	152	PF00069	0.571
MOD_CK1_1	202	208	PF00069	0.461
MOD_CK1_1	245	251	PF00069	0.549
MOD_CK1_1	290	296	PF00069	0.336
MOD_CK1_1	328	334	PF00069	0.527
MOD_CK1_1	390	396	PF00069	0.394
MOD_CK1_1	433	439	PF00069	0.418
MOD_CK1_1	573	579	PF00069	0.345
MOD_CK2_1	156	162	PF00069	0.505
MOD_CK2_1	328	334	PF00069	0.487
MOD_CK2_1	379	385	PF00069	0.501
MOD_CK2_1	559	565	PF00069	0.439
MOD_CK2_1	79	85	PF00069	0.427
MOD_GlcNHglycan	127	130	PF01048	0.725
MOD_GlcNHglycan	15	18	PF01048	0.356
MOD_GlcNHglycan	201	204	PF01048	0.320
MOD_GlcNHglycan	210	213	PF01048	0.293
MOD_GlcNHglycan	226	229	PF01048	0.357
MOD_GlcNHglycan	26	29	PF01048	0.381
MOD_GlcNHglycan	389	392	PF01048	0.328
MOD_GlcNHglycan	527	530	PF01048	0.269
MOD_GlcNHglycan	81	84	PF01048	0.505
MOD_GSK3_1	115	122	PF00069	0.403
MOD_GSK3_1	143	150	PF00069	0.596
MOD_GSK3_1	156	163	PF00069	0.443
MOD_GSK3_1	199	206	PF00069	0.555
MOD_GSK3_1	208	215	PF00069	0.499
MOD_GSK3_1	324	331	PF00069	0.459
MOD_GSK3_1	402	409	PF00069	0.468
MOD_GSK3_1	428	435	PF00069	0.458
MOD_GSK3_1	457	464	PF00069	0.473
MOD_GSK3_1	468	475	PF00069	0.330
MOD_GSK3_1	538	545	PF00069	0.433
MOD_GSK3_1	85	92	PF00069	0.483
MOD_GSK3_1	97	104	PF00069	0.368
MOD_N-GLC_1	402	407	PF02516	0.407
MOD_N-GLC_1	538	543	PF02516	0.361
MOD_NEK2_1	125	130	PF00069	0.551
MOD_NEK2_1	210	215	PF00069	0.445
MOD_NEK2_1	226	231	PF00069	0.443
MOD_NEK2_1	287	292	PF00069	0.357
MOD_NEK2_1	300	305	PF00069	0.283
MOD_NEK2_1	378	383	PF00069	0.401
MOD_NEK2_1	432	437	PF00069	0.427
MOD_NEK2_1	496	501	PF00069	0.477
MOD_NEK2_1	525	530	PF00069	0.267
MOD_NEK2_1	559	564	PF00069	0.395
MOD_NEK2_2	160	165	PF00069	0.374
MOD_NEK2_2	53	58	PF00069	0.373
MOD_PIKK_1	143	149	PF00454	0.605
MOD_PIKK_1	231	237	PF00454	0.564
MOD_PIKK_1	425	431	PF00454	0.327
MOD_PKA_1	24	30	PF00069	0.386
MOD_PKA_1	74	80	PF00069	0.425
MOD_PKA_2	147	153	PF00069	0.557
MOD_PKA_2	24	30	PF00069	0.386
MOD_PKA_2	356	362	PF00069	0.575
MOD_PKA_2	425	431	PF00069	0.317
MOD_PKA_2	496	502	PF00069	0.361
MOD_PKA_2	74	80	PF00069	0.425
MOD_Plk_1	155	161	PF00069	0.622
MOD_Plk_1	218	224	PF00069	0.464
MOD_Plk_1	300	306	PF00069	0.347
MOD_Plk_1	511	517	PF00069	0.383
MOD_Plk_2-3	156	162	PF00069	0.593
MOD_Plk_2-3	461	467	PF00069	0.362
MOD_Plk_4	205	211	PF00069	0.424
MOD_Plk_4	218	224	PF00069	0.419
MOD_Plk_4	436	442	PF00069	0.369
MOD_Plk_4	487	493	PF00069	0.359
MOD_Plk_4	542	548	PF00069	0.489
MOD_Plk_4	97	103	PF00069	0.499
MOD_ProDKin_1	120	126	PF00069	0.407
MOD_ProDKin_1	186	192	PF00069	0.410
MOD_ProDKin_1	33	39	PF00069	0.380
MOD_ProDKin_1	433	439	PF00069	0.393
MOD_ProDKin_1	472	478	PF00069	0.333
MOD_ProDKin_1	85	91	PF00069	0.541
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.360
TRG_ENDOCYTIC_2	111	114	PF00928	0.394
TRG_ENDOCYTIC_2	177	180	PF00928	0.410
TRG_ENDOCYTIC_2	222	225	PF00928	0.410
TRG_ENDOCYTIC_2	280	283	PF00928	0.462
TRG_ER_diArg_1	23	26	PF00400	0.496
TRG_ER_diArg_1	267	269	PF00400	0.335
TRG_ER_diArg_1	58	60	PF00400	0.478
TRG_ER_diArg_1	582	585	PF00400	0.273
TRG_NES_CRM1_1	486	498	PF08389	0.358
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.220
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV6	Leptomonas seymouri	79%	100%
A0A0S4J9M2	Bodo saltans	49%	100%
A0A1X0NIM0	Trypanosomatidae	57%	100%
A0A3R7LDW9	Trypanosoma rangeli	60%	100%
A4HD80	Leishmania braziliensis	90%	100%
D0A6Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AH35	Leishmania infantum	100%	100%
E9AWL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O22466	Solanum lycopersicum	24%	100%
O22467	Arabidopsis thaliana	24%	100%
O22468	Arabidopsis thaliana	24%	100%
O22469	Arabidopsis thaliana	22%	100%
O22607	Arabidopsis thaliana	23%	100%
O93377	Xenopus laevis	25%	100%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P13712	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P90916	Caenorhabditis elegans	25%	100%
P90917	Caenorhabditis elegans	25%	100%
Q09028	Homo sapiens	25%	100%
Q10G81	Oryza sativa subsp. japonica	24%	100%
Q16576	Homo sapiens	24%	100%
Q24572	Drosophila melanogaster	25%	100%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	100%
Q3MHL3	Bos taurus	25%	100%
Q3SWX8	Bos taurus	24%	100%
Q4I7L0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	24%	100%
Q4P553	Ustilago maydis (strain 521 / FGSC 9021)	26%	100%
Q4QAV7	Leishmania major	98%	100%
Q4R304	Macaca fascicularis	24%	100%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q54SD4	Dictyostelium discoideum	22%	100%
Q5M7K4	Xenopus tropicalis	25%	100%
Q5R654	Pongo abelii	24%	100%
Q5RF92	Pongo abelii	25%	100%
Q60972	Mus musculus	25%	100%
Q60973	Mus musculus	24%	100%
Q61Y48	Caenorhabditis briggsae	24%	100%
Q6C7Q4	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q6INH0	Xenopus laevis	25%	100%
Q6P315	Xenopus tropicalis	24%	100%
Q6P3H7	Danio rerio	25%	100%
Q71UF4	Rattus norvegicus	24%	100%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	22%	100%
Q7ZTY4	Danio rerio	25%	100%
Q8AVH1	Xenopus laevis	25%	100%
Q9I8G9	Gallus gallus	24%	100%
Q9W7I5	Gallus gallus	25%	100%
Q9Y825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5BAV4	Trypanosoma cruzi	58%	100%