Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IME8_LEIDO

TriTrypDb:

LdBPK_331910.1 , LdCL_330025800 , LDHU3_33.2810

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IME8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IME8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.518
CLV_NRD_NRD_1	119	121	PF00675	0.656
CLV_NRD_NRD_1	354	356	PF00675	0.506
CLV_PCSK_KEX2_1	115	117	PF00082	0.532
CLV_PCSK_SKI1_1	116	120	PF00082	0.506
CLV_PCSK_SKI1_1	205	209	PF00082	0.534
CLV_PCSK_SKI1_1	3	7	PF00082	0.569
DEG_APCC_KENBOX_2	207	211	PF00400	0.623
DOC_CKS1_1	62	67	PF01111	0.505
DOC_CYCLIN_yClb5_NLxxxL_5	162	171	PF00134	0.610
DOC_MAPK_FxFP_2	122	125	PF00069	0.665
DOC_MAPK_gen_1	355	361	PF00069	0.520
DOC_MAPK_gen_1	8	16	PF00069	0.558
DOC_MAPK_MEF2A_6	11	18	PF00069	0.485
DOC_MAPK_MEF2A_6	346	353	PF00069	0.485
DOC_PP4_FxxP_1	122	125	PF00568	0.639
DOC_USP7_MATH_1	232	236	PF00917	0.548
DOC_USP7_MATH_1	78	82	PF00917	0.656
DOC_WW_Pin1_4	61	66	PF00397	0.497
LIG_14-3-3_CanoR_1	120	125	PF00244	0.550
LIG_14-3-3_CanoR_1	144	152	PF00244	0.607
LIG_14-3-3_CanoR_1	168	172	PF00244	0.614
LIG_14-3-3_CanoR_1	233	237	PF00244	0.611
LIG_Actin_WH2_2	131	146	PF00022	0.606
LIG_Actin_WH2_2	152	170	PF00022	0.596
LIG_APCC_ABBA_1	14	19	PF00400	0.497
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	215	219	PF00533	0.597
LIG_BRCT_BRCA1_1	317	321	PF00533	0.556
LIG_deltaCOP1_diTrp_1	186	190	PF00928	0.469
LIG_FHA_1	45	51	PF00498	0.644
LIG_FHA_2	159	165	PF00498	0.505
LIG_FHA_2	32	38	PF00498	0.579
LIG_FHA_2	52	58	PF00498	0.474
LIG_HCF-1_HBM_1	254	257	PF13415	0.438
LIG_HP1_1	232	236	PF01393	0.579
LIG_LIR_Apic_2	119	125	PF02991	0.642
LIG_LIR_Apic_2	147	153	PF02991	0.556
LIG_LIR_Apic_2	209	214	PF02991	0.611
LIG_LIR_Apic_2	254	260	PF02991	0.442
LIG_LIR_Apic_2	354	360	PF02991	0.582
LIG_LIR_Gen_1	242	252	PF02991	0.675
LIG_LIR_Gen_1	268	278	PF02991	0.494
LIG_LIR_Gen_1	318	329	PF02991	0.572
LIG_LIR_Nem_3	105	111	PF02991	0.590
LIG_LIR_Nem_3	130	135	PF02991	0.599
LIG_LIR_Nem_3	146	152	PF02991	0.562
LIG_LIR_Nem_3	170	176	PF02991	0.529
LIG_LIR_Nem_3	186	190	PF02991	0.590
LIG_LIR_Nem_3	224	230	PF02991	0.487
LIG_LIR_Nem_3	242	247	PF02991	0.543
LIG_LIR_Nem_3	268	273	PF02991	0.503
LIG_LIR_Nem_3	316	322	PF02991	0.624
LIG_LIR_Nem_3	47	51	PF02991	0.590
LIG_LIR_Nem_3	55	61	PF02991	0.538
LIG_LIR_Nem_3	81	85	PF02991	0.483
LIG_MLH1_MIPbox_1	317	321	PF16413	0.556
LIG_PDZ_Class_1	383	388	PF00595	0.629
LIG_Pex14_1	58	62	PF04695	0.615
LIG_Pex14_2	169	173	PF04695	0.435
LIG_REV1ctd_RIR_1	217	225	PF16727	0.637
LIG_SH2_CRK	132	136	PF00017	0.628
LIG_SH2_CRK	257	261	PF00017	0.447
LIG_SH2_CRK	357	361	PF00017	0.529
LIG_SH2_PTP2	150	153	PF00017	0.508
LIG_SH2_PTP2	211	214	PF00017	0.635
LIG_SH2_SRC	150	153	PF00017	0.508
LIG_SH2_SRC	211	214	PF00017	0.635
LIG_SH2_SRC	85	88	PF00017	0.609
LIG_SH2_STAP1	82	86	PF00017	0.525
LIG_SH2_STAT5	150	153	PF00017	0.508
LIG_SH2_STAT5	211	214	PF00017	0.518
LIG_SH2_STAT5	227	230	PF00017	0.409
LIG_SH2_STAT5	239	242	PF00017	0.654
LIG_SH2_STAT5	280	283	PF00017	0.535
LIG_SH2_STAT5	320	323	PF00017	0.439
LIG_SH2_STAT5	357	360	PF00017	0.456
LIG_SH2_STAT5	372	375	PF00017	0.448
LIG_SH2_STAT5	62	65	PF00017	0.625
LIG_SH2_STAT5	85	88	PF00017	0.510
LIG_SH3_1	62	68	PF00018	0.509
LIG_SH3_3	196	202	PF00018	0.570
LIG_SH3_3	62	68	PF00018	0.667
LIG_SUMO_SIM_par_1	335	341	PF11976	0.489
LIG_SUMO_SIM_par_1	347	352	PF11976	0.510
LIG_WRC_WIRS_1	173	178	PF05994	0.470
MOD_CK1_1	235	241	PF00069	0.655
MOD_CK2_1	158	164	PF00069	0.488
MOD_CK2_1	239	245	PF00069	0.620
MOD_CK2_1	51	57	PF00069	0.475
MOD_GlcNHglycan	199	202	PF01048	0.640
MOD_GlcNHglycan	215	218	PF01048	0.341
MOD_GlcNHglycan	241	244	PF01048	0.658
MOD_GlcNHglycan	263	266	PF01048	0.608
MOD_GlcNHglycan	75	78	PF01048	0.629
MOD_GSK3_1	116	123	PF00069	0.567
MOD_GSK3_1	175	182	PF00069	0.555
MOD_GSK3_1	235	242	PF00069	0.604
MOD_GSK3_1	261	268	PF00069	0.569
MOD_N-GLC_1	20	25	PF02516	0.509
MOD_NEK2_1	158	163	PF00069	0.462
MOD_NEK2_1	167	172	PF00069	0.456
MOD_NEK2_1	215	220	PF00069	0.563
MOD_NEK2_1	281	286	PF00069	0.542
MOD_NEK2_2	85	90	PF00069	0.616
MOD_PIKK_1	310	316	PF00454	0.646
MOD_PKA_1	120	126	PF00069	0.677
MOD_PKA_2	143	149	PF00069	0.499
MOD_PKA_2	167	173	PF00069	0.520
MOD_PKA_2	232	238	PF00069	0.595
MOD_PKA_2	7	13	PF00069	0.699
MOD_Plk_1	20	26	PF00069	0.506
MOD_Plk_1	332	338	PF00069	0.509
MOD_Plk_2-3	332	338	PF00069	0.486
MOD_Plk_4	179	185	PF00069	0.537
MOD_Plk_4	20	26	PF00069	0.543
MOD_Plk_4	215	221	PF00069	0.543
MOD_Plk_4	235	241	PF00069	0.325
MOD_Plk_4	315	321	PF00069	0.548
MOD_Plk_4	332	338	PF00069	0.491
MOD_Plk_4	344	350	PF00069	0.474
MOD_ProDKin_1	61	67	PF00069	0.502
MOD_SUMO_for_1	100	103	PF00179	0.616
TRG_DiLeu_BaEn_2	185	191	PF01217	0.436
TRG_ENDOCYTIC_2	132	135	PF00928	0.633
TRG_ENDOCYTIC_2	149	152	PF00928	0.545
TRG_ENDOCYTIC_2	319	322	PF00928	0.467
TRG_ER_diArg_1	114	116	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM57	Leptomonas seymouri	67%	95%
A0A0S4JGX9	Bodo saltans	38%	100%
A0A1X0P3L5	Trypanosomatidae	50%	100%
A0A422N3E6	Trypanosoma rangeli	49%	97%
A4HLP1	Leishmania braziliensis	85%	100%
A4I976	Leishmania infantum	100%	100%
D0A6D2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9B417	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q407	Leishmania major	95%	100%
V5BTX0	Trypanosoma cruzi	48%	100%