Cilia- and flagella-associated protein 53

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor, Mitostatin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IMD7_LEIDO

TriTrypDb:

LdBPK_231850.1 , LdCL_230025600 , LDHU3_23.2430

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IMD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMD7

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.535
CLV_C14_Caspase3-7	286	290	PF00656	0.482
CLV_NRD_NRD_1	100	102	PF00675	0.425
CLV_NRD_NRD_1	105	107	PF00675	0.411
CLV_NRD_NRD_1	16	18	PF00675	0.459
CLV_NRD_NRD_1	165	167	PF00675	0.241
CLV_NRD_NRD_1	199	201	PF00675	0.293
CLV_NRD_NRD_1	217	219	PF00675	0.182
CLV_NRD_NRD_1	227	229	PF00675	0.231
CLV_NRD_NRD_1	245	247	PF00675	0.212
CLV_NRD_NRD_1	308	310	PF00675	0.271
CLV_NRD_NRD_1	345	347	PF00675	0.346
CLV_NRD_NRD_1	370	372	PF00675	0.271
CLV_NRD_NRD_1	387	389	PF00675	0.278
CLV_NRD_NRD_1	412	414	PF00675	0.265
CLV_NRD_NRD_1	73	75	PF00675	0.418
CLV_PCSK_FUR_1	112	116	PF00082	0.547
CLV_PCSK_FUR_1	14	18	PF00082	0.495
CLV_PCSK_FUR_1	200	204	PF00082	0.356
CLV_PCSK_FUR_1	33	37	PF00082	0.468
CLV_PCSK_FUR_1	410	414	PF00082	0.256
CLV_PCSK_FUR_1	71	75	PF00082	0.460
CLV_PCSK_KEX2_1	100	102	PF00082	0.425
CLV_PCSK_KEX2_1	114	116	PF00082	0.407
CLV_PCSK_KEX2_1	119	121	PF00082	0.412
CLV_PCSK_KEX2_1	16	18	PF00082	0.459
CLV_PCSK_KEX2_1	164	166	PF00082	0.251
CLV_PCSK_KEX2_1	202	204	PF00082	0.342
CLV_PCSK_KEX2_1	227	229	PF00082	0.268
CLV_PCSK_KEX2_1	247	249	PF00082	0.198
CLV_PCSK_KEX2_1	270	272	PF00082	0.229
CLV_PCSK_KEX2_1	308	310	PF00082	0.261
CLV_PCSK_KEX2_1	347	349	PF00082	0.251
CLV_PCSK_KEX2_1	35	37	PF00082	0.357
CLV_PCSK_KEX2_1	358	360	PF00082	0.298
CLV_PCSK_KEX2_1	370	372	PF00082	0.260
CLV_PCSK_KEX2_1	377	379	PF00082	0.229
CLV_PCSK_KEX2_1	412	414	PF00082	0.252
CLV_PCSK_KEX2_1	442	444	PF00082	0.262
CLV_PCSK_KEX2_1	71	73	PF00082	0.417
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.480
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.459
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.304
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.278
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.335
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.242
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.559
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.243
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.241
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.319
CLV_PCSK_PC7_1	115	121	PF00082	0.554
CLV_PCSK_SKI1_1	184	188	PF00082	0.335
CLV_PCSK_SKI1_1	285	289	PF00082	0.242
CLV_PCSK_SKI1_1	330	334	PF00082	0.246
CLV_PCSK_SKI1_1	364	368	PF00082	0.279
CLV_PCSK_SKI1_1	413	417	PF00082	0.302
CLV_PCSK_SKI1_1	439	443	PF00082	0.296
CLV_PCSK_SKI1_1	51	55	PF00082	0.556
DEG_APCC_DBOX_1	71	79	PF00400	0.394
DEG_APCC_KENBOX_2	222	226	PF00400	0.511
DOC_CDC14_PxL_1	475	483	PF14671	0.420
DOC_MAPK_gen_1	471	480	PF00069	0.409
DOC_PP1_RVXF_1	245	252	PF00149	0.353
DOC_PP1_RVXF_1	34	41	PF00149	0.454
DOC_PP1_RVXF_1	346	353	PF00149	0.431
DOC_USP7_MATH_1	470	474	PF00917	0.348
DOC_USP7_UBL2_3	219	223	PF12436	0.478
DOC_USP7_UBL2_3	281	285	PF12436	0.446
DOC_USP7_UBL2_3	343	347	PF12436	0.442
LIG_14-3-3_CanoR_1	33	39	PF00244	0.582
LIG_Actin_WH2_2	255	272	PF00022	0.535
LIG_deltaCOP1_diTrp_1	342	352	PF00928	0.446
LIG_eIF4E_1	475	481	PF01652	0.413
LIG_FHA_2	185	191	PF00498	0.431
LIG_FHA_2	27	33	PF00498	0.589
LIG_LIR_Gen_1	152	162	PF02991	0.535
LIG_LIR_Gen_1	276	284	PF02991	0.433
LIG_LIR_Nem_3	230	236	PF02991	0.475
LIG_LIR_Nem_3	276	280	PF02991	0.433
LIG_LIR_Nem_3	473	478	PF02991	0.406
LIG_NRBOX	74	80	PF00104	0.448
LIG_PCNA_yPIPBox_3	43	57	PF02747	0.554
LIG_Pex14_2	20	24	PF04695	0.508
LIG_RPA_C_Plants	303	314	PF08784	0.439
LIG_SH2_CRK	234	238	PF00017	0.535
LIG_SH2_STAP1	175	179	PF00017	0.478
LIG_SH2_STAP1	456	460	PF00017	0.474
LIG_SH2_STAT3	175	178	PF00017	0.535
LIG_SH2_STAT5	423	426	PF00017	0.477
LIG_SH3_1	476	482	PF00018	0.391
LIG_SH3_2	479	484	PF14604	0.439
LIG_SH3_3	476	482	PF00018	0.391
LIG_TRAF2_1	29	32	PF00917	0.481
LIG_TYR_ITIM	54	59	PF00017	0.470
LIG_UBA3_1	262	270	PF00899	0.411
LIG_UBA3_1	317	322	PF00899	0.287
LIG_UBA3_1	386	394	PF00899	0.287
MOD_CK1_1	88	94	PF00069	0.528
MOD_CK2_1	16	22	PF00069	0.413
MOD_CK2_1	184	190	PF00069	0.210
MOD_CK2_1	26	32	PF00069	0.528
MOD_CK2_1	6	12	PF00069	0.610
MOD_CK2_1	89	95	PF00069	0.490
MOD_GSK3_1	84	91	PF00069	0.503
MOD_NEK2_1	395	400	PF00069	0.360
MOD_NEK2_1	417	422	PF00069	0.377
MOD_NEK2_1	85	90	PF00069	0.581
MOD_PIKK_1	417	423	PF00454	0.333
MOD_PKA_1	16	22	PF00069	0.502
MOD_PKA_1	227	233	PF00069	0.287
MOD_PKA_1	358	364	PF00069	0.393
MOD_PKA_2	16	22	PF00069	0.576
MOD_PKA_2	227	233	PF00069	0.331
MOD_PKA_2	358	364	PF00069	0.364
MOD_PKB_1	14	22	PF00069	0.514
MOD_Plk_4	16	22	PF00069	0.480
MOD_Plk_4	358	364	PF00069	0.393
MOD_Plk_4	85	91	PF00069	0.536
MOD_SUMO_for_1	113	116	PF00179	0.410
MOD_SUMO_for_1	280	283	PF00179	0.439
MOD_SUMO_rev_2	116	121	PF00179	0.562
MOD_SUMO_rev_2	264	272	PF00179	0.392
MOD_SUMO_rev_2	278	287	PF00179	0.298
MOD_SUMO_rev_2	391	396	PF00179	0.451
MOD_SUMO_rev_2	46	53	PF00179	0.484
TRG_DiLeu_BaEn_1	232	237	PF01217	0.411
TRG_DiLeu_BaEn_1	49	54	PF01217	0.414
TRG_DiLeu_BaEn_2	390	396	PF01217	0.302
TRG_DiLeu_BaEn_4	116	122	PF01217	0.425
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.433
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.417
TRG_DiLeu_LyEn_5	232	237	PF01217	0.411
TRG_ENDOCYTIC_2	155	158	PF00928	0.331
TRG_ENDOCYTIC_2	234	237	PF00928	0.411
TRG_ENDOCYTIC_2	277	280	PF00928	0.266
TRG_ENDOCYTIC_2	475	478	PF00928	0.477
TRG_ENDOCYTIC_2	56	59	PF00928	0.552
TRG_ER_diArg_1	14	17	PF00400	0.480
TRG_ER_diArg_1	164	166	PF00400	0.329
TRG_ER_diArg_1	246	249	PF00400	0.364
TRG_ER_diArg_1	308	310	PF00400	0.388
TRG_ER_diArg_1	345	348	PF00400	0.380
TRG_ER_diArg_1	412	414	PF00400	0.300
TRG_ER_diArg_1	71	74	PF00400	0.417
TRG_NLS_MonoCore_2	199	204	PF00514	0.210
TRG_NLS_MonoExtN_4	200	205	PF00514	0.248
TRG_NLS_MonoExtN_4	482	487	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD5	Leptomonas seymouri	72%	100%
A0A0S4IRE4	Bodo saltans	38%	99%
A0A1X0NWN4	Trypanosomatidae	49%	100%
A0A422NJE4	Trypanosoma rangeli	49%	100%
A4HD29	Leishmania braziliensis	85%	100%
A4I0L6	Leishmania infantum	100%	100%
C9ZNQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AWH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QAZ3	Leishmania major	95%	100%
V5D760	Trypanosoma cruzi	50%	100%