Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMC4_LEIDO

TriTrypDb:

LdBPK_352620.1 , LdCL_350031100 , LDHU3_35.3380

Length:

190

Annotations

LeishMANIAdb annotations

Might be an organellar (mitochondrial) protein with transit signal. Localization: Mitochondrial (by feature)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IMC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.686
CLV_NRD_NRD_1	35	37	PF00675	0.811
CLV_PCSK_KEX2_1	10	12	PF00082	0.686
CLV_PCSK_KEX2_1	125	127	PF00082	0.431
CLV_PCSK_KEX2_1	35	37	PF00082	0.811
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.431
CLV_PCSK_SKI1_1	176	180	PF00082	0.410
CLV_PCSK_SKI1_1	98	102	PF00082	0.528
DEG_APCC_DBOX_1	2	10	PF00400	0.416
DEG_Nend_UBRbox_3	1	3	PF02207	0.545
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.498
DOC_PP1_RVXF_1	157	164	PF00149	0.637
DOC_PP1_RVXF_1	95	102	PF00149	0.449
DOC_PP2B_LxvP_1	20	23	PF13499	0.498
DOC_PP2B_LxvP_1	31	34	PF13499	0.387
DOC_USP7_MATH_1	180	184	PF00917	0.667
DOC_USP7_MATH_1	45	49	PF00917	0.577
DOC_USP7_MATH_1	56	60	PF00917	0.468
DOC_WW_Pin1_4	25	30	PF00397	0.496
DOC_WW_Pin1_4	40	45	PF00397	0.438
DOC_WW_Pin1_4	51	56	PF00397	0.539
LIG_14-3-3_CanoR_1	10	17	PF00244	0.555
LIG_BIR_III_2	131	135	PF00653	0.709
LIG_FHA_1	91	97	PF00498	0.442
LIG_FHA_2	165	171	PF00498	0.632
LIG_LIR_Gen_1	171	181	PF02991	0.584
LIG_LIR_LC3C_4	28	33	PF02991	0.502
LIG_LIR_Nem_3	171	177	PF02991	0.587
LIG_SH2_NCK_1	174	178	PF00017	0.588
LIG_SH2_STAP1	174	178	PF00017	0.588
LIG_SH2_STAT5	154	157	PF00017	0.654
LIG_SH3_3	133	139	PF00018	0.769
LIG_SH3_3	52	58	PF00018	0.558
LIG_TRAF2_1	167	170	PF00917	0.619
LIG_TYR_ITIM	172	177	PF00017	0.587
MOD_CDC14_SPxK_1	54	57	PF00782	0.531
MOD_CDK_SPxK_1	51	57	PF00069	0.534
MOD_CK1_1	25	31	PF00069	0.495
MOD_CK1_1	40	46	PF00069	0.408
MOD_CK1_1	90	96	PF00069	0.480
MOD_CK2_1	164	170	PF00069	0.631
MOD_CK2_1	36	42	PF00069	0.560
MOD_GlcNHglycan	12	15	PF01048	0.648
MOD_GlcNHglycan	47	50	PF01048	0.692
MOD_GlcNHglycan	58	61	PF01048	0.708
MOD_GlcNHglycan	6	9	PF01048	0.699
MOD_GSK3_1	36	43	PF00069	0.587
MOD_GSK3_1	45	52	PF00069	0.495
MOD_NEK2_1	4	9	PF00069	0.523
MOD_PIKK_1	148	154	PF00454	0.656
MOD_PIKK_1	180	186	PF00454	0.668
MOD_PIKK_1	61	67	PF00454	0.577
MOD_PKA_1	10	16	PF00069	0.542
MOD_PKA_2	9	15	PF00069	0.511
MOD_Plk_1	36	42	PF00069	0.526
MOD_Plk_2-3	164	170	PF00069	0.623
MOD_Plk_2-3	37	43	PF00069	0.470
MOD_ProDKin_1	25	31	PF00069	0.498
MOD_ProDKin_1	40	46	PF00069	0.442
MOD_ProDKin_1	51	57	PF00069	0.541
TRG_ENDOCYTIC_2	174	177	PF00928	0.590
TRG_ER_diArg_1	34	36	PF00400	0.602
TRG_ER_diArg_1	9	11	PF00400	0.487
TRG_NLS_MonoCore_2	121	126	PF00514	0.637
TRG_NLS_MonoExtC_3	121	126	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R4	Leptomonas seymouri	57%	100%
A4IBG7	Leishmania infantum	100%	100%
E9AF81	Leishmania major	94%	100%
E9AIW4	Leishmania braziliensis	65%	100%
E9B6D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%