Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMB7_LEIDO

TriTrypDb:

LdBPK_231620.1 , LdCL_230023400 , LDHU3_23.2150

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IMB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.355
CLV_MEL_PAP_1	337	343	PF00089	0.374
CLV_NRD_NRD_1	147	149	PF00675	0.652
CLV_NRD_NRD_1	186	188	PF00675	0.613
CLV_NRD_NRD_1	233	235	PF00675	0.368
CLV_NRD_NRD_1	3	5	PF00675	0.682
CLV_NRD_NRD_1	326	328	PF00675	0.327
CLV_NRD_NRD_1	99	101	PF00675	0.660
CLV_PCSK_FUR_1	324	328	PF00082	0.383
CLV_PCSK_KEX2_1	3	5	PF00082	0.682
CLV_PCSK_KEX2_1	326	328	PF00082	0.327
CLV_PCSK_KEX2_1	99	101	PF00082	0.686
CLV_PCSK_SKI1_1	187	191	PF00082	0.663
CLV_PCSK_SKI1_1	235	239	PF00082	0.418
CLV_PCSK_SKI1_1	288	292	PF00082	0.477
CLV_PCSK_SKI1_1	364	368	PF00082	0.530
DEG_SPOP_SBC_1	10	14	PF00917	0.726
DOC_CKS1_1	274	279	PF01111	0.663
DOC_PP1_RVXF_1	367	373	PF00149	0.728
DOC_PP2B_LxvP_1	7	10	PF13499	0.557
DOC_PP4_FxxP_1	257	260	PF00568	0.640
DOC_PP4_FxxP_1	274	277	PF00568	0.633
DOC_PP4_FxxP_1	33	36	PF00568	0.518
DOC_USP7_MATH_1	10	14	PF00917	0.730
DOC_USP7_MATH_1	302	306	PF00917	0.681
DOC_USP7_MATH_1	336	340	PF00917	0.681
DOC_USP7_MATH_1	355	359	PF00917	0.628
DOC_USP7_UBL2_3	122	126	PF12436	0.402
DOC_WW_Pin1_4	102	107	PF00397	0.490
DOC_WW_Pin1_4	273	278	PF00397	0.609
LIG_14-3-3_CanoR_1	3	8	PF00244	0.638
LIG_14-3-3_CanoR_1	340	344	PF00244	0.734
LIG_14-3-3_CanoR_1	42	47	PF00244	0.511
LIG_14-3-3_CanoR_1	57	63	PF00244	0.356
LIG_APCC_ABBA_1	317	322	PF00400	0.662
LIG_BRCT_BRCA1_1	249	253	PF00533	0.646
LIG_FHA_1	12	18	PF00498	0.657
LIG_FHA_1	164	170	PF00498	0.428
LIG_FHA_1	3	9	PF00498	0.640
LIG_FHA_1	398	404	PF00498	0.713
LIG_FHA_2	139	145	PF00498	0.442
LIG_FHA_2	236	242	PF00498	0.581
LIG_FHA_2	363	369	PF00498	0.713
LIG_FHA_2	47	53	PF00498	0.484
LIG_Integrin_isoDGR_2	286	288	PF01839	0.438
LIG_LIR_Apic_2	256	260	PF02991	0.697
LIG_LIR_Apic_2	271	277	PF02991	0.704
LIG_LIR_Gen_1	107	115	PF02991	0.493
LIG_LIR_Gen_1	365	375	PF02991	0.651
LIG_LIR_Gen_1	387	395	PF02991	0.636
LIG_LIR_Gen_1	83	94	PF02991	0.457
LIG_LIR_Nem_3	107	112	PF02991	0.505
LIG_LIR_Nem_3	365	370	PF02991	0.654
LIG_LIR_Nem_3	371	375	PF02991	0.600
LIG_LIR_Nem_3	387	392	PF02991	0.615
LIG_LIR_Nem_3	83	89	PF02991	0.403
LIG_MLH1_MIPbox_1	249	253	PF16413	0.646
LIG_NBox_RRM_1	216	226	PF00076	0.449
LIG_Pex14_2	253	257	PF04695	0.677
LIG_SH2_GRB2like	273	276	PF00017	0.708
LIG_SH2_SRC	172	175	PF00017	0.355
LIG_SH2_STAP1	232	236	PF00017	0.657
LIG_SH2_STAP1	289	293	PF00017	0.617
LIG_SH2_STAT3	289	292	PF00017	0.707
LIG_SH2_STAT3	308	311	PF00017	0.474
LIG_SH2_STAT5	172	175	PF00017	0.355
LIG_SH2_STAT5	178	181	PF00017	0.410
LIG_SH2_STAT5	236	239	PF00017	0.613
LIG_SH2_STAT5	252	255	PF00017	0.509
LIG_SH2_STAT5	273	276	PF00017	0.650
LIG_SH2_STAT5	308	311	PF00017	0.613
LIG_SH2_STAT5	344	347	PF00017	0.712
LIG_SH3_3	24	30	PF00018	0.728
LIG_SH3_3	340	346	PF00018	0.709
LIG_SH3_5	265	269	PF00018	0.626
LIG_TRAF2_1	157	160	PF00917	0.458
LIG_TRAF2_1	295	298	PF00917	0.649
LIG_TRAF2_1	371	374	PF00917	0.666
LIG_UBA3_1	55	63	PF00899	0.534
LIG_WRC_WIRS_1	254	259	PF05994	0.687
LIG_WRC_WIRS_1	86	91	PF05994	0.447
MOD_CK1_1	339	345	PF00069	0.736
MOD_CK1_1	358	364	PF00069	0.719
MOD_CK1_1	397	403	PF00069	0.705
MOD_CK2_1	138	144	PF00069	0.380
MOD_CK2_1	275	281	PF00069	0.661
MOD_CK2_1	292	298	PF00069	0.572
MOD_CK2_1	362	368	PF00069	0.731
MOD_CK2_1	395	401	PF00069	0.724
MOD_GlcNHglycan	294	297	PF01048	0.437
MOD_GlcNHglycan	303	307	PF01048	0.442
MOD_GlcNHglycan	33	36	PF01048	0.764
MOD_GlcNHglycan	374	378	PF01048	0.483
MOD_GlcNHglycan	411	414	PF01048	0.551
MOD_GlcNHglycan	73	76	PF01048	0.745
MOD_GSK3_1	355	362	PF00069	0.765
MOD_GSK3_1	390	397	PF00069	0.710
MOD_GSK3_1	42	49	PF00069	0.483
MOD_GSK3_1	66	73	PF00069	0.567
MOD_N-GLC_1	208	213	PF02516	0.653
MOD_NEK2_1	11	16	PF00069	0.663
MOD_NEK2_1	138	143	PF00069	0.476
MOD_NEK2_1	173	178	PF00069	0.458
MOD_NEK2_1	253	258	PF00069	0.629
MOD_NEK2_1	378	383	PF00069	0.608
MOD_NEK2_1	46	51	PF00069	0.474
MOD_NEK2_1	58	63	PF00069	0.512
MOD_PKA_1	100	106	PF00069	0.512
MOD_PKA_1	3	9	PF00069	0.689
MOD_PKA_2	2	8	PF00069	0.680
MOD_PKA_2	339	345	PF00069	0.646
MOD_PKA_2	358	364	PF00069	0.777
MOD_PKA_2	390	396	PF00069	0.645
MOD_PKB_1	206	214	PF00069	0.456
MOD_PKB_1	357	365	PF00069	0.620
MOD_PKB_1	407	415	PF00069	0.692
MOD_Plk_1	173	179	PF00069	0.387
MOD_Plk_1	208	214	PF00069	0.359
MOD_Plk_1	362	368	PF00069	0.690
MOD_Plk_1	51	57	PF00069	0.518
MOD_Plk_2-3	368	374	PF00069	0.706
MOD_Plk_4	173	179	PF00069	0.439
MOD_Plk_4	208	214	PF00069	0.330
MOD_Plk_4	253	259	PF00069	0.649
MOD_Plk_4	3	9	PF00069	0.731
MOD_Plk_4	339	345	PF00069	0.712
MOD_Plk_4	51	57	PF00069	0.493
MOD_Plk_4	85	91	PF00069	0.450
MOD_ProDKin_1	102	108	PF00069	0.487
MOD_ProDKin_1	273	279	PF00069	0.608
MOD_SUMO_for_1	130	133	PF00179	0.465
MOD_SUMO_for_1	309	312	PF00179	0.517
MOD_SUMO_rev_2	114	124	PF00179	0.429
MOD_SUMO_rev_2	330	337	PF00179	0.668
TRG_DiLeu_BaEn_4	133	139	PF01217	0.460
TRG_DiLeu_BaEn_4	312	318	PF01217	0.582
TRG_ENDOCYTIC_2	186	189	PF00928	0.449
TRG_ENDOCYTIC_2	252	255	PF00928	0.566
TRG_ER_diArg_1	326	329	PF00400	0.526
TRG_ER_diArg_1	98	100	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S8	Leptomonas seymouri	66%	98%
A0A0S4IRC9	Bodo saltans	36%	100%
A0A1X0NWQ4	Trypanosomatidae	45%	97%
A0A422NXY7	Trypanosoma rangeli	44%	100%
A4HD09	Leishmania braziliensis	78%	100%
A4I0J5	Leishmania infantum	100%	100%
C9ZVC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AWF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QB16	Leishmania major	94%	100%
V5BJ93	Trypanosoma cruzi	43%	99%