SET domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IMA4_LEIDO

TriTrypDb:

LdBPK_352420.1 , LdCL_350029100 , LDHU3_35.3080

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IMA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IMA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.605
CLV_C14_Caspase3-7	295	299	PF00656	0.486
CLV_C14_Caspase3-7	422	426	PF00656	0.612
CLV_C14_Caspase3-7	591	595	PF00656	0.708
CLV_C14_Caspase3-7	772	776	PF00656	0.531
CLV_NRD_NRD_1	13	15	PF00675	0.571
CLV_NRD_NRD_1	136	138	PF00675	0.434
CLV_NRD_NRD_1	646	648	PF00675	0.530
CLV_NRD_NRD_1	653	655	PF00675	0.531
CLV_NRD_NRD_1	703	705	PF00675	0.433
CLV_PCSK_FUR_1	416	420	PF00082	0.656
CLV_PCSK_FUR_1	502	506	PF00082	0.573
CLV_PCSK_FUR_1	700	704	PF00082	0.337
CLV_PCSK_KEX2_1	13	15	PF00082	0.612
CLV_PCSK_KEX2_1	136	138	PF00082	0.434
CLV_PCSK_KEX2_1	418	420	PF00082	0.601
CLV_PCSK_KEX2_1	504	506	PF00082	0.704
CLV_PCSK_KEX2_1	645	647	PF00082	0.531
CLV_PCSK_KEX2_1	653	655	PF00082	0.531
CLV_PCSK_KEX2_1	702	704	PF00082	0.403
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.666
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.603
CLV_PCSK_SKI1_1	13	17	PF00082	0.479
CLV_PCSK_SKI1_1	33	37	PF00082	0.294
CLV_PCSK_SKI1_1	403	407	PF00082	0.533
CLV_PCSK_SKI1_1	421	425	PF00082	0.579
CLV_PCSK_SKI1_1	451	455	PF00082	0.576
CLV_PCSK_SKI1_1	505	509	PF00082	0.647
CLV_PCSK_SKI1_1	653	657	PF00082	0.519
CLV_PCSK_SKI1_1	694	698	PF00082	0.373
DEG_APCC_DBOX_1	169	177	PF00400	0.607
DEG_APCC_DBOX_1	601	609	PF00400	0.642
DEG_APCC_DBOX_1	644	652	PF00400	0.514
DEG_Nend_UBRbox_2	1	3	PF02207	0.439
DEG_SPOP_SBC_1	343	347	PF00917	0.657
DEG_SPOP_SBC_1	358	362	PF00917	0.542
DOC_CDC14_PxL_1	527	535	PF14671	0.647
DOC_CKS1_1	522	527	PF01111	0.598
DOC_CKS1_1	59	64	PF01111	0.376
DOC_CYCLIN_RxL_1	647	657	PF00134	0.516
DOC_CYCLIN_yClb1_LxF_4	552	557	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	689	695	PF00134	0.390
DOC_MAPK_gen_1	170	179	PF00069	0.545
DOC_MAPK_gen_1	733	741	PF00069	0.444
DOC_MAPK_MEF2A_6	733	741	PF00069	0.380
DOC_MAPK_RevD_3	1	14	PF00069	0.421
DOC_PP2B_LxvP_1	689	692	PF13499	0.404
DOC_PP4_FxxP_1	695	698	PF00568	0.370
DOC_USP7_MATH_1	132	136	PF00917	0.565
DOC_USP7_MATH_1	178	182	PF00917	0.624
DOC_USP7_MATH_1	190	194	PF00917	0.568
DOC_USP7_MATH_1	205	209	PF00917	0.697
DOC_USP7_MATH_1	214	218	PF00917	0.599
DOC_USP7_MATH_1	226	230	PF00917	0.612
DOC_USP7_MATH_1	232	236	PF00917	0.774
DOC_USP7_MATH_1	237	241	PF00917	0.602
DOC_USP7_MATH_1	242	246	PF00917	0.596
DOC_USP7_MATH_1	344	348	PF00917	0.697
DOC_USP7_MATH_1	358	362	PF00917	0.511
DOC_USP7_MATH_1	394	398	PF00917	0.542
DOC_USP7_MATH_1	426	430	PF00917	0.643
DOC_USP7_MATH_1	444	448	PF00917	0.578
DOC_USP7_MATH_1	497	501	PF00917	0.642
DOC_USP7_MATH_1	545	549	PF00917	0.594
DOC_USP7_MATH_1	562	566	PF00917	0.543
DOC_USP7_MATH_1	586	590	PF00917	0.606
DOC_USP7_MATH_1	624	628	PF00917	0.604
DOC_USP7_MATH_1	633	637	PF00917	0.460
DOC_USP7_MATH_1	684	688	PF00917	0.450
DOC_USP7_MATH_1	773	777	PF00917	0.668
DOC_USP7_MATH_1	786	790	PF00917	0.437
DOC_WW_Pin1_4	155	160	PF00397	0.513
DOC_WW_Pin1_4	194	199	PF00397	0.671
DOC_WW_Pin1_4	305	310	PF00397	0.460
DOC_WW_Pin1_4	319	324	PF00397	0.486
DOC_WW_Pin1_4	345	350	PF00397	0.635
DOC_WW_Pin1_4	521	526	PF00397	0.620
DOC_WW_Pin1_4	538	543	PF00397	0.500
DOC_WW_Pin1_4	548	553	PF00397	0.519
DOC_WW_Pin1_4	58	63	PF00397	0.367
DOC_WW_Pin1_4	627	632	PF00397	0.605
DOC_WW_Pin1_4	635	640	PF00397	0.489
DOC_WW_Pin1_4	714	719	PF00397	0.530
DOC_WW_Pin1_4	800	805	PF00397	0.471
LIG_14-3-3_CanoR_1	154	161	PF00244	0.514
LIG_14-3-3_CanoR_1	252	258	PF00244	0.555
LIG_14-3-3_CanoR_1	315	320	PF00244	0.494
LIG_14-3-3_CanoR_1	33	38	PF00244	0.419
LIG_14-3-3_CanoR_1	419	424	PF00244	0.726
LIG_14-3-3_CanoR_1	602	608	PF00244	0.601
LIG_14-3-3_CanoR_1	683	693	PF00244	0.442
LIG_14-3-3_CanoR_1	736	740	PF00244	0.447
LIG_14-3-3_CanoR_1	77	82	PF00244	0.423
LIG_BIR_III_4	425	429	PF00653	0.625
LIG_BIR_III_4	799	803	PF00653	0.445
LIG_BRCT_BRCA1_1	361	365	PF00533	0.668
LIG_CaM_IQ_9	609	625	PF13499	0.645
LIG_deltaCOP1_diTrp_1	371	378	PF00928	0.577
LIG_DLG_GKlike_1	126	133	PF00625	0.449
LIG_eIF4E_1	24	30	PF01652	0.387
LIG_eIF4E_1	43	49	PF01652	0.398
LIG_FHA_1	129	135	PF00498	0.411
LIG_FHA_1	182	188	PF00498	0.606
LIG_FHA_1	306	312	PF00498	0.472
LIG_FHA_1	522	528	PF00498	0.780
LIG_FHA_1	610	616	PF00498	0.631
LIG_FHA_1	650	656	PF00498	0.513
LIG_FHA_2	568	574	PF00498	0.552
LIG_FHA_2	609	615	PF00498	0.739
LIG_FHA_2	727	733	PF00498	0.439
LIG_Integrin_RGD_1	677	679	PF01839	0.429
LIG_LIR_Apic_2	256	260	PF02991	0.544
LIG_LIR_Gen_1	128	134	PF02991	0.450
LIG_LIR_Gen_1	158	168	PF02991	0.501
LIG_LIR_Gen_1	583	588	PF02991	0.581
LIG_LIR_Gen_1	64	71	PF02991	0.436
LIG_LIR_LC3C_4	616	620	PF02991	0.593
LIG_LIR_LC3C_4	738	741	PF02991	0.374
LIG_LIR_Nem_3	128	133	PF02991	0.456
LIG_LIR_Nem_3	158	163	PF02991	0.486
LIG_LIR_Nem_3	583	587	PF02991	0.575
LIG_LIR_Nem_3	61	66	PF02991	0.388
LIG_LIR_Nem_3	80	86	PF02991	0.482
LIG_MYND_3	555	559	PF01753	0.606
LIG_NRBOX	315	321	PF00104	0.488
LIG_Pex14_2	66	70	PF04695	0.440
LIG_SH2_STAP1	779	783	PF00017	0.512
LIG_SH2_STAP1	90	94	PF00017	0.374
LIG_SH2_STAT3	637	640	PF00017	0.614
LIG_SH2_STAT5	408	411	PF00017	0.579
LIG_SH2_STAT5	607	610	PF00017	0.788
LIG_SH2_STAT5	669	672	PF00017	0.445
LIG_SH2_STAT5	747	750	PF00017	0.487
LIG_SH2_STAT5	79	82	PF00017	0.430
LIG_SH3_3	174	180	PF00018	0.516
LIG_SH3_3	35	41	PF00018	0.430
LIG_SH3_3	374	380	PF00018	0.563
LIG_SH3_3	430	436	PF00018	0.643
LIG_SH3_CIN85_PxpxPR_1	265	270	PF14604	0.546
LIG_Sin3_3	543	550	PF02671	0.486
LIG_SUMO_SIM_anti_2	516	524	PF11976	0.651
LIG_SUMO_SIM_anti_2	616	622	PF11976	0.648
LIG_SUMO_SIM_anti_2	735	742	PF11976	0.390
LIG_SUMO_SIM_par_1	315	322	PF11976	0.495
LIG_SUMO_SIM_par_1	751	756	PF11976	0.520
LIG_SUMO_SIM_par_1	794	799	PF11976	0.351
LIG_SxIP_EBH_1	51	60	PF03271	0.382
LIG_TRAF2_1	141	144	PF00917	0.468
LIG_TRAF2_1	25	28	PF00917	0.396
LIG_TRAF2_1	611	614	PF00917	0.594
LIG_TRAF2_2	380	385	PF00917	0.535
LIG_TRFH_1	695	699	PF08558	0.397
LIG_WRC_WIRS_1	179	184	PF05994	0.619
LIG_WRC_WIRS_1	581	586	PF05994	0.534
LIG_WRC_WIRS_1	727	732	PF05994	0.443
LIG_WW_3	697	701	PF00397	0.403
MOD_CDC14_SPxK_1	551	554	PF00782	0.643
MOD_CDK_SPK_2	305	310	PF00069	0.460
MOD_CDK_SPxK_1	548	554	PF00069	0.646
MOD_CK1_1	181	187	PF00069	0.601
MOD_CK1_1	188	194	PF00069	0.573
MOD_CK1_1	208	214	PF00069	0.620
MOD_CK1_1	235	241	PF00069	0.583
MOD_CK1_1	318	324	PF00069	0.489
MOD_CK1_1	342	348	PF00069	0.615
MOD_CK1_1	367	373	PF00069	0.686
MOD_CK1_1	429	435	PF00069	0.616
MOD_CK1_1	500	506	PF00069	0.691
MOD_CK1_1	535	541	PF00069	0.595
MOD_CK1_1	548	554	PF00069	0.557
MOD_CK1_1	569	575	PF00069	0.648
MOD_CK1_1	589	595	PF00069	0.641
MOD_CK1_1	627	633	PF00069	0.585
MOD_CK1_1	714	720	PF00069	0.550
MOD_CK1_1	73	79	PF00069	0.460
MOD_CK2_1	235	241	PF00069	0.611
MOD_CK2_1	287	293	PF00069	0.432
MOD_CK2_1	394	400	PF00069	0.541
MOD_CK2_1	568	574	PF00069	0.587
MOD_CK2_1	608	614	PF00069	0.635
MOD_CK2_1	684	690	PF00069	0.483
MOD_CMANNOS	381	384	PF00535	0.530
MOD_GlcNHglycan	117	120	PF01048	0.402
MOD_GlcNHglycan	155	158	PF01048	0.524
MOD_GlcNHglycan	187	190	PF01048	0.737
MOD_GlcNHglycan	194	197	PF01048	0.621
MOD_GlcNHglycan	207	210	PF01048	0.695
MOD_GlcNHglycan	228	231	PF01048	0.763
MOD_GlcNHglycan	235	238	PF01048	0.559
MOD_GlcNHglycan	245	248	PF01048	0.526
MOD_GlcNHglycan	257	260	PF01048	0.554
MOD_GlcNHglycan	311	314	PF01048	0.519
MOD_GlcNHglycan	341	344	PF01048	0.628
MOD_GlcNHglycan	354	357	PF01048	0.667
MOD_GlcNHglycan	428	431	PF01048	0.619
MOD_GlcNHglycan	494	497	PF01048	0.662
MOD_GlcNHglycan	499	502	PF01048	0.709
MOD_GlcNHglycan	537	540	PF01048	0.618
MOD_GlcNHglycan	547	550	PF01048	0.586
MOD_GlcNHglycan	562	565	PF01048	0.554
MOD_GlcNHglycan	626	629	PF01048	0.610
MOD_GlcNHglycan	63	66	PF01048	0.408
MOD_GlcNHglycan	713	716	PF01048	0.671
MOD_GlcNHglycan	768	772	PF01048	0.628
MOD_GSK3_1	128	135	PF00069	0.448
MOD_GSK3_1	181	188	PF00069	0.740
MOD_GSK3_1	190	197	PF00069	0.668
MOD_GSK3_1	226	233	PF00069	0.774
MOD_GSK3_1	255	262	PF00069	0.590
MOD_GSK3_1	305	312	PF00069	0.480
MOD_GSK3_1	315	322	PF00069	0.552
MOD_GSK3_1	335	342	PF00069	0.450
MOD_GSK3_1	345	352	PF00069	0.612
MOD_GSK3_1	359	366	PF00069	0.722
MOD_GSK3_1	394	401	PF00069	0.558
MOD_GSK3_1	453	460	PF00069	0.603
MOD_GSK3_1	49	56	PF00069	0.448
MOD_GSK3_1	531	538	PF00069	0.585
MOD_GSK3_1	558	565	PF00069	0.658
MOD_GSK3_1	582	589	PF00069	0.683
MOD_GSK3_1	603	610	PF00069	0.636
MOD_GSK3_1	635	642	PF00069	0.568
MOD_GSK3_1	69	76	PF00069	0.349
MOD_GSK3_1	735	742	PF00069	0.390
MOD_GSK3_1	767	774	PF00069	0.609
MOD_LATS_1	396	402	PF00433	0.541
MOD_N-GLC_1	115	120	PF02516	0.402
MOD_N-GLC_1	363	368	PF02516	0.551
MOD_N-GLC_1	426	431	PF02516	0.566
MOD_N-GLC_1	485	490	PF02516	0.589
MOD_N-GLC_2	686	688	PF02516	0.559
MOD_NEK2_1	200	205	PF00069	0.699
MOD_NEK2_1	359	364	PF00069	0.609
MOD_NEK2_1	453	458	PF00069	0.559
MOD_NEK2_1	49	54	PF00069	0.445
MOD_NEK2_1	532	537	PF00069	0.549
MOD_NEK2_1	558	563	PF00069	0.614
MOD_NEK2_1	608	613	PF00069	0.745
MOD_NEK2_1	70	75	PF00069	0.479
MOD_OFUCOSY	682	688	PF10250	0.510
MOD_PIKK_1	281	287	PF00454	0.431
MOD_PIKK_1	323	329	PF00454	0.519
MOD_PIKK_1	335	341	PF00454	0.612
MOD_PIKK_1	349	355	PF00454	0.614
MOD_PIKK_1	398	404	PF00454	0.571
MOD_PIKK_1	444	450	PF00454	0.652
MOD_PIKK_1	609	615	PF00454	0.614
MOD_PK_1	183	189	PF00069	0.558
MOD_PK_1	419	425	PF00069	0.674
MOD_PKA_2	153	159	PF00069	0.527
MOD_PKA_2	589	595	PF00069	0.568
MOD_PKA_2	682	688	PF00069	0.485
MOD_PKA_2	735	741	PF00069	0.531
MOD_PKB_1	490	498	PF00069	0.630
MOD_PKB_1	675	683	PF00069	0.456
MOD_Plk_1	466	472	PF00069	0.648
MOD_Plk_1	753	759	PF00069	0.502
MOD_Plk_2-3	514	520	PF00069	0.613
MOD_Plk_4	315	321	PF00069	0.509
MOD_Plk_4	326	332	PF00069	0.416
MOD_Plk_4	388	394	PF00069	0.527
MOD_Plk_4	55	61	PF00069	0.402
MOD_Plk_4	603	609	PF00069	0.626
MOD_Plk_4	639	645	PF00069	0.570
MOD_Plk_4	665	671	PF00069	0.440
MOD_Plk_4	735	741	PF00069	0.379
MOD_ProDKin_1	155	161	PF00069	0.509
MOD_ProDKin_1	194	200	PF00069	0.675
MOD_ProDKin_1	305	311	PF00069	0.462
MOD_ProDKin_1	319	325	PF00069	0.478
MOD_ProDKin_1	345	351	PF00069	0.635
MOD_ProDKin_1	521	527	PF00069	0.621
MOD_ProDKin_1	538	544	PF00069	0.504
MOD_ProDKin_1	548	554	PF00069	0.521
MOD_ProDKin_1	58	64	PF00069	0.374
MOD_ProDKin_1	627	633	PF00069	0.606
MOD_ProDKin_1	635	641	PF00069	0.482
MOD_ProDKin_1	714	720	PF00069	0.521
MOD_ProDKin_1	800	806	PF00069	0.467
MOD_SUMO_for_1	212	215	PF00179	0.615
TRG_AP2beta_CARGO_1	128	137	PF09066	0.425
TRG_DiLeu_BaEn_1	518	523	PF01217	0.656
TRG_DiLeu_BaEn_1	614	619	PF01217	0.576
TRG_DiLeu_BaEn_4	518	524	PF01217	0.656
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.646
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.511
TRG_ENDOCYTIC_2	100	103	PF00928	0.443
TRG_ENDOCYTIC_2	63	66	PF00928	0.447
TRG_ER_diArg_1	13	15	PF00400	0.576
TRG_ER_diArg_1	169	172	PF00400	0.514
TRG_ER_diArg_1	473	476	PF00400	0.637
TRG_ER_diArg_1	644	647	PF00400	0.518
TRG_ER_diArg_1	653	655	PF00400	0.531
TRG_ER_diArg_1	674	677	PF00400	0.413
TRG_ER_diArg_1	699	702	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P946	Leptomonas seymouri	51%	89%
A4HMR1	Leishmania braziliensis	78%	98%
A4IBE7	Leishmania infantum	99%	100%
E9AF61	Leishmania major	89%	100%
E9B6B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%