LeishMANIAdb
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Probable methyltransferase BMT2 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable methyltransferase BMT2 homolog
Gene product:
Probable methyltransferase BTM2 homolog
Species:
Leishmania donovani
UniProt:
A0A3Q8IM81_LEIDO
TriTrypDb:
LdBPK_231300.1 * , LdCL_230020100 , LDHU3_23.1700
Length:
672

Annotations

LeishMANIAdb annotations

Homologous to S-adenosylmethionine sensor upstream of mTORC1. Does not appear to be membrane-associated.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IM81
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM81

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 9
GO:0032259 methylation 2 9
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0032006 regulation of TOR signaling 6 1
GO:0032007 negative regulation of TOR signaling 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
GO:1903432 regulation of TORC1 signaling 7 1
GO:1904262 negative regulation of TORC1 signaling 8 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0008168 methyltransferase activity 4 9
GO:0016740 transferase activity 2 10
GO:0016741 transferase activity, transferring one-carbon groups 3 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 180 184 PF00656 0.623
CLV_C14_Caspase3-7 207 211 PF00656 0.440
CLV_C14_Caspase3-7 338 342 PF00656 0.548
CLV_C14_Caspase3-7 359 363 PF00656 0.404
CLV_C14_Caspase3-7 506 510 PF00656 0.542
CLV_C14_Caspase3-7 520 524 PF00656 0.524
CLV_C14_Caspase3-7 525 529 PF00656 0.523
CLV_NRD_NRD_1 174 176 PF00675 0.842
CLV_NRD_NRD_1 290 292 PF00675 0.540
CLV_NRD_NRD_1 373 375 PF00675 0.688
CLV_NRD_NRD_1 591 593 PF00675 0.420
CLV_NRD_NRD_1 633 635 PF00675 0.465
CLV_PCSK_KEX2_1 174 176 PF00082 0.815
CLV_PCSK_KEX2_1 290 292 PF00082 0.542
CLV_PCSK_KEX2_1 373 375 PF00082 0.688
CLV_PCSK_KEX2_1 590 592 PF00082 0.414
CLV_PCSK_KEX2_1 633 635 PF00082 0.475
CLV_PCSK_PC1ET2_1 174 176 PF00082 0.819
CLV_PCSK_PC7_1 170 176 PF00082 0.778
CLV_PCSK_SKI1_1 160 164 PF00082 0.754
CLV_PCSK_SKI1_1 284 288 PF00082 0.591
CLV_PCSK_SKI1_1 290 294 PF00082 0.568
CLV_PCSK_SKI1_1 299 303 PF00082 0.541
DEG_ODPH_VHL_1 425 437 PF01847 0.453
DEG_SPOP_SBC_1 258 262 PF00917 0.448
DEG_SPOP_SBC_1 34 38 PF00917 0.541
DOC_CKS1_1 185 190 PF01111 0.525
DOC_CKS1_1 556 561 PF01111 0.381
DOC_MAPK_DCC_7 421 430 PF00069 0.443
DOC_MAPK_gen_1 284 294 PF00069 0.445
DOC_MAPK_MEF2A_6 574 582 PF00069 0.344
DOC_PP1_RVXF_1 288 295 PF00149 0.440
DOC_PP1_RVXF_1 558 564 PF00149 0.406
DOC_PP2B_LxvP_1 276 279 PF13499 0.293
DOC_USP7_MATH_1 161 165 PF00917 0.508
DOC_USP7_MATH_1 204 208 PF00917 0.601
DOC_USP7_MATH_1 257 261 PF00917 0.547
DOC_USP7_MATH_1 325 329 PF00917 0.522
DOC_USP7_MATH_1 34 38 PF00917 0.613
DOC_USP7_MATH_1 485 489 PF00917 0.396
DOC_USP7_MATH_1 503 507 PF00917 0.553
DOC_USP7_MATH_1 518 522 PF00917 0.540
DOC_USP7_MATH_1 529 533 PF00917 0.517
DOC_USP7_MATH_1 65 69 PF00917 0.432
DOC_WW_Pin1_4 132 137 PF00397 0.535
DOC_WW_Pin1_4 184 189 PF00397 0.526
DOC_WW_Pin1_4 25 30 PF00397 0.617
DOC_WW_Pin1_4 311 316 PF00397 0.453
DOC_WW_Pin1_4 391 396 PF00397 0.545
DOC_WW_Pin1_4 452 457 PF00397 0.525
DOC_WW_Pin1_4 555 560 PF00397 0.385
DOC_WW_Pin1_4 624 629 PF00397 0.649
LIG_14-3-3_CanoR_1 103 107 PF00244 0.476
LIG_14-3-3_CanoR_1 114 122 PF00244 0.292
LIG_14-3-3_CanoR_1 160 169 PF00244 0.636
LIG_14-3-3_CanoR_1 175 185 PF00244 0.579
LIG_14-3-3_CanoR_1 212 220 PF00244 0.416
LIG_14-3-3_CanoR_1 299 306 PF00244 0.369
LIG_14-3-3_CanoR_1 502 508 PF00244 0.543
LIG_14-3-3_CanoR_1 592 602 PF00244 0.590
LIG_14-3-3_CanoR_1 633 637 PF00244 0.664
LIG_BIR_II_1 1 5 PF00653 0.563
LIG_BRCT_BRCA1_1 603 607 PF00533 0.633
LIG_deltaCOP1_diTrp_1 462 469 PF00928 0.333
LIG_FHA_1 271 277 PF00498 0.305
LIG_FHA_1 338 344 PF00498 0.467
LIG_FHA_1 345 351 PF00498 0.399
LIG_FHA_1 402 408 PF00498 0.398
LIG_FHA_1 420 426 PF00498 0.272
LIG_FHA_1 44 50 PF00498 0.498
LIG_FHA_1 556 562 PF00498 0.379
LIG_FHA_1 597 603 PF00498 0.637
LIG_FHA_2 140 146 PF00498 0.546
LIG_FHA_2 203 209 PF00498 0.554
LIG_FHA_2 300 306 PF00498 0.375
LIG_FHA_2 431 437 PF00498 0.344
LIG_FHA_2 488 494 PF00498 0.459
LIG_FHA_2 660 666 PF00498 0.609
LIG_LIR_Apic_2 127 132 PF02991 0.441
LIG_LIR_Gen_1 189 198 PF02991 0.448
LIG_LIR_Gen_1 273 283 PF02991 0.220
LIG_LIR_Gen_1 462 470 PF02991 0.337
LIG_LIR_Gen_1 542 552 PF02991 0.375
LIG_LIR_Gen_1 604 614 PF02991 0.614
LIG_LIR_Gen_1 622 630 PF02991 0.645
LIG_LIR_Nem_3 189 194 PF02991 0.449
LIG_LIR_Nem_3 273 278 PF02991 0.360
LIG_LIR_Nem_3 409 414 PF02991 0.333
LIG_LIR_Nem_3 542 547 PF02991 0.308
LIG_LIR_Nem_3 604 610 PF02991 0.608
LIG_LIR_Nem_3 622 626 PF02991 0.621
LIG_LYPXL_SIV_4 117 125 PF13949 0.451
LIG_REV1ctd_RIR_1 291 300 PF16727 0.457
LIG_REV1ctd_RIR_1 412 421 PF16727 0.379
LIG_SH2_CRK 544 548 PF00017 0.335
LIG_SH2_GRB2like 129 132 PF00017 0.510
LIG_SH2_NCK_1 544 548 PF00017 0.335
LIG_SH2_SRC 118 121 PF00017 0.448
LIG_SH2_STAP1 118 122 PF00017 0.363
LIG_SH2_STAP1 214 218 PF00017 0.431
LIG_SH2_STAP1 544 548 PF00017 0.335
LIG_SH2_STAT3 220 223 PF00017 0.366
LIG_SH2_STAT3 498 501 PF00017 0.504
LIG_SH2_STAT5 220 223 PF00017 0.374
LIG_SH2_STAT5 229 232 PF00017 0.319
LIG_SH2_STAT5 386 389 PF00017 0.486
LIG_SH2_STAT5 555 558 PF00017 0.343
LIG_SH2_STAT5 84 87 PF00017 0.440
LIG_SH3_1 421 427 PF00018 0.461
LIG_SH3_3 182 188 PF00018 0.582
LIG_SH3_3 23 29 PF00018 0.601
LIG_SH3_3 282 288 PF00018 0.387
LIG_SH3_3 421 427 PF00018 0.461
LIG_SUMO_SIM_par_1 403 409 PF11976 0.304
LIG_SUMO_SIM_par_1 577 584 PF11976 0.344
LIG_SxIP_EBH_1 549 562 PF03271 0.357
LIG_TRAF2_1 490 493 PF00917 0.432
LIG_TRAF2_1 613 616 PF00917 0.628
LIG_WW_1 92 95 PF00397 0.434
MOD_CDK_SPK_2 555 560 PF00069 0.385
MOD_CDK_SPxK_1 311 317 PF00069 0.464
MOD_CDK_SPxxK_3 555 562 PF00069 0.381
MOD_CK1_1 164 170 PF00069 0.513
MOD_CK1_1 178 184 PF00069 0.515
MOD_CK1_1 224 230 PF00069 0.407
MOD_CK1_1 3 9 PF00069 0.488
MOD_CK1_1 334 340 PF00069 0.556
MOD_CK1_1 344 350 PF00069 0.390
MOD_CK1_1 505 511 PF00069 0.565
MOD_CK1_1 583 589 PF00069 0.607
MOD_CK1_1 596 602 PF00069 0.540
MOD_CK1_1 635 641 PF00069 0.575
MOD_CK1_1 68 74 PF00069 0.481
MOD_CK2_1 299 305 PF00069 0.368
MOD_CK2_1 343 349 PF00069 0.438
MOD_CK2_1 36 42 PF00069 0.588
MOD_CK2_1 487 493 PF00069 0.495
MOD_CK2_1 610 616 PF00069 0.620
MOD_CK2_1 91 97 PF00069 0.495
MOD_DYRK1A_RPxSP_1 311 315 PF00069 0.324
MOD_GlcNHglycan 115 118 PF01048 0.663
MOD_GlcNHglycan 198 201 PF01048 0.690
MOD_GlcNHglycan 2 5 PF01048 0.772
MOD_GlcNHglycan 244 247 PF01048 0.729
MOD_GlcNHglycan 343 346 PF01048 0.626
MOD_GlcNHglycan 396 399 PF01048 0.678
MOD_GlcNHglycan 487 490 PF01048 0.610
MOD_GlcNHglycan 513 516 PF01048 0.801
MOD_GlcNHglycan 523 527 PF01048 0.726
MOD_GlcNHglycan 628 631 PF01048 0.457
MOD_GlcNHglycan 652 655 PF01048 0.435
MOD_GlcNHglycan 67 70 PF01048 0.658
MOD_GlcNHglycan 72 75 PF01048 0.702
MOD_GlcNHglycan 88 91 PF01048 0.767
MOD_GSK3_1 160 167 PF00069 0.544
MOD_GSK3_1 196 203 PF00069 0.549
MOD_GSK3_1 204 211 PF00069 0.518
MOD_GSK3_1 313 320 PF00069 0.477
MOD_GSK3_1 331 338 PF00069 0.496
MOD_GSK3_1 339 346 PF00069 0.446
MOD_GSK3_1 375 382 PF00069 0.385
MOD_GSK3_1 481 488 PF00069 0.522
MOD_GSK3_1 518 525 PF00069 0.550
MOD_GSK3_1 530 537 PF00069 0.279
MOD_GSK3_1 551 558 PF00069 0.367
MOD_GSK3_1 593 600 PF00069 0.610
MOD_GSK3_1 645 652 PF00069 0.640
MOD_GSK3_1 68 75 PF00069 0.518
MOD_GSK3_1 80 87 PF00069 0.559
MOD_N-GLC_1 447 452 PF02516 0.702
MOD_NEK2_1 198 203 PF00069 0.587
MOD_NEK2_1 35 40 PF00069 0.600
MOD_NEK2_1 384 389 PF00069 0.393
MOD_NEK2_1 419 424 PF00069 0.404
MOD_NEK2_1 430 435 PF00069 0.308
MOD_NEK2_1 534 539 PF00069 0.423
MOD_NEK2_1 551 556 PF00069 0.219
MOD_NEK2_1 649 654 PF00069 0.603
MOD_NEK2_1 80 85 PF00069 0.582
MOD_NEK2_1 86 91 PF00069 0.501
MOD_PIKK_1 27 33 PF00454 0.586
MOD_PIKK_1 3 9 PF00454 0.488
MOD_PIKK_1 36 42 PF00454 0.539
MOD_PIKK_1 583 589 PF00454 0.607
MOD_PKA_1 175 181 PF00069 0.546
MOD_PKA_2 102 108 PF00069 0.473
MOD_PKA_2 113 119 PF00069 0.300
MOD_PKA_2 176 182 PF00069 0.622
MOD_PKA_2 479 485 PF00069 0.536
MOD_PKA_2 632 638 PF00069 0.622
MOD_PKA_2 659 665 PF00069 0.637
MOD_PKB_1 500 508 PF00069 0.490
MOD_Plk_1 270 276 PF00069 0.391
MOD_Plk_1 367 373 PF00069 0.501
MOD_Plk_1 375 381 PF00069 0.437
MOD_Plk_4 124 130 PF00069 0.470
MOD_Plk_4 187 193 PF00069 0.528
MOD_Plk_4 224 230 PF00069 0.417
MOD_Plk_4 50 56 PF00069 0.487
MOD_Plk_4 551 557 PF00069 0.352
MOD_Plk_4 645 651 PF00069 0.556
MOD_Plk_4 72 78 PF00069 0.422
MOD_ProDKin_1 132 138 PF00069 0.538
MOD_ProDKin_1 184 190 PF00069 0.525
MOD_ProDKin_1 25 31 PF00069 0.620
MOD_ProDKin_1 311 317 PF00069 0.462
MOD_ProDKin_1 391 397 PF00069 0.541
MOD_ProDKin_1 452 458 PF00069 0.514
MOD_ProDKin_1 555 561 PF00069 0.383
MOD_ProDKin_1 624 630 PF00069 0.654
MOD_SUMO_rev_2 94 101 PF00179 0.471
TRG_DiLeu_BaEn_1 305 310 PF01217 0.409
TRG_DiLeu_BaEn_1 575 580 PF01217 0.401
TRG_DiLeu_BaEn_2 270 276 PF01217 0.224
TRG_ENDOCYTIC_2 297 300 PF00928 0.426
TRG_ENDOCYTIC_2 411 414 PF00928 0.325
TRG_ENDOCYTIC_2 544 547 PF00928 0.334
TRG_ER_diArg_1 289 291 PF00400 0.337
TRG_ER_diArg_1 372 374 PF00400 0.482
TRG_ER_diArg_1 495 498 PF00400 0.463
TRG_ER_diArg_1 500 503 PF00400 0.489
TRG_ER_diArg_1 559 562 PF00400 0.306
TRG_ER_diArg_1 589 592 PF00400 0.696
TRG_ER_diArg_1 632 634 PF00400 0.675
TRG_NLS_MonoExtC_3 174 180 PF00514 0.633
TRG_NLS_MonoExtN_4 174 179 PF00514 0.634
TRG_Pf-PMV_PEXEL_1 290 295 PF00026 0.646
TRG_Pf-PMV_PEXEL_1 354 358 PF00026 0.650
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.558

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHP2 Leptomonas seymouri 47% 100%
A0A1X0NWU4 Trypanosomatidae 29% 100%
A4HCX9 Leishmania braziliensis 74% 98%
A4I0G2 Leishmania infantum 99% 100%
C9ZV78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AWC5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QB47 Leishmania major 89% 100%
V5BEP9 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS