Axonemal inner arm dynein light chain, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Axonemal inner arm dynein light chain, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IM75_LEIDO

TriTrypDb:

LdBPK_331240.1 , LdCL_330018600 , LDHU3_33.1890

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IM75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM75

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.318
CLV_NRD_NRD_1	86	88	PF00675	0.219
CLV_NRD_NRD_1	97	99	PF00675	0.170
CLV_PCSK_KEX2_1	201	203	PF00082	0.315
CLV_PCSK_KEX2_1	81	83	PF00082	0.219
CLV_PCSK_KEX2_1	86	88	PF00082	0.179
CLV_PCSK_KEX2_1	97	99	PF00082	0.129
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.219
CLV_PCSK_PC7_1	82	88	PF00082	0.219
CLV_PCSK_SKI1_1	110	114	PF00082	0.244
CLV_PCSK_SKI1_1	119	123	PF00082	0.282
CLV_PCSK_SKI1_1	173	177	PF00082	0.307
CLV_PCSK_SKI1_1	97	101	PF00082	0.282
CLV_Separin_Metazoa	107	111	PF03568	0.219
DEG_Nend_UBRbox_3	1	3	PF02207	0.428
DOC_MAPK_gen_1	170	178	PF00069	0.219
DOC_MAPK_MEF2A_6	170	178	PF00069	0.333
DOC_WW_Pin1_4	35	40	PF00397	0.562
LIG_14-3-3_CanoR_1	110	115	PF00244	0.281
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.281
LIG_FHA_1	11	17	PF00498	0.472
LIG_FHA_2	111	117	PF00498	0.266
LIG_FHA_2	184	190	PF00498	0.289
LIG_FHA_2	225	231	PF00498	0.535
LIG_LIR_Gen_1	103	112	PF02991	0.307
LIG_LIR_Nem_3	103	108	PF02991	0.270
LIG_SH2_STAT5	101	104	PF00017	0.219
LIG_SH2_STAT5	211	214	PF00017	0.219
LIG_SH3_3	111	117	PF00018	0.219
LIG_SUMO_SIM_par_1	54	61	PF11976	0.495
LIG_TRAF2_1	113	116	PF00917	0.219
LIG_TRAF2_1	48	51	PF00917	0.503
LIG_UBA3_1	183	188	PF00899	0.281
MOD_CK1_1	40	46	PF00069	0.528
MOD_CK1_1	58	64	PF00069	0.219
MOD_CK2_1	110	116	PF00069	0.316
MOD_CK2_1	183	189	PF00069	0.292
MOD_CK2_1	224	230	PF00069	0.466
MOD_GlcNHglycan	230	233	PF01048	0.473
MOD_GlcNHglycan	26	29	PF01048	0.516
MOD_GlcNHglycan	39	42	PF01048	0.746
MOD_GlcNHglycan	62	65	PF01048	0.353
MOD_GSK3_1	224	231	PF00069	0.511
MOD_GSK3_1	31	38	PF00069	0.509
MOD_NEK2_1	16	21	PF00069	0.421
MOD_NEK2_1	183	188	PF00069	0.319
MOD_NEK2_1	75	80	PF00069	0.318
MOD_PKA_2	228	234	PF00069	0.546
MOD_PKA_2	88	94	PF00069	0.294
MOD_Plk_4	16	22	PF00069	0.328
MOD_ProDKin_1	35	41	PF00069	0.562
MOD_SUMO_for_1	223	226	PF00179	0.445
MOD_SUMO_rev_2	207	212	PF00179	0.447
TRG_DiLeu_BaEn_2	142	148	PF01217	0.201
TRG_DiLeu_BaEn_4	195	201	PF01217	0.286
TRG_ENDOCYTIC_2	101	104	PF00928	0.294
TRG_ER_diArg_1	200	202	PF00400	0.303
TRG_ER_diArg_1	86	89	PF00400	0.336
TRG_ER_diArg_1	96	98	PF00400	0.232
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.201
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX9	Leptomonas seymouri	39%	100%
A0A0S4J6T9	Bodo saltans	42%	98%
A0A0S4J9S1	Bodo saltans	36%	100%
A0A0S4JQQ4	Bodo saltans	32%	100%
A0A1X0NVG2	Trypanosomatidae	38%	100%
A0A1X0NXR5	Trypanosomatidae	34%	80%
A0A3Q8IC16	Leishmania donovani	36%	100%
A0A3R7KMX9	Trypanosoma rangeli	36%	100%
A0A422MW64	Trypanosoma rangeli	34%	66%
A4HBW2	Leishmania braziliensis	34%	79%
A4I0S3	Leishmania infantum	36%	100%
A4I8Y3	Leishmania infantum	100%	100%
C9ZRW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	81%
D0A1A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	90%
D0A4Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	66%
D0A753	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIH0	Leishmania braziliensis	38%	100%
E9AWS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B3V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O14645	Homo sapiens	37%	96%
Q26630	Strongylocentrotus purpuratus	37%	95%
Q39604	Chlamydomonas reinhardtii	37%	98%
Q4FZV3	Rattus norvegicus	37%	96%
Q4Q472	Leishmania major	97%	100%
Q4QAP9	Leishmania major	36%	100%
Q4R3K5	Macaca fascicularis	37%	96%
Q6GN86	Xenopus laevis	38%	97%
Q8BVN8	Mus musculus	37%	96%
Q9VGG6	Drosophila melanogaster	33%	99%
V5B9Q0	Trypanosoma cruzi	35%	68%
V5BR59	Trypanosoma cruzi	37%	100%