Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IM74_LEIDO

TriTrypDb:

LdBPK_351970.1 , LdCL_350024900 , LDHU3_35.2580

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IM74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.610
CLV_NRD_NRD_1	3	5	PF00675	0.726
CLV_NRD_NRD_1	303	305	PF00675	0.597
CLV_NRD_NRD_1	34	36	PF00675	0.415
CLV_NRD_NRD_1	401	403	PF00675	0.649
CLV_NRD_NRD_1	450	452	PF00675	0.599
CLV_NRD_NRD_1	550	552	PF00675	0.648
CLV_NRD_NRD_1	556	558	PF00675	0.552
CLV_NRD_NRD_1	569	571	PF00675	0.443
CLV_PCSK_FUR_1	32	36	PF00082	0.449
CLV_PCSK_FUR_1	551	555	PF00082	0.623
CLV_PCSK_KEX2_1	142	144	PF00082	0.560
CLV_PCSK_KEX2_1	3	5	PF00082	0.704
CLV_PCSK_KEX2_1	302	304	PF00082	0.606
CLV_PCSK_KEX2_1	34	36	PF00082	0.416
CLV_PCSK_KEX2_1	553	555	PF00082	0.602
CLV_PCSK_KEX2_1	556	558	PF00082	0.566
CLV_PCSK_KEX2_1	568	570	PF00082	0.522
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.580
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.608
CLV_PCSK_PC7_1	298	304	PF00082	0.742
CLV_PCSK_SKI1_1	114	118	PF00082	0.469
CLV_PCSK_SKI1_1	283	287	PF00082	0.525
CLV_PCSK_SKI1_1	339	343	PF00082	0.526
CLV_PCSK_SKI1_1	432	436	PF00082	0.578
DEG_APCC_DBOX_1	128	136	PF00400	0.426
DEG_APCC_DBOX_1	450	458	PF00400	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.687
DOC_ANK_TNKS_1	301	308	PF00023	0.687
DOC_CKS1_1	71	76	PF01111	0.490
DOC_MAPK_DCC_7	325	333	PF00069	0.591
DOC_MAPK_gen_1	3	9	PF00069	0.640
DOC_MAPK_gen_1	322	331	PF00069	0.602
DOC_MAPK_MEF2A_6	322	331	PF00069	0.605
DOC_MAPK_RevD_3	537	553	PF00069	0.552
DOC_PP2B_LxvP_1	196	199	PF13499	0.517
DOC_PP2B_LxvP_1	539	542	PF13499	0.582
DOC_USP7_MATH_1	182	186	PF00917	0.519
DOC_USP7_MATH_1	290	294	PF00917	0.733
DOC_USP7_MATH_1	480	484	PF00917	0.648
DOC_USP7_MATH_1	544	548	PF00917	0.727
DOC_USP7_UBL2_3	24	28	PF12436	0.508
DOC_WW_Pin1_4	403	408	PF00397	0.629
DOC_WW_Pin1_4	496	501	PF00397	0.645
DOC_WW_Pin1_4	529	534	PF00397	0.834
DOC_WW_Pin1_4	537	542	PF00397	0.592
DOC_WW_Pin1_4	70	75	PF00397	0.474
LIG_14-3-3_CanoR_1	103	108	PF00244	0.449
LIG_14-3-3_CanoR_1	205	210	PF00244	0.407
LIG_14-3-3_CanoR_1	291	299	PF00244	0.755
LIG_14-3-3_CanoR_1	3	8	PF00244	0.697
LIG_14-3-3_CanoR_1	339	347	PF00244	0.471
LIG_14-3-3_CanoR_1	451	455	PF00244	0.586
LIG_14-3-3_CanoR_1	88	95	PF00244	0.494
LIG_Actin_WH2_2	127	144	PF00022	0.514
LIG_AP_GAE_1	475	481	PF02883	0.550
LIG_BRCT_BRCA1_1	271	275	PF00533	0.431
LIG_BRCT_BRCA1_1	348	352	PF00533	0.579
LIG_BRCT_BRCA1_1	354	358	PF00533	0.648
LIG_Clathr_ClatBox_1	278	282	PF01394	0.430
LIG_FHA_1	166	172	PF00498	0.537
LIG_FHA_1	216	222	PF00498	0.461
LIG_FHA_1	248	254	PF00498	0.440
LIG_FHA_1	61	67	PF00498	0.416
LIG_FHA_1	85	91	PF00498	0.491
LIG_FHA_2	217	223	PF00498	0.514
LIG_FHA_2	250	256	PF00498	0.474
LIG_FHA_2	295	301	PF00498	0.679
LIG_FHA_2	340	346	PF00498	0.520
LIG_FHA_2	374	380	PF00498	0.677
LIG_FHA_2	71	77	PF00498	0.479
LIG_FHA_2	92	98	PF00498	0.463
LIG_LIR_Apic_2	73	78	PF02991	0.523
LIG_LIR_Gen_1	272	281	PF02991	0.426
LIG_LIR_Gen_1	408	417	PF02991	0.621
LIG_LIR_Gen_1	59	69	PF02991	0.469
LIG_LIR_Nem_3	272	278	PF02991	0.419
LIG_LIR_Nem_3	30	36	PF02991	0.487
LIG_LIR_Nem_3	408	414	PF02991	0.627
LIG_LIR_Nem_3	475	481	PF02991	0.686
LIG_LIR_Nem_3	59	65	PF02991	0.522
LIG_LIR_Nem_3	76	80	PF02991	0.518
LIG_MYND_1	537	541	PF01753	0.588
LIG_Pex14_2	42	46	PF04695	0.494
LIG_PTB_Apo_2	151	158	PF02174	0.516
LIG_PTB_Phospho_1	151	157	PF10480	0.540
LIG_SH2_GRB2like	346	349	PF00017	0.676
LIG_SH2_GRB2like	411	414	PF00017	0.735
LIG_SH2_NCK_1	411	415	PF00017	0.663
LIG_SH2_NCK_1	515	519	PF00017	0.695
LIG_SH2_SRC	411	414	PF00017	0.609
LIG_SH2_STAP1	15	19	PF00017	0.476
LIG_SH2_STAP1	270	274	PF00017	0.406
LIG_SH2_STAP1	515	519	PF00017	0.695
LIG_SH2_STAT3	81	84	PF00017	0.655
LIG_SH2_STAT5	157	160	PF00017	0.501
LIG_SH3_1	80	86	PF00018	0.543
LIG_SH3_2	83	88	PF14604	0.568
LIG_SH3_3	131	137	PF00018	0.433
LIG_SH3_3	535	541	PF00018	0.780
LIG_SH3_3	68	74	PF00018	0.389
LIG_SH3_3	80	86	PF00018	0.568
LIG_SH3_4	395	402	PF00018	0.674
LIG_SUMO_SIM_par_1	194	200	PF11976	0.495
LIG_SUMO_SIM_par_1	276	282	PF11976	0.432
LIG_TRAF2_1	293	296	PF00917	0.689
LIG_TRFH_1	157	161	PF08558	0.461
LIG_UBA3_1	274	283	PF00899	0.482
LIG_WRC_WIRS_1	384	389	PF05994	0.797
MOD_CK1_1	386	392	PF00069	0.738
MOD_CK1_1	532	538	PF00069	0.807
MOD_CK1_1	91	97	PF00069	0.474
MOD_CK2_1	178	184	PF00069	0.443
MOD_CK2_1	216	222	PF00069	0.494
MOD_CK2_1	249	255	PF00069	0.456
MOD_CK2_1	290	296	PF00069	0.707
MOD_GlcNHglycan	143	146	PF01048	0.543
MOD_GlcNHglycan	180	183	PF01048	0.584
MOD_GlcNHglycan	348	351	PF01048	0.579
MOD_GlcNHglycan	354	357	PF01048	0.638
MOD_GlcNHglycan	364	367	PF01048	0.540
MOD_GlcNHglycan	475	478	PF01048	0.710
MOD_GlcNHglycan	489	492	PF01048	0.662
MOD_GlcNHglycan	503	506	PF01048	0.616
MOD_GlcNHglycan	58	61	PF01048	0.544
MOD_GSK3_1	178	185	PF00069	0.456
MOD_GSK3_1	262	269	PF00069	0.435
MOD_GSK3_1	290	297	PF00069	0.685
MOD_GSK3_1	383	390	PF00069	0.769
MOD_GSK3_1	426	433	PF00069	0.562
MOD_GSK3_1	529	536	PF00069	0.823
MOD_GSK3_1	56	63	PF00069	0.533
MOD_GSK3_1	84	91	PF00069	0.503
MOD_N-GLC_1	165	170	PF02516	0.554
MOD_N-GLC_1	425	430	PF02516	0.568
MOD_N-GLC_1	435	440	PF02516	0.609
MOD_N-GLC_1	471	476	PF02516	0.732
MOD_N-GLC_1	496	501	PF02516	0.667
MOD_N-GLC_1	544	549	PF02516	0.755
MOD_NEK2_1	123	128	PF00069	0.489
MOD_NEK2_1	2	7	PF00069	0.665
MOD_NEK2_1	215	220	PF00069	0.450
MOD_NEK2_1	234	239	PF00069	0.294
MOD_NEK2_1	249	254	PF00069	0.417
MOD_NEK2_1	262	267	PF00069	0.429
MOD_NEK2_1	318	323	PF00069	0.575
MOD_NEK2_1	352	357	PF00069	0.650
MOD_NEK2_1	37	42	PF00069	0.393
MOD_NEK2_1	387	392	PF00069	0.781
MOD_NEK2_1	466	471	PF00069	0.615
MOD_NEK2_1	47	52	PF00069	0.514
MOD_NEK2_1	95	100	PF00069	0.441
MOD_NEK2_2	182	187	PF00069	0.526
MOD_PIKK_1	290	296	PF00454	0.779
MOD_PIKK_1	359	365	PF00454	0.581
MOD_PIKK_1	97	103	PF00454	0.396
MOD_PK_1	3	9	PF00069	0.640
MOD_PKA_1	3	9	PF00069	0.640
MOD_PKA_2	2	8	PF00069	0.700
MOD_PKA_2	290	296	PF00069	0.757
MOD_PKA_2	450	456	PF00069	0.589
MOD_PKB_1	203	211	PF00069	0.479
MOD_Plk_1	165	171	PF00069	0.549
MOD_Plk_1	216	222	PF00069	0.467
MOD_Plk_1	294	300	PF00069	0.632
MOD_Plk_1	37	43	PF00069	0.398
MOD_Plk_1	435	441	PF00069	0.660
MOD_Plk_1	544	550	PF00069	0.756
MOD_Plk_4	182	188	PF00069	0.525
MOD_Plk_4	234	240	PF00069	0.421
MOD_Plk_4	3	9	PF00069	0.701
MOD_Plk_4	329	335	PF00069	0.571
MOD_Plk_4	383	389	PF00069	0.720
MOD_Plk_4	466	472	PF00069	0.648
MOD_Plk_4	544	550	PF00069	0.752
MOD_ProDKin_1	403	409	PF00069	0.626
MOD_ProDKin_1	496	502	PF00069	0.643
MOD_ProDKin_1	529	535	PF00069	0.837
MOD_ProDKin_1	537	543	PF00069	0.590
MOD_ProDKin_1	70	76	PF00069	0.489
MOD_SUMO_rev_2	144	150	PF00179	0.515
MOD_SUMO_rev_2	184	193	PF00179	0.570
MOD_SUMO_rev_2	255	262	PF00179	0.572
MOD_SUMO_rev_2	437	444	PF00179	0.596
TRG_ENDOCYTIC_2	113	116	PF00928	0.477
TRG_ENDOCYTIC_2	411	414	PF00928	0.618
TRG_ER_diArg_1	159	162	PF00400	0.483
TRG_ER_diArg_1	2	4	PF00400	0.660
TRG_ER_diArg_1	202	205	PF00400	0.462
TRG_ER_diArg_1	227	230	PF00400	0.589
TRG_ER_diArg_1	302	304	PF00400	0.628
TRG_ER_diArg_1	33	35	PF00400	0.430
TRG_ER_diArg_1	567	570	PF00400	0.583
TRG_NES_CRM1_1	97	108	PF08389	0.490
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P326	Leptomonas seymouri	79%	98%
A0A0S4JIC7	Bodo saltans	55%	100%
A0A1X0P7C6	Trypanosomatidae	68%	100%
A4HML8	Leishmania braziliensis	90%	100%
A4IB96	Leishmania infantum	100%	100%
C9ZZM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AF20	Leishmania major	97%	100%
E9B676	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5ATF8	Trypanosoma cruzi	67%	100%