Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IM62_LEIDO

TriTrypDb:

LdBPK_367010.1 , LdCL_360082700 , LDHU3_36.9350

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IM62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.581
CLV_C14_Caspase3-7	282	286	PF00656	0.607
CLV_C14_Caspase3-7	6	10	PF00656	0.541
CLV_NRD_NRD_1	188	190	PF00675	0.431
CLV_NRD_NRD_1	395	397	PF00675	0.601
CLV_NRD_NRD_1	84	86	PF00675	0.395
CLV_PCSK_FUR_1	82	86	PF00082	0.425
CLV_PCSK_KEX2_1	188	190	PF00082	0.431
CLV_PCSK_KEX2_1	288	290	PF00082	0.436
CLV_PCSK_KEX2_1	332	334	PF00082	0.248
CLV_PCSK_KEX2_1	353	355	PF00082	0.630
CLV_PCSK_KEX2_1	395	397	PF00082	0.597
CLV_PCSK_KEX2_1	82	84	PF00082	0.387
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.436
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.280
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.630
CLV_PCSK_SKI1_1	188	192	PF00082	0.414
CLV_PCSK_SKI1_1	220	224	PF00082	0.390
CLV_PCSK_SKI1_1	71	75	PF00082	0.417
DEG_SCF_FBW7_1	435	441	PF00400	0.417
DEG_SPOP_SBC_1	208	212	PF00917	0.663
DEG_SPOP_SBC_1	280	284	PF00917	0.595
DOC_CDC14_PxL_1	252	260	PF14671	0.562
DOC_CKS1_1	137	142	PF01111	0.510
DOC_CKS1_1	407	412	PF01111	0.355
DOC_CKS1_1	435	440	PF01111	0.417
DOC_CYCLIN_RxL_1	390	402	PF00134	0.333
DOC_CYCLIN_RxL_1	458	469	PF00134	0.560
DOC_MAPK_DCC_7	250	260	PF00069	0.533
DOC_MAPK_MEF2A_6	144	151	PF00069	0.502
DOC_PP1_RVXF_1	393	400	PF00149	0.377
DOC_USP7_MATH_1	234	238	PF00917	0.616
DOC_USP7_MATH_1	264	268	PF00917	0.678
DOC_USP7_MATH_1	270	274	PF00917	0.722
DOC_USP7_MATH_1	276	280	PF00917	0.729
DOC_USP7_MATH_1	319	323	PF00917	0.742
DOC_USP7_MATH_1	438	442	PF00917	0.350
DOC_USP7_MATH_1	44	48	PF00917	0.578
DOC_WW_Pin1_4	136	141	PF00397	0.596
DOC_WW_Pin1_4	406	411	PF00397	0.438
DOC_WW_Pin1_4	434	439	PF00397	0.417
DOC_WW_Pin1_4	88	93	PF00397	0.630
LIG_14-3-3_CanoR_1	333	343	PF00244	0.289
LIG_14-3-3_CanoR_1	395	400	PF00244	0.350
LIG_14-3-3_CanoR_1	443	448	PF00244	0.622
LIG_14-3-3_CanoR_1	71	79	PF00244	0.548
LIG_14-3-3_CanoR_1	83	89	PF00244	0.583
LIG_Actin_WH2_2	142	160	PF00022	0.533
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_BIR_III_2	51	55	PF00653	0.501
LIG_BRCT_BRCA1_1	159	163	PF00533	0.536
LIG_FHA_1	208	214	PF00498	0.646
LIG_FHA_1	28	34	PF00498	0.529
LIG_FHA_1	282	288	PF00498	0.560
LIG_FHA_1	407	413	PF00498	0.446
LIG_FHA_1	417	423	PF00498	0.386
LIG_FHA_1	435	441	PF00498	0.432
LIG_FHA_1	72	78	PF00498	0.547
LIG_FHA_2	137	143	PF00498	0.602
LIG_FHA_2	280	286	PF00498	0.618
LIG_FHA_2	416	422	PF00498	0.390
LIG_GBD_Chelix_1	459	467	PF00786	0.359
LIG_GLEBS_BUB3_1	123	131	PF00400	0.537
LIG_LIR_Apic_2	409	414	PF02991	0.279
LIG_LIR_Gen_1	16	25	PF02991	0.492
LIG_LIR_Gen_1	398	407	PF02991	0.299
LIG_LIR_Gen_1	466	472	PF02991	0.556
LIG_LIR_LC3C_4	111	116	PF02991	0.532
LIG_LIR_Nem_3	16	21	PF02991	0.485
LIG_LIR_Nem_3	224	229	PF02991	0.600
LIG_LIR_Nem_3	466	471	PF02991	0.555
LIG_Pex14_1	132	136	PF04695	0.564
LIG_Pex14_2	163	167	PF04695	0.506
LIG_Pex14_2	295	299	PF04695	0.608
LIG_Rb_pABgroove_1	395	403	PF01858	0.377
LIG_SH2_CRK	165	169	PF00017	0.548
LIG_SH2_CRK	252	256	PF00017	0.559
LIG_SH2_CRK	336	340	PF00017	0.368
LIG_SH2_PTP2	18	21	PF00017	0.479
LIG_SH2_PTP2	411	414	PF00017	0.282
LIG_SH2_SRC	411	414	PF00017	0.282
LIG_SH2_STAP1	336	340	PF00017	0.308
LIG_SH2_STAP1	401	405	PF00017	0.382
LIG_SH2_STAT5	136	139	PF00017	0.592
LIG_SH2_STAT5	18	21	PF00017	0.479
LIG_SH2_STAT5	36	39	PF00017	0.512
LIG_SH2_STAT5	411	414	PF00017	0.446
LIG_SH2_STAT5	426	429	PF00017	0.368
LIG_SH2_STAT5	59	62	PF00017	0.490
LIG_SH3_3	18	24	PF00018	0.568
LIG_SUMO_SIM_par_1	256	261	PF11976	0.608
LIG_SUMO_SIM_par_1	30	35	PF11976	0.555
LIG_TRAF2_1	125	128	PF00917	0.669
LIG_TRFH_1	468	472	PF08558	0.385
LIG_TYR_ITIM	334	339	PF00017	0.368
LIG_WW_1	370	373	PF00397	0.497
MOD_CK1_1	201	207	PF00069	0.759
MOD_CK1_1	238	244	PF00069	0.445
MOD_CK1_1	27	33	PF00069	0.396
MOD_CK1_1	279	285	PF00069	0.593
MOD_CK1_1	322	328	PF00069	0.613
MOD_CK1_1	61	67	PF00069	0.593
MOD_CK2_1	122	128	PF00069	0.465
MOD_CK2_1	136	142	PF00069	0.462
MOD_CK2_1	211	217	PF00069	0.564
MOD_CK2_1	88	94	PF00069	0.525
MOD_CK2_1	95	101	PF00069	0.445
MOD_GlcNHglycan	15	18	PF01048	0.354
MOD_GlcNHglycan	213	216	PF01048	0.452
MOD_GlcNHglycan	26	29	PF01048	0.396
MOD_GlcNHglycan	266	269	PF01048	0.629
MOD_GlcNHglycan	272	275	PF01048	0.697
MOD_GlcNHglycan	278	281	PF01048	0.651
MOD_GlcNHglycan	311	314	PF01048	0.628
MOD_GlcNHglycan	316	319	PF01048	0.590
MOD_GlcNHglycan	321	324	PF01048	0.455
MOD_GlcNHglycan	336	339	PF01048	0.241
MOD_GlcNHglycan	364	367	PF01048	0.649
MOD_GlcNHglycan	385	388	PF01048	0.498
MOD_GlcNHglycan	46	49	PF01048	0.502
MOD_GlcNHglycan	60	63	PF01048	0.382
MOD_GSK3_1	207	214	PF00069	0.523
MOD_GSK3_1	224	231	PF00069	0.475
MOD_GSK3_1	23	30	PF00069	0.405
MOD_GSK3_1	234	241	PF00069	0.471
MOD_GSK3_1	276	283	PF00069	0.633
MOD_GSK3_1	297	304	PF00069	0.518
MOD_GSK3_1	319	326	PF00069	0.493
MOD_GSK3_1	434	441	PF00069	0.332
MOD_GSK3_1	84	91	PF00069	0.580
MOD_N-GLC_1	309	314	PF02516	0.486
MOD_NEK2_1	131	136	PF00069	0.523
MOD_NEK2_1	157	162	PF00069	0.413
MOD_NEK2_1	209	214	PF00069	0.615
MOD_NEK2_1	235	240	PF00069	0.396
MOD_NEK2_1	314	319	PF00069	0.714
MOD_NEK2_1	334	339	PF00069	0.337
MOD_NEK2_1	385	390	PF00069	0.430
MOD_NEK2_1	415	420	PF00069	0.489
MOD_NEK2_1	463	468	PF00069	0.432
MOD_NEK2_1	8	13	PF00069	0.502
MOD_NEK2_1	95	100	PF00069	0.500
MOD_PIKK_1	297	303	PF00454	0.420
MOD_PIKK_1	438	444	PF00454	0.514
MOD_PKA_1	395	401	PF00069	0.269
MOD_PKA_1	84	90	PF00069	0.465
MOD_PKA_2	157	163	PF00069	0.474
MOD_PKA_2	395	401	PF00069	0.269
MOD_PKA_2	84	90	PF00069	0.465
MOD_PKB_1	82	90	PF00069	0.595
MOD_Plk_1	201	207	PF00069	0.588
MOD_Plk_1	309	315	PF00069	0.580
MOD_Plk_1	461	467	PF00069	0.496
MOD_Plk_1	8	14	PF00069	0.408
MOD_Plk_2-3	123	129	PF00069	0.453
MOD_Plk_4	172	178	PF00069	0.409
MOD_Plk_4	235	241	PF00069	0.394
MOD_Plk_4	28	34	PF00069	0.367
MOD_Plk_4	323	329	PF00069	0.476
MOD_Plk_4	395	401	PF00069	0.390
MOD_Plk_4	463	469	PF00069	0.440
MOD_Plk_4	8	14	PF00069	0.490
MOD_Plk_4	95	101	PF00069	0.455
MOD_ProDKin_1	136	142	PF00069	0.500
MOD_ProDKin_1	406	412	PF00069	0.552
MOD_ProDKin_1	434	440	PF00069	0.417
MOD_ProDKin_1	88	94	PF00069	0.542
TRG_DiLeu_BaEn_1	186	191	PF01217	0.445
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.409
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.308
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.508
TRG_DiLeu_LyEn_5	186	191	PF01217	0.430
TRG_ENDOCYTIC_2	165	168	PF00928	0.420
TRG_ENDOCYTIC_2	18	21	PF00928	0.338
TRG_ENDOCYTIC_2	252	255	PF00928	0.438
TRG_ENDOCYTIC_2	336	339	PF00928	0.308
TRG_ENDOCYTIC_2	401	404	PF00928	0.341
TRG_ER_diArg_1	188	190	PF00400	0.546
TRG_ER_diArg_1	394	396	PF00400	0.497
TRG_ER_diArg_1	82	85	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR4	Leptomonas seymouri	65%	98%
A0A0S4ISX7	Bodo saltans	28%	98%
A0A1X0NN06	Trypanosomatidae	44%	100%
A0A3R7MQC3	Trypanosoma rangeli	42%	100%
A4HQJ3	Leishmania braziliensis	81%	100%
D0A3P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AI02	Leishmania infantum	100%	100%
E9AUA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q085	Leishmania major	93%	100%
V5BHM6	Trypanosoma cruzi	42%	100%