Chitobiase/beta-hexosaminidase_C-inal_domain_cont aining_protein_putative/Pfam:PF13290

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IM61_LEIDO

TriTrypDb:

LdBPK_231130.1 , LdCL_230018600 , LDHU3_23.1490

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IM61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.546
CLV_C14_Caspase3-7	50	54	PF00656	0.606
CLV_C14_Caspase3-7	650	654	PF00656	0.636
CLV_NRD_NRD_1	244	246	PF00675	0.524
CLV_NRD_NRD_1	350	352	PF00675	0.434
CLV_NRD_NRD_1	37	39	PF00675	0.353
CLV_NRD_NRD_1	44	46	PF00675	0.408
CLV_NRD_NRD_1	445	447	PF00675	0.439
CLV_NRD_NRD_1	521	523	PF00675	0.460
CLV_PCSK_FUR_1	35	39	PF00082	0.418
CLV_PCSK_FUR_1	41	45	PF00082	0.452
CLV_PCSK_KEX2_1	244	246	PF00082	0.524
CLV_PCSK_KEX2_1	35	37	PF00082	0.352
CLV_PCSK_KEX2_1	350	352	PF00082	0.394
CLV_PCSK_KEX2_1	43	45	PF00082	0.394
CLV_PCSK_KEX2_1	445	447	PF00082	0.463
CLV_PCSK_KEX2_1	520	522	PF00082	0.467
CLV_PCSK_SKI1_1	390	394	PF00082	0.369
CLV_PCSK_SKI1_1	446	450	PF00082	0.449
CLV_PCSK_SKI1_1	49	53	PF00082	0.406
CLV_PCSK_SKI1_1	510	514	PF00082	0.399
CLV_PCSK_SKI1_1	547	551	PF00082	0.306
CLV_PCSK_SKI1_1	643	647	PF00082	0.332
DEG_COP1_1	401	410	PF00400	0.602
DEG_SIAH_1	271	279	PF03145	0.673
DEG_SPOP_SBC_1	299	303	PF00917	0.656
DOC_CKS1_1	110	115	PF01111	0.625
DOC_CKS1_1	306	311	PF01111	0.700
DOC_CKS1_1	407	412	PF01111	0.581
DOC_CYCLIN_RxL_1	38	52	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	533	536	PF00134	0.609
DOC_MAPK_gen_1	36	48	PF00069	0.577
DOC_MAPK_MEF2A_6	6	14	PF00069	0.338
DOC_MAPK_RevD_3	22	36	PF00069	0.341
DOC_PP1_RVXF_1	444	451	PF00149	0.658
DOC_PP1_RVXF_1	545	551	PF00149	0.508
DOC_PP2B_LxvP_1	211	214	PF13499	0.670
DOC_PP2B_LxvP_1	338	341	PF13499	0.575
DOC_PP2B_LxvP_1	533	536	PF13499	0.533
DOC_PP2B_PxIxI_1	536	542	PF00149	0.502
DOC_PP4_FxxP_1	110	113	PF00568	0.607
DOC_PP4_FxxP_1	172	175	PF00568	0.521
DOC_PP4_FxxP_1	550	553	PF00568	0.523
DOC_USP7_MATH_1	105	109	PF00917	0.628
DOC_USP7_MATH_1	226	230	PF00917	0.816
DOC_USP7_MATH_1	408	412	PF00917	0.572
DOC_WW_Pin1_4	100	105	PF00397	0.531
DOC_WW_Pin1_4	109	114	PF00397	0.537
DOC_WW_Pin1_4	209	214	PF00397	0.754
DOC_WW_Pin1_4	261	266	PF00397	0.773
DOC_WW_Pin1_4	290	295	PF00397	0.597
DOC_WW_Pin1_4	305	310	PF00397	0.516
DOC_WW_Pin1_4	312	317	PF00397	0.582
DOC_WW_Pin1_4	406	411	PF00397	0.635
DOC_WW_Pin1_4	571	576	PF00397	0.587
DOC_WW_Pin1_4	605	610	PF00397	0.679
LIG_14-3-3_CanoR_1	320	324	PF00244	0.532
LIG_14-3-3_CanoR_1	337	341	PF00244	0.561
LIG_14-3-3_CanoR_1	384	388	PF00244	0.632
LIG_14-3-3_CanoR_1	413	423	PF00244	0.625
LIG_14-3-3_CanoR_1	498	503	PF00244	0.533
LIG_14-3-3_CanoR_1	510	518	PF00244	0.555
LIG_14-3-3_CanoR_1	558	564	PF00244	0.591
LIG_BIR_III_4	281	285	PF00653	0.620
LIG_BIR_III_4	62	66	PF00653	0.651
LIG_CaM_IQ_9	30	46	PF13499	0.380
LIG_Clathr_ClatBox_1	133	137	PF01394	0.532
LIG_Clathr_ClatBox_1	438	442	PF01394	0.540
LIG_eIF4E_1	159	165	PF01652	0.579
LIG_FHA_1	110	116	PF00498	0.566
LIG_FHA_1	165	171	PF00498	0.556
LIG_FHA_1	210	216	PF00498	0.763
LIG_FHA_1	233	239	PF00498	0.776
LIG_FHA_1	25	31	PF00498	0.425
LIG_FHA_1	258	264	PF00498	0.696
LIG_FHA_1	301	307	PF00498	0.554
LIG_FHA_1	430	436	PF00498	0.520
LIG_FHA_1	464	470	PF00498	0.667
LIG_FHA_1	633	639	PF00498	0.552
LIG_FHA_2	222	228	PF00498	0.783
LIG_FHA_2	299	305	PF00498	0.615
LIG_FHA_2	306	312	PF00498	0.559
LIG_FHA_2	432	438	PF00498	0.596
LIG_FHA_2	560	566	PF00498	0.648
LIG_FHA_2	629	635	PF00498	0.652
LIG_GBD_Chelix_1	22	30	PF00786	0.341
LIG_Integrin_isoDGR_2	488	490	PF01839	0.384
LIG_Integrin_isoDGR_2	556	558	PF01839	0.396
LIG_LIR_Apic_2	108	113	PF02991	0.616
LIG_LIR_Apic_2	171	175	PF02991	0.562
LIG_LIR_Apic_2	329	335	PF02991	0.549
LIG_LIR_Apic_2	401	405	PF02991	0.568
LIG_LIR_Gen_1	434	444	PF02991	0.571
LIG_LIR_LC3C_4	112	116	PF02991	0.584
LIG_LIR_Nem_3	161	166	PF02991	0.530
LIG_LIR_Nem_3	27	32	PF02991	0.464
LIG_LIR_Nem_3	324	330	PF02991	0.561
LIG_LIR_Nem_3	434	439	PF02991	0.552
LIG_LYPXL_yS_3	327	330	PF13949	0.578
LIG_MYND_1	213	217	PF01753	0.650
LIG_Pex14_2	645	649	PF04695	0.589
LIG_Pex14_2	682	686	PF04695	0.511
LIG_Pex14_2	86	90	PF04695	0.564
LIG_PTB_Apo_2	152	159	PF02174	0.657
LIG_PTB_Phospho_1	152	158	PF10480	0.664
LIG_RPA_C_Fungi	239	251	PF08784	0.575
LIG_RPA_C_Fungi	31	43	PF08784	0.432
LIG_SH2_CRK	166	170	PF00017	0.518
LIG_SH2_CRK	332	336	PF00017	0.407
LIG_SH2_CRK	678	682	PF00017	0.427
LIG_SH2_GRB2like	58	61	PF00017	0.530
LIG_SH2_GRB2like	687	690	PF00017	0.554
LIG_SH2_NCK_1	332	336	PF00017	0.483
LIG_SH2_NCK_1	436	440	PF00017	0.491
LIG_SH2_SRC	225	228	PF00017	0.630
LIG_SH2_SRC	622	625	PF00017	0.540
LIG_SH2_STAP1	436	440	PF00017	0.484
LIG_SH2_STAT3	178	181	PF00017	0.564
LIG_SH2_STAT3	620	623	PF00017	0.409
LIG_SH2_STAT5	117	120	PF00017	0.396
LIG_SH2_STAT5	126	129	PF00017	0.509
LIG_SH2_STAT5	166	169	PF00017	0.410
LIG_SH2_STAT5	200	203	PF00017	0.457
LIG_SH2_STAT5	332	335	PF00017	0.412
LIG_SH2_STAT5	402	405	PF00017	0.575
LIG_SH2_STAT5	422	425	PF00017	0.270
LIG_SH2_STAT5	47	50	PF00017	0.446
LIG_SH2_STAT5	561	564	PF00017	0.396
LIG_SH2_STAT5	620	623	PF00017	0.498
LIG_SH2_STAT5	639	642	PF00017	0.367
LIG_SH2_STAT5	687	690	PF00017	0.554
LIG_SH3_1	402	408	PF00018	0.516
LIG_SH3_3	210	216	PF00018	0.642
LIG_SH3_3	260	266	PF00018	0.725
LIG_SH3_3	283	289	PF00018	0.500
LIG_SH3_3	303	309	PF00018	0.316
LIG_SH3_3	402	408	PF00018	0.442
LIG_SH3_3	570	576	PF00018	0.460
LIG_SH3_3	641	647	PF00018	0.388
LIG_SH3_3	69	75	PF00018	0.568
LIG_Sin3_3	391	398	PF02671	0.411
LIG_SUMO_SIM_par_1	131	137	PF11976	0.399
LIG_SUMO_SIM_par_1	20	25	PF11976	0.451
LIG_SUMO_SIM_par_1	461	467	PF11976	0.533
LIG_TRAF2_1	94	97	PF00917	0.543
LIG_TYR_ITIM	115	120	PF00017	0.390
LIG_TYR_ITSM	432	439	PF00017	0.492
LIG_WRC_WIRS_1	48	53	PF05994	0.502
LIG_WW_2	213	216	PF00397	0.568
MOD_CDK_SPxxK_3	406	413	PF00069	0.541
MOD_CK1_1	103	109	PF00069	0.555
MOD_CK1_1	142	148	PF00069	0.670
MOD_CK1_1	209	215	PF00069	0.692
MOD_CK1_1	326	332	PF00069	0.460
MOD_CK1_1	375	381	PF00069	0.612
MOD_CK1_1	386	392	PF00069	0.365
MOD_CK2_1	221	227	PF00069	0.756
MOD_CK2_1	290	296	PF00069	0.578
MOD_CK2_1	298	304	PF00069	0.537
MOD_CK2_1	305	311	PF00069	0.465
MOD_CK2_1	431	437	PF00069	0.503
MOD_CK2_1	539	545	PF00069	0.457
MOD_CK2_1	628	634	PF00069	0.551
MOD_DYRK1A_RPxSP_1	406	410	PF00069	0.361
MOD_GlcNHglycan	105	108	PF01048	0.509
MOD_GlcNHglycan	208	211	PF01048	0.675
MOD_GlcNHglycan	229	232	PF01048	0.714
MOD_GlcNHglycan	272	275	PF01048	0.748
MOD_GlcNHglycan	277	281	PF01048	0.689
MOD_GlcNHglycan	369	373	PF01048	0.584
MOD_GlcNHglycan	374	377	PF01048	0.587
MOD_GlcNHglycan	381	384	PF01048	0.504
MOD_GlcNHglycan	417	420	PF01048	0.341
MOD_GlcNHglycan	479	482	PF01048	0.552
MOD_GlcNHglycan	669	672	PF01048	0.663
MOD_GlcNHglycan	80	83	PF01048	0.576
MOD_GSK3_1	105	112	PF00069	0.499
MOD_GSK3_1	142	149	PF00069	0.627
MOD_GSK3_1	205	212	PF00069	0.623
MOD_GSK3_1	257	264	PF00069	0.721
MOD_GSK3_1	272	279	PF00069	0.754
MOD_GSK3_1	319	326	PF00069	0.425
MOD_GSK3_1	341	348	PF00069	0.584
MOD_GSK3_1	368	375	PF00069	0.629
MOD_GSK3_1	379	386	PF00069	0.506
MOD_GSK3_1	473	480	PF00069	0.507
MOD_GSK3_1	506	513	PF00069	0.505
MOD_GSK3_1	559	566	PF00069	0.380
MOD_GSK3_1	628	635	PF00069	0.429
MOD_GSK3_1	63	70	PF00069	0.710
MOD_GSK3_1	663	670	PF00069	0.591
MOD_N-GLC_1	232	237	PF02516	0.695
MOD_N-GLC_1	563	568	PF02516	0.515
MOD_NEK2_1	139	144	PF00069	0.619
MOD_NEK2_1	164	169	PF00069	0.454
MOD_NEK2_1	257	262	PF00069	0.793
MOD_NEK2_1	323	328	PF00069	0.435
MOD_NEK2_1	330	335	PF00069	0.389
MOD_NEK2_1	336	341	PF00069	0.405
MOD_NEK2_1	414	419	PF00069	0.434
MOD_NEK2_1	632	637	PF00069	0.667
MOD_NEK2_1	78	83	PF00069	0.643
MOD_PIKK_1	147	153	PF00454	0.534
MOD_PIKK_1	345	351	PF00454	0.593
MOD_PIKK_1	429	435	PF00454	0.454
MOD_PIKK_1	632	638	PF00454	0.593
MOD_PK_1	498	504	PF00069	0.527
MOD_PKA_2	139	145	PF00069	0.656
MOD_PKA_2	319	325	PF00069	0.401
MOD_PKA_2	336	342	PF00069	0.448
MOD_PKA_2	383	389	PF00069	0.465
MOD_PKA_2	414	420	PF00069	0.470
MOD_PKB_1	413	421	PF00069	0.334
MOD_Plk_1	233	239	PF00069	0.687
MOD_Plk_4	24	30	PF00069	0.402
MOD_Plk_4	326	332	PF00069	0.398
MOD_Plk_4	341	347	PF00069	0.487
MOD_Plk_4	383	389	PF00069	0.433
MOD_Plk_4	398	404	PF00069	0.437
MOD_Plk_4	417	423	PF00069	0.297
MOD_Plk_4	431	437	PF00069	0.425
MOD_Plk_4	616	622	PF00069	0.421
MOD_Plk_4	628	634	PF00069	0.398
MOD_Plk_4	68	74	PF00069	0.557
MOD_ProDKin_1	100	106	PF00069	0.409
MOD_ProDKin_1	109	115	PF00069	0.412
MOD_ProDKin_1	209	215	PF00069	0.718
MOD_ProDKin_1	261	267	PF00069	0.741
MOD_ProDKin_1	290	296	PF00069	0.514
MOD_ProDKin_1	305	311	PF00069	0.395
MOD_ProDKin_1	312	318	PF00069	0.468
MOD_ProDKin_1	406	412	PF00069	0.541
MOD_ProDKin_1	571	577	PF00069	0.470
MOD_ProDKin_1	605	611	PF00069	0.602
MOD_SUMO_rev_2	542	549	PF00179	0.383
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.657
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.478
TRG_ENDOCYTIC_2	117	120	PF00928	0.422
TRG_ENDOCYTIC_2	327	330	PF00928	0.469
TRG_ENDOCYTIC_2	436	439	PF00928	0.369
TRG_ENDOCYTIC_2	678	681	PF00928	0.502
TRG_ENDOCYTIC_2	87	90	PF00928	0.440
TRG_ER_diArg_1	118	121	PF00400	0.501
TRG_ER_diArg_1	35	38	PF00400	0.457
TRG_ER_diArg_1	41	44	PF00400	0.491
TRG_ER_diArg_1	412	415	PF00400	0.448
TRG_ER_diArg_1	520	522	PF00400	0.621
TRG_NLS_MonoExtN_4	445	450	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q7	Leptomonas seymouri	54%	100%
A0A1X0NWT3	Trypanosomatidae	33%	100%
A0A3R7NT57	Trypanosoma rangeli	34%	100%
A4HCW5	Leishmania braziliensis	73%	98%
A4I0E5	Leishmania infantum	100%	100%
C9ZV90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AWA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QB67	Leishmania major	92%	100%
V5BEP2	Trypanosoma cruzi	34%	100%