Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IM56_LEIDO

TriTrypDb:

LdBPK_351830.1 , LdCL_350023200 , LDHU3_35.2400

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3Q8IM56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DOC_CKS1_1	43	48	PF01111	0.347
DOC_CYCLIN_yCln2_LP_2	60	66	PF00134	0.617
DOC_USP7_MATH_1	136	140	PF00917	0.761
DOC_WW_Pin1_4	128	133	PF00397	0.678
DOC_WW_Pin1_4	141	146	PF00397	0.615
DOC_WW_Pin1_4	42	47	PF00397	0.347
LIG_FHA_1	114	120	PF00498	0.584
LIG_FHA_1	36	42	PF00498	0.295
LIG_FHA_1	43	49	PF00498	0.347
LIG_FHA_1	83	89	PF00498	0.696
LIG_GBD_Chelix_1	11	19	PF00786	0.316
LIG_LIR_Gen_1	138	147	PF02991	0.647
LIG_LIR_Gen_1	38	48	PF02991	0.347
LIG_LIR_Nem_3	138	143	PF02991	0.652
LIG_LIR_Nem_3	34	39	PF02991	0.440
LIG_Pex14_1	36	40	PF04695	0.307
LIG_SH2_PTP2	40	43	PF00017	0.403
LIG_SH2_STAT5	30	33	PF00017	0.510
LIG_SH2_STAT5	40	43	PF00017	0.467
LIG_SH2_STAT5	57	60	PF00017	0.351
LIG_SH3_3	21	27	PF00018	0.312
LIG_SH3_3	40	46	PF00018	0.365
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.316
LIG_SUMO_SIM_anti_2	87	92	PF11976	0.613
LIG_TYR_ITSM	36	43	PF00017	0.332
LIG_WRC_WIRS_1	137	142	PF05994	0.599
MOD_CDC14_SPxK_1	131	134	PF00782	0.641
MOD_CDK_SPxK_1	128	134	PF00069	0.634
MOD_CDK_SPxxK_3	141	148	PF00069	0.638
MOD_CK1_1	138	144	PF00069	0.680
MOD_CK1_1	14	20	PF00069	0.463
MOD_CK1_1	69	75	PF00069	0.637
MOD_CK2_1	136	142	PF00069	0.616
MOD_CK2_1	69	75	PF00069	0.608
MOD_GlcNHglycan	2	5	PF01048	0.424
MOD_GSK3_1	31	38	PF00069	0.434
MOD_GSK3_1	65	72	PF00069	0.644
MOD_GSK3_1	82	89	PF00069	0.662
MOD_NEK2_1	19	24	PF00069	0.366
MOD_NEK2_1	35	40	PF00069	0.417
MOD_Plk_1	86	92	PF00069	0.644
MOD_Plk_4	11	17	PF00069	0.264
MOD_Plk_4	114	120	PF00069	0.645
MOD_Plk_4	31	37	PF00069	0.407
MOD_Plk_4	66	72	PF00069	0.666
MOD_Plk_4	86	92	PF00069	0.502
MOD_ProDKin_1	128	134	PF00069	0.679
MOD_ProDKin_1	141	147	PF00069	0.616
MOD_ProDKin_1	42	48	PF00069	0.347
MOD_SUMO_for_1	105	108	PF00179	0.644
TRG_ENDOCYTIC_2	137	140	PF00928	0.663
TRG_ENDOCYTIC_2	40	43	PF00928	0.403
TRG_ENDOCYTIC_2	57	60	PF00928	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJI6	Leptomonas seymouri	62%	100%
A0A1X0P639	Trypanosomatidae	36%	100%
A4HMK5	Leishmania braziliensis	67%	100%
A4IB84	Leishmania infantum	100%	100%
C9ZZK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AF05	Leishmania major	93%	100%
E9B661	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BHZ7	Trypanosoma cruzi	45%	99%