Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IM39_LEIDO

TriTrypDb:

LdBPK_231010.1 , LdCL_230016700 , LDHU3_23.1360

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 0
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IM39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.486
CLV_C14_Caspase3-7	376	380	PF00656	0.722
CLV_NRD_NRD_1	224	226	PF00675	0.691
CLV_PCSK_KEX2_1	224	226	PF00082	0.691
CLV_PCSK_KEX2_1	409	411	PF00082	0.523
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.523
CLV_PCSK_SKI1_1	109	113	PF00082	0.734
CLV_PCSK_SKI1_1	13	17	PF00082	0.729
CLV_PCSK_SKI1_1	188	192	PF00082	0.582
CLV_Separin_Metazoa	153	157	PF03568	0.526
DEG_APCC_DBOX_1	12	20	PF00400	0.660
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DEG_SPOP_SBC_1	91	95	PF00917	0.529
DOC_CKS1_1	227	232	PF01111	0.554
DOC_CYCLIN_RxL_1	185	195	PF00134	0.402
DOC_MAPK_DCC_7	109	118	PF00069	0.532
DOC_MAPK_FxFP_2	370	373	PF00069	0.731
DOC_MAPK_gen_1	204	213	PF00069	0.467
DOC_MAPK_HePTP_8	10	22	PF00069	0.566
DOC_MAPK_HePTP_8	106	118	PF00069	0.533
DOC_MAPK_MEF2A_6	109	118	PF00069	0.532
DOC_MAPK_MEF2A_6	13	22	PF00069	0.660
DOC_MAPK_MEF2A_6	204	213	PF00069	0.467
DOC_MAPK_NFAT4_5	13	21	PF00069	0.661
DOC_PP1_RVXF_1	186	192	PF00149	0.431
DOC_PP2B_PxIxI_1	113	119	PF00149	0.524
DOC_PP4_FxxP_1	191	194	PF00568	0.441
DOC_PP4_FxxP_1	370	373	PF00568	0.731
DOC_PP4_FxxP_1	414	417	PF00568	0.727
DOC_USP7_MATH_1	137	141	PF00917	0.549
DOC_USP7_MATH_1	293	297	PF00917	0.428
DOC_USP7_MATH_1	373	377	PF00917	0.778
DOC_USP7_MATH_1	380	384	PF00917	0.689
DOC_USP7_MATH_1	50	54	PF00917	0.621
DOC_WW_Pin1_4	116	121	PF00397	0.513
DOC_WW_Pin1_4	226	231	PF00397	0.484
DOC_WW_Pin1_4	25	30	PF00397	0.663
DOC_WW_Pin1_4	40	45	PF00397	0.565
LIG_14-3-3_CanoR_1	197	203	PF00244	0.451
LIG_14-3-3_CanoR_1	299	307	PF00244	0.571
LIG_14-3-3_CanoR_1	410	415	PF00244	0.704
LIG_Actin_WH2_2	231	247	PF00022	0.488
LIG_APCC_ABBA_1	392	397	PF00400	0.719
LIG_BRCT_BRCA1_1	366	370	PF00533	0.751
LIG_BRCT_BRCA1_1	400	404	PF00533	0.719
LIG_eIF4E_1	11	17	PF01652	0.661
LIG_eIF4E_1	185	191	PF01652	0.413
LIG_FHA_1	1	7	PF00498	0.622
LIG_FHA_1	172	178	PF00498	0.516
LIG_FHA_1	182	188	PF00498	0.382
LIG_FHA_1	227	233	PF00498	0.557
LIG_FHA_1	285	291	PF00498	0.440
LIG_FHA_1	306	312	PF00498	0.523
LIG_FHA_1	64	70	PF00498	0.559
LIG_FHA_1	73	79	PF00498	0.564
LIG_FHA_1	94	100	PF00498	0.609
LIG_FHA_2	131	137	PF00498	0.485
LIG_FHA_2	366	372	PF00498	0.819
LIG_LIR_Apic_2	36	42	PF02991	0.672
LIG_LIR_Apic_2	367	373	PF02991	0.729
LIG_LIR_Apic_2	411	417	PF02991	0.717
LIG_LIR_Gen_1	163	172	PF02991	0.514
LIG_LIR_Gen_1	305	311	PF02991	0.516
LIG_LIR_Gen_1	401	412	PF02991	0.721
LIG_LIR_Gen_1	54	65	PF02991	0.509
LIG_LIR_Nem_3	163	169	PF02991	0.515
LIG_LIR_Nem_3	401	407	PF02991	0.720
LIG_MLH1_MIPbox_1	400	404	PF16413	0.719
LIG_NRBOX	15	21	PF00104	0.660
LIG_PCNA_yPIPBox_3	4	13	PF02747	0.579
LIG_PTB_Apo_2	179	186	PF02174	0.550
LIG_PTB_Phospho_1	179	185	PF10480	0.548
LIG_SH2_CRK	158	162	PF00017	0.514
LIG_SH2_CRK	166	170	PF00017	0.427
LIG_SH2_CRK	39	43	PF00017	0.674
LIG_SH2_NCK_1	11	15	PF00017	0.564
LIG_SH2_NCK_1	166	170	PF00017	0.516
LIG_SH2_NCK_1	39	43	PF00017	0.674
LIG_SH2_STAP1	11	15	PF00017	0.659
LIG_SH2_STAP1	278	282	PF00017	0.470
LIG_SH2_STAP1	307	311	PF00017	0.589
LIG_SH2_STAT3	395	398	PF00017	0.718
LIG_SH2_STAT5	178	181	PF00017	0.561
LIG_SH2_STAT5	307	310	PF00017	0.534
LIG_SH2_STAT5	354	357	PF00017	0.701
LIG_SH2_STAT5	403	406	PF00017	0.723
LIG_SH3_3	108	114	PF00018	0.535
LIG_SH3_3	166	172	PF00018	0.515
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.457
LIG_SUMO_SIM_par_1	15	21	PF11976	0.656
LIG_SUMO_SIM_par_1	254	259	PF11976	0.512
LIG_TRAF2_1	119	122	PF00917	0.503
MOD_CK1_1	138	144	PF00069	0.603
MOD_CK1_1	192	198	PF00069	0.518
MOD_CK1_1	25	31	PF00069	0.725
MOD_CK1_1	297	303	PF00069	0.570
MOD_CK1_1	51	57	PF00069	0.524
MOD_CK1_1	95	101	PF00069	0.534
MOD_CK2_1	116	122	PF00069	0.512
MOD_GlcNHglycan	101	104	PF01048	0.815
MOD_GlcNHglycan	169	172	PF01048	0.707
MOD_GlcNHglycan	191	194	PF01048	0.732
MOD_GlcNHglycan	50	53	PF01048	0.823
MOD_GSK3_1	128	135	PF00069	0.553
MOD_GSK3_1	137	144	PF00069	0.513
MOD_GSK3_1	167	174	PF00069	0.511
MOD_GSK3_1	18	25	PF00069	0.589
MOD_GSK3_1	192	199	PF00069	0.452
MOD_GSK3_1	273	280	PF00069	0.490
MOD_GSK3_1	284	291	PF00069	0.453
MOD_GSK3_1	293	300	PF00069	0.420
MOD_GSK3_1	360	367	PF00069	0.803
MOD_GSK3_1	408	415	PF00069	0.744
MOD_GSK3_1	90	97	PF00069	0.622
MOD_N-GLC_1	181	186	PF02516	0.741
MOD_N-GLC_1	207	212	PF02516	0.665
MOD_N-GLC_1	285	290	PF02516	0.745
MOD_N-GLC_1	361	366	PF02516	0.536
MOD_N-GLC_1	398	403	PF02516	0.519
MOD_NEK2_1	165	170	PF00069	0.601
MOD_NEK2_1	18	23	PF00069	0.564
MOD_NEK2_1	220	225	PF00069	0.574
MOD_NEK2_1	284	289	PF00069	0.462
MOD_NEK2_1	294	299	PF00069	0.453
MOD_NEK2_1	412	417	PF00069	0.724
MOD_NEK2_1	74	79	PF00069	0.582
MOD_NEK2_1	99	104	PF00069	0.521
MOD_PIKK_1	130	136	PF00454	0.499
MOD_PIKK_1	141	147	PF00454	0.585
MOD_PKA_2	196	202	PF00069	0.442
MOD_PKA_2	298	304	PF00069	0.507
MOD_Plk_1	135	141	PF00069	0.549
MOD_Plk_1	181	187	PF00069	0.537
MOD_Plk_1	207	213	PF00069	0.460
MOD_Plk_1	256	262	PF00069	0.512
MOD_Plk_1	314	320	PF00069	0.493
MOD_Plk_1	365	371	PF00069	0.726
MOD_Plk_1	380	386	PF00069	0.616
MOD_Plk_1	398	404	PF00069	0.597
MOD_Plk_4	18	24	PF00069	0.645
MOD_Plk_4	209	215	PF00069	0.423
MOD_Plk_4	306	312	PF00069	0.492
MOD_Plk_4	314	320	PF00069	0.443
MOD_ProDKin_1	116	122	PF00069	0.512
MOD_ProDKin_1	226	232	PF00069	0.482
MOD_ProDKin_1	25	31	PF00069	0.668
MOD_ProDKin_1	40	46	PF00069	0.566
MOD_SUMO_rev_2	239	247	PF00179	0.504
TRG_DiLeu_BaEn_2	174	180	PF01217	0.497
TRG_ENDOCYTIC_2	166	169	PF00928	0.482
TRG_ENDOCYTIC_2	307	310	PF00928	0.499
TRG_ER_diArg_1	224	226	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HCV4	Leishmania braziliensis	44%	100%
A4I0D5	Leishmania infantum	99%	100%