WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IM25_LEIDO

TriTrypDb:

LdBPK_230790.1 , LdCL_230014400 , LDHU3_23.1080

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IM25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM25

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	547	551	PF00656	0.539
CLV_C14_Caspase3-7	650	654	PF00656	0.600
CLV_MEL_PAP_1	109	115	PF00089	0.344
CLV_NRD_NRD_1	26	28	PF00675	0.578
CLV_NRD_NRD_1	440	442	PF00675	0.276
CLV_NRD_NRD_1	482	484	PF00675	0.482
CLV_NRD_NRD_1	494	496	PF00675	0.466
CLV_NRD_NRD_1	540	542	PF00675	0.510
CLV_NRD_NRD_1	641	643	PF00675	0.711
CLV_NRD_NRD_1	74	76	PF00675	0.433
CLV_PCSK_KEX2_1	129	131	PF00082	0.484
CLV_PCSK_KEX2_1	39	41	PF00082	0.512
CLV_PCSK_KEX2_1	470	472	PF00082	0.607
CLV_PCSK_KEX2_1	494	496	PF00082	0.498
CLV_PCSK_KEX2_1	640	642	PF00082	0.699
CLV_PCSK_KEX2_1	676	678	PF00082	0.539
CLV_PCSK_KEX2_1	73	75	PF00082	0.455
CLV_PCSK_KEX2_1	84	86	PF00082	0.435
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.484
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.503
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.595
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.634
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.497
CLV_PCSK_PC7_1	70	76	PF00082	0.481
CLV_PCSK_PC7_1	80	86	PF00082	0.380
CLV_PCSK_SKI1_1	228	232	PF00082	0.318
CLV_PCSK_SKI1_1	317	321	PF00082	0.352
CLV_PCSK_SKI1_1	371	375	PF00082	0.374
CLV_PCSK_SKI1_1	412	416	PF00082	0.360
CLV_PCSK_SKI1_1	444	448	PF00082	0.331
CLV_PCSK_SKI1_1	529	533	PF00082	0.559
CLV_PCSK_SKI1_1	542	546	PF00082	0.563
CLV_PCSK_SKI1_1	59	63	PF00082	0.461
CLV_PCSK_SKI1_1	601	605	PF00082	0.603
CLV_PCSK_SKI1_1	608	612	PF00082	0.581
CLV_PCSK_SKI1_1	676	680	PF00082	0.597
CLV_PCSK_SKI1_1	85	89	PF00082	0.532
DEG_SPOP_SBC_1	2	6	PF00917	0.664
DEG_SPOP_SBC_1	233	237	PF00917	0.393
DOC_CYCLIN_RxL_1	601	613	PF00134	0.377
DOC_MAPK_gen_1	129	135	PF00069	0.367
DOC_MAPK_gen_1	178	187	PF00069	0.417
DOC_MAPK_gen_1	601	611	PF00069	0.457
DOC_PP1_RVXF_1	140	146	PF00149	0.312
DOC_PP2B_LxvP_1	417	420	PF13499	0.294
DOC_PP2B_LxvP_1	633	636	PF13499	0.549
DOC_PP4_FxxP_1	288	291	PF00568	0.382
DOC_USP7_MATH_1	233	237	PF00917	0.357
DOC_USP7_MATH_1	3	7	PF00917	0.807
DOC_USP7_MATH_1	377	381	PF00917	0.471
DOC_USP7_MATH_1	496	500	PF00917	0.565
DOC_USP7_MATH_1	597	601	PF00917	0.707
DOC_USP7_UBL2_3	523	527	PF12436	0.639
DOC_USP7_UBL2_3	545	549	PF12436	0.586
DOC_USP7_UBL2_3	554	558	PF12436	0.580
DOC_USP7_UBL2_3	604	608	PF12436	0.631
DOC_USP7_UBL2_3	84	88	PF12436	0.540
DOC_WW_Pin1_4	287	292	PF00397	0.316
DOC_WW_Pin1_4	378	383	PF00397	0.446
LIG_14-3-3_CanoR_1	10	14	PF00244	0.535
LIG_14-3-3_CanoR_1	112	118	PF00244	0.398
LIG_14-3-3_CanoR_1	130	134	PF00244	0.370
LIG_14-3-3_CanoR_1	165	170	PF00244	0.492
LIG_14-3-3_CanoR_1	180	188	PF00244	0.488
LIG_14-3-3_CanoR_1	317	323	PF00244	0.465
LIG_14-3-3_CanoR_1	334	340	PF00244	0.374
LIG_14-3-3_CanoR_1	412	418	PF00244	0.294
LIG_14-3-3_CanoR_1	495	501	PF00244	0.638
LIG_14-3-3_CanoR_1	556	562	PF00244	0.558
LIG_14-3-3_CanoR_1	59	67	PF00244	0.462
LIG_14-3-3_CanoR_1	642	648	PF00244	0.545
LIG_APCC_ABBA_1	399	404	PF00400	0.318
LIG_APCC_ABBAyCdc20_2	579	585	PF00400	0.612
LIG_BRCT_BRCA1_1	410	414	PF00533	0.276
LIG_CSL_BTD_1	288	291	PF09270	0.304
LIG_FHA_1	148	154	PF00498	0.327
LIG_FHA_1	263	269	PF00498	0.478
LIG_FHA_1	277	283	PF00498	0.308
LIG_FHA_1	3	9	PF00498	0.591
LIG_FHA_1	348	354	PF00498	0.315
LIG_FHA_1	39	45	PF00498	0.466
LIG_FHA_1	413	419	PF00498	0.355
LIG_FHA_1	445	451	PF00498	0.349
LIG_FHA_1	504	510	PF00498	0.654
LIG_FHA_1	526	532	PF00498	0.566
LIG_FHA_1	591	597	PF00498	0.568
LIG_FHA_1	62	68	PF00498	0.584
LIG_FHA_1	98	104	PF00498	0.573
LIG_FHA_2	247	253	PF00498	0.414
LIG_FHA_2	290	296	PF00498	0.467
LIG_FHA_2	336	342	PF00498	0.490
LIG_GBD_Chelix_1	445	453	PF00786	0.276
LIG_GBD_Chelix_1	617	625	PF00786	0.570
LIG_Integrin_isoDGR_2	315	317	PF01839	0.240
LIG_IRF3_LxIS_1	348	354	PF10401	0.382
LIG_LIR_Apic_2	428	434	PF02991	0.294
LIG_LIR_Gen_1	236	247	PF02991	0.366
LIG_LIR_Gen_1	345	353	PF02991	0.336
LIG_LIR_Gen_1	380	390	PF02991	0.357
LIG_LIR_Gen_1	411	420	PF02991	0.276
LIG_LIR_Nem_3	241	247	PF02991	0.427
LIG_LIR_Nem_3	345	351	PF02991	0.363
LIG_LIR_Nem_3	380	386	PF02991	0.385
LIG_LIR_Nem_3	411	417	PF02991	0.294
LIG_NRP_CendR_1	677	680	PF00754	0.601
LIG_Pex14_1	370	374	PF04695	0.360
LIG_PTB_Apo_2	423	430	PF02174	0.276
LIG_SH2_CRK	131	135	PF00017	0.500
LIG_SH2_CRK	390	394	PF00017	0.276
LIG_SH2_CRK	431	435	PF00017	0.294
LIG_SH2_GRB2like	431	434	PF00017	0.294
LIG_SH2_SRC	244	247	PF00017	0.406
LIG_SH2_SRC	431	434	PF00017	0.294
LIG_SH2_STAP1	131	135	PF00017	0.386
LIG_SH2_STAP1	342	346	PF00017	0.382
LIG_SH2_STAP1	583	587	PF00017	0.641
LIG_SH2_STAP1	631	635	PF00017	0.604
LIG_SH2_STAT5	204	207	PF00017	0.342
LIG_SH2_STAT5	225	228	PF00017	0.368
LIG_SH2_STAT5	244	247	PF00017	0.233
LIG_SH3_3	290	296	PF00018	0.356
LIG_SH3_3	376	382	PF00018	0.391
LIG_SUMO_SIM_par_1	349	357	PF11976	0.321
LIG_TRAF2_1	249	252	PF00917	0.408
LIG_TRAF2_1	338	341	PF00917	0.380
LIG_TRAF2_1	533	536	PF00917	0.652
LIG_TYR_ITIM	388	393	PF00017	0.276
LIG_UBA3_1	297	304	PF00899	0.534
MOD_CDK_SPxxK_3	378	385	PF00069	0.442
MOD_CK1_1	237	243	PF00069	0.397
MOD_CK1_1	347	353	PF00069	0.452
MOD_CK1_1	354	360	PF00069	0.458
MOD_CK1_1	557	563	PF00069	0.554
MOD_CK1_1	6	12	PF00069	0.812
MOD_CK2_1	246	252	PF00069	0.372
MOD_CK2_1	335	341	PF00069	0.451
MOD_CK2_1	496	502	PF00069	0.588
MOD_CK2_1	530	536	PF00069	0.563
MOD_CK2_1	660	666	PF00069	0.630
MOD_GlcNHglycan	119	122	PF01048	0.475
MOD_GlcNHglycan	421	424	PF01048	0.342
MOD_GlcNHglycan	550	553	PF01048	0.556
MOD_GlcNHglycan	662	665	PF01048	0.620
MOD_GSK3_1	143	150	PF00069	0.317
MOD_GSK3_1	2	9	PF00069	0.658
MOD_GSK3_1	202	209	PF00069	0.423
MOD_GSK3_1	233	240	PF00069	0.334
MOD_GSK3_1	347	354	PF00069	0.335
MOD_GSK3_1	408	415	PF00069	0.355
MOD_GSK3_1	557	564	PF00069	0.551
MOD_GSK3_1	643	650	PF00069	0.674
MOD_LATS_1	410	416	PF00433	0.355
MOD_N-GLC_1	147	152	PF02516	0.318
MOD_NEK2_1	147	152	PF00069	0.337
MOD_NEK2_1	232	237	PF00069	0.387
MOD_NEK2_1	245	250	PF00069	0.311
MOD_NEK2_1	318	323	PF00069	0.465
MOD_NEK2_1	351	356	PF00069	0.447
MOD_NEK2_1	561	566	PF00069	0.544
MOD_NEK2_1	643	648	PF00069	0.663
MOD_PIKK_1	111	117	PF00454	0.404
MOD_PIKK_1	123	129	PF00454	0.385
MOD_PIKK_1	172	178	PF00454	0.381
MOD_PIKK_1	9	15	PF00454	0.534
MOD_PKA_1	129	135	PF00069	0.497
MOD_PKA_1	27	33	PF00069	0.577
MOD_PKA_1	494	500	PF00069	0.616
MOD_PKA_1	548	554	PF00069	0.560
MOD_PKA_2	111	117	PF00069	0.404
MOD_PKA_2	129	135	PF00069	0.365
MOD_PKA_2	179	185	PF00069	0.467
MOD_PKA_2	494	500	PF00069	0.641
MOD_PKA_2	561	567	PF00069	0.539
MOD_PKA_2	659	665	PF00069	0.660
MOD_PKA_2	9	15	PF00069	0.768
MOD_Plk_1	143	149	PF00069	0.360
MOD_Plk_1	188	194	PF00069	0.312
MOD_Plk_2-3	38	44	PF00069	0.459
MOD_Plk_2-3	456	462	PF00069	0.276
MOD_Plk_4	129	135	PF00069	0.497
MOD_Plk_4	289	295	PF00069	0.391
MOD_Plk_4	354	360	PF00069	0.269
MOD_Plk_4	413	419	PF00069	0.276
MOD_ProDKin_1	287	293	PF00069	0.323
MOD_ProDKin_1	378	384	PF00069	0.439
MOD_SUMO_for_1	44	47	PF00179	0.517
MOD_SUMO_rev_2	47	56	PF00179	0.608
MOD_SUMO_rev_2	524	533	PF00179	0.560
MOD_SUMO_rev_2	536	544	PF00179	0.505
TRG_DiLeu_BaEn_1	32	37	PF01217	0.509
TRG_DiLeu_BaEn_4	591	597	PF01217	0.653
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.498
TRG_ENDOCYTIC_2	131	134	PF00928	0.389
TRG_ENDOCYTIC_2	239	242	PF00928	0.375
TRG_ENDOCYTIC_2	244	247	PF00928	0.338
TRG_ENDOCYTIC_2	383	386	PF00928	0.306
TRG_ENDOCYTIC_2	390	393	PF00928	0.319
TRG_ENDOCYTIC_2	92	95	PF00928	0.583
TRG_ER_diArg_1	493	495	PF00400	0.584
TRG_ER_diArg_1	640	642	PF00400	0.686
TRG_ER_diArg_1	67	70	PF00400	0.498
TRG_ER_diArg_1	73	75	PF00400	0.508
TRG_NLS_Bipartite_1	470	487	PF00514	0.570
TRG_NLS_MonoExtN_4	480	487	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ4	Leptomonas seymouri	81%	100%
A0A0S4IXY1	Bodo saltans	68%	100%
A0A1X0NYJ7	Trypanosomatidae	72%	100%
A0A3S5IR25	Trypanosoma rangeli	69%	100%
A4H6H1	Leishmania braziliensis	89%	100%
A4I0B3	Leishmania infantum	99%	100%
C9ZV23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AW77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q9NF84	Leishmania major	96%	100%